Ron Vale, PhD
Professor Emeritus
Cellular Molecular Pharmacology
School of Medicine
Awards
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- Canada Gairdner International Award, 2019
- Institute of Medicine Member, 2014
- Albert Lasker Basic Medical Research Award, 2012
Websites
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- UCSF Professor Receives 2012 Lasker Award (ucsf.edu)
Grants and Projects
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- Regulation of Microtubule-Based Motility, NIH, 2016-2021
- Creating an online resource center for training and professional development in the biomedical sciences, NIH, 2015-2020
- Structure and mechanism of the dynein motor, NIH, 2011-2019
- Interdisciplinary Training in Quantitative Cell Biology, NIH, 2004-2018
- Microtubule Complexes Involved in Intracelluar Transport, NIH, 1988-2016
- Open Source Microscopy Software, NIH, 2007-2015
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- Cell Migration Consortium, NIH, 2001-2014
- Structure and Function of Molecular Motors, NIH, 1994-2010
- Interdisciplinary Training in Quantitative Cell Biology, NIH, 2004-2007
- Macromoleclar Complexes Involved in Cellular Transport, NIH, 1988-2006
- Protein Modulators of Microtubule Dynamics, NIH, 1993-1998
Publications (168)
Top publication keywords:
MicrotubulesDynactin ComplexScienceMicrotubule-Associated ProteinsMicroscopy, FluorescenceMolecular Motor ProteinsCentrosomeReceptors, Antigen, T-CellPeer Review, ResearchCytoplasmic DyneinsSpindle ApparatusDrosophila ProteinsDrosophila melanogasterDyneinsT-Lymphocytes
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Recommendations for accelerating open preprint peer review to improve the culture of science.
PLoS biology 2024 Avissar-Whiting M, Belliard F, Bertozzi SM, Brand A, Brown K, Clément-Stoneham G, Dawson S, Dey G, Ecer D, Edmunds SC, Farley A, Fischer TD, Franko M, Fraser JS, Funk K, Ganier C, Harrison M, Hatch A,… -
Mechanical stretch regulates macropinocytosis in Hydra vulgaris.
Molecular biology of the cell 2024 Skokan TD, Hobmayer B, McKinley KL, Vale RD -
Bridging gaps in traditional research training with iBiology Courses.
PLoS biology 2024 Schnoes AM, Green NH, Nguyen TA, Vale RD, Goodwin SS, Behrman SL -
De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.
Cell 2023 Chen Z, Shiozaki M, Haas KM, Skinner WM, Zhao S, Guo C, Polacco BJ, Yu Z, Krogan NJ, Lishko PV, Kaake RM, Vale RD, Agard DA -
Nucleolar dynamics are determined by the ordered assembly of the ribosome.
bioRxiv : the preprint server for biology 2023 Sheu-Gruttadauria J, Yan X, Stuurman N, Floor SN, Vale RD
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CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Immunity 2023 Morrissey MA, Kern N, Vale RD -
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2023 Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A -
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.
Nature structural & molecular biology 2023 Chen Z, Greenan GA, Shiozaki M, Liu Y, Skinner WM, Zhao X, Zhao S, Yan R, Yu Z, Lishko PV, Agard DA, Vale RD -
DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation.
Proceedings of the National Academy of Sciences of the United States of America 2021 Dong R, Aksel T, Chan W, Germain RN, Vale RD, Douglas SM -
Direct detection of SARS-CoV-2 RNA using high-contrast pH-sensitive dyes.
Journal of biomolecular techniques : JBT 2021 Brown TA, Schaefer KS, Tsang A, Yi HA, Grimm JB, Lemire AL, Jradi FM, Kim C, McGowan K, Ritola K, Armstrong DT, Mostafa HH, Korff W, Vale RD, Lavis LD -
Three-color single-molecule imaging reveals conformational dynamics of dynein undergoing motility.
