Ronald Clyman, MD
Professor
Pediatrics
School of Medicine

He has helped define the role of oxygen and prostaglandins in ductus patency and is currently studying the mechanisms leading to irreversible ductal closure. Clyman is a professor of pediatrics at the University of California, San Francisco and a member of the Cardiovascular Research Institute. He earned his medical degree at Columbia University and is board certified in pediatrics and neonatal and perinatal medicine.

Education Columbia University School of Medicine 1971

• Effects of prophylactic indomethacin on morbidity and mortality in infants <25 weeks' gestation: a protocol driven intention to treat analysis.
  Journal of perinatology : official journal of the California Perinatal Association 2022 Clyman RI, Hills NK
• An Update on Patent Ductus Arteriosus and What is Coming Next.
  Turkish archives of pediatrics 2022 Erdeve Ö, Okulu E, Singh Y, Sindelar R, Oncel MY, Terrin G, Boscarino G, Bülbül A, Sallmon H, Atasay B, Ovali F, Clyman RI
• Management of persistent ductus arteriosus in very premature neonates. Results of the French TRIOCAPI trial, perspectives for clinicians, and subsequent studies on this topic.
  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2021 Cambonie G, Clyman RI, Rozé JC
• Corrigendum: Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: An Updated Systematic Review and Meta-Analysis.
  Frontiers in pediatrics 2021 González-Luis G, Ghirardello S, Bas-Suárez P, Cavallaro G, Mosca F, Clyman RI, Villamor E
• Interactions between PDA-associated polymorphisms and genetic ancestry alter ductus arteriosus gene expression.
  Pediatric research 2021 Clyman RI, Hills NK, Dagle JM, Murray JC, Kelsey K
• Patent ductus arteriosus, tracheal ventilation, and the risk of bronchopulmonary dysplasia.
  Pediatric research 2021 Clyman RI, Hills NK, Cambonie G, Debillon T, Ligi I, Gascoin G, Patkai J, Beuchee A, Favrais G, Durrmeyer X, Flamant C, Rozé JC
• Reply.
  The Journal of pediatrics 2021 Clyman RI
• Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: An Updated Systematic Review and Meta-Analysis.
  Frontiers in pediatrics 2021 González-Luis G, Ghiradello S, Bas-Suárez P, Cavallaro G, Mosca F, Clyman RI, Villamor E
• Effect of Early Targeted Treatment of Ductus Arteriosus with Ibuprofen on Survival Without Cerebral Palsy at 2 Years in Infants with Extreme Prematurity: A Randomized Clinical Trial.
  The Journal of pediatrics 2020 Rozé JC, Cambonie G, Le Thuaut A, Debillon T, Ligi I, Gascoin G, Patkai J, Beuchee A, Favrais G, Flamant C, Durrmeyer X, Clyman R
• Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial.
  The Journal of pediatrics 2020 Clyman RI, Kaempf J, Liebowitz M, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, Farooqi A, Katheria A, Sauberan J, Singh J, Nelson K, Wickremasinghe A, Dong L, Hassinger DC, Aucott SW, Hayashi M, …
• The effect of prolonged tracheal intubation on the association between patent ductus arteriosus and bronchopulmonary dysplasia (grades 2 and 3).
  Journal of perinatology : official journal of the California Perinatal Association 2020 Clyman RI, Hills NK
• A role for neonatal bacteremia in deaths due to intestinal perforation: spontaneous intestinal perforation compared with perforated necrotizing enterocolitis.
  Journal of perinatology : official journal of the California Perinatal Association 2020 Clyman RI, Jin C, Hills NK
• Paracetamol (Acetaminophen) for Patent Ductus Arteriosus: Where Do We Stand?
  The Journal of pediatrics 2020 Hills NK, Clyman R
• Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks.
  American journal of perinatology 2019 Clyman RI, Hills NK, Liebowitz M, Johng S
• Transcatheter patent ductus arteriosus closure-will history repeat itself?
  Journal of perinatology : official journal of the California Perinatal Association 2019 Clyman RI, Benitz WE
• CYP2C9*2 is associated with indomethacin treatment failure for patent ductus arteriosus.
  Pharmacogenomics 2019 Rooney SR, Shelton EL, Aka I, Shaffer CM, Clyman RI, Dagle JM, Ryckman K, Lewis TR, Reese J, Van Driest SL, Kannankeril PJ
• Lack of Equipoise in the PDA-TOLERATE Trial: A Comparison of Eligible Infants Enrolled in the Trial and Those Treated Outside the Trial.
  The Journal of pediatrics 2019 Liebowitz M, Katheria A, Sauberan J, Singh J, Nelson K, Hassinger DC, Aucott SW, Kaempf J, Kimball A, Fernandez E, Carey WA, Perez J, Serize A, Wickremasinghe A, Dong L, Derrick M, Wolf IS, Heuchan AM…
• Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).
  Journal of perinatology : official journal of the California Perinatal Association 2019 Liebowitz M, Kaempf J, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, Farooqi A, Katheria A, Sauberan J, Singh J, Nelson K, Wickremasinghe A, Dong L, Hassinger DC, Aucott SW, Hayashi M, Heuchan AM, …
• Intrauterine Growth Restriction and Patent Ductus Arteriosus in Very and Extremely Preterm Infants: A Systematic Review and Meta-Analysis.
