Roy Gerona, PhD
Associate Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

In biomonitoring, my laboratory is pioneering the application of high resolution mass spectrometry to the suspect screening of environmental chemicals in biological samples. We have have also continuously developed innovative and sensitive liquid chromatography- mass spectrometry (LC-MS) methods for measuring environmental chemicals (e.g. environmental phenols such as BPA, BPS and triclosan; phthalate metabolites; perfluorinated compounds; pesticides; and, flame retardants) in a variety of biological matrices including serum, urine, amniotic fluid, placenta, hair, and other human and animal tissues.

My laboratory also specializes in the analysis of new psychoactive substances (NPS) using high resolution and tandem mass spectrometry to aid Poison Centers, Medical Examiner’s Offices, and various government agencies including the Drug Enforcement Administration, the Centers for Disease Control and Prevention, and the National Institute of Occupational Safety and Health, in tracking down synthetic drug intoxications and epidemics. In 2016 I established the Pshychoactive Substances Consortium and Analysis Network (PSCAN), a consortium of ten medical centers prospectively collecting cases that may have NPS etiology to pair comprehensive clinical data with NPS analysis data in their corresponding biological samples with the aim of potentially defining toxidromes specific to various NPS classes. This year my laboratory has been awarded by a Department of Justice (DOJ)- DEA research contract to conduct the national surveillance on NPS intoxications and mass outbreak.

More recently, I have also started working with the Positive Health Program at San Francisco General Hospital to develop LC-MS methods for hair TB drug monitoring in HIV/AIDS patients and related studies. We have successfully developed an LC-MS/MS panel to simultaneously measure 11 TB drugs in hair including new drug-resistant TB medications. The panel is currently being used for drug adherence monitoring among multi-drug resistant TB patients.

• Alternative Methods for Therapeutic Drug Monitoring and Dose Adjustment of Tuberculosis Treatment in Clinical Settings: A Systematic Review.
  Clinical pharmacokinetics 2023 Rao PS, Modi N, Nguyen NT, Vu DH, Xie YL, Gandhi M, Gerona R, Metcalfe J, Heysell SK, Alffenaar JC
• Glyphosate exposure and preterm birth: A nested case-control pilot study.
  Reproductive toxicology (Elmsford, N.Y.) 2023 Varde M, Gerona RR, Newman RB, Reckers A, Braak DC, Vena JE, Bloom MS
• Profound Hyperthermia Associated With Fentanyl and Cocaine Use With Suspected Synephrine Adulteration.
  The Journal of emergency medicine 2023 Choe AJ, Ellison R, Ramaswamy SR, Schult RF, Gerona R, Nacca N
• Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients.
  Journal of medical toxicology : official journal of the American College of Medical Toxicology 2023 Shaker K, Nillas A, Ellison R, Martin K, Trecki J, Gerona R, Aldy K
• Reduction of daily-use parabens and phthalates reverses accumulation of cancer-associated phenotypes within disease-free breast tissue of study subjects.
  Chemosphere 2023 Dairkee SH, Moore DH, Luciani MG, Anderle N, Gerona R, Ky K, Torres SM, Marshall PV, Goodson Iii WH
• Comprehensive Characterization of a Systematic Library of Alkyl and Alicyclic Synthetic Cannabinoids Related to CUMYL-PICA, CUMYL-BUTICA, CUMYL-CBMICA, and CUMYL-PINACA.
  ACS chemical neuroscience 2022 Janssens LK, Ametovski A, Sparkes E, Boyd R, Lai F, Maloney CJ, Rhook D, Gerona RR, Connolly M, Liu H, Hibbs DE, Cairns EA, Banister SD, Stove CP
• Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies.
  Environmental health : a global access science source 2022 Gerona RR, Reiter JL, Zakharevich I, Proctor C, Ying J, Mesnage R, Antoniou M, Winchester PD
• Agreement Between Measures of Adherence to Isoniazid Preventive Therapy Among People With HIV in Uganda.
  Open forum infectious diseases 2022 Forman LS, Lodi S, Fatch R, Emenyonu NI, Adong J, Ngabirano C, Jacobson KR, Gerona R, Reckers AR, Gandhi M, Muyindike WR, Hahn JA
• Synthesis and pharmacological evaluation of newly detected synthetic cannabinoid receptor agonists AB-4CN-BUTICA, MMB-4CN-BUTINACA, MDMB-4F-BUTICA, MDMB-4F-BUTINACA and their analogs.
  Frontiers in psychiatry 2022 Sparkes E, Boyd R, Chen S, Markham JW, Luo JL, Foyzun T, Zaman H, Fletcher C, Ellison R, McGregor IS, Santiago MJ, Lai F, Gerona RR, Connor M, Hibbs DE, Cairns EA, Glass M, Ametovski A, Banister SD
• Drug testing in the era of new psychoactive substances.
  Advances in clinical chemistry 2022 Gerona RR, French D
• Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
  Nature microbiology 2022 Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh…
• Obstetric risk in pregnancy interacts with hair cortisone levels to reduce gestational length.
