Sanjay Kakar, MBBS, MD
Professor
Pathology
School of Medicine

Education & Training

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• M.D. School of Medicine Christian 1992

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Publications (156)

Top publication keywords:
Biomarkers, TumorGlutamate-Ammonia LigaseNeoplasms, Glandular and Epithelialbeta CateninAppendiceal NeoplasmsCarcinoid TumorBile Duct NeoplasmsAdenocarcinomaImmunohistochemistryFocal Nodular HyperplasiaCarcinoma, HepatocellularCholangiocarcinomaNeoplasms, Cystic, Mucinous, and SerousLiver NeoplasmsAdenoma, Liver Cell

• There are benefits of subtyping hepatocellular adenoma also in men - reply.
  Human pathology 2024 González IA, Torbenson M, Kakar S, Jain D
• Severe acute liver disease in adults: Contemporary role of histopathology.
  Histopathology 2024 Clouston AD, Gouw ASH, Tiniakos D, Bedossa P, Brunt EM, Callea F, Dienes HP, Goodman ZD, Hubscher SG, Kakar S, Kleiner DE, Lackner C, Park YN, Roberts EA, Schirmacher P, Terracciano L, Torbenson M, …
• Assessment of large droplet fat in frozen sections of donor liver biopsies: utility and interobserver variability of the newly described Banff method compared to a simplified Average of Fields method.
  Journal of clinical pathology 2024 Kikuchi AT, Akanuma N, Choi WT, Gill RM, Kakar S
• Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma.
  Gastroenterology clinics of North America 2023 Wen KW, Kakar S
• Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease: A 13 Center Correlative Study.
  The American journal of surgical pathology 2023 Patel N, Leffler DA, Al-Toma A, Mulder CJ, Elli L, Gan G, Patil P, Atsawarungruangkit A, Kuijpers KC, Del Gobbo A, Goldsmith J, Hintze Z, Pacheco MC, Vieth M, Melcher B, Salomao M, Pai R, Hart J, …

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• Focal nodular hyperplasia-like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation.
  Human pathology 2023 Umetsu SE, Joseph NM, Cho SJ, Morotti R, Deshpande V, Jain D, Kakar S
• Issues in Assigning the T Category in the Staging of Low-Grade Appendiceal Mucinous Neoplasm and High-Grade Appendiceal Mucinous Neoplasm.
  Archives of pathology & laboratory medicine 2023 Umetsu SE, Kakar S
• CRP Versus SAA for Identification of Inflammatory Hepatic Adenomas.
  Applied immunohistochemistry & molecular morphology : AIMM 2023 Soon GST, Yasir S, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson MS, Chen ZE
• Genomic Analysis in the Categorization of Poorly Differentiated Primary Liver Carcinomas.
  The American journal of surgical pathology 2023 Kikuchi AT, Umetsu S, Joseph N, Kakar S
• Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer.
  CA: a cancer journal for clinicians 2023 Janczewski LM, Browner AE, Cotler JH, Nelson H, Kakar S, Carr NJ, Hanna NN, Holowatyj AN, Goldberg RM, Washington MK, Asare EA, Overman MJ, American Joint Committee on Cancer Expert Panel on Cancers …
• Evaluating Liver Biopsies with Well-Differentiated Hepatocellular Lesions.
  Surgical pathology clinics 2023 Umetsu SE, Kakar S
• Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience.
  Human pathology 2023 González IA, Torbenson M, Sharifai N, Byrnes K, Chatterjee D, Kakar S, Yeh MM, Wu TT, Zhang X, Jain D
• Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
• Influence of progestin-only hormonal use on hepatocellular adenomas: A retrospective cohort study.
  Contraception 2022 Qureshy Z, Lokken RP, Kakar S, Grab J, Mehta N, Sarkar M
• Staging of appendiceal mucinous neoplasms: challenges and recent updates.
  Human pathology 2022 Umetsu SE, Kakar S
• Hepatic Adenomas in Patients 60 and Older Are Enriched for HNF1A Inactivation and Malignant Transformation.
