Sara Nolbrant, PhD, MS
Employee of Affiliated Org.
Neurology
School of Medicine

Publications (17)

Top publication keywords:
Cellular ReprogrammingHepatocyte Nuclear Factor 3-betaDopaminergic NeuronsEmbryonic Stem CellsDyskinesia, Drug-InducedCell DifferentiationStem Cell TransplantationParkinson DiseaseMesencephalonHuman Embryonic Stem CellsFetal Stem CellsTyrosine 3-MonooxygenaseNeural Stem CellsNeurogliaGuanine Nucleotide Exchange Factors

• Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo.
  Molecular therapy. Methods & clinical development 2023 Rájová J, Davidsson M, Avallone M, Hartnor M, Aldrin-Kirk P, Cardoso T, Nolbrant S, Mollbrink A, Storm P, Heuer A, Parmar M, Björklund T
• Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery.
  Nature communications 2022 Alekseenko Z, Dias JM, Adler AF, Kozhevnikova M, van Lunteren JA, Nolbrant S, Jeggari A, Vasylovska S, Yoshitake T, Kehr J, Carlén M, Alexeyenko A, Parmar M, Ericson J
• Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia.
  Journal of Parkinson's disease 2022 Elabi OF, Pass R, Sormonta I, Nolbrant S, Drummond N, Kirkeby A, Kunath T, Parmar M, Lane EL
• A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants.
  Stem cell reports 2021 Aldrin-Kirk P, Åkerblom M, Cardoso T, Nolbrant S, Adler AF, Liu X, Heuer A, Davidsson M, Parmar M, Björklund T
• Neural tube patterning: from a minimal model for rostrocaudal patterning toward an integrated 3D model.
  iScience 2021 Brambach M, Ernst A, Nolbrant S, Drouin-Ouellet J, Kirkeby A, Parmar M, Olariu V

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• Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons.
  Stem cell reports 2020 Nolbrant S, Giacomoni J, Hoban DB, Bruzelius A, Birtele M, Chandler-Militello D, Pereira M, Ottosson DR, Goldman SA, Parmar M
• Author Correction: Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.
  Nature communications 2020 Tiklová K, Nolbrant S, Fiorenzano A, Björklund ÅK, Sharma Y, Heuer A, Gillberg L, Hoban DB, Cardoso T, Adler AF, Birtele M, Lundén-Miguel H, Volakakis N, Kirkeby A, Perlmann T, Parmar M
• Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.
  Nature communications 2020 Tiklová K, Nolbrant S, Fiorenzano A, Björklund ÅK, Sharma Y, Heuer A, Gillberg L, Hoban DB, Cardoso T, Adler AF, Birtele M, Lundén-Miguel H, Volakakis N, Kirkeby A, Perlmann T, Parmar M
• Profiling of lincRNAs in human pluripotent stem cell derived forebrain neural progenitor cells.
  Heliyon 2019 Grassi DA, Brattås PL, Jönsson ME, Atacho D, Karlsson O, Nolbrant S, Parmar M, Jakobsson J
• A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Davidsson M, Wang G, Aldrin-Kirk P, Cardoso T, Nolbrant S, Hartnor M, Mudannayake J, Parmar M, Björklund T
• hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease.
  Cell reports 2019 Adler AF, Cardoso T, Nolbrant S, Mattsson B, Hoban DB, Jarl U, Wahlestedt JN, Grealish S, Björklund A, Parmar M
• Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.
  Nature communications 2019 Tiklová K, Björklund ÅK, Lahti L, Fiorenzano A, Nolbrant S, Gillberg L, Volakakis N, Yokota C, Hilscher MM, Hauling T, Holmström F, Joodmardi E, Nilsson M, Parmar M, Perlmann T
• Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats.
  The Journal of comparative neurology 2018 Cardoso T, Adler AF, Mattsson B, Hoban DB, Nolbrant S, Wahlestedt JN, Kirkeby A, Grealish S, Björklund A, Parmar M
• Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation.
  Nature protocols 2017 Nolbrant S, Heuer A, Parmar M, Kirkeby A
• Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.
  Cell stem cell 2016 Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Ottosson DR, Lelos MJ, Rifes P, Dunnett SB, Grealish S, Perlmann T, Parmar M
• Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.
  Cell stem cell 2016 Kee N, Volakakis N, Kirkeby A, Dahl L, Storvall H, Nolbrant S, Lahti L, Björklund ÅK, Gillberg L, Joodmardi E, Sandberg R, Parmar M, Perlmann T
• The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
  Oncotarget 2016 Prost G, Braun S, Hertwig F, Winkler M, Jagemann L, Nolbrant S, Leefa IV, Offen N, Miharada K, Lang S, Artner I, Nuber UA