  Frontiers in endocrinology 2019 Villamor-Martinez E, Kilani MA, Degraeuwe PL, Clyman RI, Villamor E
• PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age.
  The Journal of pediatrics 2018 Clyman RI, Liebowitz M, Kaempf J, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, Farooqi A, Katheria A, Sauberan J, Singh J, Nelson K, Wickremasinghe A, Dong L, Hassinger DC, Aucott SW, Hayashi M, …
• Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data.
  Pediatric research 2018 Shelton EL, Waleh N, Plosa EJ, Benjamin JT, Milne GL, Hooper CW, Ehinger NJ, Poole S, Brown N, Seidner S, McCurnin D, Reese J, Clyman RI
• Patent ductus arteriosus, its treatments, and the risks of pulmonary morbidity.
  Seminars in perinatology 2018 Clyman RI
• Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing.
  Seminars in perinatology 2018 Yarboro MT, Durbin MD, Herington JL, Shelton EL, Zhang T, Ebby CG, Stoller JZ, Clyman RI, Reese J
• Bronchopulmonary Dysplasia: Executive Summary of a Workshop.
  The Journal of pediatrics 2018 Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi RM, Hartert TV, Ryan RM, Kallapur SG, Steinhorn RH, Konduri GG, Davis SD, Thebaud B, Clyman RI, Collaco JM, Martin CR, Woods JC, Finer NN, …
• Treatment and Nontreatment of the Patent Ductus Arteriosus: Identifying Their Roles in Neonatal Morbidity.
  The Journal of pediatrics 2017 Clyman RI, Liebowitz M
• Response to Coceani et al.
  Pediatric research 2017 Goyal R, Clyman RI
• Prophylactic Indomethacin Compared with Delayed Conservative Management of the Patent Ductus Arteriosus in Extremely Preterm Infants: Effects on Neonatal Outcomes.
  The Journal of pediatrics 2017 Liebowitz M, Clyman RI
• Effects of Prophylactic Indomethacin on Vasopressor-Dependent Hypotension in Extremely Preterm Infants.
  The Journal of pediatrics 2016 Liebowitz M, Koo J, Wickremasinghe A, Allen IE, Clyman RI
• Antenatal Betamethasone: A Prolonged Time Interval from Administration to Delivery Is Associated with an Increased Incidence of Severe Intraventricular Hemorrhage in Infants Born before 28 Weeks Gestation.
  The Journal of pediatrics 2016 Liebowitz M, Clyman RI
• Microarray gene expression analysis in ovine ductus arteriosus during fetal development and birth transition.
  Pediatric research 2016 Goyal R, Goyal D, Longo LD, Clyman RI
• Clamp late and maintain perfusion (CLAMP) policy: delayed cord clamping in preterm infants.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2015 Jelin AC, Zlatnik MG, Kuppermann M, Gregorich SE, Nakagawa S, Clyman R
• Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression.
  The Journal of pediatrics 2015 Waleh N, Barrette AM, Dagle JM, Momany A, Jin C, Hills NK, Shelton EL, Reese J, Clyman RI
• Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.
  Neonatology 2015 Simon SR, van Zogchel L, Bas-Suárez MP, Cavallaro G, Clyman RI, Villamor E
• Predicting the Need for Home Oxygen Therapy in Preterm Infants Born Before 28 Weeks' Gestation.
  American journal of perinatology 2015 Liebowitz MC, Clyman RI
• Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.
  Journal of perinatology : official journal of the California Perinatal Association 2014 Noori S, McNamara P, Jain A, Lavoie PM, Wickremasinghe A, Merritt TA, Solomon T, Sekar K, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, Poindexter BB, Brook M, Auchus RJ, Clyman RI, PDA …
• Managing the patent ductus arteriosus: current treatment options.
  Archives of disease in childhood. Fetal and neonatal edition 2014 Heuchan AM, Clyman RI
• Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones.
  The Journal of pediatrics 2014 Clyman RI, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, Singh J, Chu A, Noori S, Sekar K, Lavoie PM, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, DeMauro S, Poindexter B, …
• Obstetricians' attitudes and beliefs regarding umbilical cord clamping.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2013 Jelin AC, Kuppermann M, Erickson K, Clyman R, Schulkin J
• Superior mesenteric artery blood flow velocities following medical treatment of a patent ductus arteriosus.
  The Journal of pediatrics 2013 Yanowitz TD, Reese J, Gillam-Krakauer M, Cochran CM, Jegatheesan P, Lau J, Tran VT, Walsh M, Carey WA, Fujii A, Fabio A, Clyman R
• The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia.
  Seminars in perinatology 2013 Clyman RI
• Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus.
  The Journal of pediatrics 2013 Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka U, Polin R, Gillam-Krakauer M, Reese J, Mammel M, Couser R, Mulrooney N, Yanowitz TD, Derrick M, Jegatheesan P, Walsh M, Fujii…
• Dopamine-resistant hypotension and severe retinopathy of prematurity.
