Sam Hawgood, MBBS
Chancellor
Office of the Chancellor
Chancellor/EVC/FAS

Hawgood was dean of the UCSF School of Medicine and vice chancellor for medical affairs from 2009-2014, after assuming the role of interim dean in December of 2007. His distinguished career at UCSF includes serving as chair of the Department of Pediatrics and associate director of the Cardiovascular Research Institute.

Hawgood joined UCSF as a research fellow in 1982 and was active in research until 2015. His focus on the proteins associated with pulmonary surfactant gained him an international reputation in neonatology research.

Hawgood is a member of the American Academy of Pediatrics, the American Association of Physicians, and the National Academy of Medicine, part of the National Academy of Sciences.

Hawgood maintained an active presence in clinical medicine for almost thirty years including serving first as division chief of the Division of Neonatology, then as chair of Pediatrics and physician-in-chief of the UCSF Benioff Children’s Hospital prior to becoming dean. He was also president of the UCSF Medical Group, the faculty association that represents more than 1,800 physicians.

As dean of the School of Medicine, he oversaw an organization with nearly 8,000 faculty and staff, and approximately 3,655 medical and graduate students, residents, fellows, and postdoctoral scholars.

Under his leadership, the school become the top medical school in the nation in research funding from the National Institutes of Health ($439.6 million in 2013), with many of its departments also leading the nation in their fields, reflecting the caliber of scientific research on campus. In that time, the school also became the only medical school in the nation to rank in the top five in both research and primary care education (#4 in each) in the US News & World Report’s annual assessment of graduate schools.

The school’s clinical faculty is renowned for world-class medical care through its practice in the top-ranked UCSF Medical Center, UCSF Benioff Children’s Hospital, Langley Porter Psychiatric Institute, Zuckerberg San Francisco General Hospital and Trauma Center, and the San Francisco Veterans’ Administration Medical Center.

As chancellor, Hawgood oversees the entire $6.7 billion UCSF enterprise, which also includes top-ranking schools of dentistry, nursing, and pharmacy, as well as a graduate division and affiliated hospitals.

A native of Australia, Hawgood graduated medical school with First Class Honors from the University of Queensland in Brisbane. He trained in pediatrics as a resident, followed by specialization in neonatology as a fellow.

• Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes.
  Endocrinology 2012 Montalbano AP, Hawgood S, Mendelson CR
• Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia.
  PloS one 2012 Stidsen JV, Khorooshi R, Rahbek MK, Kirketerp-Møller KL, Hansen PB, Bie P, Kejling K, Mandrup S, Hawgood S, Nielsen O, Nielsen CH, Owens T, Holmskov U, Sørensen GL
• Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity.
  American journal of respiratory and critical care medicine 2010 Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR
• Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis.
  Molecular immunology 2010 Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U
• Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model.
  Infection and immunity 2009 Mun JJ, Tam C, Kowbel D, Hawgood S, Barnett MJ, Evans DJ, Fleiszig SM
• A recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient mice.
  Anatomical record (Hoboken, N.J. : 2007) 2009 Knudsen L, Wucherpfennig K, Mackay RM, Townsend P, Mühlfeld C, Richter J, Hawgood S, Reid K, Clark H, Ochs M
• Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice.
  American journal of physiology. Lung cellular and molecular physiology 2008 Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY
• Expression of surfactant protein D in human corneal epithelial cells is upregulated by Pseudomonas aeruginosa.
  FEMS immunology and medical microbiology 2008 Ni M, Tam C, Verma A, Ramphal R, Hawgood S, Evans DJ, Fleiszig SM
• Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type).
  Pediatric research 2008 Wagner AJ, Stumbaugh A, Tigue Z, Edmondson J, Paquet AC, Farmer DL, Hawgood S
• Laser microdissection allows detection of abnormal gene expression in cystic adenomatoid malformation of the lung.
  Journal of pediatric surgery 2008 Jancelewicz T, Nobuhara K, Hawgood S
• Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice.
  Respiratory research 2007 Knudsen L, Ochs M, Mackay R, Townsend P, Deb R, Mühlfeld C, Richter J, Gilbert F, Hawgood S, Reid K, Clark H
• Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
  American journal of respiratory cell and molecular biology 2007 Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG
• N-linked glycosylation attenuates H3N2 influenza viruses.
  Journal of virology 2007 Vigerust DJ, Ulett KB, Boyd KL, Madsen J, Hawgood S, McCullers JA
• Helicobacter infection in the surfactant protein D-deficient mouse.
  Helicobacter 2007 Khamri W, Worku ML, Anderson AE, Walker MM, Hawgood S, Reid KB, Clark HW, Thursz MR
• Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.
  Toxicology and applied pharmacology 2006 Haque R, Umstead TM, Ponnuru P, Guo X, Hawgood S, Phelps DS, Floros J
• Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2006 Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR
• Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis.
  The Journal of biological chemistry 2006 Baldán A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA
• IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Haczku A, Cao Y, Vass G, Kierstein S, Nath P, Atochina-Vasserman EN, Scanlon ST, Li L, Griswold DE, Chung KF, Poulain FR, Hawgood S, Beers MF, Crouch EC
• Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa.
  American journal of respiratory cell and molecular biology 2006 Giannoni E, Sawa T, Allen L, Wiener-Kronish J, Hawgood S
• Surfactant protein D is proatherogenic in mice.
  American journal of physiology. Heart and circulatory physiology 2005 Sorensen GL, Madsen J, Kejling K, Tornoe I, Nielsen O, Townsend P, Poulain F, Nielsen CH, Reid KB, Hawgood S, Falk E, Holmskov U
• Mast cells protect mice from Mycoplasma pneumonia.
  American journal of respiratory and critical care medicine 2005 Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH
• Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice.
  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005 Jung A, Allen L, Nyengaard JR, Gundersen HJ, Richter J, Hawgood S, Ochs M
• Alveolar surfactant protein D content modulates bleomycin-induced lung injury.
  American journal of respiratory and critical care medicine 2005 Casey J, Kaplan J, Atochina-Vasserman EN, Gow AJ, Kadire H, Tomer Y, Fisher JH, Hawgood S, Savani RC, Beers MF
• Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Palaniyar N, Clark H, Nadesalingam J, Shih MJ, Hawgood S, Reid KB
• Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa.
  Infection and immunity 2005 Ni M, Evans DJ, Hawgood S, Anders EM, Sack RA, Fleiszig SM
• Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species.
  Infection and immunity 2004 Atochina EN, Beck JM, Preston AM, Haczku A, Tomer Y, Scanlon ST, Fusaro T, Casey J, Hawgood S, Gow AJ, Beers MF
• Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia.
  Pediatric research 2004 Keller RL, Hawgood S, Neuhaus JM, Farmer DL, Lee H, Albanese CT, Harrison MR, Kitterman JA
• GM-CSF mediates alveolar epithelial type II cell changes, but not emphysema-like pathology, in SP-D-deficient mice.
  American journal of physiology. Lung cellular and molecular physiology 2004 Ochs M, Knudsen L, Allen L, Stumbaugh A, Levitt S, Nyengaard JR, Hawgood S
• Pulmonary collectins modulate strain-specific influenza a virus infection and host responses.
  Journal of virology 2004 Hawgood S, Brown C, Edmondson J, Stumbaugh A, Allen L, Goerke J, Clark H, Poulain F
• Surfactant protein B: structure and function.
  Biology of the neonate 2004 Hawgood S
• Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice.
  The Journal of infectious diseases 2004 Atochina EN, Gow AJ, Beck JM, Haczku A, Inch A, Kadire H, Tomer Y, Davis C, Preston AM, Poulain F, Hawgood S, Beers MF
• Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004 Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S
• A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema.
  Annals of the New York Academy of Sciences 2003 Clark H, Palaniyar N, Hawgood S, Reid KB
• Surfactant protein D binds genomic DNA and apoptotic cells, and enhances their clearance, in vivo.
  Annals of the New York Academy of Sciences 2003 Palaniyar N, Clark H, Nadesalingam J, Hawgood S, Reid KB
• A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia.
  The New England journal of medicine 2003 Harrison MR, Keller RL, Hawgood SB, Kitterman JA, Sandberg PL, Farmer DL, Lee H, Filly RA, Farrell JA, Albanese CT
• Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.
  The Journal of biological chemistry 2003 Brasch F, Ochs M, Kahne T, Guttentag S, Schauer-Vukasinovic V, Derrick M, Johnen G, Kapp N, Muller KM, Richter J, Giller T, Hawgood S, Buhling F
• Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs.
  American journal of respiratory cell and molecular biology 2003 Brasch F, Johnen G, Winn-Brasch A, Guttentag SH, Schmiedl A, Kapp N, Suzuki Y, Müller KM, Richter J, Hawgood S, Ochs M
• Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism.
  American journal of respiratory cell and molecular biology 2003 Atochina EN, Beers MF, Hawgood S, Poulain F, Davis C, Fusaro T, Gow AJ
• Neurodevelopmental outcome of infants supported with extracorporeal membrane oxygenation after cardiac surgery.
  Pediatrics 2003 Hamrick SE, Gremmels DB, Keet CA, Leonard CH, Connell JK, Hawgood S, Piecuch RE
• Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation.
  American journal of physiology. Lung cellular and molecular physiology 2003 Haddad IY, Milla C, Yang S, Panoskaltsis-Mortari A, Hawgood S, Lacey DL, Blazar BR
• Resolution of hydrops fetalis in congenital cystic adenomatoid malformation after prenatal steroid therapy.
  Journal of pediatric surgery 2003 Tsao K, Hawgood S, Vu L, Hirose S, Sydorak R, Albanese CT, Farmer DL, Harrison MR, Lee H
• MR imaging of hepatic pulmonary fusion in neonates.
  AJR. American journal of roentgenology 2003 Keller RL, Aaroz PA, Hawgood S, Higgins CB
• SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues.
  American journal of physiology. Lung cellular and molecular physiology 2003 Jain D, Dodia C, Bates SR, Hawgood S, Poulain FR, Fisher AB
• Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema.
  American journal of physiology. Lung cellular and molecular physiology 2002 Hawgood S, Ochs M, Jung A, Akiyama J, Allen L, Brown C, Edmondson J, Levitt S, Carlson E, Gillespie AM, Villar A, Epstein CJ, Poulain FR
• Surfactant protein D reduces alveolar macrophage apoptosis in vivo.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Clark H, Palaniyar N, Strong P, Edmondson J, Hawgood S, Reid KB
• Tissue distribution of surfactant proteins A and D in the mouse.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Akiyama J, Hoffman A, Brown C, Allen L, Edmondson J, Poulain F, Hawgood S
• Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus.
  American journal of respiratory cell and molecular biology 2002 Li G, Siddiqui J, Hendry M, Akiyama J, Edmondson J, Brown C, Allen L, Levitt S, Poulain F, Hawgood S
• Intracellular and intraalveolar localization of surfactant protein A (SP-A) in the parenchymal region of the human lung.
  American journal of respiratory cell and molecular biology 2002 Ochs M, Johnen G, Müller KM, Wahlers T, Hawgood S, Richter J, Brasch F