Roland Wu, MD
Assistant Clinical Professor
Medicine
School of Medicine

Since 2020, my primary appointment has been with Amgen where I focus on leveraging human genetics and basic scientific insights to create clinically meaningful advances in cardiovascular medicine. My research focuses on understanding human cardiovascular disease by studying the genetics and gene regulation underlying these disorders, utilizing technologies such as in vivo genetic and enhancer screens coupled with computational biology.

• Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter.
  Molecular cell 2018 Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X
• Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter.
  Molecular cell 2018 Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X
• An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish.
  eLife 2015 Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger…
• Coronary reperfusion and clinical outcomes after thrombus aspiration during primary percutaneous coronary intervention: findings from the HORIZONS-AMI trial.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2013 Nilsen DW, Mehran R, Wu RS, Yu J, Nordrehaug JE, Brodie BR, Witzenbichler B, Nikolsky E, Fahy M, Stone GW
• Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels.
  PloS one 2013 Niu X, Liu G, Wu RS, Chudasama N, Zakharov SI, Karlin A, Marx SO
• Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel.
  The Journal of general physiology 2013 Wu RS, Liu G, Zakharov SI, Chudasama N, Motoike H, Karlin A, Marx SO
• The BK potassium channel in the vascular smooth muscle and kidney: α- and β-subunits.
  Kidney international 2010 Wu RS, Marx SO
• Location of modulatory beta subunits in BK potassium channels.
  The Journal of general physiology 2010 Liu G, Niu X, Wu RS, Chudasama N, Yao Y, Jin X, Weinberg R, Zakharov SI, Motoike H, Marx SO, Karlin A
• Clinical outcomes after cardiac transplantation in muscular dystrophy patients.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009 Wu RS, Gupta S, Brown RN, Yancy CW, Wald JW, Kaiser P, Kirklin NM, Patel PC, Markham DW, Drazner MH, Garry DJ, Mammen PP
• Location of the beta 4 transmembrane helices in the BK potassium channel.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Wu RS, Chudasama N, Zakharov SI, Doshi D, Motoike H, Liu G, Yao Y, Niu X, Deng SX, Landry DW, Karlin A, Marx SO
• Locations of the beta1 transmembrane helices in the BK potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Liu G, Zakharov SI, Yang L, Wu RS, Deng SX, Landry DW, Karlin A, Marx SO