  The Journal of pediatrics 2013 Catenacci M, Miyagi S, Wickremasinghe AC, Lucas SS, de Alba Campomanes AG, Good WV, Clyman RI
• Neurodevelopmental outcomes following two different treatment approaches (early ligation and selective ligation) for patent ductus arteriosus.
  The Journal of pediatrics 2012 Wickremasinghe AC, Rogers EE, Piecuch RE, Johnson BC, Golden S, Moon-Grady AJ, Clyman RI
• Surgical ligation of the patent ductus arteriosus: treatment or morbidity?
  The Journal of pediatrics 2012 Clyman RI
• Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
  Seminars in perinatology 2012 Clyman RI, Couto J, Murphy GM
• Effects of ibuprofen treatment on the developing preterm baboon kidney.
  American journal of physiology. Renal physiology 2012 Sutherland MR, Yoder BA, McCurnin D, Seidner S, Gubhaju L, Clyman RI, Black MJ
• Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation.
  Pediatric research 2011 Waleh N, Seidner S, McCurnin D, Giavedoni L, Hodara V, Goelz S, Liu BM, Roman C, Clyman RI
• Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons.
  Pediatric research 2011 Waleh N, McCurnin DC, Yoder BA, Shaul PW, Clyman RI
• Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment.
  The Journal of pediatrics 2010 Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R
• Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology.
  Pediatric research 2010 Loeliger M, Shields A, McCurnin D, Clyman RI, Yoder B, Inder TE, Rees SM
• Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency.
  Pediatric research 2010 Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI
• Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment.
  The Journal of pediatrics 2010 Jhaveri N, Moon-Grady A, Clyman RI
• How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude?
  Journal of perinatology : official journal of the California Perinatal Association 2010 Chen S, Tacy T, Clyman R
• Feeding practices and patent ductus arteriosus ligation preferences-are they related?
  American journal of perinatology 2010 Jhaveri N, Soll RF, Clyman RI
• Vessel remodeling in the newborn: platelets fill the gap.
  Nature medicine 2010 Clyman R, Chemtob S
• Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure.
  Pediatric research 2009 Reese J, Waleh N, Poole SD, Brown N, Roman C, Clyman RI
• The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial.
  The Journal of pediatrics 2009 Clyman R, Cassady G, Kirklin JK, Collins M, Philips JB
• Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation.
  Pediatric research 2009 Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman RI
• Developmental and neuropathological consequences of ductal ligation in the preterm baboon.
  Pediatric research 2009 Loeliger M, Inder TE, Dalitz PA, Cain S, Camm EJ, Yoder B, McCurnin D, Shaul PW, Clyman R, Rees SM
• Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia.
  American journal of respiratory and critical care medicine 2009 McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW
• A randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants.
  American journal of perinatology 2008 Aranda JV, Clyman R, Cox B, Van Overmeire B, Wozniak P, Sosenko I, Carlo WA, Ward RM, Shalwitz R, Baggs G, Seth A, Darko L
• Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons.
  Pediatrics 2008 McCurnin D, Clyman RI
• Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus.
  Pediatric research 2008 Liu H, Manganiello V, Waleh N, Clyman RI
• Transcriptional regulation during development of the ductus arteriosus.
  Circulation research 2008 Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D
• Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung.
  Pediatrics 2008 McCurnin D, Seidner S, Chang LY, Waleh N, Ikegami M, Petershack J, Yoder B, Giavedoni L, Albertine KH, Dahl MJ, Wang ZM, Clyman RI
• Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial.
  The Journal of pediatrics 2008 Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R
• Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus.
  Pediatric research 2008 Chang LY, McCurnin D, Yoder B, Shaul PW, Clyman RI
• Risk factors for persistent ductus arteriosus patency during indomethacin treatment.
  The Journal of pediatrics 2007 Chorne N, Jegatheesan P, Lin E, Shi R, Clyman RI
• The effects of caffeine on the preterm sheep ductus arteriosus.
  Pediatric research 2007 Clyman RI, Roman C
• Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosus.
  American journal of physiology. Regulatory, integrative and comparative physiology 2007 Clyman RI, Waleh N, Kajino H, Roman C, Mauray F
• Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity.
  Pediatrics 2007 Chorne N, Leonard C, Piecuch R, Clyman RI
• Patent ductus arteriosus: evidence for and against treatment.
  The Journal of pediatrics 2007 Clyman RI, Chorne N
• Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice.
  The Journal of pediatrics 2007 Clyman RI, Saha S, Jobe A, Oh W
• Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice.
  American journal of physiology. Regulatory, integrative and comparative physiology 2006 Reese J, Anderson JD, Brown N, Roman C, Clyman RI
• Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW
• Mechanisms regulating the ductus arteriosus.
  Biology of the neonate 2006 Clyman RI
• Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo.
  American journal of physiology. Lung cellular and molecular physiology 2006 Asikainen TM, Waleh NS, Schneider BK, Clyman RI, White CW
• Patent ductus arteriosus: pathophysiology and management.
  Journal of perinatology : official journal of the California Perinatal Association 2006 Hermes-DeSantis ER, Clyman RI
• Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth.