  The American journal of surgical pathology 2022 Yasir S, Chen ZE, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson MS
• Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology.
  Liver international : official journal of the International Association for the Study of the Liver 2022 Lohse AW, Sebode M, Bhathal PS, Clouston AD, Dienes HP, Jain D, Gouw ASH, Guindi M, Kakar S, Kleiner DE, Krech T, Lackner C, Longerich T, Saxena R, Terracciano L, Washington K, Weidemann S, Hübscher …
• Dataset for Pathology Reporting of Colorectal Cancer: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
  Annals of surgery 2022 Loughrey MB, Webster F, Arends MJ, Brown I, Burgart LJ, Cunningham C, Flejou JF, Kakar S, Kirsch R, Kojima M, Lugli A, Rosty C, Sheahan K, West NP, Wilson RH, Nagtegaal ID
• Hepatocellular neoplasms with loss of liver fatty acid binding protein: Clinicopathologic features and molecular profiling.
  Human pathology 2022 Joseph NM, Blank A, Shain AH, Gill RM, Umetsu SE, Shafizadeh N, Torbenson MS, Kakar S
• Pediatric Hepatocellular Adenomas: The Influence of Age and Syndrome on Subtype.
  The American journal of surgical pathology 2021 Pacheco MC, Torbenson MS, Wu TT, Kakar S, Jain D, Yeh MM
• Dataset for the reporting of carcinoma of the exocrine pancreas: recommendations from the International Collaboration on Cancer Reporting (ICCR).
  Histopathology 2021 Verbeke C, Webster F, Brosens L, Campbell F, Del Chiaro M, Esposito I, Feakins RM, Fukushima N, Gill AJ, Kakar S, Kench JG, Krasinskas AM, van Laethem JL, Schaeffer DF, Washington K
• Inhibin-positive hepatic carcinoma: proposal for a solid-tubulocystic variant of intrahepatic cholangiocarcinoma.
  Human pathology 2021 Wen KW, Joseph NM, Srivastava A, Saunders TA, Jain D, Rank J, Feely M, Zarrinpar A, Al Diffalha S, Shyn PB, Graham RP, Drage MG, Kakar S
• Persistent or recurrent Barrett's neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2021 Bowman CJ, Zhang R, Balitzer D, Wang D, Rabinovitch PS, Kovári BP, Mattis AN, Kakar S, Lauwers GY, Choi WT
• Challenges in Diagnosis of Hepatocellular Carcinoma in Cirrhotic Liver: A Pathologist's Perspective.
  Clinical liver disease 2021 Balitzer D, Kakar S
• Improving tumor budding reporting in colorectal cancer: a Delphi consensus study.
  Virchows Archiv : an international journal of pathology 2021 Haddad TS, Lugli A, Aherne S, Barresi V, Terris B, Bokhorst JM, Brockmoeller SF, Cuatrecasas M, Simmer F, El-Zimaity H, Fléjou JF, Gibbons D, Cathomas G, Kirsch R, Kuhlmann TP, Langner C, Loughrey MB,…
• Hans Popper Hepatopathology Society: minisymposium.
  Human pathology 2020 Kakar S
• Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver.
  Human pathology 2020 Cheng L, Jain D, Kakar S, Torbenson MS, Wu TT, Yeh MM
• Spectrum of Hepatic Manifestations of Common Variable Immunodeficiency.
  The American journal of surgical pathology 2020 Crotty R, Taylor MS, Farmer JR, Kakar S, Yilmaz F, Ardeniz Ö, Patil DT, Deshpande V
• Clinicopathological features and outcomes of parenchymal rejection in liver transplant biopsies.
  Histopathology 2020 Fels Elliott DR, Tavakol M, Lucas CH, Sheahon K, Kakar S, Hameed B, Ferrell LD, Gill RM
• DNA flow cytometric analysis of paraffin-embedded tissue for the diagnosis of malignancy in bile duct biopsies.