  Frontiers in global women's health 2022 Musana J, Cohen CR, Kuppermann M, Gerona R, Wanyoro A, Aguilar D, Santos N, Temmerman M, Weiss SJ
• Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors.
  ACS chemical neuroscience 2022 Kevin RC, Mirlohi S, Manning JJ, Boyd R, Cairns EA, Ametovski A, Lai F, Luo JL, Jorgensen W, Ellison R, Gerona RR, Hibbs DE, McGregor IS, Glass M, Connor M, Bladen C, Zamponi GW, Banister SD
• Defining Steric Requirements at CB1 and CB2 Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and Their Analogues.
  ACS chemical neuroscience 2022 Markham J, Sparkes E, Boyd R, Chen S, Manning JJ, Finlay D, Lai F, McGregor E, Maloney CJ, Gerona RR, Connor M, McGregor IS, Hibbs DE, Glass M, Kevin RC, Banister SD
• Notes from the Field: Increased Incidence of Fentanyl-Related Deaths Involving Para-fluorofentanyl or Metonitazene - Knox County, Tennessee, November 2020-August 2021.
  MMWR. Morbidity and mortality weekly report 2022 Trecki J, Gerona RR, Ellison R, Thomas C, Mileusnic-Polchan D
• Diaporthe/Phomopsis longicolla degrades an array of bisphenol analogues with secreted laccase.
  Microbiological research 2022 Baluyot JC, Santos HK, Batoctoy DCR, Torreno VPM, Ghimire LB, Joson SEA, Obusan MCM, Yu ET, Bela-Ong DB, Gerona RR, Velarde MC
• A critical review of drug testing policy in the Philippines.
  Drug Science Policy and Law 2022 Carissa Paz Dioquino, Roy Roberto Gerona
• Bisphenol-A analogs induce lower urinary tract dysfunction in male mice.
  Biochemical pharmacology 2022 Nguyen JL, Ricke EA, Liu TT, Gerona R, MacGillivray L, Wang Z, Timms BG, Bjorling DE, Vom Saal FS, Ricke WA
• Organophosphate and Organohalogen Flame-Retardant Exposure and Thyroid Hormone Disruption in a Cross-Sectional Study of Female Firefighters and Office Workers from San Francisco.
  Environmental science & technology 2021 Trowbridge J, Gerona R, McMaster M, Ona K, Clarity C, Bessonneau V, Rudel R, Buren H, Morello-Frosch R
• Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies.
  The American journal of case reports 2021 Akpunonu P, Baum RA, Reckers A, Davidson B, Ellison R, Riley M, Trecki J, Gerona R
• Structure-activity relationships of valine, tert-leucine, and phenylalanine amino acid-derived synthetic cannabinoid receptor agonists related to ADB-BUTINACA, APP-BUTINACA, and ADB-P7AICA.
  RSC medicinal chemistry 2021 Sparkes E, Cairns EA, Kevin RC, Lai F, Grafinger KE, Chen S, Deventer MH, Ellison R, Boyd R, Martin LJ, McGregor IS, Gerona RR, Hibbs DE, Auwärter V, Glass M, Stove C, Banister SD
• NNL-3: A Synthetic Intermediate or a New Class of Hydroxybenzotriazole Esters with Cannabinoid Receptor Activity?
  ACS chemical neuroscience 2021 Ametovski A, Cairns EA, Grafinger KE, Cannaert A, Deventer MH, Chen S, Wu X, Shepperson CE, Lai F, Ellison R, Gerona R, Blakey K, Kevin R, McGregor IS, Hibbs DE, Glass M, Stove C, Auwärter V, Banister…
• Quantity of phenibut in dietary supplements before and after FDA warnings.
  Clinical toxicology (Philadelphia, Pa.) 2021 Cohen PA, Ellison RR, Travis JC, Gaufberg SV, Gerona R
• Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco.
  Environmental health : a global access science source 2021 Clarity C, Trowbridge J, Gerona R, Ona K, McMaster M, Bessonneau V, Rudel R, Buren H, Morello-Frosch R
• A pilot study of glyphosate, and preterm birth among blacks and whites.
  ISEE Conference Abstracts 2021 David C. Braak, Michael S. Bloom, Roger B. Newman, Roy R. Gerona, John E. Vena
• Associations Between Gestational Environmental Phenols and Preterm Birth; a Nested Case-Control Study.
  ISEE Conference Abstracts 2021 Michael S. Bloom, Kelly Garcia, Roy R. Gerona, Edward L. Valachovic, Victor Y. Fujimoto, Roger B. Newman
• Organophosphate and organohalogen flame retardant exposure and thyroid hormone disruption in women firefighters and office workers from San Francisco.
  ISEE Conference Abstracts 2021 Jessica Trowbridge, Roy Gerona, Michael Mcmaster, Katerine Ona, Cassidy Clarity, Vincent Bessonneau, Ruthann Rudel, Heather Buren, Rachel Morello Frosch
• Running the Red Queen's race-investigating environmental phenols as potential contributors to preterm birth.
  Fertility and sterility 2021 Bloom MS, Gerona R, Fujimoto VY
• Elevated levels of perfluoroalkyl substances in breast cancer patients within the Greater Manila Area.