  Pediatrics 2006 Miller SP, Mayer EE, Clyman RI, Glidden DV, Hamrick SE, Barkovich AJ
• Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns.
  Pediatric research 2005 Keller RL, Tacy TA, Fields S, Ofenstein JP, Aranda JV, Clyman RI
• Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus.
  American journal of physiology. Regulatory, integrative and comparative physiology 2005 Levin M, McCurnin D, Seidner SR, Yoder B, Waleh N, Goldbarg S, Roman C, Liu BM, Borén J, Clyman RI
• Effect of ductus ligation on cardiopulmonary function in premature baboons.
  American journal of respiratory and critical care medicine 2005 McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, Breuer C, Siler-Khodr T, Shaul PW, Clyman R
• Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Günzler V, White CW
• ATP depletion and cell death in the neonatal lamb ductus arteriosus.
  Pediatric research 2005 Levin M, Goldbarg S, Lindqvist A, Swärd K, Roman C, Liu BM, Hultén LM, Borén J, Clyman RI
• The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling.
  Pediatric research 2004 Waleh N, Seidner S, McCurnin D, Yoder B, Liu BM, Roman C, Mauray F, Clyman RI
• Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control.
  Circulation 2004 Waleh N, Kajino H, Marrache AM, Ginzinger D, Roman C, Seidner SR, Moss TJ, Fouron JC, Vazquez-Tello A, Chemtob S, Clyman RI
• Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain.
  American journal of physiology. Regulatory, integrative and comparative physiology 2004 Vazquez-Tello A, Fan L, Hou X, Joyal JS, Mancini JA, Quiniou C, Clyman RI, Gobeil F, Varma DR, Chemtob S
• Oxygen-saturation targets and outcomes in extremely preterm infants.
  The Journal of pediatrics 2004 Clyman R
• Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus.
  American journal of physiology. Regulatory, integrative and comparative physiology 2004 Bouayad A, Fouron JC, Hou X, Beauchamp M, Quiniou C, Abran D, Peri K, Clyman RI, Varma DR, Chemtob S
• Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus.
  Pediatrics 2003 Keller RL, Clyman RI
• Effects of hypoxia, hypoglycemia, and muscle shortening on cell death in the sheep ductus arteriosus.
  Pediatric research 2003 Goldbarg S, Quinn T, Waleh N, Roman C, Liu BM, Mauray F, Clyman RI
• Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapy.
  Pediatrics 2002 Quinn D, Cooper B, Clyman RI
• Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus.
  Pediatric research 2002 Kajino H, Goldbarg S, Roman C, Liu BM, Mauray F, Chen YQ, Takahashi Y, Koch CJ, Clyman RI
• In utero indomethacin alters O2 delivery to the fetal ductus arteriosus: implications for postnatal patency.
  American journal of physiology. Regulatory, integrative and comparative physiology 2002 Goldbarg SH, Takahashi Y, Cruz C, Kajino H, Roman C, Liu BM, Chen YQ, Mauray F, Clyman RI
• VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus.
  American journal of physiology. Regulatory, integrative and comparative physiology 2002 Clyman RI, Seidner SR, Kajino H, Roman C, Koch CJ, Ferrara N, Waleh N, Mauray F, Chen YQ, Perkett EA, Quinn T
• Prostanoid receptors: ontogeny and implications in vascular physiology.
  American journal of physiology. Regulatory, integrative and comparative physiology 2001 Wright DH, Abran D, Bhattacharya M, Hou X, Bernier SG, Bouayad A, Fouron JC, Vazquez-Tello A, Beauchamp MH, Clyman RI, Peri K, Varma DR, Chemtob S
• Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus.
  American journal of physiology. Heart and circulatory physiology 2001 Bouayad A, Kajino H, Waleh N, Fouron JC, Andelfinger G, Varma DR, Skoll A, Vazquez A, Gobeil F, Clyman RI, Chemtob S
• In utero remodeling of the fetal lamb ductus arteriosus: the role of antenatal indomethacin and avascular zone thickness on vasa vasorum proliferation, neointima formation, and cell death.
  Circulation 2001 Clyman RI, Chen YQ, Chemtob S, Mauray F, Kohl T, Varma DR, Roman C
• Characterization of PGE2 receptors in fetal and newborn ductus arteriosus in the pig.
  Seminars in perinatology 2001 Bouayad A, Bernier SG, Asselin P, Hardy P, Bhattacharya M, Quiniou C, Fouron JC, Guerguerian AM, Varma DR, Clyman RI, Chemtob S
• Ibuprofen and patent ductus arteriosus.
  The New England journal of medicine 2000 Clyman RI
• Tissue hypoxia inhibits prostaglandin and nitric oxide production and prevents ductus arteriosus reopening.
  American journal of physiology. Regulatory, integrative and comparative physiology 2000 Kajino H, Chen YQ, Chemtob S, Waleh N, Koch CJ, Clyman RI
• Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo.
  American journal of physiology. Regulatory, integrative and comparative physiology 2000 Takahashi Y, Roman C, Chemtob S, Tse MM, Lin E, Heymann MA, Clyman RI
• Parental attitudes regarding interviews about injuries to their children.
  Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention 2000 Scheidt PC, Brenner RA, Rossi MW, Clyman R, Boyle KE
• Prophylactic indomethacin: factors determining permanent ductus arteriosus closure.
  The Journal of pediatrics 2000 Narayanan M, Cooper B, Weiss H, Clyman RI
• Developmental changes in prostaglandin E(2) receptor subtypes in porcine ductus arteriosus. Possible contribution in altered responsiveness to prostaglandin E(2).
  Circulation 1999 Bhattacharya M, Asselin P, Hardy P, Guerguerian AM, Shichi H, Hou X, Varma DR, Bouayad A, Fouron JC, Clyman RI, Chemtob S
• Incidence and outcome of a 10-fold indomethacin overdose in premature infants.
  The Journal of pediatrics 1999 Narayanan M, Schlueter M, Clyman RI
• Cyclooxygenase-2 plays a significant role in regulating the tone of the fetal lamb ductus arteriosus.
  The American journal of physiology 1999 Clyman RI, Hardy P, Waleh N, Chen YQ, Mauray F, Fouron JC, Chemtob S
• Permanent anatomic closure of the ductus arteriosus in newborn baboons: the roles of postnatal constriction, hypoxia, and gestation.
  Pediatric research 1999 Clyman RI, Chan CY, Mauray F, Chen YQ, Cox W, Seidner SR, Lord EM, Weiss H, Waleh N, Evans SM, Koch CJ
• Expression of cyclooxygenases in ductus arteriosus of fetal and newborn pigs.
  American journal of obstetrics and gynecology 1998 Guerguerian AM, Hardy P, Bhattacharya M, Olley P, Clyman RI, Fouron JC, Chemtob S
• Endothelin-receptor blockade does not alter closure of the ductus arteriosus.
  The American journal of physiology 1998 Fineman JR, Takahashi Y, Roman C, Clyman RI
• Regulation of ductus arteriosus patency by nitric oxide in fetal lambs: the role of gestation, oxygen tension, and vasa vasorum.
  Pediatric research 1998 Clyman RI, Waleh N, Black SM, Riemer RK, Mauray F, Chen YQ
• Risk factors associated with infant death among very low birth weight infants after discharge from an intensive care nursery.
  Journal of developmental and behavioral pediatrics : JDBP 1998 Piecuch RE, Leonard CH, Clyman RI, Cooper BA
• Imaging hypoxia and blood flow in normal tissues.
  Advances in experimental medicine and biology 1997 Koch CJ, Lord EM, Shapiro IM, Clyman RI, Evans SM
• Changes in endothelial cell and smooth muscle cell integrin expression during closure of the ductus arteriosus: an immunohistochemical comparison of the fetal, preterm newborn, and full-term newborn rhesus monkey ductus.
  Pediatric research 1996 Clyman RI, Goetzman BW, Chen YQ, Mauray F, Kramer RH, Pytela R, Schnapp LM
• Recommendations for the postnatal use of indomethacin: an analysis of four separate treatment strategies.
  The Journal of pediatrics 1996 Clyman RI
• Transforming growth factor-beta protein and messenger RNA expression is increased in the closing ductus arteriosus.
  Pediatric research 1996 Tannenbaum JE, Waleh NS, Mauray F, Gold L, Perkett EA, Clyman RI
• Factors determining reopening of the ductus arteriosus after successful clinical closure with indomethacin.
  The Journal of pediatrics 1995 Weiss H, Cooper B, Brook M, Schlueter M, Clyman R
• Transforming growth factor beta 1 inhibits fetal lamb ductus arteriosus smooth muscle cell migration.
  Pediatric research 1995 Tannenbaum JE, Waleh NS, Mauray F, Breuss J, Pytela R, Kramer RH, Clyman RI
• Indomethacin as a tocolytic agent: the controversy continues.
  The Journal of pediatrics 1994 Merrill JD, Clyman RI, Norton ME
• Ductus arteriosus smooth muscle cell migration on collagen: dependence on laminin and its receptors.
  Journal of cell science 1994 Clyman RI, Tannenbaum J, Chen YQ, Cooper D, Yurchenco PD, Kramer RH, Waleh NS
• Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis.
  Cell adhesion and communication 1994 Clyman RI, Peters KG, Chen YQ, Escobedo J, Williams LT, Ives HE, Wilson E
• Neonatal complications after the administration of indomethacin for preterm labor.
  The New England journal of medicine 1993 Norton ME, Merrill J, Cooper BA, Kuller JA, Clyman RI
• Beta 1 and beta 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix.
  Experimental cell research 1992 Clyman RI, Mauray F, Kramer RH
• Patent ductus arteriosus increases lung fluid filtration in preterm lambs.
  Pediatric research 1991 Alpan G, Scheerer R, Bland R, Clyman R
• Patent ductus arteriosus, indomethacin, and intestinal distension: effects on intestinal blood flow and oxygen consumption.
  Pediatric research 1991 Meyers RL, Alpan G, Lin E, Clyman RI
• The integrin complex alpha v beta 3 participates in the adhesion of microvascular endothelial cells to fibronectin.