  Human pathology 2020 Lee H, Rabinovitch PS, Mattis AN, Kakar S, Choi WT
• Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020 Alpert L, Al-Sabti R, Graham RP, Pai RK, Gonzalez RS, Zhang X, Smith V, Wang HL, Westbrook L, Goldblum JR, Bakhshwin A, Shetty S, Klimstra DS, Shia J, Askan G, Robert ME, Thomas C, Frankel WL, …
• Hans Popper Hepatopathology Society: mini-symposium.
  Human pathology 2019 Kakar S
• Etiology of cirrhosis in the young.
  Human pathology 2019 Olave MC, Gurung A, Mistry PK, Kakar S, Yeh M, Xu M, Wu TT, Torbenson M, Jain D
• Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials.
  Alimentary pharmacology & therapeutics 2019 Pai RK, Kleiner DE, Hart J, Adeyi OA, Clouston AD, Behling CA, Jain D, Kakar S, Brahmania M, Burgart L, Batts KP, Valasek MA, Torbenson MS, Guindi M, Wang HL, Ajmera V, Adams LA, Parker CE, Feagan BG,…
• DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease.
  Histopathology 2019 Wen KW, Umetsu SE, Goldblum JR, Gill RM, Kim GE, Joseph NM, Rabinovitch PS, Kakar S, Lauwers GY, Choi WT
• Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019 Joseph NM, Umetsu SE, Shafizadeh N, Ferrell L, Kakar S
• Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019 Balitzer D, Joseph NM, Ferrell L, Shafizadeh N, Jain D, Zhang X, Yeh M, di Tommaso L, Kakar S
• Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma.
  The Journal of pathology 2019 Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G
• Identification of key challenges in liver pathology: data from a multicenter study of extramural consults.
  Human pathology 2019 Torbenson MS, Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh M
• Knowledge gaps in the appendix: a multi-institutional study from seven academic centers.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019 Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh MM, Torbenson MS
• Identification of high-risk human papillomavirus and Rb/E2F pathway genomic alterations in mutually exclusive subsets of colorectal neuroendocrine carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Shamir ER, Devine WP, Pekmezci M, Umetsu SE, Krings G, Federman S, Cho SJ, Saunders TA, Jen KY, Bergsland E, Jones K, Kim GE, Kakar S, Chiu CY, Joseph NM
• Tumor Budding in Colorectal Carcinoma: Translating a Morphologic Score Into Clinically Meaningful Results.
  Archives of pathology & laboratory medicine 2018 Cho SJ, Kakar S
• A Point-based Histologic Scoring System for Hepatocellular Carcinoma Can Stratify Risk of Posttransplant Tumor Recurrence.
  The American journal of surgical pathology 2018 Roberts DE, Kakar S, Mehta N, Gill RM
• Atypical Hepatocellular Neoplasms: Review of Clinical, Morphologic, Immunohistochemical, Molecular, and Cytogenetic Features.
  Advances in anatomic pathology 2018 Choi WT, Kakar S
• Data set for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR).
  Histopathology 2018 Burt AD, Alves V, Bedossa P, Clouston A, Guido M, Hübscher S, Kakar S, Ng I, Park YN, Reeves H, Wyatt J, Yeh MM, Ellis DW
• Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis.
  Histopathology 2018 Yan Z, Grenert JP, Joseph NM, Ren C, Chen X, Shafizadeh N, Kakar S
• Genomic profile of appendiceal goblet cell carcinoid is distinct compared to appendiceal neuroendocrine tumor and conventional adenocarcinoma.
  Human pathology 2018 Wen KW, Grenert JP, Joseph NM, Shafizadeh N, Huang A, Hosseini M, Kakar S
• Resection of the largest reported hepatic small vessel neoplasm.
  Human pathology 2018 Walcott-Sapp S, Tang E, Kakar S, Shen J, Hansen P
• Glutamine synthetase staining and CTTNB1 mutation in hepatocellular adenomas.
