Sarah Knox, PhD
Professor
Cell and Tissue Biology
School of Dentistry

Education & Training

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• Post-doctoral Fellow Laboratory of Cell and Developmental Biology NIDCR 2011
• PhD Biomedical Engineering University of NSW 2002

Websites

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• SlideShare (slideshare.net)

Grants and Projects

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• Lacritin Regulation of Homeostasis and Ocular Surface Health, NIH, 2021-2026
• Defining mechanisms driving dry eye disease progression, NIH, 2021-2026
• Defining mechanisms driving salivary gland regeneration, NIH, 2018-2026
• Autonomic regulation of lacrimal stem cells, NIH, 2017-2021
• Defining the role of the nervous system in aqueous-deficient dry eye, NIH, 2015-2021
• Defining the role of immune-neuronal crosstalk in dry eye disease, NIH, 2016-2020
• 2018 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar, NIH, 2019-2020
• Neuronal regulation of salivary stem cells, NIH, 2014-2018
• Impact of aging on salivary stem cells and organ regeneration, NIH, 2016-2018
• 2016 Proteoglycans Gordon Research Conference & Gordon Research Seminar, NIH, 2016-2017
• Neuronal-epithelial interactions that regulate mouse salivary gland development, NIH, 2012-2015
• Salivary gland repair and regeneration via Schwann cell-nerve interactions, NIH, 2012-2015

Publications (35)

Top publication keywords:
MorphogenesisNeuregulinsSubmandibular GlandSalivary DuctsOrganogenesisTearsSalivary GlandsLacrimal ApparatusSOXB1 Transcription FactorsGanglia, ParasympatheticAutoimmunityRadiation InjuriesAcinar CellsDry Eye SyndromesRegeneration

• The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice.
  Cells 2023 Delcroix V, Mauduit O, Lee HS, Ivanova A, Umazume T, Knox SM, de Paiva CS, Dartt DA, Makarenkova HP
• Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel.
  Science advances 2022 Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, Cruz Pacheco N, Chang JC, Jeon O, Lombaert IMA, May AJ, Alsberg E, Bahney CS, Knox SM
• Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling.
  Developmental cell 2022 May AJ, Mattingly AJ, Gaylord EA, Griffin N, Sudiwala S, Cruz-Pacheco N, Emmerson E, Mohabbat S, Nathan S, Sinada H, Lombaert IMA, Knox SM
• A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.
  Cell reports 2022 Efraim Y, Chen FYT, Cheong KN, Gaylord EA, McNamara NA, Knox SM
• A mechanism of gene evolution generating mucin function.
  Science advances 2022 Pajic P, Shen S, Qu J, May AJ, Knox S, Ruhl S, Gokcumen O

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• Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
  PNAS nexus 2022 Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, …
• Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis.
  International forum of allergy & rhinology 2021 Nnabue OE, Pletcher SD, Gurrola JG, Goldberg AN, Jordan KM, Knox SM, May AJ
• Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.
  Cell reports 2020 Saitou M, Gaylord EA, Xu E, May AJ, Neznanova L, Nathan S, Grawe A, Chang J, Ryan W, Ruhl S, Knox SM, Gokcumen O
• Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease.
  Journal of autoimmunity 2020 Efraim Y, Chen FYT, Stashko C, Cheong KN, Gaylord E, McNamara N, Knox SM
• 2155-P: Peripheral Nervous System Innervation of the Developing Pancreas.
  Diabetes 2019 SEAN DE LA O, LAUREN BYRNES, DANIEL M. WONG, SARAH KNOX, JULIE B. SNEDDON
• The emerging role of cranial nerves in shaping craniofacial development.
  Genesis (New York, N.Y. : 2000) 2019 Sudiwala S, Knox SM
• Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome.
  International journal of molecular sciences 2018 Chen FY, Gaylord E, McNamara N, Knox S
• Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.
  Development (Cambridge, England) 2018 May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM
• Lineage dynamics of murine pancreatic development at single-cell resolution.
  Nature communications 2018 Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB
• Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-…
• Salivary gland stem cells: A review of development, regeneration and cancer.
  Genesis (New York, N.Y. : 2000) 2018 Emmerson E, Knox SM
• Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement.
  EMBO molecular medicine 2018 Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM
• Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.
  PloS one 2017 Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA
• SOX2 regulates acinar cell development in the salivary gland.
  eLife 2017 Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM
• Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands.
  Scientific reports 2017 Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO
• Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
  Development (Cambridge, England) 2017 Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM
• miR-205 is a critical regulator of lacrimal gland development.
  Developmental biology 2017 Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT
• Salivary gland development and disease.
  Wiley interdisciplinary reviews. Developmental biology 2015 Mattingly A, Finley JK, Knox SM
• Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.
  Developmental cell 2015 Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP
• Manipulating the Murine Lacrimal Gland.
  Journal of Visualized Experiments 2014 Jennifer K. Finley, D'Juan Farmer, Elaine Emmerson, Noel Cruz Pacheco, Sarah M. Knox
• Manipulating the murine lacrimal gland.
  Journal of visualized experiments : JoVE 2014 Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM
• Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
  Developmental cell 2014 Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM
• The society of craniofacial genetics and developmental biology 35th annual meeting.
  American Journal of Medical Genetics Part A 2013 Ophir D. Klein, Jeffrey O. Bush, Sarah M. Knox, Andrew H. Jheon, Dwight R. Cordero, Joan T. Richtsmeier
• Parasympathetic stimulation improves epithelial organ regeneration.
  Nature communications 2013 Knox SM, Lombaert IM, Haddox CL, Abrams SR, Cotrim A, Wilson AJ, Hoffman MP
• Salivary gland organogenesis.
  Wiley interdisciplinary reviews. Developmental biology 2011 Knosp WM, Knox SM, Hoffman MP
• Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration.
  Oral diseases 2011 Lombaert IM, Knox SM, Hoffman MP
• Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.
  Science (New York, N.Y.) 2010 Knox SM, Lombaert IM, Reed X, Vitale-Cross L, Gutkind JS, Hoffman MP
• Recombinant heparan sulfate for use in tissue engineering applications.
  Journal of Chemical Technology & Biotechnology 2008 John Whitelock, J Leo, Neil Davies, Natasja Nielsen, Christine Chuang, Martin Rees, Renato V Iozzo, Sarah Knox, Megan Lord
• Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
  Development (Cambridge, England) 2007 Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP
• The function of a Drosophila glypican does not depend entirely on heparan sulfate modification.
  Developmental biology 2006 Kirkpatrick CA, Knox SM, Staatz WD, Fox B, Lercher DM, Selleck SB