Ruby Ghadially, MD
Professor
Dermatology
School of Medicine

Education & Training

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• Residency Dermatology University of Toronto 1988
• University of Sheffield England 1982

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Grants and Projects

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• The role of IL17A and keratinocyte stem cells in human psoriasis., NIH, 2020-2024
• The role of IL17A and keratinocyte stem cells in human psoriasis, Merit Review, 2020-2024
• Characterization of Human Epidermal Stem Cells, NIH, 2010-2014
• Reversing Epidermal Stem Cell Aging: Role of Bmi-1 and the Stem Cell Niche, NIH, 2010-2013
• Characterization of Epidermal Stem Cells, NIH, 2005-2011
• Epidermal Stem Cells: Age-Related Changes, NIH, 2002-2005
• Age-Related Changes in Epidermal Stem Cells, NIH, 2001-2003
• Cytokine Expression and Signalling in Aged Epidermis, NIH, 1996-2002

Publications (49)

Top publication keywords:
PsoriasisAldehyde DehydrogenasePluripotent Stem CellsSkin AgingKeratinocytesInterleukin-17Retinal DehydrogenaseCell ProliferationRNAi TherapeuticsEpidermisCell Self RenewalStem CellsAdult Stem CellsSkinAsymmetric Cell Division

• Short cell cycle duration is a phenotype of human epidermal stem cells.
  Stem cell research & therapy 2024 Xiao T, Eze UC, Charruyer-Reinwald A, Weisenberger T, Khalifa A, Abegaze B, Schwab GK, Elsabagh RH, Parenteau TR, Kochanowski K, Piper M, Xia Y, Cheng JB, Cho RJ, Ghadially R
• Classification of human chronic inflammatory skin disease based on single-cell immune profiling.
  Science immunology 2022 Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB
• Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI
• Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis.
  Aging cell 2021 Charruyer A, Weisenberger T, Li H, Khalifa A, Schroeder AW, Belzer A, Ghadially R
• Facial psoriasis in a mask-like distribution.
  JAAD case reports 2020 Zachary CMB, Belzer A, Fackler NP, Shiu J, Smith J, Ghadially R

