Samuel Mann, PhD
Postdoctoral Scholar
Pharmaceutical Chemistry
School of Pharmacy
Publications (8)
Top publication keywords:
HemeproteinsImmunoconjugatesCoordination ComplexesMetalloporphyrinsMetalloproteinsManganeseAzurinStreptavidinHydrogen BondingPeroxidesAzidesSulfidesProtein EngineeringLigandsCopper
-
De novo design of drug-binding proteins with predictable binding energy and specificity.
Science (New York, N.Y.) 2024 Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF -
De novo design of drug-binding proteins with predictable binding energy and specificity.
bioRxiv : the preprint server for biology 2023 Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF -
Copper assisted sequence-specific chemical protein conjugation at a single backbone amide.
Nature communications 2023 Guo M, Zhao K, Guo L, Zhou R, He Q, Lu K, Li T, Liu D, Chen J, Tang J, Fu X, Zhou J, Zheng B, Mann SI, Zhang Y, Huang J, Yang B, Zhou T, Lei Y, Dang B -
De novo metalloprotein design.
Nature reviews. Chemistry 2021 Chalkley MJ, Mann SI, DeGrado WF -
De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species.
Journal of the American Chemical Society 2020 Mann SI, Nayak A, Gassner GT, Therien MJ, DeGrado WF -
Coordination chemistry within a protein host: regulation of the secondary coordination sphere.
Chemical communications (Cambridge, England) 2018 Mann SI, Heinisch T, Ward TR, Borovik AS -
Peroxide Activation Regulated by Hydrogen Bonds within Artificial Cu Proteins.
Journal of the American Chemical Society 2017 Mann SI, Heinisch T, Ward TR, Borovik AS -
Modular Artificial Cupredoxins.
Journal of the American Chemical Society 2016 Mann SI, Heinisch T, Weitz AC, Hendrich MP, Ward TR, Borovik AS