Roland Bainton, MD, PhD
Professor
Anesthesia
School of Medicine

Education & Training

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• M.D. Medicine University of California, San Francisco 1994
• Ph.D. Graduate Division (Biochemistry) University of California, San Francisco 1992

Grants and Projects

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• Discovering fundamental metabolic control processes of the blood brain barrier, NIH, 2013-2017
• A platform for rapid characterization of metabolic disrupters in whole animals, NIH, 2012-2015
• Physiology and regulation of drug transport across the blood brain barrier, NIH, 2007-2013
• A Genetic Study of Drosophila Responses to Cocaine, NIH, 2000-2006

Publications (28)

Top publication keywords:
Gonadal Steroid HormonesCell-Free Nucleic AcidsNeurogliaBlood PlateletsBlood-Brain BarrierDrosophila ProteinsDrosophila melanogasterEyeCocaineDrosophilaBlood Coagulation DisordersCentral Nervous SystemBrain Injuries, TraumaticXenobioticsPlatelet Aggregation

• Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.
  Frontiers in immunology 2023 Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nuñez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith…
• COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
  American journal of respiratory and critical care medicine 2022 Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID…
• A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients.
  The journal of trauma and acute care surgery 2022 Fields AT, Lee MC, Mayer F, Santos YA, Bainton CMV, Matthay ZA, Callcut RA, Mayer N, Cuschieri J, Kober KM, Bainton RJ, Kornblith LZ
• Good Platelets Gone Bad: The Effects of Trauma Patient Plasma on Healthy Platelet Aggregation.
  Shock (Augusta, Ga.) 2021 Fields AT, Matthay ZA, Nunez-Garcia B, Matthay EC, Bainton RJ, Callcut RA, Kornblith LZ
• Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples.
  medRxiv : the preprint server for health sciences 2020 Lee W, Straube S, Sincic R, Noble JA, Montoy JC, Kornblith AE, Prakash A, Wang R, Bainton RJ, Kurien PA

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• A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology.
  The journal of trauma and acute care surgery 2020 Kornblith LZ, Bainton CMV, Fields AT, Matthay ZA, Magid NT, Nunez-Garcia B, Prakash A, Kurien PA, Callcut RA, Cohen MJ, Bainton RJ
• Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior.
  Cell reports 2017 Hindle SJ, Munji RN, Dolghih E, Gaskins G, Orng S, Ishimoto H, Soung A, DeSalvo M, Kitamoto T, Keiser MJ, Jacobson MP, Daneman R, Bainton RJ
• Barrier mechanisms in the Drosophila blood-brain barrier.
  Frontiers in neuroscience 2014 Hindle SJ, Bainton RJ
• The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes.
  Frontiers in neuroscience 2014 DeSalvo MK, Hindle SJ, Rusan ZM, Orng S, Eddison M, Halliwill K, Bainton RJ
• In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.
  PLoS biology 2013 Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K
• A whole-organism screen identifies new regulators of fat storage.
  Nature chemical biology 2011 Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z
• Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila.
  Glia 2011 DeSalvo MK, Mayer N, Mayer F, Bainton RJ
• Novel models for studying the blood-brain and blood-eye barriers in Drosophila.
  Methods in molecular biology (Clifton, N.J.) 2011 Pinsonneault RL, Mayer N, Mayer F, Tegegn N, Bainton RJ
• A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila.
  PloS one 2010 Kong EC, Woo K, Li H, Lebestky T, Mayer N, Sniffen MR, Heberlein U, Bainton RJ, Hirsh J, Wolf FW
• Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton RJ
• Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila.
  Developmental biology 2008 Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA
• Organization and function of the blood-brain barrier in Drosophila.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C
• Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.
  Cell 2006 Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U
• Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine.
  Molecular psychiatry 2006 Chang HY, Grygoruk A, Brooks ES, Ackerson LC, Maidment NT, Bainton RJ, Krantz DE
• GPCR signaling is required for blood-brain barrier formation in drosophila.
  Cell 2005 Schwabe T, Bainton RJ, Fetter RD, Heberlein U, Gaul U
• moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila.
  Cell 2005 Bainton RJ, Tsai LT, Schwabe T, DeSalvo M, Gaul U, Heberlein U
• A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine.
  Journal of neurobiology 2005 Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, Bainton RJ, Diantonio A, Krantz DE
• Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors.
  PLoS biology 2004 Tsai LT, Bainton RJ, Blau J, Heberlein U
• Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.
  PLoS biology 2003 Kunwar PS, Starz-Gaiano M, Bainton RJ, Heberlein U, Lehmann R
• Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila.
  Current biology : CB 2000 Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U
• Multiple DNA processing reactions underlie Tn7 transposition.
  Journal of molecular biology 1996 Gary PA, Biery MC, Bainton RJ, Craig NL
• Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system.
  Cell 1993 Bainton RJ, Kubo KM, Feng JN, Craig NL
• Tn7 transposition in vitro proceeds through an excised transposon intermediate generated by staggered breaks in DNA.
  Cell 1991 Bainton R, Gamas P, Craig NL