Rosalie Lawrence, PhD
Postdoctoral Research Fellow
Howard Hughes Medical Instit
School of Medicine

Publications (5)

Top publication keywords:
PhosphorylationViral ProteinsCryoelectron MicroscopySignal TransductionMolecular BiologyAllosteric RegulationEukaryotic Initiation Factor-2NucleotidesMicroscopy, FluorescenceGuanine Nucleotide Exchange FactorsK562 CellsPhlebovirusStress, PhysiologicalEukaryotic Initiation Factor-2BMolecular Imaging

• A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.
  Nature chemical biology 2023 Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
• A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
  eLife 2022 Boone M, Wang L, Lawrence RE, Frost A, Walter P, Schoof M
• Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.
  Nature communications 2021 Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P
• eIF2B conformation and assembly state regulate the integrated stress response.
  eLife 2021 Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P
• PhotoGate microscopy to track single molecules in crowded environments.
  Nature communications 2017 Belyy V, Shih SM, Bandaria J, Huang Y, Lawrence RE, Zoncu R, Yildiz A