Roberto Ricardo Gonzalez, MD, PhD
Associate Professor
Dermatology
School of Medicine

Awards

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• Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation, 2017

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2018
• Fellowship Dermatology University of California San Francisco 2016
• Residency Dermatology University of California San Francisco 2015
• Internship Internal Medicine Brigham and Women's Hospital 2012
• M.D. Medicine Stanford University School of Medicine 2011
• Ph.D. Immunology Stanford University School of Medicine 2009
• B.S. Industrial Biotechnology University of Puerto Rico - Mayagüez 2001

Grants and Projects

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• Elucidating the role of type 2 immunity in skin homeostasis, NIH, 2019-2024
• Minority Predoctoral Fellowship Program, NIH, 2005-2009

Publications (32)

Top publication keywords:
Lymphocyte SubsetsPityriasis Rubra PilarisDEAD-box RNA HelicasesDermatomyositisSkin Diseases, InfectiousPlasma CellsHair FollicleMite InfestationsMitesPanniculitisSTAT6 Transcription FactorSubcutaneous FatLymphocytesFat NecrosisImmunity, Innate

• Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
  Immunity 2022 Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, …
• 012 Tissue-specific manipulation of regulatory T cells reveals the skin to be a site of immune tolerance.
  Journal of Investigative Dermatology 2022 J. Cohen, J. Moreau, V. Gouirand, C. Macon, I. Boothby, I. Gratz, A. Stoecklinger, C. Weaver, A. Sharpe, R. Ricardo-Gonzalez, M. Rosenblum
• Classification of human chronic inflammatory skin disease based on single-cell immune profiling.
  Science immunology 2022 Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB
• Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
  Science immunology 2022 O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM
• ILC2s - development, divergence, dispersal.
  Current opinion in immunology 2022 Ricardo-Gonzalez RR, Molofsky AB, Locksley RM

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• CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
  Mucosal immunology 2021 Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM
• A role for IL-33-activated ILC2s in eosinophilic vasculitis.
  JCI insight 2021 Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B
• Skin-resident innate lymphoid cells converge on a pathogenic effector state.
  Nature 2021 Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, …
• Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.
  iScience 2020 Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC…
• 095 Single-cell Profiling Reveals a Highly Specific, Compartmentalized Functional Response in the Cutaneous Immune System.
  Journal of Investigative Dermatology 2020 Y. Liu, C. Cook, P. Haririchian, R. Ricardo-Gonzalez, J.P. North, A. Charruyer, R. Ghadially, R.J. Cho, J.B. Cheng
• 716 Supporting diversity in skin science: Development of a summer curriculum for underrepresented minority medical students.
  Journal of Investigative Dermatology 2020 M. Paul, J. Lester, R. Ricardo-Gonzalez, H. Naik
• Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.
  The Journal of experimental medicine 2020 Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM
• Skin-Resident Innate Lymphoid Cells - Cutaneous Innate Guardians and Regulators.
  Trends in immunology 2020 Kobayashi T, Ricardo-Gonzalez RR, Moro K
• ILC2s chew the fat.
  The Journal of experimental medicine 2019 Ricardo-Gonzalez RR, Locksley RM
• Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
  Immunity 2019 Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM
• Tissue signals imprint ILC2 identity with anticipatory function.
  Nature immunology 2018 Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM
• 1021 Origin of type 2 innate lymphoid cells in the skin.
  Journal of Investigative Dermatology 2018 J. Lee, C. Schneider, H. Liang, R. Ricardo-Gonzalez, J. Nussbaum, L. Smith, S. Villeda, R. Locksley
• 940 ILC2s and Type 2 immunity influence hair follicle stem cell proliferation and skin homeostasis.
  Journal of Investigative Dermatology 2018 R. Ricardo-Gonzalez, S. Van Dyken, R. Locksley
• LB973 Characterization of tissue-resident ILC2 heterogeneity in homeostasis.
  Journal of Investigative Dermatology 2017 R. Ricardo-Gonzalez, S. Van Dyken, A. Molofsky, J. Nussbaum, J. Lee, R. Locksley
• Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
  Cell 2017 Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, …
• Neutrophil-rich subcutaneous fat necrosis of the newborn: A potential mimic of infection.
  Journal of the American Academy of Dermatology 2016 Ricardo-Gonzalez RR, Lin JR, Mathes EF, McCalmont TH, Pincus LB
• A case of Wong-type dermatomyositis with concomitant anti-MDA5 features.
  Journal of the American Academy of Dermatology 2014 Canavan T, Sidorsky T, Doan LT, Ricardo-Gonzalez RR, Shen G, Rosenblum MD
• Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread.
  The Journal of urology 2012 Ricardo-Gonzalez RR, Nguyen M, Gokden N, Sangoi AR, Presti JC, McKenney JK
• Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
  Science (New York, N.Y.) 2011 Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM
• IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A
• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.
  Nature medicine 2009 Mukundan L, Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, Goh YP, Eagle AR, Dunn SE, Awakuni JU, Nguyen KD, Steinman L, Michie SA, Chawla A
• Regulation of macrophage activation and function by PPARs.
  Cytokine 2009 Justin Odegaard, Lata Mukundan, Roberto Ricardo-Gonzalez, Christine Morel, Ajay Chawla
• Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.
  Cell metabolism 2008 Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A
• A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
  Developmental biology 2008 Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE
• Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.
  Nature 2007 Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A
• Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages.
  Journal of leukocyte biology 2006 Odegaard JI, Vats D, Zhang L, Ricardo-Gonzalez R, Smith KL, Sykes DB, Kamps MP, Chawla A
• Clinical benefits in patients with psoriasis after efalizumab therapy: clinical trials versus practice.
  Cutis 2004 Ricardo RR, Rhoa M, Orenberg EK, Li N, Rundle AC, Caro I