  Chemosphere 2021 Velarde MC, Chan AFO, Sajo MEJV, Zakharevich I, Melamed J, Uy GLB, Teves JMY, Corachea AJM, Valparaiso AP, Macalindong SS, Cabaluna ND, Dofitas RB, Giudice LC, Gerona RR
• A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum.
  The Journal of antimicrobial chemotherapy 2021 Reckers A, Wu AHB, Ong CM, Gandhi M, Metcalfe J, Gerona R
• Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease During Mid-Gestation.
  Toxicological sciences : an official journal of the Society of Toxicology 2021 Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Gao S, Smith SC, Park JS, Zakharevich I, Gerona RR, Fisher SJ, Woodruff TJ
• Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays: Part I-Synthesis, analytical characterization, and binding affinity for human CB1 receptors.
  Drug testing and analysis 2021 Pike E, Grafinger KE, Cannaert A, Ametovski A, Luo JL, Sparkes E, Cairns EA, Ellison R, Gerona R, Stove CP, Auwärter V, Banister SD
• Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites.
  Scientific reports 2021 Bessonneau V, Gerona RR, Trowbridge J, Grashow R, Lin T, Buren H, Morello-Frosch R, Rudel RA
• Gamma-Butyrolactone Overdose Potentially Complicated by Co-Ingestion of Industrial Solvent N-Methyl-2-Pyrrolidone.
  Journal of analytical toxicology 2021 Melamed J, Gerona R, Blanc PD, Takamoto P, Conner S, Goodnough R
• Diagnostic accuracy of a liquid chromatography-tandem mass spectrometry assay in small hair samples for rifampin-resistant tuberculosis drug concentrations in a routine care setting.
  BMC infectious diseases 2021 Metcalfe J, Bacchetti P, Esmail A, Reckers A, Aguilar D, Wen A, Huo S, Muyindike WR, Hahn JA, Dheda K, Gandhi M, Gerona R
• Measuring TB drug levels in the hair in adults and children to monitor drug exposure and outcomes.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2021 Mave V, Kadam D, Gaikwad S, Kinikar A, Aguilar D, Chavan A, Paradkar M, Yogendra SVB, Bharadwaj R, Kagal A, Suryavanshi N, Golub J, Kulkarni V, Dooley KE, Gupta A, Bacchetti P, Gerona R, Gupte N, …
• Development and validation of a liquid chromatography-tandem mass spectrometry method for quantifying delamanid and its metabolite in small hair samples.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2020 Reckers A, Huo S, Esmail A, Dheda K, Bacchetti P, Gandhi M, Metcalfe J, Gerona R
• A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes.
  Reproductive toxicology (Elmsford, N.Y.) 2020 Begum TF, Fujimoto VY, Gerona R, McGough A, Lenhart N, Wong R, Mok-Lin E, Melamed J, Butts CD, Bloom MS
• Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA.
  ACS chemical neuroscience 2020 Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, Ellison R, Gerona R, Banister SD, Stove CP
• Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco.
  medRxiv : the preprint server for health sciences 2020 Clarity C, Trowbridge J, Gerona R, Ona K, McMaster M, Bessonneau V, Rudel R, Buren H, Morello-Frosch R
• Associations between Potential Exposure Sources and Urinary Phthalate Concentrations among Couples Undergoing Infertility Treatment.
  ISEE Conference Abstracts 2020 T.F. Begum, V.Y. Fujimoto, A. McGough, N. Lenhart, R. Wong, E. Mok-Lin, J. Melamed, R. Gerona, C.D. Butts, B.J. Feingold, X.X. Romeiko, M.S. Bloom
• Associations between Preconception Phthalate Exposure and Infertility Treatment Outcomes among Couples Undergoing In Vitro Fertilization.
  ISEE Conference Abstracts 2020 T.F. Begum, V.Y. Fujimoto, A. McGough, N. Lenhart, R. Wong, E. Mok-Lin, R. Gerona, J. Melamed, C.D. Butts, M.S. Bloom
• Exploring Stereochemical and Conformational Requirements at Cannabinoid Receptors for Synthetic Cannabinoids Related to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA.
  ACS chemical neuroscience 2020 Ametovski A, Macdonald C, Manning JJ, Haneef SAS, Santiago M, Martin L, Sparkes E, Reckers A, Gerona RR, Connor M, Glass M, Banister SD
• Sources of exposure to urinary phthalates among couples undergoing infertility treatment.
  International journal of hygiene and environmental health 2020 Begum TF, Gerona R, Melamed J, McGough A, Lenhart N, Wong R, Mok-Lin E, Butts CD, Feingold BJ, Romeiko XX, Fujimoto VY, Bloom MS
• Flualprazolam: Report of an Outbreak of a New Psychoactive Substance in Adolescents.
  Pediatrics 2020 Blumenberg A, Hughes A, Reckers A, Ellison R, Gerona R
• Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples.
  Journal of visualized experiments : JoVE 2020 Reckers A, Wen A, Aguilar D, Bacchetti P, Gandhi M, Metcalfe J, Gerona R
• BPA and risk assessment - Authors' reply.