  Hepatology (Baltimore, Md.) 2017 Kakar S, Ferrell LD
• Grading and staging mucinous neoplasms of the appendix: a case series and review of the literature.
  Human pathology 2017 Umetsu SE, Shafizadeh N, Kakar S
• Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Graham RP, Yeh MM, Lam-Himlin D, Roberts LR, Terracciano L, Cruise MW, Greipp PT, Zreik RT, Jain D, Zaid N, Salaria SN, Jin L, Wang X, Rustin JG, Kerr SE, Sukov WR, Solomon DA, Kakar S, Waterhouse E, …
• Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease.
  Gastroenterology 2017 Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT
• Diagnosis and predictors of sessile serrated adenoma after educational training in a large, community-based, integrated healthcare setting.
  Gastrointestinal endoscopy 2017 Li D, Woolfrey J, Jiang SF, Jensen CD, Zhao WK, Kakar S, Santamaria M, Rumore G, Armstrong MA, Postlethwaite D, Corley DA, Levin TR
• Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue.
  Gut 2017 Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S
• Acute liver injury in a Glatopa-treated patient with MS.
  Neurology(R) neuroimmunology & neuroinflammation 2017 Sabatino JJ, Mehta NJ, Kakar S, Zamvil SS, Cree BAC
• Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma.
  Gastroenterology clinics of North America 2017 Choi WT, Kakar S
• Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Lugli A, Kirsch R, Ajioka Y, Bosman F, Cathomas G, Dawson H, El Zimaity H, Fléjou JF, Hansen TP, Hartmann A, Kakar S, Langner C, Nagtegaal I, Puppa G, Riddell R, Ristimäki A, Sheahan K, Smyrk T, …
• Appendiceal goblet cell carcinoid: common errors in staging and clinical interpretation with a proposal for an improved terminology.
  Human pathology 2017 Wen KW, Hale G, Shafizadeh N, Hosseini M, Huang A, Kakar S
• Autoimmune hepatitis: review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Balitzer D, Shafizadeh N, Peters MG, Ferrell LD, Alshak N, Kakar S
• Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
  Human pathology 2017 Choi WT, Ramachandran R, Kakar S
• HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology.
  American journal of clinical pathology 2016 Bartley AN, Washington MK, Ventura CB, Ismaila N, Colasacco C, Benson AB, Carrato A, Gulley ML, Jain D, Kakar S, Mackay HJ, Streutker C, Tang L, Troxell M, Ajani JA
• HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology.
  Archives of pathology & laboratory medicine 2016 Bartley AN, Washington MK, Ventura CB, Ismaila N, Colasacco C, Benson AB, Carrato A, Gulley ML, Jain D, Kakar S, Mackay HJ, Streutker C, Tang L, Troxell M, Ajani JA
• HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016 Bartley AN, Washington MK, Colasacco C, Ventura CB, Ismaila N, Benson AB, Carrato A, Gulley ML, Jain D, Kakar S, Mackay HJ, Streutker C, Tang L, Troxell M, Ajani JA
• Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion.
  Human pathology 2016 Cohen JN, Solomon DA, Horvai AE, Kakar S
• Correlation of exon 3 β-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016 Hale G, Liu X, Hu J, Xu Z, Che L, Solomon D, Tsokos C, Shafizadeh N, Chen X, Gill R, Kakar S
• Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016 Nguyen TB, Roncalli M, Di Tommaso L, Kakar S
• The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base.
  Cancer 2015 Asare EA, Compton CC, Hanna NN, Kosinski LA, Washington MK, Kakar S, Weiser MR, Overman MJ
• Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma.
  Archives of pathology & laboratory medicine 2015 Nguyen T, Phillips D, Jain D, Torbenson M, Wu TT, Yeh MM, Kakar S
• Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
  PLoS genetics 2015 Evason KJ, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino Mdel P, Gordan JD, Kakar S, Spitsbergen J, Goga A, Stainier DY
• Template for Reporting Results of Biomarker Testing of Specimens From Patients With Gastrointestinal Stromal Tumors.
