Sandhya Kharbanda, MD
Professor
Pediatrics
School of Medicine

Having a special interest in stem cell transplantation for children with inherited metabolic disorders, Kharbanda aims to provide state-of-the-art care while improving both short- and long-term outcomes for these patients. She works with a multidisciplinary team to care for children who need a stem cell transplant due to leukodystrophies (genetic disorders affecting white tissues of the central nervous system), mucopolysaccharidoses, and other lysosomal storage disorders (genetic diseases in which a protein deficiency leads to toxic chemicals accumulating in cells). She is also interested in in inherited disorders of red blood cells, including thalassemia and sickle cell disease, and leads UCSF studies that evaluate new therapies for these conditions.

• Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease.
  Blood 2022 Subburaj D, Ng B, Kariminia A, Abdossamadi S, Lauener M, Nemecek ER, Rozmus J, Kharbanda S, Kitko CL, Lewis VA, Schechter-Finklestein T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, …
• Consensus statement for the perinatal management of patients with α thalassemia major.
  Blood advances 2021 MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, …
• Advances in the management of α-thalassemia major: reasons to be optimistic.
  Hematology. American Society of Hematology. Education Program 2021 Horvei P, MacKenzie T, Kharbanda S
• Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation.
  Frontiers in pharmacology 2021 Brooks JT, Keizer RJ, Long-Boyle JR, Kharbanda S, Dvorak CC, Friend BD
• Hematopoietic Cell Transplantation-Comorbidity Index Score Is Correlated with Treatment-Related Mortality and Overall Survival following Second Allogeneic Hematopoietic Cell Transplantation in Children.
  Transplantation and cellular therapy 2021 Forlanini F, Zinter MS, Dvorak CC, Bailey-Olson M, Winestone LE, Shimano KA, Higham CS, Melton A, Chu J, Kharbanda S
• The Beginning of the End of Allogeneic Transplantation for Hurler Syndrome?
  The New England journal of medicine 2021 Kharbanda S, Dvorak CC
• Transplant-associated thrombotic microangiopathy in pediatric patients: pre-HSCT risk stratification and prophylaxis.
  Blood advances 2021 Higham CS, Collins G, Shimano KA, Melton A, Kharbanda S, Winestone LE, Huang JN, Dara J, Long-Boyle JR, Dvorak CC
• The pulmonary metatranscriptome prior to pediatric HCT identifies post-HCT lung injury.
  Blood 2021 Zinter MS, Lindemans CA, Versluys BA, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL
• The Relationship Between Busulfan Exposure and Achievement of Sustained Donor Myeloid Chimerism in Patients with Non-Malignant Disorders.
  Transplantation and cellular therapy 2020 Apsel Winger B, Shukla P, Kharbanda S, Keizer RJ, Goswami S, Cowan MJ, Dvorak CC, Long-Boyle J
• Lower Exposure to Busulfan Allows for Stable Engraftment of Donor Hematopoietic Stem Cells in Children with Mucopolysaccharidosis Type I: A Case Report of Four Patients.
  International journal of molecular sciences 2020 Shukla P, Dvorak CC, Long-Boyle J, Kharbanda S
• Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population.
  Frontiers in pharmacology 2020 Shukla P, Goswami S, Keizer RJ, Winger BA, Kharbanda S, Dvorak CC, Long-Boyle J
• Reduced Toxicity Conditioning for Nonmalignant Hematopoietic Cell Transplants.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2020 Contreras CF, Long-Boyle JR, Shimano KA, Melton A, Kharbanda S, Dara J, Higham C, Huang JN, Cowan MJ, Dvorak CC
• The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation.
  Pediatric blood & cancer 2019 Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC
• In ALD, I feel the need for speed.
  Blood 2019 Kharbanda S, Dvorak CC
• High human herpesvirus 6 viral load in pediatric allogeneic hematopoietic stem cell transplant patients is associated with detection in end organs and high mortality.
  Pediatric transplantation 2017 Winestone LE, Punn R, Tamaresis JS, Buckingham J, Pinsky BA, Waggoner JJ, Kharbanda S
• Numerous uncharacterized and highly divergent microbes which colonize humans are revealed by circulating cell-free DNA.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Kowarsky M, Camunas-Soler J, Kertesz M, De Vlaminck I, Koh W, Pan W, Martin L, Neff NF, Okamoto J, Wong RJ, Kharbanda S, El-Sayed Y, Blumenfeld Y, Stevenson DK, Shaw GM, Wolfe ND, Quake SR
• Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype.
