Ruchi Malik, PhD
Associate Specialist
Psychiatry
School of Medicine

Awards

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• NARSAD Young Investigator Award, Brain and Behavior Research Foundation, 2018
• Carl Storm International Diversity Fellowship, Gordon Research Conference, 2011
• IBRO-SFN travel award, 2010

Education & Training

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• PhD National Centre for Biological Sciences
• Postdoc University of Texas

Interests

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• Long-range synchrony
• Interneuron physiology
• Prefrontal cortex
• Hippocampus
• Autism
• Biophysics

Websites

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• Google Scholar Profile (scholar.google.com)

Grants and Projects

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• Identification of cortical interneuron deficits underlying autism spectrum disorder in Tuberous Sclerosis Complex, NARSAD, Brain and Behavior Research Foundation, 2019-2021

Publications (13)

Top publication keywords:
Action PotentialsHippocampusParvalbuminsPrefrontal CortexVasoactive Intestinal PeptideDendritesExcitatory Postsynaptic PotentialsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsInterneuronsSomatostatinPyramidal CellsCA1 Region, HippocampalPatch-Clamp TechniquesLong-Term PotentiationMembrane Potentials

• Tsc1 Loss in VIP-Lineage Cortical Interneurons Results in More VIP+ Interneurons and Enhanced Excitability.
  Cells 2023 Hu JS, Malik R, Sohal VS, Rubenstein JL, Vogt D
• Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Kupferschmidt DA, Cummings KA, Joffe ME, MacAskill A, Malik R, Sánchez-Bellot C, Tejeda HA, Yarur Castillo H
• Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition.
  Cell 2022 Malik R, Li Y, Schamiloglu S, Sohal VS
• Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
  bioRxiv 2021 Ruchi Malik, Yi Li, Selin Schamiloglu, Vikaas S. Sohal
• Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons.
  eNeuro 2020 Rubin AN, Malik R, Cho KKA, Lim KJ, Lindtner S, Robinson Schwartz SE, Vogt D, Sohal VS, Rubenstein JLR

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• GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons.
  PloS one 2020 Garst-Orozco J, Malik R, Lanz TA, Weber ML, Xi H, Arion D, Enwright JF, Lewis DA, O'Donnell P, Sohal VS, Buhl DL
• Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Southwell DG, Seifikar H, Malik R, Lavi K, Vogt D, Rubenstein JL, Sohal VS
• Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons.
  Nature communications 2019 Malik R, Pai EL, Rubin AN, Stafford AM, Angara K, Minasi P, Rubenstein JL, Sohal VS, Vogt D
• Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion.
  Neuron 2019 Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS
• Dendritic GIRK Channels Gate the Integration Window, Plateau Potentials, and Induction of Synaptic Plasticity in Dorsal But Not Ventral CA1 Neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Malik R, Johnston D
• Transient potassium channels augment degeneracy in hippocampal active dendritic spectral tuning.
  Scientific reports 2016 Rathour RK, Malik R, Narayanan R
• Mapping the electrophysiological and morphological properties of CA1 pyramidal neurons along the longitudinal hippocampal axis.
  Hippocampus 2015 Malik R, Dougherty KA, Parikh K, Byrne C, Johnston D
• Enhanced intrinsic excitability and EPSP-spike coupling accompany enriched environment-induced facilitation of LTP in hippocampal CA1 pyramidal neurons.
  Journal of neurophysiology 2011 Malik R, Chattarji S