  Archives of pathology & laboratory medicine 2015 Hameed M, Corless C, George S, Hornick JL, Kakar S, Lazar AJ, Tang L, Members of the Cancer Biomarker Reporting Committee, College of American Pathologists
• Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms.
  The American journal of surgical pathology 2015 Shahid M, Mubeen A, Tse J, Kakar S, Bateman AC, Borger D, Rivera MN, Ting DT, Deshpande V
• Immunohistochemical pitfalls in the diagnosis of hepatocellular adenomas and focal nodular hyperplasia: accurate understanding of diverse staining patterns is essential for diagnosis and risk assessment.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2015 Kakar S, Torbenson M, Jain D, Wu TT, Yeh M, Ferrell LD
• Well-differentiated hepatocellular neoplasm of uncertain malignant potential.
  Human pathology 2014 Balabaud C, Bioulac-Sage P, Ferrell L, Kakar S, Paradis V, Quaglia A, Sempoux C, Thung S, Zucman-Rossi J
• Significant Racial Disparities Exist in Noncardia Gastric Cancer Outcomes Among Kaiser Permanente's Patient Population.
  Digestive diseases and sciences 2014 Bautista MC, Jiang SF, Armstrong MA, Kakar S, Postlethwaite D, Li D
• Template for Reporting Results of HER2 (ERBB2) Biomarker Testing of Specimens From Patients With Adenocarcinoma of the Stomach or Esophagogastric Junction.
  Archives of pathology & laboratory medicine 2014 Bartley AN, Christ J, Fitzgibbons PL, Hamilton SR, Kakar S, Shah MA, Tang LH, Troxell ML, Members of the Cancer Biomarker Reporting Committee, College of American Pathologists
• MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway.
  Oncogene 2014 Macha MA, Rachagani S, Pai P, Gupta S, Lydiatt WM, Smith RB, Johansson SL, Lele SM, Kakar SS, Farghaly H, Lee JH, Meza J, Ganti AK, Jain M, Batra SK
• Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2014 Kakar S, Grenert JP, Paradis V, Pote N, Jakate S, Ferrell LD
• Hepatocellular adenomas in a large community population, 2000 to 2010: reclassification per current World Health Organization classification and results of long-term follow-up.
  Human pathology 2014 Shafizadeh N, Genrich G, Ferrell L, Kakar S
• Well-differentiated hepatocellular neoplasm of uncertain malignant potential: proposal for a new diagnostic category--reply.
  Human pathology 2013 Kakar S, Evason KJ, Ferrell LD
• Appropriate use of special stains for identifying Helicobacter pylori: Recommendations from the Rodger C. Haggitt Gastrointestinal Pathology Society.
  The American journal of surgical pathology 2013 Batts KP, Ketover S, Kakar S, Krasinskas AM, Mitchell KA, Wilcox R, Westerhoff M, Rank J, Gibson J, Mattia AR, Cummings OW, Davison JM, Naini BV, Dry SM, Yantiss RK, Rodger C Haggitt Gastrointestinal …
• Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S
• Hepatocellular Carcinoma: Histologic Subtypes.
  Surgical pathology clinics 2013 Shafizadeh N, Kakar S
• Nonalcoholic Steatohepatitis: Diagnostic Challenges.
  Surgical pathology clinics 2013 Gill RM, Kakar S
• Liver Pathology: Unraveling the Art of Pattern Recognition.
  Surgical pathology clinics 2013 Kakar S, Jain D
• Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S
• Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT.
  Radiology 2012 Varenika V, Fu Y, Maher JJ, Gao D, Kakar S, Cabarrus MC, Yeh BM
• Atypical hepatocellular adenoma-like neoplasms with β-catenin activation show cytogenetic alterations similar to well-differentiated hepatocellular carcinomas.
