Sam Pleasure, MD, PhD
Professor
Neurology
School of Medicine

Pleasure has two main areas of inquiry for his research. He studies processes that regulate early brain development in both normal and diseased situations. He also studies autoimmune forms of meningoencephalitis, where inflammation in specific brain areas causes severe neurologic dysfunction.

Pleasure received his medical degree and a doctorate in neuroscience from the University of Pennsylvania. He was chief resident during his neurology residency at UCSF, where he then completed a research fellowship in neuroscience.

Pleasure is a fellow of the American Neurological Association and a member of the American Academy of Neurology, American Epilepsy Society, Society for Neuroscience, Society for Developmental Biology and Cajal Club. He has won numerous awards for his research and has received research funding from a wide variety of private, state and federal sources. He has served in leadership roles in national organizations and in the UCSF Department of Neurology.

Pleasure is the Glenn W. Johnson, Jr. Memorial Endowed Chair in Neurology at UCSF.

• Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging.
  bioRxiv : the preprint server for biology 2023 Noguchi H, Arela JC, Ngo TT, Cocas L, Pleasure SJ
• Viral co-infection, autoimmunity, and CSF HIV antibody profiles in HIV central nervous system escape.
  Journal of neuroimmunology 2023 Hawes IA, Alvarenga BD, Browne W, Wapniarski A, Dandekar R, Bartley CM, Sowa GM, DeRisi JL, Cinque P, Dravid AN, Pleasure SJ, Gisslen M, Price RW, Wilson MR
• Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable.
  Journal of personalized medicine 2023 Frye RE, Nanda H, Pleasure SJ, Casanova MF, Boles RG, Lewine J, Gaitanis J, Adams JB
• Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report.
  Frontiers in neurology 2023 Bartley CM, Ngo TT, Cadwell CR, Harroud A, Schubert RD, Alvarenga BD, Hawes IA, Zorn KC, Hunyh T, Teliska LH, Kung AF, Shah S, Gelfand JM, Chow FC, Rasband MN, Dubey D, Pittock SJ, DeRisi JL, Wilson …
• Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers.
  Brain pathology (Zurich, Switzerland) 2023 Jung HJ, Yeo S, Jang J, Pleasure S, Choe Y
• Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin.
  Biological psychiatry 2022 McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Chen P, Dandekar R, Alvarenga BD, Browne WD, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM
• The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties.
  EMBO reports 2022 Kwon M, Lee JH, Yoon Y, Pleasure SJ, Yoon K
• ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD.
  Annals of neurology 2022 Mandel-Brehm C, Benson LA, Tran B, Kung AF, Mann SA, Vazquez SE, Retallack H, Sample HA, Zorn KC, Khan LM, Kerr LM, McAlpine PL, Zhang L, McCarthy F, Elias JE, Katwa U, Astley CM, Tomko S, Dalmau J, …
• βIV-Spectrin Autoantibodies in 2 Individuals With Neuropathy of Possible Paraneoplastic Origin: A Case Series.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Bartley CM, Ngo TT, Alvarenga BD, Kung AF, Teliska LH, Sy M, DeRisi JL, Rasband MN, Pittock SJ, Dubey D, Wilson MR, Pleasure SJ
• Corrigendum: Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy.
  Frontiers in neurology 2022 Bartley CM, Parikshak NN, Ngo TT, Alexander JA, Zorn KC, Alvarenga BD, Kang MK, Pedriali M, Pleasure SJ, Wilson MR
• Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19.
  Annals of clinical and translational neurology 2022 Apple AC, Oddi A, Peluso MJ, Asken BM, Henrich TJ, Kelly JD, Pleasure SJ, Deeks SG, Allen IE, Martin JN, Ndhlovu LC, Miller BL, Stephens ML, Hellmuth J
• Synaptic memory requires CaMKII.
  eLife 2021 Tao W, Lee J, Chen X, Díaz-Alonso J, Zhou J, Pleasure S, Nicoll RA
• Anti-SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms.
  JAMA neurology 2021 Bartley CM, Johns C, Ngo TT, Dandekar R, Loudermilk RL, Alvarenga BD, Hawes IA, Zamecnik CR, Zorn KC, Alexander JR, Wapniarski AE, DeRisi JL, Francisco C, Nash KB, Wietstock SO, Pleasure SJ, Wilson MR
• Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy.
  Frontiers in neurology 2021 Bartley CM, Parikshak NN, Ngo TT, Alexander JA, Zorn KC, Alvarenga BA, Kang MK, Pedriali M, Pleasure SJ, Wilson MR
• Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.
  Cell reports. Medicine 2021 Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J…
• RETRACTED: Remission of Subacute Psychosis in a COVID-19 Patient With an Antineuronal Autoantibody After Treatment With Intravenous Immunoglobulin.
  Biological psychiatry 2021 McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM
• NMDA receptors control development of somatosensory callosal axonal projections.
  eLife 2021 Zhou J, Lin Y, Huynh T, Noguchi H, Bush JO, Pleasure SJ
• The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Yabut OR, Ng HX, Yoon K, Arela JC, Ngo T, Pleasure SJ
• The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines.
  JAMA neurology 2020 Pleasure SJ, Green AJ, Josephson SA
• Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation.
  Scientific reports 2020 Han D, Kwon M, Lee SM, Pleasure SJ, Yoon K
• ANA Investigates: Pioneering Unbiased Diagnostics.
  Annals of neurology 2020 Richie M, Pleasure S, Hurley J, Goss A, Wilson M
• Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
  The New England journal of medicine 2019 Mandel-Brehm C, Dubey D, Kryzer TJ, O'Donovan BD, Tran B, Vazquez SE, Sample HA, Zorn KC, Khan LM, Bledsoe IO, McKeon A, Pleasure SJ, Lennon VA, DeRisi JL, Wilson MR, Pittock SJ
• Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism.
  Biology open 2019 Gomez HG, Noguchi H, Castillo JG, Aguilar D, Pleasure SJ, Yabut OR
• Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.
  eLife 2019 Noguchi H, Castillo JG, Nakashima K, Pleasure SJ
• Foxg1 Regulates the Postnatal Development of Cortical Interneurons.
  Cerebral cortex (New York, N.Y. : 1991) 2019 Shen W, Ba R, Su Y, Ni Y, Chen D, Xie W, Pleasure SJ, Zhao C
• Neural-Derived Extracellular Vesicles in Clinical Trials: Message in a Bottle.
  JAMA neurology 2019 Dubal DB, Pleasure SJ
• Meningeal Bmps Regulate Cortical Layer Formation.
  Brain plasticity (Amsterdam, Netherlands) 2018 Choe Y, Pleasure SJ
• FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development.
  Frontiers in cellular neuroscience 2018 Han X, Gu X, Zhang Q, Wang Q, Cheng Y, Pleasure SJ, Zhao C
• Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway.
  EMBO reports 2018 Kim J, Han D, Byun SH, Kwon M, Cho JY, Pleasure SJ, Yoon K
• Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development.
  Brain plasticity (Amsterdam, Netherlands) 2018 Yabut OR, Pleasure SJ
• Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia.
  Neuroscience 2018 Nisimov H, Orenbuch A, Pleasure SJ, Golan HM
• The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ
• Focal cerebral β-amyloid angiopathy: A distinct clinicopathologic presentation.
  Neurology. Clinical practice 2017 Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT
• Human Cytomegalovirus IE2 Protein Disturbs Brain Development by the Dysregulation of Neural Stem Cell Maintenance and the Polarization of Migrating Neurons.
  Journal of virology 2017 Han D, Byun SH, Kim J, Kwon M, Pleasure SJ, Ahn JH, Yoon K
• TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.
  Development (Cambridge, England) 2017 Byun SH, Kim J, Han D, Kwon M, Cho JY, Ng HX, Pleasure SJ, Yoon K
• TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.
  Neuron 2017 Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN
• The Crossroads of Neural Stem Cell Development and Tumorigenesis.
  Opera medica et physiologica 2016 Yabut OR, Pleasure SJ
• Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors.
  Journal of developmental biology 2016 Yabut OR, Ng HX, Fernandez G, Yoon K, Kuhn J, Pleasure SJ
• Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.