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• Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.
  iScience 2020 Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC…
• IL-1α, IL-6, and GM-CSF Are Downstream Mediators of IL-17A that Promote Asymmetric Stem Cell Self-Renewal in Human Keratinocytes.
  The Journal of investigative dermatology 2020 Li H, Charruyer A, Weisenberger T, Khalifa A, Nguyen R, Ghadially R
• Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects.
  BMC dermatology 2019 Charruyer A, Silvander M, Caputo-Janhager M, Raymond I, Ghadially R
• Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution.
  Cell reports 2018 Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu …
• Influence of pH on Skin Stem Cells and Their Differentiation.
  Current problems in dermatology 2018 Charruyer A, Ghadially R
• Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation.
  Stem cells (Dayton, Ohio) 2017 Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R
• Phycosaccharide AI, a mixture of alginate polysaccharides, increases stem cell proliferation in aged keratinocytes.
  Experimental dermatology 2016 Charruyer A, Fong S, Yue L, Arron ST, Ghadially R
• Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma.
  Melanoma research 2015 Yue L, Huang ZM, Fong S, Leong S, Jakowatz JG, Charruyer-Reinwald A, Wei M, Ghadially R
• The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.
  Stem cells (Dayton, Ohio) 2013 Szabo AZ, Fong S, Yue L, Zhang K, Strachan LR, Scalapino K, Mancianti ML, Ghadially R
• CD133 is a marker for long-term repopulating murine epidermal stem cells.
  The Journal of investigative dermatology 2012 Charruyer A, Strachan LR, Yue L, Toth AS, Cecchini G, Mancianti ML, Ghadially R
• 25 years of epidermal stem cell research.
  The Journal of investigative dermatology 2011 Ghadially R
• The role of stem and circulating cells in cancer metastasis.
  Journal of surgical oncology 2011 Ghadially R
• What's new in dermatology: epidermal stem cells.
  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2011 Charruyer A, Ghadially R
• Selection of tumorigenic melanoma cells using ALDH.
  The Journal of investigative dermatology 2010 Boonyaratanakornkit JB, Yue L, Strachan LR, Scalapino KJ, LeBoit PE, Lu Y, Leong SP, Smith JE, Ghadially R
• Limiting dilution analysis of murine epidermal stem cells using an in vivo regeneration assay.
  Methods in molecular biology (Clifton, N.J.) 2010 Strachan LR, Ghadially R
• Transit-amplifying cell frequency and cell cycle kinetics are altered in aged epidermis.
  The Journal of investigative dermatology 2009 Charruyer A, Barland CO, Yue L, Wessendorf HB, Lu Y, Lawrence HJ, Mancianti ML, Ghadially R
• Stem cells and tissue-engineered skin.
  Skin pharmacology and physiology 2009 Charruyer A, Ghadially R
• Tiers of clonal organization in the epidermis: the epidermal proliferation unit revisited.
  Stem cell reviews 2008 Strachan LR, Ghadially R
• Rapid adhesion to collagen isolates murine keratinocytes with limited long-term repopulating ability in vivo despite high clonogenicity in vitro.
  Stem cells (Dayton, Ohio) 2007 Strachan LR, Scalapino KJ, Lawrence HJ, Ghadially R
• A new water-based topical carrier with polar skin-lipids.
  Lipids in health and disease 2006 Silvander M, Ringstad L, Ghadially R, Sköld T
• Epidermal stem cells.
  Advances in dermatology 2005 Ghadially R
• In search of the elusive epidermal stem cell.
  Ernst Schering Research Foundation workshop 2005 Ghadially R
• Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis.
  The Journal of investigative dermatology 2004 Barland CO, Zettersten E, Brown BS, Ye J, Elias PM, Ghadially R
• Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Schneider TE, Barland C, Alex AM, Mancianti ML, Lu Y, Cleaver JE, Lawrence HJ, Ghadially R
• Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family.
  Experimental dermatology 2002 Ye J, Garg A, Calhoun C, Feingold KR, Elias PM, Ghadially R
• The aged epidermal permeability barrier: basis for functional abnormalities.
  Clinics in geriatric medicine 2002 Elias PM, Ghadially R
• Testosterone perturbs epidermal permeability barrier homeostasis.
  The Journal of investigative dermatology 2001 Kao JS, Garg A, Mao-Qiang M, Crumrine D, Ghadially R, Feingold KR, Elias PM
• Recessive x-linked ichthyosis: role of cholesterol-sulfate accumulation in the barrier abnormality.
  The Journal of investigative dermatology 1998 Zettersten E, Man MQ, Sato J, Denda M, Farrell A, Ghadially R, Williams ML, Feingold KR, Elias PM
• Aging and the epidermal permeability barrier: implications for contact dermatitis.
  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 1998 Ghadially R
• Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin.
  Journal of the American Academy of Dermatology 1997 Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM
• Stratum corneum structure and function correlates with phenotype in psoriasis.
  The Journal of investigative dermatology 1996 Ghadially R, Reed JT, Elias PM
• Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice.
  The Journal of investigative dermatology 1996 Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM
• Tumours of the skin.
  IARC scientific publications 1996 Ghadially FN, Ghadially R
• Skin type, but neither race nor gender, influence epidermal permeability barrier function.
  Archives of dermatology 1995 Reed JT, Ghadially R, Elias PM
• The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.
  The Journal of clinical investigation 1995 Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM
• Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses.
  The Journal of investigative dermatology 1992 Ghadially R, Williams ML, Hou SY, Elias PM
• Exogenous origin of n-alkanes in pathologic scale.
  Archives of dermatology 1992 Williams ML, Vogel JS, Ghadially R, Brown BE, Elias PM
• Ichthyoses and hyperkeratotic disorders.
  Dermatologic clinics 1992 Ghadially R, Chong LP
• Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation.
  The British journal of dermatology 1992 Menon GK, Ghadially R, Williams ML, Elias PM
• Effects of petrolatum on stratum corneum structure and function.
  Journal of the American Academy of Dermatology 1992 Ghadially R, Halkier-Sorensen L, Elias PM
• Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction.
  The Journal of investigative dermatology 1991 Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM
• Anchoring fibrils in a spindle cell squamous carcinoma.
  Journal of submicroscopic cytology and pathology 1989 Ghadially R, Ghadially FN
• Simple method for purification of phospholipase A from cobra venom.
  Toxicon : official journal of the International Society on Toxinology 1969 Braganca BM, Sambray YM, Ghadially RC
• Myo-Inositol activity of oxidtion products derived from myo-inositol.
  Archives of biochemistry and biophysics 1962 JOHNSTON JA, GHADIALLY RC, ROBERTS RN, FUHR BW