  The lancet. Diabetes & endocrinology 2020 Hunt PA, Vom Saal FS, Stahlhut R, Gerona R
• A Pilot Cancer-Phenome Biobanking System in a Low-Resource Southeast Asian Setting: The Philippine General Hospital Biobank Experience.
  Biopreservation and biobanking 2020 Sajo MEJV, Teves JMY, Corachea AJM, Diaz LA, Chan AFO, Valparaiso AP, Dy Echo AVV, Macalindong SS, Uy GLB, Dofitas RB, Habana MAE, Gerona RR, Irwin JC, Giudice LC, Velarde MC
• Integrating Exposure Knowledge and Serum Suspect Screening as a New Approach to Biomonitoring: An Application in Firefighters and Office Workers.
  Environmental science & technology 2020 Grashow R, Bessonneau V, Gerona RR, Wang A, Trowbridge J, Lin T, Buren H, Rudel RA, Morello-Frosch R
• Presence of Piracetam in Cognitive Enhancement Dietary Supplements.
  JAMA internal medicine 2020 Cohen PA, Zakharevich I, Gerona R
• Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco.
  Environmental science & technology 2020 Trowbridge J, Gerona RR, Lin T, Rudel RA, Bessonneau V, Buren H, Morello-Frosch R
• Correlation of Linezolid Hair Concentrations with Plasma Exposure in Patients with Drug-Resistant Tuberculosis.
  Antimicrobial agents and chemotherapy 2020 Wasserman S, Huo S, Ky K, Malig YN, Esmail A, Dheda K, Bacchetti P, Gerona R, Maartens G, Gandhi M, Metcalfe J
• Case Report: Analytically Confirmed Severe Albenzadole Overdose Presenting with Alopecia and Pancytopenia.
  The American journal of tropical medicine and hygiene 2020 Riggan MAA, Perreault G, Wen A, Raco V, Vassallo S, Gerona R, Hoffman RS
• Chapter 15.2 Rhabdomyolysis associated with laboratory-confirmed FUB-AMB use.
  2020 Stephen L. Thornton, Roy Gerona
• Association of differential symptoms of stress to hair cortisol and cortisone concentrations among pregnant women in Kenya.
  Stress (Amsterdam, Netherlands) 2019 Musana JW, Cohen CR, Kuppermann M, Gerona R, Wanyoro A, Aguilar D, Santos N, Temmerman M, Weiss SJ
• BPA: have flawed analytical techniques compromised risk assessments?
  The lancet. Diabetes & endocrinology 2019 Gerona R, Vom Saal FS, Hunt PA
• Simultaneous analysis of 29 synthetic cannabinoids and metabolites, amphetamines, and cannabinoids in human whole blood by liquid chromatography-tandem mass spectrometry - A New Zealand perspective of use in 2018.
  Drug testing and analysis 2019 Ong RS, Kappatos DC, Russell SGG, Poulsen HA, Banister SD, Gerona RR, Glass M, Johnson CS, McCarthy MJ
• The Psychoactive Surveillance Consortium and Analysis Network (PSCAN): the first year.
  Addiction (Abingdon, England) 2019 Monte AA, Hopkinson A, Saben J, Shelton SK, Thornton S, Schneir A, Pomerleau A, Hendrickson RG, Arens AM, Cole JB, Chenoweth J, Martin S, Adams A, Banister SD, Gerona RR
• Evidence of a potential mechanism for Kratom-related cardiac arrest.
  Clinical toxicology (Philadelphia, Pa.) 2019 Wolfer H, Gerona R, Blumenberg A
• Drug resistant gut bacteria mimic a host mechanism for anticancer drug clearance.
  bioRxiv 2019 Peter Spanogiannopoulos, Patrick H Bradley, Jonathan Melamed, Ysabella Noelle Amora Malig, Kathy N. Lam, Roy R. Gerona, Katherine S Pollard, Peter Turnbaugh
• Ibogaine Consumption With Seizure-Like Episodes, QTc-Prolongation, and Captured Cardiac Dysrhythmias.
  The Journal of emergency medicine 2019 Grogan J, Gerona R, Snow JW, Kao L
• Exposure to perfluoroalkyl substances in a cohort of women firefighters and office workers in San Francisco.
  medRxiv 2019 Jessica A Trowbridge, Roy R Gerona, Thomas Lin, Ruthann A Rudel, Vincent Bessonneau, Heather Buren, Rachel Morello-Frosch
• Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2019 Gerona R, Wen A, Aguilar D, Shum J, Reckers A, Bacchetti P, Gandhi M, Metcalfe J
• Commercial cannabidiol oil contaminated with the synthetic cannabinoid AB-FUBINACA given to a pediatric patient.
  Clinical toxicology (Philadelphia, Pa.) 2019 Rianprakaisang T, Gerona R, Hendrickson RG
• Integrating exposure knowledge and serum suspect screening as a new approach to biomonitoring: An application in firefighters and office workers.
  bioRxiv 2019 Rachel Grashow, Vincent Bessonneau, Roy R Gerona, Aolin Wang, Jessica Trowbridge, Thomas Lin, Heather Buren, Ruthann A Rudel, Rachel Morello-Frosch
• The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogs.
