Roselle Abraham, MD
Associate Professor
Medicine
School of Medicine

RESEARCH INTERESTS: Dr. Roselle Abraham is a physician scientist with a background in electrophysiology, imaging and stem cell research. She is using multi-modality imaging for risk stratification of atrial and ventricular arrhythmias. The overall goal of her research program is to use a combination of multi-modality clinical imaging and studies in model systems to tailor therapies for patients with hypertrophic cardiomyopathy.

• Basal Septal Hypertrophy as the Early Imaging Biomarker for Adaptive Phase of Remodeling Prior to Heart Failure.
  Journal of clinical medicine 2021 Yalçin F, Yalçin H, Küçükler N, Arslan S, Akkus O, Kurtul A, Abraham MR
• Ultimate phases of hypertensive heart disease and stressed heart morphology by conventional and novel cardiac imaging.
  American journal of cardiovascular disease 2021 Yalçin F, Yalçin H, Abraham MR, Abraham TP
• A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI.
  Magnetic resonance in medicine 2020 Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ
• Correction to: Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2019 Yalcin H, Valenta I, Zhao M, Tahari A, Lu DY, Higuchi T, Yalcin F, Kucukler N, Soleimanifard Y, Zhou Y, Pomper MG, Abraham TP, Tsui B, Lodge MA, Schindler TH, Abraham MR
• Identifying Ventricular Arrhythmias and Their Predictors by Applying Machine Learning Methods to Electronic Health Records in Patients With Hypertrophic Cardiomyopathy (HCM-VAr-Risk Model).
  The American journal of cardiology 2019 Bhattacharya M, Lu DY, Kudchadkar SM, Greenland GV, Lingamaneni P, Corona-Villalobos CP, Guan Y, Marine JE, Olgin JE, Zimmerman S, Abraham TP, Shatkay H, Abraham MR
• Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.
  JCI insight 2018 Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, Abraham MR
• Clinical Outcomes in Patients With Nonobstructive, Labile, and Obstructive Hypertrophic Cardiomyopathy.
  Journal of the American Heart Association 2018 Lu DY, Pozios I, Haileselassie B, Ventoulis I, Liu H, Sorensen LL, Canepa M, Phillip S, Abraham MR, Abraham TP
• Rest and Stress Longitudinal Systolic Left Ventricular Mechanics in Hypertrophic Cardiomyopathy: Implications for Prognostication.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2018 Pozios I, Pinheiro A, Corona-Villalobos C, Sorensen LL, Dardari Z, Liu HY, Cresswell K, Phillip S, Bluemke DA, Zimmerman SL, Abraham MR, Abraham TP
• Stress Myocardial Blood Flow Heterogeneity Is a Positron Emission Tomography Biomarker of Ventricular Arrhythmias in Patients With Hypertrophic Cardiomyopathy.
  The American journal of cardiology 2018 Lu DY, Yalçin H, Yalçin F, Zhao M, Sivalokanathan S, Valenta I, Tahari A, Pomper MG, Abraham TP, Schindler TH, Abraham MR
• Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2018 Yalcin H, Valenta I, Zhao M, Tahari A, Lu DY, Higuchi T, Yalcin F, Kucukler N, Soleimanifard Y, Zhou Y, Pomper MG, Abraham TP, Tsui B, Lodge MA, Schindler TH, Roselle Abraham M
• E/e' ratio and outcome prediction in hypertrophic cardiomyopathy: the influence of outflow tract obstruction.
  European heart journal. Cardiovascular Imaging 2018 Lu DY, Haileselassie B, Ventoulis I, Liu HY, Liang HY, Pozios I, Canepa M, Phillip S, Abraham MR, Abraham T
• Impact of peak provoked left ventricular outflow tract gradients on clinical outcomes in hypertrophic cardiomyopathy.
  International journal of cardiology 2017 Lu DY, Hailesealassie B, Ventoulis I, Liu H, Liang HY, Nowbar A, Pozios I, Canepa M, Cresswell K, Luo HC, Abraham MR, Abraham TP
• Plasma homocysteine levels associated with a corrected QT interval.
  BMC cardiovascular disorders 2017 Li Z, Guo X, Sun G, Zheng L, Sun Y, Liu Y, Abraham MR
• Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients With Hypertrophic Cardiomyopathy.
  Journal of computer assisted tomography 2017 Chu LC, Corona-Villalobos CP, Halushka MK, Zhang Y, Pozzessere C, Kamel IR, Pozios I, Van Der Geest RJ, Gai N, Abraham RM, Abraham TP, Bluemke DA, Zimmerman SL
• Role of Global Longitudinal Strain in Predicting Outcomes in Hypertrophic Cardiomyopathy.