  Human pathology 2012 Evason KJ, Grenert JP, Ferrell LD, Kakar S
• Reticulin loss in benign fatty liver: an important diagnostic pitfall when considering a diagnosis of hepatocellular carcinoma.
  The American journal of surgical pathology 2012 Singhi AD, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson M
• Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012 Kakar S, Deng G, Smyrk TC, Cun L, Sahai V, Kim YS
• Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
  Advances in anatomic pathology 2011 Shafizadeh N, Kakar S
• SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
  Molecular cell 2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, …
• Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury.
  PloS one 2011 Na B, Huang Z, Wang Q, Qi Z, Tian Y, Lu CC, Yu J, Hanes MA, Kakar S, Huang EJ, Ou JH, Liu L, Yen TS
• MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer.
  Carcinogenesis 2011 Suh SO, Chen Y, Zaman MS, Hirata H, Yamamura S, Shahryari V, Liu J, Tabatabai ZL, Kakar S, Deng G, Tanaka Y, Dahiya R
• MicroRNA-124a and microRNA-34b/c are frequently methylated in all histological types of colorectal cancer and polyps, and in the adjacent normal mucosa.
  Oncology letters 2010 Deng G, Kakar S, Kim YS
• MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues.
  International journal of oncology 2010 Okudaira K, Kakar S, Cun L, Choi E, Wu Decamillis R, Miura S, Sleisenger MH, Kim YS, Deng G
• Protocol for the examination of specimens from patients with carcinoma of the distal extrahepatic bile ducts.
  Archives of pathology & laboratory medicine 2010 Washington MK, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Vauthey JN, Members of the Cancer Committee, College of …
• Protocol for the examination of specimens from patients with carcinoma of the intrahepatic bile ducts.
  Archives of pathology & laboratory medicine 2010 Washington MK, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Vauthey JN, Members of the Cancer Committee, College of American …
• Protocol for the examination of specimens from patients with carcinoma of the perihilar bile ducts.
  Archives of pathology & laboratory medicine 2010 Washington MK, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Vauthey JN, Members of the Cancer Committee, College of …
• S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis.
  Science translational medicine 2010 Wei W, Li B, Hanes MA, Kakar S, Chen X, Liu L
• Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the appendix.
  Archives of pathology & laboratory medicine 2010 Washington MK, Tang LH, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Members of the Cancer Committee, College of …
• Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the colon and rectum.
  Archives of pathology & laboratory medicine 2010 Washington MK, Tang LH, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Members of the Cancer Committee, College of …
• Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the small intestine and ampulla.
  Archives of pathology & laboratory medicine 2010 Washington MK, Tang LH, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Members of the Cancer Committee, College of …
• Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the stomach.
  Archives of pathology & laboratory medicine 2010 Washington MK, Tang LH, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Members of the Cancer Committee, College of …
• Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder.
  Human pathology 2009 Shafizadeh N, Grenert JP, Sahai V, Kakar S
• Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum.
  Archives of pathology & laboratory medicine 2009 Washington MK, Berlin J, Branton P, Burgart LJ, Carter DK, Fitzgibbons PL, Halling K, Frankel W, Jessup J, Kakar S, Minsky B, Nakhleh R, Compton CC, Members of the Cancer Committee, College of …
• Reversible surgical model of biliary inflammation and obstructive jaundice in mice.
  The Journal of surgical research 2009 Kirkland JG, Godfrey CB, Garrett R, Kakar S, Yeh BM, Corvera CU
• Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms.
  Histopathology 2009 Kakar S, Chen X, Ho C, Burgart LJ, Adeyi O, Jain D, Sahai V, Ferrell LD
• Histological patterns in drug-induced liver disease.
  Journal of clinical pathology 2009 Ramachandran R, Kakar S
• Association of large serrated polyps with synchronous advanced colorectal neoplasia.
  The American journal of gastroenterology 2009 Li D, Jin C, McCulloch C, Kakar S, Berger BM, Imperiale TF, Terdiman JP
• Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Deng G, Kakar S, Okudiara K, Choi E, Sleisenger MH, Kim YS
• Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps.