  Drug testing and analysis 2019 Banister SD, Kevin RC, Martin L, Adams A, Macdonald C, Manning JJ, Boyd R, Cunningham M, Stevens MY, McGregor IS, Glass M, Connor M, Gerona RR
• Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB.
  ERJ open research 2019 Metcalfe J, Bacchetti P, Gerona R, Esmail A, Dheda K, Gandhi M
• Highly potent fentanyl analogs: apnea from exposure to small quantities of ß-hydroxyfentanyl and furanylfentanyl.
  Clinical toxicology (Philadelphia, Pa.) 2019 Hendrickson RG, Akpunonu P, Hughes AR, Gerona R
• Organic diet intervention significantly reduces urinary pesticide levels in U.S. children and adults.
  Environmental research 2019 Hyland C, Bradman A, Gerona R, Patton S, Zakharevich I, Gunier RB, Klein K
• Chemical Contaminants from Plastics in the Animal Environment.
  Journal of the American Association for Laboratory Animal Science : JAALAS 2019 Gorence GJ, Pulcastro HC, Lawson CA, Gerona RR, Friesen M, Horan TS, Gieske MC, Sartain CV, Hunt PA
• Deaths in Colorado Attributed to Kratom.
  The New England journal of medicine 2019 Gershman K, Timm K, Frank M, Lampi L, Melamed J, Gerona R, Monte AA
• Clonazolam: a novel liquid benzodiazepine.
  Toxicology Communications 2019 Lauren Murphy, Jonathan Melamed, Roy Gerona, Robert G. Hendrickson
• Prohibited Stimulants in Dietary Supplements After Enforcement Action by the US Food and Drug Administration.
  JAMA internal medicine 2018 Cohen PA, Wen A, Gerona R
• A novel synthetic cannabinoid (Cumyl-4-cyano-BINACA) resulting in hyperthermia, rhabdomyolysis, and renal failure in a 29-year-old patient: it's not meningitis.
  Clinical toxicology (Philadelphia, Pa.) 2018 El Zahran T, Gerona R, Morgan BW, Pomerleau AC
• An outbreak of synthetic cannabinoid exposures reported to a regional poison center: "K2" identified as 5F-ADB.
  Clinical toxicology (Philadelphia, Pa.) 2018 Arens AM, Olives TD, Simpson NS, Laes JR, Anderson DL, Bangh SA, Lee SC, Martin S, Banister SD, Gerona RR, Cole JB
• The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogues.
  bioRxiv 2018 Samuel Banister, Richard Kevin, Lewis Martin, Axel Adams, Christa Macdonald, Jamie Manning, Boyd Rochelle, Cunningham Michael, Marc Stevens, Iain McGregor, Michelle Glass, Mark Connor, Roy Gerona
• Seizures, Systemic Inflammatory Response, and Rhabdomyolysis Associated With Laboratory-Confirmed 2C-I and 25-I Exposure.
  Pediatric emergency care 2018 Thornton SL, Hoehn S, Gerona RR
• Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold- hopping analog of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA.
  Drug testing and analysis 2018 Banister SD, Adams A, Kevin RC, Macdonald C, Glass M, Boyd R, Connor M, McGregor IS, Havel CM, Bright SJ, Vilamala MV, Lladanosa CG, Barratt MJ, Gerona RR
• Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.
  Current biology : CB 2018 Horan TS, Pulcastro H, Lawson C, Gerona R, Martin S, Gieske MC, Sartain CV, Hunt PA
• A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco.
  Environmental health perspectives 2018 Wang A, Gerona RR, Schwartz JM, Lin T, Sirota M, Morello-Frosch R, Woodruff TJ
• Severe illness associated with reported use of synthetic cannabinoids: a public health investigation (Mississippi, 2015).
  Clinical toxicology (Philadelphia, Pa.) 2018 Kasper AM, Ridpath AD, Gerona RR, Cox R, Galli R, Kyle PB, Parker C, Arnold JK, Chatham-Stephens K, Morrison MA, Olayinka O, Preacely N, Kieszak SM, Martin C, Schier JG, Wolkin A, Byers P, Dobbs T
• Stimulant drugs are associated with violent and penetrating trauma.
  The American journal of emergency medicine 2018 Armenian P, Effron Z, Garbi N, Dirks R, Benowitz NL, Gerona RR
• Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study.
  Environmental health : a global access science source 2018 Parvez S, Gerona RR, Proctor C, Friesen M, Ashby JL, Reiter JL, Lui Z, Winchester PD
• The chemistry and pharmacology of synthetic cannabinoid SDB-006 and its regioisomeric fluorinated and methoxylated analogs.
  Drug testing and analysis 2018 Banister SD, Olson A, Winchester M, Stuart J, Edington AR, Kevin RC, Longworth M, Herrera M, Connor M, McGregor IS, Gerona RR, Kassiou M
• A Case of Opioid Overdose? Or Is It?
  The journal of applied laboratory medicine 2018 French D, Gerona RR
• A Case of Opioid Overdose? Or Is It?.