  Developmental biology 2016 Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA
• Diverse Functions of Retinoic Acid in Brain Vascular Development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA
• Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Cocas LA, Fernandez G, Barch M, Doll J, Zamora Diaz I, Pleasure SJ
• Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules.
  Cold Spring Harbor perspectives in biology 2015 Choe Y, Pleasure SJ, Mira H
• Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.
  eLife 2015 Choe Y, Huynh T, Pleasure SJ
• Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis.
  Cell reports 2015 Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ
• A Notch above Sonic Hedgehog.
  Developmental cell 2015 Yabut O, Pleasure SJ, Yoon K
• Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor β family proteins during corticogenesis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Choe Y, Huynh T, Pleasure SJ
• Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S
• Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.
  Nature communications 2014 Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS
• Wrong place, wrong time: ectopic progenitors cause cortical heterotopias.
  Nature neuroscience 2014 Cocas L, Pleasure SJ
• The quintessence of quiescence.
  Neuron 2014 Yabut O, Pleasure SJ
• Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline.
  PloS one 2014 Choe Y, Zarbalis KS, Pleasure SJ
• Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.
  Development (Cambridge, England) 2013 Yang S, Edman LC, Sánchez-Alcañiz JA, Fritz N, Bonilla S, Hecht J, Uhlén P, Pleasure SJ, Villaescusa JC, Marín O, Arenas E
• The development of hippocampal cellular assemblies.
  Wiley interdisciplinary reviews. Developmental biology 2013 Li G, Pleasure SJ
• Importance and hurdles to drug discovery for neurological disease.
  Annals of neurology 2013 Berger JR, Choi D, Kaminski HJ, Gordon MF, Hurko O, D'Cruz O, Pleasure SJ, Feldman EL
• A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.
  PloS one 2013 Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, Wójcicki P, Mostowska A, Davidson B, Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS
• Foxc1 is required by pericytes during fetal brain angiogenesis.
  Biology open 2013 Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ
• The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.
  Neuron 2013 Li G, Fang L, Fernández G, Pleasure SJ
• Bone morphogenic protein signaling is a major determinant of dentate development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Choe Y, Kozlova A, Graf D, Pleasure SJ
• CoupTFI interacts with retinoic acid signaling during cortical development.
  PloS one 2013 Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ
• Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.
  Nature neuroscience 2013 Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S
• Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression.
  Developmental neuroscience 2012 Choe Y, Pleasure SJ
• The GAP between axon pruning and repulsion.
  Developmental cell 2012 Choe Y, Pleasure SJ
• Wnt signaling and forebrain development.
  Cold Spring Harbor perspectives in biology 2012 Harrison-Uy SJ, Pleasure SJ
• Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
  Neuron 2012 Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN
• A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.
  Neuron 2012 Choe Y, Siegenthaler JA, Pleasure SJ
• Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG
• Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice.
  Neural development 2012 Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ
• Inducible genetic lineage tracing of cortical hem derived Cajal-Retzius cells reveals novel properties.
  PloS one 2011 Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y, Pleasure SJ, Zhao C
• An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis.
  Genesis (New York, N.Y. : 2000) 2011 Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C
• Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.
  Translational stroke research 2011 Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H
• Wnt5a controls neurite development in olfactory bulb interneurons.
  ASN neuro 2011 Pino D, Choe Y, Pleasure SJ
• Exciting information for inhibitory neurons.
  Neuron 2011 Li G, Pleasure SJ
• Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ
• We have got you 'covered': how the meninges control brain development.
  Current opinion in genetics & development 2011 Siegenthaler JA, Pleasure SJ
• CXCR4 and CXCR7 have distinct functions in regulating interneuron migration.
  Neuron 2011 Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL
• Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ
• Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Langseth AJ, Munji RN, Choe Y, Huynh T, Pozniak CD, Pleasure SJ
• Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.
  Annals of neurology 2010 Hecht JH, Siegenthaler JA, Patterson KP, Pleasure SJ
• There's no place like home for a neural stem cell.
  Cell stem cell 2010 Siegenthaler JA, Pleasure SJ
• A transgenic Cre mouse line for the study of cortical and hippocampal development.