  International journal of cancer 2008 Kim YH, Kakar S, Cun L, Deng G, Kim YS
• Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Kakar S, Chen X, Ho C, Burgart LJ, Sahai V, Dachrut S, Yabes A, Jain D, Ferrell LD
• Protocol for the examination of specimens from patients with primary carcinomas of the colon and rectum.
  Archives of pathology & laboratory medicine 2008 Washington MK, Berlin J, Branton PA, Burgart LJ, Carter DK, Fitzgibbons PL, Frankel WL, Jessup JM, Kakar S, Minsky B, Nakhleh RE, Compton CC, Cancer Committee, College of American Pathologists
• Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Shafizadeh N, Ferrell LD, Kakar S
• Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability.
  Archives of pathology & laboratory medicine 2008 Kakar S, Deng G, Sahai V, Matsuzaki K, Tanaka H, Miura S, Kim YS
• Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.
  European journal of cancer (Oxford, England : 1990) 2008 Deng G, Kakar S, Tanaka H, Matsuzaki K, Miura S, Sleisenger MH, Kim YS
• Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions.
  International journal of cancer 2008 Park ET, Gum JR, Kakar S, Kwon SW, Deng G, Kim YS
• Tumor histology helps to identify Lynch syndrome among colorectal cancer patients.
  Familial cancer 2008 Truta B, Chen YY, Blanco AM, Deng G, Conrad PG, Kim YH, Park ET, Kakar S, Kim YS, Velayos F, Sleisenger MH, Terdiman JP
• Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma.
  American journal of clinical pathology 2008 Buckley AF, Burgart LJ, Sahai V, Kakar S
• Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms.
  Archives of pathology & laboratory medicine 2007 Kakar S, Gown AM, Goodman ZD, Ferrell LD
• CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.
  Human pathology 2007 Kakar S, Deng G, Cun L, Sahai V, Kim YS
• Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma.
  Applied immunohistochemistry & molecular morphology : AIMM 2007 Buckley AF, Kakar S
• Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury.
  Journal of lipid research 2007 Lee GS, Yan JS, Ng RK, Kakar S, Maher JJ
• Chromosomal instability in microsatellite-unstable and stable colon cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Trautmann K, Terdiman JP, French AJ, Roydasgupta R, Sein N, Kakar S, Fridlyand J, Snijders AM, Albertson DG, Thibodeau SN, Waldman FM
• HATH1 expression in mucinous cancers of the colorectum and related lesions.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Park ET, Oh HK, Gum JR, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS
• Contributions to hepatic fibrosis in HIV-HCV coinfected and HCV monoinfected patients.
  The American journal of gastroenterology 2006 Monto A, Kakar S, Dove LM, Bostrom A, Miller EL, Wright TL
• Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer.
  International journal of cancer 2006 Deng G, Nguyen A, Tanaka H, Matsuzaki K, Bell I, Mehta KR, Terdiman JP, Waldman FM, Kakar S, Gum J, Crawley S, Sleisenger MH, Kim YS
• BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer.
  International journal of cancer 2006 Tanaka H, Deng G, Matsuzaki K, Kakar S, Kim GE, Miura S, Sleisenger MH, Kim YS
• Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.
  Human pathology 2006 Buckley AF, Burgart LJ, Kakar S
• The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS
• Accuracy of liver fat quantification at MR imaging: comparison of out-of-phase gradient-echo and fat-saturated fast spin-echo techniques--initial experience.
  Radiology 2005 Qayyum A, Goh JS, Kakar S, Yeh BM, Merriman RB, Coakley FV
• Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 Kakar S, Burgart LJ, Batts KP, Garcia J, Jain D, Ferrell LD
• Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum.
  International journal of oncology 2005 Kim DH, Kim JW, Cho JH, Baek SH, Kakar S, Kim GE, Sleisenger MH, Kim YS
• Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfection.
  Hepatology (Baltimore, Md.) 2005 Monto A, Dove LM, Bostrom A, Kakar S, Tien PC, Wright TL
• Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.