  The American journal of cardiology 2017 Liu H, Pozios I, Haileselassie B, Nowbar A, Sorensen LL, Phillip S, Lu DY, Ventoulis I, Luo H, Abraham MR, Abraham TP
• Exercise-QTc is associated with diffuse interstitial fibrosis reflected by lower approximated T1 relaxation time in hypertrophic cardiomyopathy patients.
  Journal of electrocardiology 2017 Corona-Villalobos CP, Saha S, Pozios I, Hurtado-de-Mendoza Paz D, Sorensen L, Gonzalez Cordoba J, Dolores-Cerna K, Kamel IR, Mormontoy Laurel W, Bluemke DA, Abraham TP, Zimmerman SL, Abraham MR
• Diffuse interstitial fibrosis assessed by cardiac magnetic resonance is associated with dispersion of ventricular repolarization in patients with hypertrophic cardiomyopathy.
  Journal of arrhythmia 2016 Hurtado-de-Mendoza D, Corona-Villalobos CP, Pozios I, Gonzales J, Soleimanifard Y, Sivalokanathan S, Montoya-Cerrillo D, Vakrou S, Kamel I, Mormontoy-Laurel W, Dolores-Cerna K, Suarez J, Perez-Melo S,…
• Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy.
  American heart journal 2016 Sorensen LL, Liang HY, Pinheiro A, Hilser A, Dimaano V, Olsen NT, Hansen TF, Sogaard P, Nowbar A, Pisanello C, Pozios I, Phillip S, Zhou X, Abraham R, Abraham TP
• Effect of Diffuse Subendocardial Hypoperfusion on Left Ventricular Cavity Size by 13N-Ammonia Perfusion PET in Patients With Hypertrophic Cardiomyopathy.
  The American journal of cardiology 2016 Yalçin H, Valenta I, Yalçin F, Corona-Villalobos C, Vasquez N, Ra J, Kucukler N, Tahari A, Pozios I, Zhou Y, Pomper M, Abraham TP, Schindler TH, Abraham MR
• Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China.
  SpringerPlus 2016 Li Z, Guo X, Liu Y, Zhang N, Chang Y, Chen Y, Sun Y, Abraham MR
• The Relation of Moderate Alcohol Consumption to Hyperuricemia in a Rural General Population.
  International journal of environmental research and public health 2016 Li Z, Guo X, Liu Y, Chang Y, Sun Y, Zhu G, Abraham MR
• Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.
  PloS one 2016 Lin X, Steinberg S, Kandasamy SK, Afzal J, Mbiyangandu B, Liao SE, Guan Y, Corona-Villalobos CP, Matkovich SJ, Epstein N, Tripodi D, Huo Z, Cutting G, Abraham TP, Fukunaga R, Abraham MR
• Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography.
  The international journal of cardiovascular imaging 2016 Corona-Villalobos CP, Sorensen LL, Pozios I, Chu L, Eng J, Abraham MR, Abraham TP, Kamel IR, Zimmerman SL
• Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2.
  Comparative medicine 2016 Sørensen LL, Bedja D, Sysa-Shah P, Liu H, Maxwell A, Yi X, Pozios I, Olsen NT, Abraham TP, Abraham R, Gabrielson K
• Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry.
  Medical image analysis 2015 Ardekani S, Jain S, Sanzi A, Corona-Villalobos CP, Abraham TP, Abraham MR, Zimmerman SL, Wu KC, Winslow RL, Miller MI, Younes L
• Comparison of Outcomes in Patients With Nonobstructive, Labile-Obstructive, and Chronically Obstructive Hypertrophic Cardiomyopathy.
  The American journal of cardiology 2015 Pozios I, Corona-Villalobos C, Sorensen LL, Bravo PE, Canepa M, Pisanello C, Pinheiro A, Dimaano VL, Luo H, Dardari Z, Zhou X, Kamel I, Zimmerman SL, Bluemke DA, Abraham MR, Abraham TP
• Late gadolinium enhancement confined to the right ventricular insertion points in hypertrophic cardiomyopathy: an intermediate stage phenotype?
  European heart journal. Cardiovascular Imaging 2015 Bravo PE, Luo HC, Pozios I, Zimmerman SL, Corona-Villalobos CP, Sorensen L, Kamel IR, Bluemke DA, Wahl RL, Abraham MR, Abraham TP
• Apparent left ventricular cavity dilatation during PET/CT in hypertrophic cardiomyopathy: Clinical predictors and potential mechanisms.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015 Bravo PE, Tahari A, Pozios I, Luo HC, Bengel FM, Wahl RL, Abraham MR, Abraham TP
• Utilizing ECG-Based Heartbeat Classification for Hypertrophic Cardiomyopathy Identification.