  Experimental cell research 1991 Cheng YF, Clyman RI, Enenstein J, Waleh N, Pytela R, Kramer RH
• Persistent patent ductus arteriosus.
  International journal of technology assessment in health care 1991 Clyman RI
• The effects of the patent ductus arteriosus on diaphragmatic blood flow and function.
  Pediatric research 1990 Alpan G, Mauray F, Clyman RI
• Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin.
  The Journal of cell biology 1990 Kramer RH, Cheng YF, Clyman R
• Integrin receptors on aortic smooth muscle cells mediate adhesion to fibronectin, laminin, and collagen.
  Circulation research 1990 Clyman RI, McDonald KA, Kramer RH
• An alpha 1/beta 1-like integrin receptor on rat aortic smooth muscle cells mediates adhesion to laminin and collagen types I and IV.
  Arteriosclerosis (Dallas, Tex.) 1990 Clyman RI, Turner DC, Kramer RH
• Effect of medical and social risk factors on outcome of prematurity and very low birth weight.
  The Journal of pediatrics 1990 Leonard CH, Clyman RI, Piecuch RE, Juster RP, Ballard RA, Behle MB
• The effect of methylprednisolone on hypoxic pulmonary vasoconstriction in the newborn late-gestation lamb.
  Pediatric research 1990 Alpan G, Clyman RI
• Effect of patent ductus arteriosus on water accumulation and protein permeability in the lungs of mechanically ventilated premature lambs.
  Pediatric research 1989 Alpan G, Mauray F, Clyman RI
• Bradykinin produces pulmonary vasodilation in fetal lambs: role of prostaglandin production.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Frantz E, Soifer SJ, Clyman RI, Heymann MA
• Meclofenamate does not affect lung development in fetal sheep.
  Journal of developmental physiology 1989 Wallen LD, Murai DT, Clyman RI, Lee CH, Mauray FE, Ballard PL, Kitterman JA
• Influence of increased pulmonary vascular pressures on the closure of the ductus arteriosus in newborn lambs.
  Pediatric research 1989 Clyman RI, Mauray F, Heymann MA, Roman C
• Meclofenamate increases ventilation in lambs.
  Journal of developmental physiology 1989 Guerra FA, Savich RD, Clyman RI, Kitterman JA
• Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production.
  Circulation research 1989 Clyman RI, Saugstad OD, Mauray F
• Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension.
  The Journal of pediatrics 1988 Soifer SJ, Clyman RI, Heymann MA
• Prostaglandin E2 causes hypoventilation and apnea in newborn lambs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Guerra FA, Savich RD, Wallen LD, Lee CH, Clyman RI, Mauray FE, Kitterman JA
• Leukotriene synthesis inhibition increases pulmonary blood flow in fetal lambs.
  Chest 1988 Heymann MA, LeBidois J, Soifer SJ, Clyman RI
• The role of beta-adrenoreceptor stimulation and contractile state in the preterm lamb's response to altered ductus arteriosus patency.
  Pediatric research 1988 Clyman RI, Teitel D, Padbury J, Roman C, Mauray F
• Effects of meclofenamate on breathing movements in fetal sheep before delivery.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Wallen LD, Murai DT, Clyman RI, Lee CH, Mauray FE, Kitterman JA
• Indomethacin and patent ductus arteriosus: effects on renal function in preterm lambs.
  The American journal of physiology 1988 Gleason CA, Clyman RI, Heymann MA, Mauray F, Leake R, Roman C
• Lung vascular effects of lipid infusion in awake lambs.
  Pediatric research 1987 Teague WG, Raj JU, Braun D, Berner ME, Clyman RI, Bland RD
• Respiratory effects of a patent ductus arteriosus in premature newborn lambs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1987 Pérez Fontán JJ, Clyman RI, Mauray F, Heymann MA, Roman C
• How a patent ductus arteriosus effects the premature lamb's ability to handle additional volume loads.
  Pediatric research 1987 Clyman RI, Roman C, Heymann MA, Mauray F
• Indomethacin therapy for patent ductus arteriosus: when is prophylaxis not prophylactic?
  The Journal of pediatrics 1987 Clyman RI, Campbell D
• Theophylline treatment in the extubation of infants weighing less than 1,250 grams: a controlled trial.
  Pediatrics 1987 Durand DJ, Goodman A, Ray P, Ballard RA, Clyman RI
• Cardiovascular effects of patent ductus arteriosus in preterm lambs with respiratory distress.
  The Journal of pediatrics 1987 Clyman RI, Mauray F, Heymann MA, Roman C
• Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs.
  Pediatric research 1987 Lebidois J, Soifer SJ, Clyman RI, Heymann MA
• Visual acuity development in normal and abnormal preterm human infants.
  Journal of pediatric ophthalmology and strabismus 1987 Norcia AM, Tyler CW, Piecuch R, Clyman R, Grobstein J
• Ductus arteriosus: current theories of prenatal and postnatal regulation.
  Seminars in perinatology 1987 Clyman RI
• Effects of prostaglandins on fetal breathing do not involve peripheral chemoreceptors.
