Sarah Kaufman, MD, PhD
Assistant Professor
Neurology
School of Medicine

Grants and Projects

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• Elucidating the Mechanisms that Underlie Tau Aggregation and Neurotoxicity, NIH, 2025-2030
• Investigating the Propagation and Pattern of Spread of Unique Tau Strains, NIH, 2014-2018

Publications (13)

Top publication keywords:
Entorhinal CortexPrion ProteinsTemporal LobeVisual CortexFixativesTauopathiesBrainFormaldehydeGlypicansTissue Fixationtau ProteinsChronic Traumatic EncephalopathyPrionsNeurodegenerative DiseasesAlzheimer Disease

• β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.
  Molecular neurodegeneration 2025 Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Miller BL, Condello C, …
• Acute Cerebrovascular Accident, Renal Failure, and Thrombotic Microangiopathy in a 27-Year-Old Male With Malignant Hypertension.
  Clinical case reports 2025 Gusan T, Hong A, Kaufman S, Santiago L, Zaher N
• β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.
  bioRxiv : the preprint server for biology 2025 Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Condello C, Kampmann M, …
• Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer's Disease.
  Journal of Alzheimer's disease : JAD 2024 Del Tredici K, Schön M, Feldengut S, Ghebremedhin E, Kaufman SK, Wiesner D, Roselli F, Mayer B, Amunts K, Braak H
• Tau seeding in chronic traumatic encephalopathy parallels disease severity.
  Acta neuropathologica 2021 Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI

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• Rebuttal to Drs. Grinberg and Heinsen.
  Acta neuropathologica 2018 Kaufman SK, Del Tredici K, Braak H, Diamond MI
• Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART.
  Acta neuropathologica 2018 Kaufman SK, Del Tredici K, Thomas TL, Braak H, Diamond MI
• Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue.
  Acta neuropathologica communications 2017 Kaufman SK, Thomas TL, Del Tredici K, Braak H, Diamond MI
• Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.
  Neuron 2016 Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI
• Prions and Protein Assemblies that Convey Biological Information in Health and Disease.
  Neuron 2016 Sanders DW, Kaufman SK, Holmes BB, Diamond MI
• Distinct tau prion strains propagate in cells and mice and define different tauopathies.
  Neuron 2014 Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI
• Prion-like propagation of protein aggregation and related therapeutic strategies.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013 Kaufman SK, Diamond MI
• Effects of sildenafil on nigrostriatal dopamine neurons in a murine model of Parkinson's disease.
  Journal of Alzheimer's disease : JAD 2008 Janis KL, Brennan RT, Drolet RE, Behrouz B, Kaufman SK, Lookingland KJ, Goudreau JL