Proceedings of the National Academy of Sciences of the United States of America 2021 Niekamp S, Stuurman N, Zhang N, Vale RD -
Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis.
eLife 2021 Kern N, Dong R, Douglas SM, Vale RD, Morrissey MA -
High-content imaging-based pooled CRISPR screens in mammalian cells.
The Journal of cell biology 2021 Yan X, Stuurman N, Ribeiro SA, Tanenbaum ME, Horlbeck MA, Liem CR, Jost M, Weissman JS, Vale RD -
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating.
Nature structural & molecular biology 2020 Grossman-Haham I, Coudray N, Yu Z, Wang F, Zhang N, Bhabha G, Vale RD -
Coupled membrane lipid miscibility and phosphotyrosine-driven protein condensation phase transitions.
Biophysical journal 2020 Chung JK, Huang WYC, Carbone CB, Nocka LM, Parikh AN, Vale RD, Groves JT -
Cell Sorting in Hydra vulgaris Arises from Differing Capacities for Epithelialization between Cell Types.
Current biology : CB 2020 Skokan TD, Vale RD, McKinley KL -
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Immunity 2020 Morrissey MA, Kern N, Vale RD -
Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR).
The EMBO journal 2020 Dong R, Libby KA, Blaeschke F, Fuchs W, Marson A, Vale RD, Su X -
Tuning the Antigen Density Requirement for CAR T-cell Activity.
Cancer discovery 2020 Majzner RG, Rietberg SP, Sotillo E, Dong R, Vachharajani VT, Labanieh L, Myklebust JH, Kadapakkam M, Weber EW, Tousley AM, Richards RM, Heitzeneder S, Nguyen SM, Wiebking V, Theruvath J, Lynn RC, Xu P… -
A 6-nm ultra-photostable DNA FluoroCube for fluorescence imaging.
Nature methods 2020 Niekamp S, Stuurman N, Vale RD -
Electron cryotomography of intact motile cilia defines the basal body to axoneme transition.
The Journal of cell biology 2020 Greenan GA, Vale RD, Agard DA -
A composition-dependent molecular clutch between T cell signaling condensates and actin.
eLife 2019 Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK -
Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.
The EMBO journal 2019 Niekamp S, Coudray N, Zhang N, Vale RD, Bhabha G -
Keep Your Eyes on the Prize.
Cell 2019 Vale RD -
CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic.
The Journal of cell biology 2019 Wang Y, Huynh W, Skokan TD, Lu W, Weiss A, Vale RD -
Nanometer-accuracy distance measurements between fluorophores at the single-molecule level.
Proceedings of the National Academy of Sciences of the United States of America 2019 Niekamp S, Sung J, Huynh W, Bhabha G, Vale RD, Stuurman N -
Spatial control of Draper receptor signaling initiates apoptotic cell engulfment.
The Journal of cell biology 2018 Williamson AP, Vale RD -
Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles.
eLife 2018 Greenan GA, Keszthelyi B, Vale RD, Agard DA -
Publish peer reviews.
Nature 2018 Polka JK, Kiley R, Konforti B, Stern B, Vale RD -
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell 2018 Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA, Heath JR, Evavold BD, Vale RD, Garcia … -
Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes.
Nature reviews. Molecular cell biology 2018 Reck-Peterson SL, Redwine WB, Vale RD, Carter AP -
Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.
eLife 2018 McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD -
Chimeric antigen receptors that trigger phagocytosis.
eLife 2018 Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale RD -
The cytoplasmic dynein transport machinery and its many cargoes.
Nature reviews. Molecular cell biology 2018 Reck-Peterson SL, Redwine WB, Vale RD, Carter AP -
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 2017 Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD -
Not just Salk.
Science (New York, N.Y.) 2017 Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, … -
Disease-associated mutations in human BICD2 hyperactivate motility of dynein-dynactin.
The Journal of cell biology 2017 Huynh W, Vale RD -
RNA phase transitions in repeat expansion disorders.