  Journal of applied physiology (Bethesda, Md. : 1985) 1987 Murai DT, Wallen LD, Lee CC, Clyman RI, Mauray F, Kitterman JA
• Regulation of breathing movements in fetal sheep by prostaglandin E2.
  Journal of applied physiology (Bethesda, Md. : 1985) 1986 Wallen LD, Murai DT, Clyman RI, Lee CH, Mauray FE, Kitterman JA
• Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs.
  Pediatric research 1985 Clozel M, Clyman RI, Soifer SJ, Heymann MA
• Effects of a protein-free, synthetic surfactant on survival and pulmonary function in preterm lambs.
  The Journal of pediatrics 1985 Durand DJ, Clyman RI, Heymann MA, Clements JA, Mauray F, Kitterman J, Ballard P
• Does indomethacin cause extension of intracranial hemorrhages: a preliminary study.
  Pediatrics 1985 Maher P, Lane B, Ballard R, Piecuch R, Clyman RI
• Persistent responsiveness of the neonatal ductus arteriosus in immature lambs: a possible cause for reopening of patent ductus arteriosus after indomethacin-induced closure.
  Circulation 1985 Clyman RI, Campbell D, Heymann MA, Mauray F
• Meclofenamate and prostaglandin E2 affect breathing movements independently of glucose concentrations in fetal sheep.
  American journal of obstetrics and gynecology 1984 Murai DT, Clyman RI, Mauray FE, Lee CC, Kitterman JA
• Decreased contractility of the ductus arteriosus in experimental pulmonic stenosis.
  Circulation 1984 Mahony L, Clyman RI, Heymann MA
• The role of the patent ductus arteriosus in respiratory distress syndrome.
  Seminars in perinatology 1984 Clyman R
• Factors determining the loss of ductus arteriosus responsiveness to prostaglandin E.
  Circulation 1983 Clyman RI, Mauray F, Roman C, Heymann MA, Payne B
• Videophone use improves maternal interest in transported infants.
  Critical care medicine 1983 Piecuch RE, Roth RS, Clyman RI, Sniderman SH, Riedel PA, Ballard RA
• A comparison of continuous wave Doppler ultrasonography with microsphere measured left-to-right shunt through the patent ductus arteriosus.
  Critical care medicine 1983 Karsdon J, Clyman RI
• Effect of gestational age on ductus arteriosus response to circulating prostaglandin E2.
  The Journal of pediatrics 1983 Clyman RI, Mauray F, Roman C, Heymann MA, Payne B
• Role of circulating prostaglandin E2 in regulation of the ductus arteriosus.
  Advances in prostaglandin, thromboxane, and leukotriene research 1983 Clyman RI, Heymann MA, Mauray F
• When to treat the patent ductus arteriosus with indomethacin in very-low-birth-weight infants.
  Advances in prostaglandin, thromboxane, and leukotriene research 1983 Mahony L, Heymann MA, Carnero V, Brett C, Clyman RI
• Evaluation of alprostadil (prostaglandin E1) in the management of congenital heart disease in infancy.
  Pharmacotherapy 1982 Heymann MA, Clyman RI
• Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants.
  The New England journal of medicine 1982 Mahony L, Carnero V, Brett C, Heymann MA, Clyman RI
• Ontogeny and regulation of corticosteroid binding globulin capacity in plasma of fetal and newborn lambs.
  Endocrinology 1982 Ballard PL, Kitterman JA, Bland RD, Clyman RI, Gluckman PD, Platzker AC, Kaplan SL, Grumbach MM
• Increased shunt through the patent ductus arteriosus after surfactant replacement therapy.
  The Journal of pediatrics 1982 Clyman RI, Jobe A, Heymann M, Ikegami M, Roman C, Payne B, Mauray F
• Developmental follow-up of hyperventilated neonates: preliminary observations.
  Pediatrics 1981 Brett C, Dekle M, Leonard CH, Clark C, Sniderman S, Roth R, Ballard R, Clyman R
• Risk factor analysis of intraventricular hemorrhage in low-birth-weight infants.
  The Journal of pediatrics 1981 Clark CE, Clyman RI, Roth RS, Sniderman SH, Lane B, Ballard RA
• Effects of antenatal glucocorticoid administration on ductus arteriosus of preterm lambs.
  The American journal of physiology 1981 Clyman RI, Mauray F, Roman C, Heymann MA, Ballard PL, Rudolph AM, Payne B
• Effect of gestational age on pulmonary metabolism of prostaglandin E1 & E2.
  Prostaglandins 1981 Clyman RI, Mauray F, Heymann MA, Roman C
• Pharmacology of the ductus arteriosus.
  Pediatric clinics of North America 1981 Clyman RI, Heymann MA
• Glucocorticoids alter the sensitivity of the lamb ductus arteriosus to prostaglandin E2.
  The Journal of pediatrics 1981 Clyman RI, Mauray F, Roman C, Rudolph AM, Heymann MA
• Prenatal administration of betamethasone for prevention of patient ductus arteriosus.
  The Journal of pediatrics 1981 Clyman RI, Ballard PL, Sniderman S, Ballard RA, Roth R, Heymann MA, Granberg JP
• Circulating prostaglandin E2 concentrations and incidence of patent ductus arteriosus in preterm infants with respiratory distress syndrome.
