Sammy Elmariah, MD, MPH
Associate Professor
Medicine
School of Medicine

Clinical Interests

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Dr. Sammy Elmariah is an interventional cardiologist who specializes in caring for patients with heart valve disease, coronary artery disease, and adult congenital heart disease. He has particular interest and renowned expertise in transcatheter heart valve procedures including transcatheter aortic valve replacement (TAVR), edge-to-edge mitral valve repair (MitraClip and TEER), mitral valve replacement (TMVR), and the use of investigational devices for repair and replacement of the tricuspid valve.

Research Interests Dr. Elmariah's research focuses on the prediction and optimization of clinical outcomes of patients with aortic stenosis and after transcatheter aortic valve replacement. Aortic valve stenosis is a disorder predominantly affecting the elderly and characterized by severe narrowing of the aortic valve, the doorway through which blood exits the heart. Aortic stenosis ultimately leads to heart failure and death. Surgical or transcatheter replacement of the valve cures the valve obstruction, but valve replacement is routinely reserved until compensatory mechanisms within the heart have failed. For many patients, this point is too late. Despite valve replacement, damage to the heart muscle may be permanent, resulting in persistent symptoms and increased risk for death. Methods capable of identifying early stages of irreversible heart injury due to aortic valve stenosis are needed in order to help optimize the timing of surgery.

Education & Training

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  • MD Medicine University of Pennsylvania School of Medicine 05/2022
  • Interventional Cardiology and Structural Heart Disease Fellowships Massachusetts General Hospital 06/2012
  • Cardiovascular Medicine Fellowship Mount Sinai Medical Center 06/2010
  • MPH Clinical Effectiveness Harvard School of Public Health 03/2010
  • Internal Medicine Residency Hospital of the University of Pennsylvania 06/2005
  • BS Biology Emory University 05/1998

Grants and Projects

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  • Promoting Shared decision Making for Decisions about Treatment of Severe Aortic Stenosis: The IMPACT SDM Study, Patient-Centered Research Outcomes Institute (PCORI), 2023-2028
  • Multi-Omic Markers of Cardiac Function and Structure within the Pressure Overloaded Heart, NIH, 2020-2025
  • Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial, Edwards Lifesciences, 2020-2024
  • Circulating Biomarkers of Hypo-Attenuated Leaflet Thickening after Transcatheter Aortic Valve Replacement – The HALT Biomarker Study, Medtronic, 2020-2024

Publications (183)

Top publication keywords:
Aortic Valve StenosisVentricular Dysfunction, LeftStroke VolumeMitral ValveVentricular Function, LeftAortic ValveHeart Valve ProsthesisForamen Ovale, PatentTranscatheter Aortic Valve ReplacementPercutaneous Coronary InterventionMitral Valve InsufficiencyHeart Valve Prosthesis ImplantationPlatelet Aggregation InhibitorsDrug-Eluting StentsCardiac Catheterization

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