  Genesis (New York, N.Y. : 2000) 2010 Zhou W, Zhang Y, Li Y, Wei YS, Liu G, Liu DP, Pleasure SJ, Xie W, Zhao C
• Ongoing interplay between the neural network and neurogenesis in the adult hippocampus.
  Current opinion in neurobiology 2010 Li G, Pleasure SJ
• Retinoic acid from the meninges regulates cortical neuron generation.
  Cell 2009 Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ
• Wnt signaling in development and disease.
  Neurobiology of disease 2009 Freese JL, Pino D, Pleasure SJ
• Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture.
  Anesthesiology 2009 Sall JW, Stratmann G, Leong J, McKleroy W, Mason D, Shenoy S, Pleasure SJ, Bickler PE
• Genes and signaling events that establish regional patterning of the mammalian forebrain.
  Seminars in cell & developmental biology 2009 Hoch RV, Rubenstein JL, Pleasure S
• Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development.
  Genesis (New York, N.Y. : 2000) 2009 Gu X, Yan Y, Li H, He D, Pleasure SJ, Zhao C
• Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.
  Development (Cambridge, England) 2009 Li G, Kataoka H, Coughlin SR, Pleasure SJ
• Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.
  Developmental dynamics : an official publication of the American Association of Anatomists 2008 Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ
• Generation of Frizzled10-Cre transgenic mouse line: a useful tool for the study of dorsal telencephalic development.
  Genesis (New York, N.Y. : 2000) 2008 Gu X, He D, Li Y, Hu C, Wei YS, Liu G, Liu D, Pleasure SJ, Xie W, Zhao C
• NMDA receptors inhibit synapse unsilencing during brain development.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Adesnik H, Li G, During MJ, Pleasure SJ, Nicoll RA
• Hypothalamic hamartomas and hedgehogs: not a laughing matter.
  Neurology 2008 Pleasure SJ, Guerrini R
• Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Li G, Adesnik H, Li J, Long J, Nicoll RA, Rubenstein JL, Pleasure SJ
• COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
  Cerebral cortex (New York, N.Y. : 1991) 2007 Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL
• Hilar mossy cells share developmental influences with dentate granule neurons.
  Developmental neuroscience 2007 Li G, Berger O, Han SM, Paredes M, Wu NC, Pleasure SJ
• Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Zarbalis K, Siegenthaler JA, Choe Y, May SR, Peterson AS, Pleasure SJ
• Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.
  Developmental neuroscience 2007 Berger O, Li G, Han SM, Paredes M, Pleasure SJ
• Genetic regulation of dentate gyrus morphogenesis.
  Progress in brain research 2007 Li G, Pleasure SJ
• Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats.
  Developmental neuroscience 2007 Grandgirard D, Bifrare YD, Pleasure SJ, Kummer J, Leib SL, Tauber MG
• Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ
• Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.
  Neuroscience 2006 Zhou CJ, Borello U, Rubenstein JL, Pleasure SJ
• Genetic control of hippocampal neurogenesis.
  Genome biology 2006 Pozniak CD, Pleasure SJ
• Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.
  The Journal of comparative neurology 2006 Paredes M, Pleasure SJ, Baraban SC
• A transgenic marker mouse line labels Cajal-Retzius cells from the cortical hem and thalamocortical axons.
  Brain research 2006 Zhao C, Guan W, Pleasure SJ
• A tale of two signals: Wnt and Hedgehog in dentate neurogenesis.
  Science's STKE : signal transduction knowledge environment 2006 Pozniak CD, Pleasure SJ
• Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy.
  Annals of neurology 2006 Parent JM, Elliott RC, Pleasure SJ, Barbaro NM, Lowenstein DH
• Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval.
  Development (Cambridge, England) 2005 Zhao C, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ
• Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region.
  Brain research. Developmental brain research 2005 Zhao C, Pleasure SJ
• Morphogenesis of the dentate gyrus: what we are learning from mouse mutants.
  Developmental neuroscience 2005 Li G, Pleasure SJ
• Laminar organization of the mouse dentate gyrus: insights from BETA2/Neuro D mutant mice.
  The Journal of comparative neurology 2004 Del Turco D, Gebhardt C, Burbach GJ, Pleasure SJ, Lowenstein DH, Deller T
• Frizzled-9 promoter drives expression of transgenes in the medial wall of the cortex and its chief derivative the hippocampus.