  Carcinogenesis 2005 Patil MA, Gütgemann I, Zhang J, Ho C, Cheung ST, Ginzinger D, Li R, Dykema KJ, So S, Fan ST, Kakar S, Furge KA, Büttner R, Chen X
• Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines.
  The American journal of gastroenterology 2005 Velayos FS, Allen BA, Conrad PG, Gum J, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP
• Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics.
  International journal of oncology 2005 Song GA, Deng G, Bell I, Kakar S, Sleisenger MH, Kim YS
• Prognostic significance of DCC and p27Kip1 in colorectal cancer.
  Applied immunohistochemistry & molecular morphology : AIMM 2005 Wu JT, Kakar S, Nelson RL, Mihalov ML, Hayward B, Gilbert PB, Ghosh L
• Signet ring cell carcinoma of the colorectum: correlations between microsatellite instability, clinicopathologic features and survival.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 Kakar S, Smyrk TC
• Management of patients with metastatic cancer of unknown primary.
  Current problems in surgery 2005 Ghosh L, Dahut W, Kakar S, Posadas EM, Torres CG, Cancel-Santiago R, Ghosh BC
• Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon.
  Molecular cancer research : MCR 2004 Gum JR, Hicks JW, Crawley SC, Yang SC, Borowsky AD, Dahl CM, Kakar S, Kim DH, Cardiff RD, Kim YS
• Sinusoidal dilatation and congestion in liver biopsy: is it always due to venous outflow impairment?
  Archives of pathology & laboratory medicine 2004 Kakar S, Kamath PS, Burgart LJ
• Histologic changes mimicking biliary disease in liver biopsies with venous outflow impairment.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004 Kakar S, Batts KP, Poterucha JJ, Burgart LJ
• Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004 Kakar S, Aksoy S, Burgart LJ, Smyrk TC
• Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture.
  The American journal of gastroenterology 2003 Kakar S, Nehra V, Murray JA, Dayharsh GA, Burgart LJ
• Colonic ulcers accompanying collagenous colitis: implication of nonsteroidal anti-inflammatory drugs.
  The American journal of gastroenterology 2003 Kakar S, Pardi DS, Burgart LJ
• Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age.
  Cancer 2003 Kakar S, Burgart LJ, Thibodeau SN, Rabe KG, Petersen GM, Goldberg RM, Lindor NM
• Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma.
  American journal of clinical pathology 2003 Kakar S, Muir T, Murphy LM, Lloyd RV, Burgart LJ
• Noninfectious lung pathology in patients with Crohn's disease.
  The American journal of surgical pathology 2003 Casey MB, Tazelaar HD, Myers JL, Hunninghake GW, Kakar S, Kalra SX, Ashton R, Colby TV
• Origin of adenocarcinoma in a transplanted liver determined by microsatellite analysis.
  Human pathology 2002 Kakar S, Burgart LJ, Charlton MR, Saito Y, Halling K, Thibodeau SN
• The fate of low grade dysplasia in ulcerative colitis.
  The American journal of gastroenterology 2002 Ullman TA, Loftus EV, Kakar S, Burgart LJ, Sandborn WJ, Tremaine WJ
• Characterization of a polyclonal antibody to human pituitary tumor transforming gene 1 (PTTG1) protein.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001 Kakar SS, Chen L, Puri R, Flynn SE, Jennes L
• Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization.
  Gene 2000 Chen L, Puri R, Lefkowitz EJ, Kakar SS
• Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG).
  Gene 1999 Kakar SS
• Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization.
  Cytogenetics and cell genetics 1998 Kakar SS
• Chronic administration of the luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix decreases gonadotrope responsiveness and pituitary LHRH receptor messenger ribonucleic acid levels in rats.
  Endocrinology 1996 Pinski J, Lamharzi N, Halmos G, Groot K, Jungwirth A, Vadillo-Buenfil M, Kakar SS, Schally AV