  The Journal of Applied Laboratory Medicine 2018 Deborah French, Roy R. Gerona
• Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis.
  PloS one 2017 Mave V, Kinikar A, Kagal A, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Gerona R, Wen A, Ramachandran G, Kumar H, Bacchetti P, Dooley KE, Gupte N, Gupta A, Gandhi M
• New Psychoactive Substances in Pediatric Patients.
  Pediatric clinics of North America 2017 Warrick BJ, Tataru AP, Gerona R
• Synthetic Cannabinoid and Mitragynine Exposure of Law Enforcement Agents During the Raid of an Illegal Laboratory - Nevada, 2014.
  MMWR. Morbidity and mortality weekly report 2017 Tapp L, Ramsey JG, Wen A, Gerona R
• Use of Diethylone, a New Psychoactive Substance, Associated with Multi- system Toxicity: A Case Report of Two Patients
  Journal of Drug Metabolism and Toxicology 2017 Pomerleau AC, Hindman D, Ralston A, El Zahran T, King A, Gerona R
• Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry.
  Journal of exposure science & environmental epidemiology 2017 Gerona RR, Schwartz JM, Pan J, Friesen MM, Lin T, Woodruff TJ
• Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial.
  Lancet (London, England) 2017 Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR
• An LC-MS/MS-based method to analyze the anti-tuberculosis drug bedaquiline in hair.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 Metcalfe J, Gerona R, Wen A, Bacchetti P, Gandhi M
• Synthetic cannabinoid "Black Mamba" infidelity in patients presenting for emergency stabilization in Colorado: a P SCAN Cohort.
  Clinical toxicology (Philadelphia, Pa.) 2017 Brandehoff N, Adams A, McDaniel K, Banister SD, Gerona R, Monte AA
• Beyond Ketamine and Phencyclidine: Analytically Confirmed Use of Multiple Novel Arylcyclohexylamines.
  Journal of psychoactive drugs 2017 Thornton S, Lisbon D, Lin T, Gerona R
• Epinephrine Concentrations in EpiPens After the Expiration Date.
  Annals of internal medicine 2017 Cantrell FL, Cantrell P, Wen A, Gerona R
• "Zombie" Outbreak Caused by Synthetic Cannabinoid.
  The New England journal of medicine 2017 Gerona R, Adams A, Banister SD
• Characteristics and Treatment of Patients with Clinical Illness Due to Synthetic Cannabinoid Inhalation Reported by Medical Toxicologists: A ToxIC Database Study.
  Journal of medical toxicology : official journal of the American College of Medical Toxicology 2017 Monte AA, Calello DP, Gerona RR, Hamad E, Campleman SL, Brent J, Wax P, Carlson RG, ACMT Toxicology Investigators Consortium (ToxIC)
• α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
  Nature medicine 2017 Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P
• Hot and Cold Drugs: National Park Service Medication Stability at the Extremes of Temperature.
  Prehospital emergency care 2017 Armenian P, Campagne D, Stroh G, Ives Tallman C, Zeng WZD, Lin T, Gerona RR
• "Zombie" Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York.
  The New England journal of medicine 2016 Adams AJ, Banister SD, Irizarry L, Trecki J, Schwartz M, Gerona R
• Unintentional Pediatric Ingestion of Electronic Cigarette Nicotine Refill Liquid Necessitating Intubation.
  Annals of emergency medicine 2016 Noble MJ, Longstreet B, Hendrickson RG, Gerona R
• Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey.
  PloS one 2016 VandeVoort CA, Gerona RR, Vom Saal FS, Tarantal AF, Hunt PA, Hillenweck A, Zalko D
• Fatal Fentanyl: One Pill Can Kill.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2016 Sutter ME, Gerona RR, Davis MT, Roche BM, Colby DK, Chenoweth JA, Adams AJ, Owen KP, Ford JB, Black HB, Albertson TE
• Increase in Adverse Reactions Associated with Use of Synthetic Cannabinoids - Anchorage, Alaska, 2015-2016.
  MMWR. Morbidity and mortality weekly report 2016 Springer YP, Gerona R, Scheunemann E, Shafer SL, Lin T, Banister SD, Cooper MP, Castrodale LJ, Levy M, Butler JC, McLaughlin JB
• A Case of 3,4-Dimethoxyamphetamine (3,4-DMA) and 3,4-Methylenedioxymethamphetamine (MDMA) Toxicity with Possible Metabolic Interaction.
  Journal of psychoactive drugs 2016 Darracq MA, Thornton SL, Minns AB, Gerona RR
• Fentanyl and other synthetic opioids sold as counterfeits in deadly new trend
  The Conversation 2016 Banister S, Adams A, Gerona R
• Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street "Norco" in Central California: A Case Report.
  Annals of emergency medicine 2016 Armenian P, Olson A, Anaya A, Kurtz A, Ruegner R, Gerona RR
• A multi-analyte panel for non-invasive pharmacokinetic monitoring of second-line anti-tuberculosis drugs.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016 Gerona R, Wen A, Koss C, Bacchetti P, Gandhi M, Metcalfe J
• Quantifying Isoniazid Levels in Small Hair Samples: A Novel Method for Assessing Adherence during the Treatment of Latent and Active Tuberculosis.
