Ruzbeh Mosadeghi, MD, PhD
Assistant Professor
Medicine
School of Medicine

Education & Training

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• Fellowship Gastroenterology UCSF 06/2023
• Residency Internal Medicine Columbia University Medical Center 06/2019
• MD Medicine Keck School of Medicine of USC 05/2017
• PhD Biology California Institute of Technology 06/2015

Publications (4)

Top publication keywords:
Mass SpectrometryCryoelectron MicroscopyNEDD8 ProteinKineticsIntracellular Signaling Peptides and ProteinsS-Phase Kinase-Associated ProteinsCullin ProteinsMultiprotein ComplexesUbiquitinUbiquitinsPeptide HydrolasesF-Box ProteinsHydrolysisOxygenasesMultienzyme Complexes

• Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.
  eLife 2016 Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, Enchev RI
• A far downstream enhancer for murine Bcl11b controls its T-cell specific expression.
  Blood 2013 Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F, Rothenberg EV
• Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
  The Journal of biological chemistry 2012 Emberley ED, Mosadeghi R, Deshaies RJ
• Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.
  Journal of biochemical and molecular toxicology 2007 Zhang J, Cerny MA, Lawson M, Mosadeghi R, Cashman JR