  Genesis (New York, N.Y. : 2000) 2004 Zhao C, Pleasure SJ
• Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Zhou CJ, Pinson KI, Pleasure SJ
• Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Zhou CJ, Zhao C, Pleasure SJ
• Expression of the BMP antagonist Dan during murine forebrain development.
  Brain research. Developmental brain research 2003 Kim AS, Pleasure SJ
• Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family.
  Cell 2003 Bagri A, Cheng HJ, Yaron A, Pleasure SJ, Tessier-Lavigne M
• ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination.
  The Journal of comparative neurology 2002 Zhou CJ, Inagaki N, Pleasure SJ, Zhao LX, Kikuyama S, Shioda S
• PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways.
  Current protein & peptide science 2002 Zhou CJ, Shioda S, Yada T, Inagaki N, Pleasure SJ, Kikuyama S
• Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
  Neuron 2002 Bagri A, Marín O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M
• Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.
  Neuron 2001 Cheng HJ, Bagri A, Yaron A, Stein E, Pleasure SJ, Tessier-Lavigne M
• Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.
  Mechanisms of development 2001 Kim AS, Lowenstein DH, Pleasure SJ
• Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ
• An arrow hits the Wnt signaling pathway.
  Trends in neurosciences 2001 Pleasure SJ
• Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus.
  Neuroscience 2001 Elliott RC, Khademi S, Pleasure SJ, Parent JM, Lowenstein DH
• Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons.
  Neuron 2000 Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL
• Correlation of clinical and neuroimaging findings in a case of rabies encephalitis.
  Archives of neurology 2000 Pleasure SJ, Fischbein NJ
• Unique expression patterns of cell fate molecules delineate sequential stages of dentate gyrus development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Pleasure SJ, Collins AE, Lowenstein DH
• Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Liu M, Pleasure SJ, Collins AE, Noebels JL, Naya FJ, Tsai MJ, Lowenstein DH
• Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections.
  Neuron 2000 Chen H, Bagri A, Zupicich JA, Zou Y, Stoeckli E, Pleasure SJ, Lowenstein DH, Skarnes WC, Chédotal A, Tessier-Lavigne M
• Ventricular volume and transmural pressure gradient in normal pressure hydrocephalus.
  Archives of neurology 1999 Pleasure SJ, Fishman RA
• Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression.
  Neurology 1998 Pleasure SJ, Abosch A, Friedman J, Ko NU, Barbaro N, Dillon W, Fishman RA, Poncelet AN
• Glial cells of the lamprey nervous system contain keratin-like proteins.
  The Journal of comparative neurology 1995 Merrick SE, Pleasure SJ, Lurie DI, Pijak DS, Selzer ME, Lee VM
• Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM
• NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
  Journal of neuroscience research 1993 Pleasure SJ, Lee VM
• Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Younkin DP, Tang CM, Hardy M, Reddy UR, Shi QY, Pleasure SJ, Lee VM, Pleasure D
• Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1992 Pleasure SJ, Page C, Lee VM
• Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
  Laboratory investigation; a journal of technical methods and pathology 1991 He XM, Wikstrand CJ, Friedman HS, Bigner SH, Pleasure S, Trojanowski JQ, Bigner DD
• Primitive neuroectodermal tumors (PNETs) of the CNS and PNS that express functional nerve growth factor receptors (NGFR) but fail to differentiate in response to NGF.
  Progress in clinical and biological research 1991 Reddy UR, Pleasure S, Baker D, Lee VM, Ross AH, Pleasure D
• Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.
  Proceedings of the National Academy of Sciences of the United States of America 1990 Pleasure SJ, Reddy UR, Venkatakrishnan G, Roy AK, Chen J, Ross AH, Trojanowski JQ, Pleasure DE, Lee VM
• Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707m.
  Annals of neurology 1990 Baker DL, Reddy UR, Pleasure S, Hardy M, Williams M, Tartaglione M, Biegel JA, Emanuel BS, Lo Presti P, Kreider B
• Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Pleasure SJ, Lee VM, Nelson DL
• Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1989 Pleasure SJ, Selzer ME, Lee VM