Nature 2017 Jain A, Vale RD -
Ten simple rules to consider regarding preprint submission.
PLoS computational biology 2017 Bourne PE, Polka JK, Vale RD, Kiley R -
Architectures of Lipid Transport Systems for the Bacterial Outer Membrane.
Cell 2017 Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD -
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
Cell 2017 Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD -
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Science (New York, N.Y.) 2017 Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD -
Reconstitution of TCR Signaling Using Supported Lipid Bilayers.
Methods in molecular biology (Clifton, N.J.) 2017 Su X, Ditlev JA, Rosen MK, Vale RD -
An acquisition and analysis pipeline for scanning angle interference microscopy.
Nature methods 2016 Carbone CB, Vale RD, Stuurman N -
Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy.
Nature methods 2016 Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF -
Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
The Journal of cell biology 2016 Schroeder CM, Vale RD -
Impact of New Camera Technologies on Discoveries in Cell Biology.
The Biological bulletin 2016 Stuurman N, Vale RD -
Priority of discovery in the life sciences.
eLife 2016 Vale RD, Hyman AA -
SCIENTIFIC COMMUNITY. Preprints for the life sciences.
Science (New York, N.Y.) 2016 Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, … -
Dynamics of Translation of Single mRNA Molecules In Vivo.
Cell 2016 Yan X, Hoek TA, Vale RD, Tanenbaum ME -
Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.
Neuron 2016 Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN -
Phase separation of signaling molecules promotes T cell receptor signal transduction.
Science (New York, N.Y.) 2016 Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD -
Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility.
The EMBO journal 2016 McKenney RJ, Huynh W, Vale RD, Sirajuddin M -
How Dynein Moves Along Microtubules.
Trends in biochemical sciences 2015 Bhabha G, Johnson GT, Schroeder CM, Vale RD -
Accelerating scientific publication in biology.
Proceedings of the National Academy of Sciences of the United States of America 2015 Vale RD -
iBioChina and iBiology: spreading scientific knowledge together.
Science China. Life sciences 2015 Dell KR, Vale RD -
Microtubule nucleation at the centrosome and beyond.
Nature cell biology 2015 Petry S, Vale RD -
Total Internal Reflection Fluorescence Microscopy.
Cold Spring Harbor protocols 2015 Yildiz A, Vale RD -
Tracking Movements of the Microtubule Motors Kinesin and Dynein Using Total Internal Reflection Fluorescence Microscopy.
Cold Spring Harbor protocols 2015 Yildiz A, Vale RD -
Regulation of mRNA translation during mitosis.
eLife 2015 Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale RD -
Clustering of a kinesin-14 motor enables processive retrograde microtubule-based transport in plants.
Nature plants 2015 Jonsson E, Yamada M, Vale RD, Goshima G -
De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.
Annals of clinical and translational neurology 2015 Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, … -
HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.
Journal of immunology (Baltimore, Md. : 1950) 2015 Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD -
Allosteric communication in the dynein motor domain.
Cell 2014 Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD -
A protein-tagging system for signal amplification in gene expression and fluorescence imaging.
Cell 2014 Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD -
A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
eLife 2014 Schroeder CM, Ostrem JM, Hertz NT, Vale RD -
Induction of focal adhesions and motility in Drosophila S2 cells.
Molecular biology of the cell 2014 Ribeiro SA, D'Ambrosio MV, Vale RD -
Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.
Science (New York, N.Y.) 2014 McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD -
Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin.
Proceedings of the National Academy of Sciences of the United States of America 2014 Hendershott MC, Vale RD -
Regulation of microtubule motors by tubulin isotypes and post-translational modifications.
Nature cell biology 2014 Sirajuddin M, Rice LM, Vale RD -
In vitro membrane reconstitution of the T-cell receptor proximal signaling network.
Nature structural & molecular biology 2014 Hui E, Vale RD -
A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion.