  Pediatrics 1980 Clyman RI, Brett C, Mauray F
• Circulating prostaglandin E2 concentrations and patent ductus arteriosus in fetal and neonatal lambs.
  The Journal of pediatrics 1980 Clyman RI, Mauray F, Roman C, Rudolph AM, Heymann MA
• Control of oxygenation during the transport of sick neonates.
  Pediatrics 1980 Miller C, Clyman RI, Roth RS, Sniderman SH, Ballard RA, Henning D, Riedel P, Rosen A, Burden L
• Does a belief in a 'just world' affect health care providers' reactions to perinatal illness?
  Journal of medical education 1980 Clyman RI, Roth RS, Sniderman SH, Charrier J
• Issues concerning parents after the death of their newborn.
  Critical care medicine 1980 Clyman RI, Green C, Rowe J, Mikkelsen C, Ataide L
• Ontogeny of the ductus arteriosus response to prostaglandins and inhibitors of their synthesis.
  Seminars in perinatology 1980 Clyman RI
• Does oxygen regulate prostaglandin-induced relaxation in the lamb ductus arteriosus?
  Prostaglandins 1980 Clyman RI, Mauray F, Demers LM, Rudolph AM, Roman C
• Age-dependent sensitivity of the lamb ductus arteriosus to indomethacin and prostaglandins.
  The Journal of pediatrics 1980 Clyman RI, Mauray F, Rudolph AM, Heymann MA
• Ductus arteriosus: developmental response to endogenous prostaglandins, oxygen, and indomethacin.
  Advances in prostaglandin and thromboxane research 1980 Clyman RI
• Preliminary observations on the behavior of children present at the birth of a sibling.
  Pediatrics 1979 Leonard CH, Irwin N, Ballard RA, Ferris C, Clyman R
• Developmental response to indomethacin: a comparison of isometric tension with PGE2 formation in the lamb ductus arteriosus.
  Prostaglandins 1979 Clyman RI, Mauray F, Demers LM, Rudolph AM, Roman C
• Do parents utilize physician follow-up after death of their newborn?
  Pediatrics 1979 Clyman RI, Green C, Mikkelsen C, Rowe J, Ataide L
• What pediatricians say to mothers of sick newborns: an indirect evaluation of the counseling process.
  Pediatrics 1979 Clyman RI, Sniderman SH, Ballard RA, Roth RS
• Developmental responses to oxygen, arachidonic acid, and indomethacin in the fetal lamb ductus arteriosus in vitro.
  Prostaglandins and medicine 1978 Clyman RI
• Follow-up families who experience a perinatal death.
  Pediatrics 1978 Rowe J, Clyman R, Green C, Mikkelsen C, Haight J, Ataide L
• Ductus arteriosus: developmental response to oxygen and indomethacin.
  Prostaglandins 1978 Clyman RI, Mauray F, Heymann MA, Rudolph AM
• Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion.
  Journal of immunology (Baltimore, Md. : 1950) 1978 Gallin JI, Sandler JA, Clyman RI, Manganiello VC, Vaughan M
• Patent ductus arteriosus: a new light on an old problem.
  Pediatric research 1978 Clyman RI, Rudolph AM
• Responsiveness of the lamb ductus arteriosus to prostaglandins and their metabolites.
  Prostaglandins 1978 Clyman RI, Wong L, Heymann MA, Rudolph AM
• Regulation of Cyclic nucleotide metabolism in the human umbilical artery.
  Advances in prostaglandin and thromboxane research 1978 Clyman RI
• The developmental response of the ductus arteriosus to oxygen.
  Biology of the neonate 1978 Clyman RI, Mauray F, Wong L, Heymann MA, Rudolph AM
• Oxygen tension and the response of the ductus arteriosus to PGE: searching high and low for a solution.
  Prostaglandins 1977 Clyman RI, Heymann MA, Rudolph AM
• Ductus arteriosus responses to prostaglandin E1 at high and low oxygen concentrations.
  Prostaglandins 1977 Clyman RI, Heymann MA, Rudolph AM
• Oxygen: influence on cyclic nucleotides and calcium sequestration in the human umbilical artery.
  Chest 1977 Clyman RI, Manganiello VC, Vaughan M
• Oxygen and cyclic nucleotides in human umbilical artery.
  Proceedings of the National Academy of Sciences of the United States of America 1975 Clyman RI, Blacksin AS, Manganiello VC, Vaughan M
• The role of calcium in regulation of cyclic nucleotide content in human umbilical artery.
  The Journal of biological chemistry 1975 Clyman RI, Blacksin AS, Sandler JA, Manganiello VC, Vaughan M
• Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery.
  The Journal of clinical investigation 1975 Clyman RI, Sandler JA, Manganiello VC, Vaughan M
• The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.
  The Journal of clinical investigation 1975 Sandler JA, Clyman RI, Manganiello VC, Vaughan M
• Nucleic acid deficiency in the prothanic homozygous mutant of creeper fowl.
  The Journal of experimental zoology 1969 Wallace H, Clyman RI, Pierro LP