Sachin Sharma, PhD
Postdoctoral Scholar
Medicine
School of Medicine

Completed doctoral research in 2022 from Amity University, India with research specialization in liver injury and fibrosis progression. Outside of lab, I like to go hanging out with friends, outdoors hiking and exploring new places!

Awards

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• Senior Research Fellowship, Council of Scientific and Industrial Research, Government of India, India, 2017-2020
• Junior Research Fellowship, Council of Scientific and Industrial Research, Government of India, India, 2015-2017

Education & Training

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• Ph.D. Liver Diseases Amity University 2022
• M.Sc. Biotechnology (Molecular Biology) Chaudhary Charan Singh University 2012
• B.Sc. Biotechnology (Molecular Biology) Chaudhary Charan Singh University 2010

Interests

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• Cirrhosis
• Liver Disease
• Hepatocellular Carcinoma
• Nonalcoholic Fatty Liver Disease (NAFLD)
• Hepatic fibrosis
• Inflammation

Websites

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• Jennifer Chen Lab (chenlab.ucsf.edu)

Publications (12)

Top publication keywords:
HumansHepatocytesLiver CirrhosisHepatic Stellate CellsEndothelial CellsAnimalsNon-alcoholic Fatty Liver DiseaseAMP-Activated Protein KinasesMiceSignal Transduction

• AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis.
  Scientific reports 2024 Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY
• Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis.
  Nature reviews. Gastroenterology & hepatology 2023 Sharma S, Le Guillou D, Chen JY
• Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis.
  Frontiers in medicine 2022 Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY
• Context dependent role of p53 during the interaction of hepatocellular carcinoma and endothelial cells
  Microvascular Research 2022 Shaikh Maryam Ghufrana, Sachin Sharma, Sampa Ghose, Subhrajit Biswas
• Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction
  Hepatology International 2021 Nidhi Nautiyal, Deepanshu Maheshwari, Dinesh Mani Tripathi, Dhananjay Kumar, Rekha Kumari, Suchi Gupta, Sachin Sharma, Sujata Mohanty, Anupama Parasar, Chhagan Bihari, Subhrajit Biswas, Archana …

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• Divergent Effect of Birinapant, BV6 SMAC Mimetic on TNFα induced NF-κB Signaling and Cell Viability in Activated Hepatic Stellate Cell
  Researchsquare(Preprint) 2021 Sachin Sharma, Shaikh Maryam Ghufran, Sampa Ghose, Subhrajit Biswas
• Survivin expression is essential for early activation of hepatic stellate cells and fibrosis progression in chronic liver injury
  Life Science Life Sciences 2021 Sachin Sharma, Shaikh Maryam Ghufran, Basundhara Das, Bornika Roy, Sampa Ghose Subhrajit Biswas
• Cytoplasmic vacuolation with endoplasmic reticulum stress directs sorafenib induced non-apoptotic cell death in hepatic stellate cells
  Scientific Reports 2021 Sachin Sharma, Shaikh Maryam Ghufran, Sampa Ghose, Subhrajit Biswas
• Extracellular Vesicles From Hepatitis B Patients Serve As Reservoir Of Hepatitis B Virus DNA
  Journal of Viral Hepatitis 2019 Sukriti Sukriti, Manish Chandra Choudhary, Jaswinder Singh Maras, Sachin Sharma, Swati Thangariyal, Avishek Singh, Sukanto Das, Mojahidul Islam, Shvetank Sharma, Nirupama Trehanpati, Ekta Gupta, Shiv …
• Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis
  Scientific Reports 2018 Jaswinder Singh Maras, Sukanta Das, Sachin Sharma, Sukriti Sukriti, Jitendra kumar, Ashish Kumar Vyas, Dhananjay Kumar, Adil Bhat, Gaurav Yadav, Manish Chandra Choudhary, Shvetank Sharma, Guresh kumar…
• Immunology and Cell Biology
  Impact of inhibitor of apoptosis proteins on immune modulation and inflammation 2017 Sachin Sharma, Thomas Kaufmann, Subhrajit Biswas
• BioMed Research International
  Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development 2014 Madhu Khanna, Sachin Sharma, Binod Kumar, Roopali Rajput