The Journal of cell biology 2014 Toret CP, D'Ambrosio MV, Vale RD, Simon MA, Nelson WJ -
Advanced methods of microscope control using μManager software.
Journal of biological methods 2014 Edelstein AD, Tsuchida MA, Amodaj N, Pinkard H, Vale RD, Stuurman N -
Preface: the role of reconstitution in cytoskeleton research.
Methods in enzymology 2014 Vale RD -
Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells.
Proceedings of the National Academy of Sciences of the United States of America 2013 Moutinho-Pereira S, Stuurman N, Afonso O, Hornsveld M, Aguiar P, Goshima G, Vale RD, Maiato H -
Creating opportunities for science PhDs to pursue careers in high school education.
Molecular biology of the cell 2013 Doyle KM, Vale RD -
Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains.
eLife 2013 Tanenbaum ME, Vale RD, McKenney RJ -
The value of asking questions.
Molecular biology of the cell 2013 Vale RD -
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.
Cell 2013 Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD -
Graduate education. Interdisciplinary graduate training in teaching labs.
Science (New York, N.Y.) 2012 Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ -
How lucky can one be? A perspective from a young scientist at the right place at the right time.
Nature medicine 2012 Vale RD -
Evaluating how we evaluate.
Molecular biology of the cell 2012 Vale RD -
Biophysical mechanism of T-cell receptor triggering in a reconstituted system.
Nature 2012 James JR, Vale RD -
Autophagy genes promote apoptotic cell corpse clearance.
Autophagy 2012 Zou W, Wang X, Vale RD, Ou G -
Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.
The Journal of cell biology 2012 Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X, Vale RD, Ou G -
Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters.
Cell 2012 Laan L, Pavin N, Husson J, Romet-Lemonne G, van Duijn M, López MP, Vale RD, Jülicher F, Reck-Peterson SL, Dogterom M -
A new cap for kinetochore fibre minus ends.
Nature cell biology 2011 Petry S, Vale RD -
The mechanism of dynein motility: insight from crystal structures of the motor domain.
Biochimica et biophysica acta 2011 Cho C, Vale RD -
Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts.
Proceedings of the National Academy of Sciences of the United States of America 2011 Petry S, Pugieux C, Nédélec FJ, Vale RD -
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Current biology : CB 2011 Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G -
Crystal structure of the dynein motor domain.
Science (New York, N.Y.) 2011 Carter AP, Cho C, Jin L, Vale RD -
Kinesin-73 is a processive motor that localizes to Rab5-containing organelles.
The Journal of biological chemistry 2010 Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale RD -
Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.
Proceedings of the National Academy of Sciences of the United States of America 2010 Yudushkin IA, Vale RD -
A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis.
The Journal of cell biology 2010 D'Ambrosio MV, Vale RD -
Patronin regulates the microtubule network by protecting microtubule minus ends.
Cell 2010 Goodwin SS, Vale RD -
Computer control of microscopes using µManager.
Current protocols in molecular biology 2010 Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N -
Polarized myosin produces unequal-size daughters during asymmetric cell division.
Science (New York, N.Y.) 2010 Ou G, Stuurman N, D'Ambrosio M, Vale RD -
Young leaders for biology in India.
Science (New York, N.Y.) 2010 Tole S, Vale RD -
Altered actin centripetal retrograde flow in physically restricted immunological synapses.
PloS one 2010 Yu CH, Wu HJ, Kaizuka Y, Vale RD, Groves JT -
Determinants of myosin II cortical localization during cytokinesis.
Current biology : CB 2010 Uehara R, Goshima G, Mabuchi I, Vale RD, Spudich JA, Griffis ER -
Communication between the AAA+ ring and microtubule-binding domain of dynein.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2010 Carter AP, Vale RD -
It's a wonderful life: a career as an academic scientist.
Molecular biology of the cell 2010 Vale RD -
Regulators of the cytoplasmic dynein motor.
Nature reviews. Molecular cell biology 2009 Kardon JR, Vale RD -
Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells.
The Journal of cell biology 2009 Vale RD, Spudich JA, Griffis ER -
Introducing simulated cellular architecture to the quantitative analysis of fluorescent microscopy.
Progress in biophysics and molecular biology 2009 DePristo MA, Chang L, Vale RD, Khan SM, Lipkow K -
The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells.
The Journal of cell biology 2009 Kaizuka Y, Douglass AD, Vardhana S, Dustin ML, Vale RD -
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.
Proceedings of the National Academy of Sciences of the United States of America 2009 Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G -
Molecular signatures of cell migration in C. elegans Q neuroblasts.
The Journal of cell biology 2009 Ou G, Vale RD -
Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin.
Proceedings of the National Academy of Sciences of the United States of America 2009 Kardon JR, Reck-Peterson SL, Vale RD -
The biological sciences in India: aiming high for the future.
The Journal of cell biology 2009 Vale RD, Dell K -
Walking the walk: how kinesin and dynein coordinate their steps.
Current opinion in cell biology 2009 Gennerich A, Vale RD -
Structure and functional role of dynein's microtubule-binding domain.
Science (New York, N.Y.) 2008 Carter AP, Garbarino JE, Wilson-Kubalek EM, Shipley WE, Cho C, Milligan RA, Vale RD, Gibbons IR -
Microscopes for fluorimeters: the era of single molecule measurements.
Cell 2008 Vale RD -
Intramolecular strain coordinates kinesin stepping behavior along microtubules.
Cell 2008 Yildiz A, Tomishige M, Gennerich A, Vale RD -
Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation.
The Journal of biological chemistry 2008 Cho C, Reck-Peterson SL, Vale RD -
Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle.
The Journal of cell biology 2008 Goshima G, Mayer M, Zhang N, Stuurman N, Vale RD -
Mob4 plays a role in spindle focusing in Drosophila S2 cells.
Journal of cell science 2008 Trammell MA, Mahoney NM, Agard DA, Vale RD -
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.
Nature 2008 Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV -
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
Nature 2008 Roll-Mecak A, Vale RD -
Single-molecule imaging of fluorescent proteins.
Methods in cell biology 2008 Douglass AD, Vale RD -
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells.
Proceedings of the National Academy of Sciences of the United States of America 2007 Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale RD -
Force-induced bidirectional stepping of cytoplasmic dynein.
Cell 2007 Gennerich A, Carter AP, Reck-Peterson SL, Vale RD -
How kinesin waits between steps.
Nature 2007 Mori T, Vale RD, Tomishige M -
Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.
The Journal of biological chemistry 2007 Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A -
Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.
Molecular cell 2007 Slep KC, Vale RD -
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore.
The Journal of cell biology 2007 Griffis ER, Stuurman N, Vale RD -
Genes required for mitotic spindle assembly in Drosophila S2 cells.
Science (New York, N.Y.) 2007 Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale RD, Stuurman N -
Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays?
The Journal of cell biology 2006 Roll-Mecak A, Vale RD -
Single-molecule observations of neck linker conformational changes in the kinesin motor protein.
Nature structural & molecular biology 2006 Tomishige M, Stuurman N, Vale RD -
Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3.
The Journal of cell biology 2006 Imanishi M, Endres NF, Gennerich A, Vale RD -
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors.
The Journal of cell biology 2006 Pan X, Ou G, Civelekoglu-Scholey G, Blacque OE, Endres NF, Tao L, Mogilner A, Leroux MR, Vale RD, Scholey JM -
Single-molecule analysis of dynein processivity and stepping behavior.
Cell 2006 Reck-Peterson SL, Yildiz A, Carter AP, Gennerich A, Zhang N, Vale RD -
Making microtubules and mitotic spindles in cells without functional centrosomes.
Current biology : CB 2006 Mahoney NM, Goshima G, Douglass AD, Vale RD -
A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd.
Nature 2005 Endres NF, Yoshioka C, Milligan RA, Vale RD -
Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2005 Jambhekar A, McDermott K, Sorber K, Shepard KA, Vale RD, Takizawa PA, DeRisi JL -
Length control of the metaphase spindle.
Current biology : CB 2005 Goshima G, Wollman R, Stuurman N, Scholey JM, Vale RD -
Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins.
The Journal of cell biology 2005 Goshima G, Nédélec F, Vale RD -
Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen.
Proceedings of the National Academy of Sciences of the United States of America 2005 Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale RD, Portnoy DA -
Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America 2005 Dean SO, Rogers SL, Stuurman N, Vale RD, Spudich JA -
Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends.
Journal of cell science 2005 Dzhindzhev NS, Rogers SL, Vale RD, Ohkura H -
Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.
Cell 2005 Douglass AD, Vale RD -
Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells.
Molecular biology of the cell 2005 Goshima G, Vale RD -
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.
Current biology : CB 2005 Roll-Mecak A, Vale RD -
The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk.
The Journal of biological chemistry 2005 Gibbons IR, Garbarino JE, Tan CE, Reck-Peterson SL, Vale RD, Carter AP -
Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase.
Nature cell biology 2005 Mennella V, Rogers GC, Rogers SL, Buster DW, Vale RD, Sharp DJ -
Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.
The Journal of cell biology 2005 Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale RD -
Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner.
Current biology : CB 2004 Rogers SL, Wiedemann U, Häcker U, Turck C, Vale RD -
A standardized kinesin nomenclature.
The Journal of cell biology 2004 Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, … -
Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2004 Reck-Peterson SL, Vale RD -
Mechanism of prion propagation: amyloid growth occurs by monomer addition.
PLoS biology 2004 Collins SR, Douglass A, Vale RD, Weissman JS -
The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans.
Molecular biology of the cell 2004 Klopfenstein DR, Vale RD -
A tribute to Shinya Inoue and innovation in light microscopy.
The Journal of cell biology 2004 Dell KR, Vale RD -
Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 2004 Reck-Peterson SL, Vale RD -
Kinesin walks hand-over-hand.
Science (New York, N.Y.) 2003 Yildiz A, Tomishige M, Vale RD, Selvin PR -
Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase.
Nature 2003 Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ -
Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition.
The Journal of cell biology 2003 Al-Bassam J, Cui Y, Klopfenstein D, Carragher BO, Vale RD, Milligan RA -
Myosin V motor proteins: marching stepwise towards a mechanism.
The Journal of cell biology 2003 Vale RD -
Molecular requirements for actin-based lamella formation in Drosophila S2 cells.
The Journal of cell biology 2003 Rogers SL, Wiedemann U, Stuurman N, Vale RD -
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line.
The Journal of cell biology 2003 Goshima G, Vale RD -
Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles.
Proceedings of the National Academy of Sciences of the United States of America 2003 Yaffe MP, Stuurman N, Vale RD -
Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons.
Neuron 2003 Rothenberg ME, Rogers SL, Vale RD, Jan LY, Jan YN -
Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules.
Science (New York, N.Y.) 2003 Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale RD, Kollman PA, Car R, Yount RG, Cooke R, Pate E -
EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain.
Biophysical journal 2003 Naber N, Rice S, Matuska M, Vale RD, Cooke R, Pate E -
The molecular motor toolbox for intracellular transport.
Cell 2003 Vale RD -
Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle.
The Journal of cell biology 2002 Rogers SL, Rogers GC, Sharp DJ, Vale RD -
Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor.
Cell 2002 Klopfenstein DR, Tomishige M, Stuurman N, Vale RD -
The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast.
The EMBO journal 2002 Irie K, Tadauchi T, Takizawa PA, Vale RD, Matsumoto K, Herskowitz I -
Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum.
Journal of muscle research and cell motility 2002 Klopfenstein DR, Holleran EA, Vale RD