  PloS one 2016 Gerona R, Wen A, Chin AT, Koss CA, Bacchetti P, Metcalfe J, Gandhi M
• Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study.
  Environmental health : a global access science source 2016 Gerona RR, Pan J, Zota AR, Schwartz JM, Friesen M, Taylor JA, Hunt PA, Woodruff TJ
• Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology".
  Environmental health perspectives 2016 Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, vom Saal FS
• Non-targeted screening for novel psychoactive substances among agitated emergency department patients.
  Clinical toxicology (Philadelphia, Pa.) 2016 Lung D, Wilson N, Chatenet FT, LaCroix C, Gerona R
• Quantitative analysis of powdered caffeine products purchased from the Internet using liquid chromatography-quadrupole time-of-flight mass spectrometry.
  Clinical toxicology (Philadelphia, Pa.) 2016 Beauchamp GA, Lin T, Zeng WZ, Hendrickson RG, Gerona R
• Increase in Hospital Emergency Department Visits Related to Use of Synthetic Cannabinoids— Municipality of Anchorage, July to September, 2015
  State of Alaska Epidemiology Bulletin 2015 Springer Y, Shafer S, Gerona R
• An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA.
  Clinical toxicology (Philadelphia, Pa.) 2015 Tyndall JA, Gerona R, De Portu G, Trecki J, Elie MC, Lucas J, Slish J, Rand K, Bazydlo L, Holder M, Ryan MF, Myers P, Iovine N, Plourde M, Weeks E, Hanley JR, Endres G, St Germaine D, Dobrowolski PJ, …
• Labs make new, dangerous synthetic cannabinoid drugs faster than we can ban them
  The Conversation 2015 Banister S, McGregor I, Gerona R
• Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015.
  MMWR. Morbidity and mortality weekly report 2015 Kasper AM, Ridpath AD, Arnold JK, Chatham-Stephens K, Morrison M, Olayinka O, Parker C, Galli R, Cox R, Preacely N, Anderson J, Kyle PB, Gerona R, Martin C, Schier J, Wolkin A, Dobbs T
• Unintentional Pediatric Exposure to a Synthetic Cannabinoid (AB-PINACA) Resulting in Coma and Intubation.
  Annals of emergency medicine 2015 Thornton SL, Akpunonu P, Glauner K, Hoehn KS, Gerona R
• Synthetic Cannabinoid-Related Illnesses and Deaths.
  The New England journal of medicine 2015 Trecki J, Gerona RR, Schwartz MD
• Unusually Prolonged Presentation of Designer Drug Encephalopathy Responsive to Steroids.
  Pediatrics 2015 Albadareen R, Thornton S, Heshmati A, Gerona R, Lowry J
• An amphetamine isomer whose efficacy and safety in humans has never been studied, β-methylphenylethylamine (BMPEA), is found in multiple dietary supplements.
  Drug testing and analysis 2015 Cohen PA, Bloszies C, Yee C, Gerona R
• Altered mental status and end organ damage associated with the use of gacyclidine: a case series.
  Journal of medical toxicology : official journal of the American College of Medical Toxicology 2015 Chenoweth JA, Gerona RR, Ford JB, Sutter ME, Rose JS, Albertson TE, Clarke SO, Owen KP
• A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA.
  The Journal of emergency medicine 2015 Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR
• Internet-purchased ibogaine toxicity confirmed with serum, urine, and product content levels.
  The American journal of emergency medicine 2014 O'Connell CW, Gerona RR, Friesen MW, Ly BT
• "Smoking" guns: Questions. “Smoking” guns: Answers.
  Pediatric nephrology (Berlin, Germany) 2014 Cooks T, Davis TK, Hu J, Metheny R, Schwartz M, Gerona R
• Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
  Clinical toxicology (Philadelphia, Pa.) 2014 Spiller HA, Russell JL, Casavant MJ, Ho RY, Gerona RR
• Invalid controls undermine conclusions of FDA studies.
  Toxicological sciences : an official journal of the Society of Toxicology 2014 Hunt PA, VandeVoort C, Woodruff T, Gerona R
• Acute kidney injury associated with smoking synthetic cannabinoid.
  Clinical toxicology (Philadelphia, Pa.) 2014 Buser GL, Gerona RR, Horowitz BZ, Vian KP, Troxell ML, Hendrickson RG, Houghton DC, Rozansky D, Su SW, Leman RF
• Comprehensive analysis of "bath salts" purchased from California stores and the internet.
  Clinical toxicology (Philadelphia, Pa.) 2014 Schneir A, Ly BT, Casagrande K, Darracq M, Offerman SR, Thornton S, Smollin C, Vohra R, Rangun C, Tomaszewski C, Gerona RR
• Health care worker exposures to the antibacterial agent triclosan.
  Journal of occupational and environmental medicine 2014 MacIsaac JK, Gerona RR, Blanc PD, Apatira L, Friesen MW, Coppolino M, Janssen S
• A case of rivaroxaban associated intracranial hemorrhage.
  The western journal of emergency medicine 2014 Lo JC, Gerona RR
• 'Crazy Monkey' poisons man and dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid.
