Roshanak Irannejad, PhD
Associate Professor
Cardiovascular Research Inst
School of Medicine

Awards

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• Early Career Award, American Society for Pharmacology and Experimental Therapeutics-Division of Molecular Pharmacology, 2023
• NIH Pathway to Independence Award (K99/R00), NIH-NHLBI, 2014-2020
• Postdotoral Fellowship, American Heart Association, 2012-2014
• Predoctoral Fellowship, American Heart Association, 2008-2010

Websites

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• Irannejad Lab (Irannejadlab.ucsf.edu)

Grants and Projects

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• Investigation of a Newly Discovered Organelle-based Signaling Paradigm, NIH/NIGMS, 2019-2029
• Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes, NIH/NHLBI, 2017-2020
• Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes, NIH, 2014-2017

Publications (21)

Top publication keywords:
EpinephrineAdrenergic beta-AntagonistsGTP-Binding Protein beta SubunitsEndocytosisEndosomesGTP-Binding Protein gamma SubunitsSignal TransductionSecond Messenger SystemsReceptors, G-Protein-CoupledOrganic Cation Transporter 2Receptors, Dopamine D1DobutamineReceptors, Adrenergic, beta-1Golgi ApparatusCell Membrane

• Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R
• cAMP signaling: a remarkably regional affair.
  Trends in biochemical sciences 2024 Bock A, Irannejad R, Scott JD
• Selective activation of intracellular β1AR using a spatially restricted antagonist.
  bioRxiv : the preprint server for biology 2023 Liccardo F, Morstein J, Lin TY, Pampel J, Shokat KM, Irannejad R
• Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
  Nature chemical biology 2023 Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R
• The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
  eLife 2022 Puri NM, Romano GR, Lin TY, Mai QN, Irannejad R

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• G protein-regulated endocytic trafficking of adenylyl cyclase type 9.
  eLife 2020 Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M
• Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field.
  ACS pharmacology & translational science 2020 Plouffe B, Thomsen ARB, Irannejad R
• Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
  PLoS genetics 2019 Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM
• Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy.
  eLife 2019 Nash CA, Wei W, Irannejad R, Smrcka AV
• Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles.
  Journal of the American Chemical Society 2018 Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L
• Functional selectivity of GPCR-directed drug action through location bias.
  Nature chemical biology 2017 Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M
• Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
  Current biology : CB 2016 Varandas KC, Irannejad R, von Zastrow M
• The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.
  The Journal of biological chemistry 2016 Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL
• Effects of endocytosis on receptor-mediated signaling.
  Current opinion in cell biology 2015 Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M
• G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.
  Molecular biology of the cell 2015 Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV
• G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
  The Journal of biological chemistry 2015 Tsvetanova NG, Irannejad R, von Zastrow M
• Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
  Methods in enzymology 2014 Irannejad R, Kotowski SJ, von Zastrow M
• GPCR signaling along the endocytic pathway.
  Current opinion in cell biology 2013 Irannejad R, von Zastrow M
• Conformational biosensors reveal GPCR signalling from endosomes.
  Nature 2013 Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M
• Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.
  The Journal of biological chemistry 2010 Irannejad R, Wedegaertner PB
• Assembly and trafficking of heterotrimeric G proteins.
  Biochemistry 2007 Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB