Sakeen Kashem, MD, PhD
Assistant Professor
Dermatology
School of Medicine

Education & Training

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• Residency Dermatology University of California, San Francisco 2022
• Internship Internal Medicine University of Texas Southwestern 2019
• MD University of Minnesota 2018
• PhD Immunology University of Minnesota 2016
• BA Chemistry New York University 2008
• Diversity, Equity, and Inclusion Champion Training University of California, San Francisco

Interests

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• Immunology
• Immunotherapy
• Dermatology
• Inflammation

Publications (25)

Top publication keywords:
Opportunistic InfectionsInterleukin-23Antigen-Presenting CellsCandidiasis, Chronic MucocutaneousCandida albicansSkinPrurigoTh17 CellsCandidiasisArthritisScleroderma, LocalizedImmunityDendritic CellsLangerhans CellsReceptors, Neuropeptide

• Antigen-Presenting Cells in the Skin.
  Annual review of immunology 2017 Kashem SW, Haniffa M, Kaplan DH
• Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.
  Immunity 2015 Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L, Kaplan DH
• Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.
  Immunity 2015 Kashem SW, Igyarto BZ, Gerami-Nejad M, Kumamoto Y, Mohammed JA, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, Iwasaki A, Brown GD, Kaplan DH
• Neuropeptide substance P alters stem cell fate to aid wound healing and promote epidermal stratification through asymmetric stem cell divisions.
  Stem cells (Dayton, Ohio) 2024 Khalifa A, Xiao T, Abegaze B, Weisenberger T, Charruyer A, Sanad S, AbuElnasr T, Kashem SW, Fassett M, Ghadially R
• CCR2-targeting pepducins reduce T cell-nociceptor interaction driving bone cancer pain
  bioRxiv 2023 Midavaine E, Brouillette RR, Theberge E, Mona CE, Kashem SW, Cote J, Zeugin V, Besserer-Offroy E, Longpre JM, Marsault E, Sarret P

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• Can Serum Biomarkers for Prurigo Nodularis Expose Pathophysiology or Just Treatment Response?
  JAMA dermatology 2023 Kashem SW, Fassett MS
• Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch
  bioRxiv 2023 Crowther AJ, Kashem SW, Jewell ME, Chang HL, Casillas MR, Midavaine E, Rodriguez S, Braz JM, Kania A, Basbaum AI
• Spontaneous resolution of intractable prurigo nodularis after subinsular cortex stroke.
  JAAD case reports 2022 Kashem SW, Motzkin JC, Leslie KS
• Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells.
  Science immunology 2022 Whitley SK, Li M, Kashem SW, Hirai T, Igyártó BZ, Knizner K, Ho J, Ferris LK, Weaver CT, Cua DJ, McGeachy MJ, Kaplan DH
• A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity.
  Cell reports. Medicine 2022 Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SBV, Cheng JB, Cho RJ
• Association of Facial Pustular Neutrophilic Eruption With Messenger RNA-1273 SARS-CoV-2 Vaccine.
  JAMA dermatology 2021 Merrill ED, Kashem SW, Amerson EH, Pincus LB, Lang UE, Shinkai K, Chang AY
• Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.
  iScience 2020 Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC…
• Isolation of Murine Skin Resident and Migratory Dendritic Cells via Enzymatic Digestion.
  Current protocols in immunology 2018 Kashem SW, Kaplan DH
• Inflammatory arthritis in pediatric patients with morphea.
  Journal of the American Academy of Dermatology 2018 Kashem SW, Correll CK, Vehe RK, Hobday PM, Binstadt BA, Maguiness SM
• Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
  Antibodies (Basel, Switzerland) 2017 Kashem SW, Binstadt BA
• Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Wiesner DL, Smith KD, Kashem SW, Bohjanen PR, Nielsen K
• Brief Report: Arthritis in KRN T Cell Receptor-Transgenic Mice Does Not Require Interleukin-17 or Th17 Cells.
  Arthritis & rheumatology (Hoboken, N.J.) 2016 Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA
• Skin Immunity to Candida albicans.
  Trends in immunology 2016 Kashem SW, Kaplan DH
• Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
  Nature immunology 2016 Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, …
• Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK
• Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS
• Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Haley K, Igyártó BZ, Ortner D, Bobr A, Kashem S, Schenten D, Kaplan DH
• G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2.
  European journal of pharmacology 2011 Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H
• PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
  Molecular pharmacology 2011 Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, Ali H
• Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo.
  American journal of physiology. Heart and circulatory physiology 2007 Hassan S, Sainz IM, Khan MM, Bradford HN, Isordia-Salas I, Kashem SW, Sartor RB, Colman RW