  Clinical toxicology (Philadelphia, Pa.) 2014 Gugelmann H, Gerona R, Li C, Tsutaoka B, Olson KR, Lung D
• The electric Kool-Aid NBOMe test: LC-TOF/MS confirmed 2C-C-NBOMe (25C) intoxication at Burning Man.
  The American journal of emergency medicine 2014 Armenian P, Gerona RR
• A round robin approach to the analysis of bisphenol A (BPA) in human blood samples.
  Environmental health : a global access science source 2014 Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ
• Notes from the Field: Severe Illness Associated with Synthetic Cannabinoid Use — Brunswick, Georgia, 2013
  MMWR. Morbidity and mortality weekly report 2013 Drenzek C, Geller R, Steck A, Arnold J, Lopez G, Gerona R, Edison L
• Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population.
  Environmental science & technology 2013 Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA
• Prolonged ventilatory failure and flaccid quadriparesis after ingestion of poison hemlock.
  Muscle & nerve 2013 Lung DD, Scott BJ, Wu AH, Gerona RR
• Cardiotoxicity in a citalopram and olanzapine overdose.
  The Journal of emergency medicine 2013 Lung DD, Wu AH, Gerona RR
• Comment regarding the stability of active ingredients in long-expired prescription medications--reply.
  JAMA internal medicine 2013 Cantrell L, Suchard J, Gerona R
• High times, low sats: diffuse pulmonary infiltrates associated with chronic synthetic cannabinoid use.
  Journal of medical toxicology : official journal of the American College of Medical Toxicology 2013 Alhadi S, Tiwari A, Vohra R, Gerona R, Acharya J, Bilello K
• Synthetic cannabinoid use associated with acute kidney injury.
  Clinical toxicology (Philadelphia, Pa.) 2013 Thornton SL, Wood C, Friesen MW, Gerona RR
• Morbidity and Mortality Weekly Report
  Acute Kidney Injury Associated with Synthetic Cannabinoid Use — Multiple States, 2012 2013 Murphy T, Van Houten C, Gerona RR, Moran J, Kirschner R, Marraffa J, Stork CM, Birkhead G, Newman A, Hendrickson R, Horowitz Z, Vian K, Lehman R, Thornton S, Wood C, Myers S, Orr E, Devlin J, Schwartz…
• A 120-hour case of priapism from an over-the-counter herbal supplement.
  The Annals of pharmacotherapy 2013 Coralic Z, Lenhoff T, Kanzaria HK, Gerona R
• Stability of active ingredients in long-expired prescription medications.
  Archives of internal medicine 2012 Cantrell L, Suchard JR, Wu A, Gerona RR
• Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis.
  Clinical toxicology (Philadelphia, Pa.) 2012 Thornton SL, Lo J, Clark RF, Wu AH, Gerona RR
• Bath salts.
  Clinics in laboratory medicine 2012 Gerona RR, Wu AH
• Psychosis from a bath salt product containing flephedrone and MDPV with serum, urine, and product quantification.
  Journal of medical toxicology : official journal of the American College of Medical Toxicology 2012 Thornton SL, Gerona RR, Tomaszewski CA
• Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.
  Clinical toxicology (Philadelphia, Pa.) 2012 Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL
• Catecholaminergic polymorphic ventricular tachycardia found in an adolescent after a methylenedioxymethamphetamine and marijuana-induced cardiac arrest.
  Critical care medicine 2012 Diffley M, Armenian P, Gerona R, Reinhartz O, Avasarala K
• Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score.
  Breast cancer research and treatment 2012 Wu AH, Lorizio W, Tchu S, Lynch K, Gerona R, Ji W, Ruan W, Ruddy KJ, Desantis SD, Burstein HJ, Ziv E
• Multiple MDMA (Ecstasy) overdoses at a rave event: a case series.
  Journal of intensive care medicine 2012 Armenian P, Mamantov TM, Tsutaoka BT, Gerona RR, Silman EF, Wu AH, Olson KR
• 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use.
  The Journal of emergency medicine 2011 Armenian P, Gerona RR, Blanc PD, Wu AH, Mookherjee S
• Confirmed glyburide poisoning from ingestion of "street Valium".
  The Journal of emergency medicine 2011 Lung DD, Gerona RR, Wu AH, Smollin CG
• Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.
  Molecular biology of the cell 2008 Lynch KL, Gerona RR, Kielar DM, Martens S, McMahon HT, Martin TF
• Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis.
  Molecular biology of the cell 2007 Lynch KL, Gerona RR, Larsen EC, Marcia RF, Mitchell JC, Martin TF
• Role of phosphoinositide signaling in the control of insulin exocytosis.
  Molecular endocrinology (Baltimore, Md.) 2005 Waselle L, Gerona RR, Vitale N, Martin TF, Bader MF, Regazzi R
• CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein.
  Neuron 2004 Grishanin RN, Kowalchyk JA, Klenchin VA, Ann K, Earles CA, Chapman ER, Gerona RR, Martin TF
• The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes.
  The Journal of biological chemistry 2000 Gerona RR, Larsen EC, Kowalchyk JA, Martin TF