Rosalyn Sayaman, PhD
Professional Research Assoc.
Laboratory Medicine
School of Medicine

Awards

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• NCI K01 Mentored Research Scientist Development Award to Promote Diversity, National Cancer Institute (NCI), 2023-2028
• Butler-Williams Scholar Program, National Institute on Aging (NIA), 2021
• American Association for Cancer Research (AACR) Associate Award Merit Recipient, San Antonio Breast Cancer Symposium (SABCS), 2019
• Young Investigator Award, Society for Immunotherapy of Cancer (SITC), 2019
• NIH T32 Cancer Metabolism Training Grant Postdoctoral Fellowship, Beckman Research Institute, City of Hope Comprehensive Cancer Center, 2018-2020
• NIH T32 Stem Cell Engineering Training Grant Graduate Fellowship, Berkeley Stem Cell Center, University of California, Berkeley, 2012-2014
• Chancellor’s Fellowship for Graduate Research, University of California, Berkeley, 2011-2015

Education & Training

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• PhD Comparative Biochemistry University of California, Berkeley 12/2016
• MS Bioengineering California Institute of Technology 06/2010
• BA Integrative Biology University of California, Berkeley 12/2001

Grants and Projects

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• A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer, NIH/NCI, 2023-2028
• The I SPY 2.2 TRIAL: Evolving to Imaging and Molecular Biomarker Response Directed Adaptive Sequential Treatment to Optimize Breast Cancer Outcomes, NIH/NCI, 2023-2028

Publications (26)

Top publication keywords:
NeoplasmsBreastMammary Glands, HumanGerm-Line MutationKiller Cells, NaturalBreast NeoplasmsLymphocytes, Tumor-InfiltratingGenes, BRCA1T-LymphocytesRetinoblastoma-Like Protein p107Flight, AnimalImmunotherapyGenome-Wide Association StudyGerm CellsCirculating Tumor DNA

• Cell-free DNA concentration as a biomarker of response and recurrence in HER2-negative breast cancer receiving neoadjuvant chemotherapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Magbanua MJM, Ahmed Z, Sayaman RW, Brown Swigart L, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Perlmutter J, Pohlmann P, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer …
• Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells.
  Genome research 2023 Senapati P, Miyano M, Sayaman RW, Basam M, Leung A, LaBarge MA, Schones DE
• An integrated tumor, immune and microbiome atlas of colon cancer.
  Nature medicine 2023 Roelands J, Kuppen PJK, Ahmed EI, Mall R, Masoodi T, Singh P, Monaco G, Raynaud C, de Miranda NFCC, Ferraro L, Carneiro-Lobo TC, Syed N, Rawat A, Awad A, Decock J, Mifsud W, Miller LD, Sherif S, …
• Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy.
  Cancer cell 2023 Magbanua MJM, Brown Swigart L, Ahmed Z, Sayaman RW, Renner D, Kalashnikova E, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Asare S, Liu MC, Albain K, Chien AJ, Forero-Torres A, Isaacs C, Nanda R, …
• Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors.
  STAR protocols 2022 Sayaman RW, Saad M, Heimann C, Hu D, Kunji K, Roelands J, Wolf DM, Huntsman S, Ceccarelli M, Thorsson V, Ziv E, Bedognetti D

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• Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility
  bioRxiv 2022 Sayaman RW, Miyano M, Senapati P, Zirbes A, Shalabi S, Todhunter ME, Seewaldt V, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA
• A cellular and transcriptomic dissection of the human breast for studying mechanisms of cell and tissue function
  bioRxiv 2022 Del Toro K, Sayaman RW, Thi K, Licon-Munoz Y, Hines WC
• Comprehensive identification, isolation, and culture of human breast cell types
  bioRxiv 2022 Thi K, Del Toro K, Licon-Munoz Y, Sayaman RW, Hines WC
• Analysis of germline-driven ancestry-associated gene expression in cancers.
  STAR protocols 2022 Chambwe N, Sayaman RW, Hu D, Huntsman S, Cancer Genome Analysis Network, Kemal A, Caesar-Johnson S, Zenklusen JC, Ziv E, Beroukhim R, Cherniack AD
• Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies.
  Cancer cell 2022 Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J, I-SPY2 Investigators, Asare SM, Sit L, …
• Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations.
  Nature aging 2021 Shalabi SF, Miyano M, Sayaman RW, Lopez JC, Jokela TA, Todhunter ME, Hinz S, Garbe JC, Stampfer MR, Kessenbrock K, Seewaldt VE, LaBarge MA
• Deep proteome profiling of human mammary epithelia at lineage and age resolution.
  iScience 2021 Hinz S, Manousopoulou A, Miyano M, Sayaman RW, Aguilera KY, Todhunter ME, Lopez JC, Sohn LL, Wang LD, LaBarge MA
• Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression.
  Journal of mammary gland biology and neoplasia 2021 Zirbes A, Joseph J, Lopez JC, Sayaman RW, Basam M, Seewaldt VL, LaBarge MA
• Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.
  Cancer prevention research (Philadelphia, Pa.) 2021 Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA
• Volume-constrained microcontainers enable myoepithelial functional differentiation in highly parallel mammary organoid culture.
  iScience 2021 Todhunter ME, Miyano M, Moolamalla DS, Filippov A, Sayaman RW, LaBarge MA
• Epigenetic changes with age primes mammary luminal epithelia for cancer initiation
  bioRxiv 2021 Sayaman RW, Miyano M, Senapati P, Shalabi S, Zirbes A, Todhunter ME, Seewaldt V, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA
• Germline genetic contribution to the immune landscape of cancer.
  Immunity 2021 Sayaman RW, Saad M, Thorsson V, Hu D, Hendrickx W, Roelands J, Porta-Pardo E, Mokrab Y, Farshidfar F, Kirchhoff T, Sweis RF, Bathe OF, Heimann C, Campbell MJ, Stretch C, Huntsman S, Graff RE, Syed N, …
• Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry.
  NPJ breast cancer 2021 Roelands J, Mall R, Almeer H, Thomas R, Mohamed MG, Bedri S, Al-Bader SB, Junejo K, Ziv E, Sayaman RW, Kuppen PJK, Bedognetti D, Hendrickx W, Decock J
• The landscape of interactions between cancer polygenic risk scores and somatic alterations in cancer cells
  bioRxiv 2020 Porta-Pardo E, Sayaman RW, Ziv E, Valencia A
• Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.
  Cancer cell 2020 Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, …
• Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications.
  Frontiers in oncology 2019 Shan J, Chouchane A, Mokrab Y, Saad M, Boujassoum S, Sayaman RW, Ziv E, Bouaouina N, Remadi Y, Gabbouj S, Roelands J, Ma X, Bedognetti D, Chouchane L
• Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.
  Current opinion in cell biology 2018 Todhunter ME, Sayaman RW, Miyano M, LaBarge MA
• Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells.
  Aging 2017 Miyano M, Sayaman RW, Stoiber MH, Lin CH, Stampfer MR, Brown JB, LaBarge MA
• Discriminating external and internal causes for heading changes in freely flying Drosophila.
  PLoS computational biology 2013 Censi A, Straw AD, Sayaman RW, Murray RM, Dickinson MH
• The aerodynamics of hovering flight in Drosophila.
  The Journal of experimental biology 2005 Fry SN, Sayaman R, Dickinson MH
• The aerodynamics of free-flight maneuvers in Drosophila.
  Science (New York, N.Y.) 2003 Fry SN, Sayaman R, Dickinson MH