  IEEE transactions on nanobioscience 2015 Rahman QA, Tereshchenko LG, Kongkatong M, Abraham T, Abraham MR, Shatkay H
• Exercise heart rates in patients with hypertrophic cardiomyopathy.
  The American journal of cardiology 2015 Luo HC, Dimaano VL, Kembro JM, Hilser A, Hurtado-de-Mendoza D, Pozios I, Tomas MS, Yalcin H, Dolores-Cerna K, Mormontoy W, Aon MA, Cameron D, Bluemke DA, Stewart KJ, Russell SD, Cordova JG, Abraham TP…
• Identifying Hypertrophic Cardiomyopathy Patients by Classifying Individual Heartbeats from 12-lead ECG Signals.
  Proceedings. IEEE International Conference on Bioinformatics and Biomedicine 2014 Rahman QA, Tereshchenko LG, Kongkatong M, Abraham T, Abraham MR, Shatkay H
• Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans.
  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Luo HC, Pozios I, Vakrou S, Sorensen L, Abraham RM, Abraham T
• Hypertrophic cardiomyopathy: a heart in need of an energy bar?
  Frontiers in physiology 2014 Vakrou S, Abraham MR
• Comparison of clinical presentation, left ventricular morphology, hemodynamics, and exercise tolerance in obese versus nonobese patients with hypertrophic cardiomyopathy.
  The American journal of cardiology 2013 Canepa M, Sorensen LL, Pozios I, Dimaano VL, Luo HC, Pinheiro AC, Strait JB, Brunelli C, Abraham MR, Ferrucci L, Abraham TP
• Electromechanical relationship in hypertrophic cardiomyopathy.
  Journal of cardiovascular translational research 2013 Lin X, Liang HY, Pinheiro A, Dimaano V, Sorensen L, Aon M, Tereshchenko LG, Chen Y, Xiang M, Abraham TP, Abraham MR
• Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy.
  The American journal of cardiology 2013 Abraham MR, Bottomley PA, Dimaano VL, Pinheiro A, Steinberg A, Traill TA, Abraham TP, Weiss RG
• Relationship of delayed enhancement by magnetic resonance to myocardial perfusion by positron emission tomography in hypertrophic cardiomyopathy.
  Circulation. Cardiovascular imaging 2013 Bravo PE, Zimmerman SL, Luo HC, Pozios I, Rajaram M, Pinheiro A, Steenbergen C, Kamel IR, Wahl RL, Bluemke DA, Bengel FM, Abraham MR, Abraham TP
• In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness.
  PloS one 2012 Hueper K, Zapf A, Skrok J, Pinheiro A, Goldstein TA, Zheng J, Zimmerman SL, Kamel IR, Abraham R, Wacker F, Bluemke DA, Abraham T, Vogel-Claussen J
• Comparison and effectiveness of regadenoson versus dipyridamole on stress electrocardiographic changes during positron emission tomography evaluation of patients with hypertrophic cardiomyopathy.
  The American journal of cardiology 2012 Bravo PE, Pozios I, Pinheiro A, Merrill J, Tsui BM, Wahl RL, Bengel FM, Abraham MR, Abraham TP
• Cardiac MRI evaluation of hypertrophic cardiomyopathy: left ventricular outflow tract/aortic valve diameter ratio predicts severity of LVOT obstruction.
  Journal of magnetic resonance imaging : JMRI 2012 Vogel-Claussen J, Santaularia Tomas M, Newatia A, Boyce D, Pinheiro A, Abraham R, Abraham T, Bluemke DA
• PET/CT assessment of symptomatic individuals with obstructive and nonobstructive hypertrophic cardiomyopathy.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012 Bravo PE, Pinheiro A, Higuchi T, Rischpler C, Merrill J, Santaularia-Tomas M, Abraham MR, Wahl RL, Abraham TP, Bengel FM
• Constitutive HIF-1α expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart by altering paracrine factor balance.
  Journal of cardiovascular translational research 2011 Bonios M, Chang CY, Terrovitis J, Pinheiro A, Barth A, Dong P, Santaularia M, Foster DB, Raman V, Abraham TP, Abraham MR
• Anatomy of the tendinous cords of the interventricular septum of the human heart.
  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2008 Wafae N, Ruiz CR, Abraham M, Freire CH, Demarchi GT, Wafae GC
• Stem cell: "KANT" you see it?
  Journal of cardiovascular translational research 2008 Bonios MJ, Terrovitis JV, Abraham MR
• Angiotensin-converting enzyme genotype modulates pulmonary function and exercise capacity in treated patients with congestive stable heart failure.
  Circulation 2002 Abraham MR, Olson LJ, Joyner MJ, Turner ST, Beck KC, Johnson BD