  PLoS computational biology 2017 Sharon E, Shi H, Kharbanda S, Koh W, Martin LR, Khush KK, Valantine H, Pritchard JK, De Vlaminck I
• Bone marrow oedema predicts bone collapse in paediatric and adolescent leukaemia patients with corticosteroid-induced osteonecrosis.
  European radiology 2017 Theruvath AJ, Sukerkar PA, Bao S, Rosenberg J, Luna-Fineman S, Kharbanda S, Daldrup-Link HE
• A Multicenter Retrospective Analysis Stressing the Importance of Long-Term Follow-Up after Hematopoietic Cell Transplantation for β-Thalassemia.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Chaudhury S, Ayas M, Rosen C, Ma M, Viqaruddin M, Parikh S, Kharbanda S, Chiang KY, Haight A, Bhatia M, Guilcher G, Thompson A, Shenoy S
• Pericardial Effusion Following Hematopoietic Cell Transplantation in Children and Young Adults Is Associated with Increased Risk of Mortality.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Cox K, Punn R, Weiskopf E, Pinsky BA, Kharbanda S
• Predictive Value of Fecal Calprotectin in Pediatric Graft-Versus-Host Disease.
  Journal of pediatric gastroenterology and nutrition 2016 Wadhwani SI, Nakayuenyongsuk W, Shinn L, Chase P, Kharbanda S, Bass D, Park KT
• Invasive Fungal Disease in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant.
  Journal of pediatric hematology/oncology 2016 Aftandilian C, Weinberg K, Willert J, Kharbanda S, Porteus M, Maldonado Y, Agarwal R
• A pediatric case of T-cell prolymphocytic leukemia.
  Pediatric blood & cancer 2014 Mitton B, Coutre S, Willert J, Schlis K, Porteus M, Kharbanda S, Agarwal-Hashmi R
• A reduced-toxicity regimen is associated with durable engraftment and clinical cure of nonmalignant genetic diseases among children undergoing blood and marrow transplantation with an HLA-matched related donor.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2014 Mahadeo KM, Weinberg KI, Abdel-Azim H, Miklos DB, Killen R, Kohn D, Crooks GM, Shah AJ, Kharbanda S, Agarwal R, Kapoor N
• Improved outcomes after autologous bone marrow transplantation for children with relapsed or refractory Hodgkin lymphoma: twenty years experience at a single institution.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2014 Garfin PM, Link MP, Donaldson SS, Advani RH, Luna-Fineman S, Kharbanda S, Porteus M, Weinberg KI, Agarwal-Hashmi R
• Unrelated donor allogeneic hematopoietic stem cell transplantation for patients with hemoglobinopathies using a reduced-intensity conditioning regimen and third-party mesenchymal stromal cells.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013 Kharbanda S, Smith AR, Hutchinson SK, McKenna DH, Ball JB, Lamb LS, Agarwal R, Weinberg KI, Wagner JE
• Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiation.
  Radiation research 2011 Filiano AN, Fathallah-Shaykh HM, Fiveash J, Gage J, Cantor A, Kharbanda S, Johnson MR
• Stable long-term donor engraftment following reduced-intensity hematopoietic cell transplantation for sickle cell disease.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008 Krishnamurti L, Kharbanda S, Biernacki MA, Zhang W, Baker KS, Wagner JE, Wu CJ
• Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disorders.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006 Kharbanda S, Panoskaltsis-Mortari A, Haddad IY, Blazar BR, Orchard PJ, Cornfield DN, Grewal SS, Peters C, Regelmann WE, Milla CE, Baker KS
• All-trans retinoic acid reverses phorbol ester resistance in a human myeloid leukemia cell line.
  Blood 1994 Yang KD, Mizobuchi T, Kharbanda SM, Datta R, Huberman E, Kufe DW, Stone RM
• Regulation of c-jun gene expression in human T lymphocytes.
  Blood 1993 Chauhan D, Kharbanda SM, Rubin E, Barut BA, Mohrbacher A, Kufe DW, Anderson KC
• Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells.
  Blood 1990 Kharbanda SM, Sherman ML, Kufe DW