Robert Warren, MD
Professor
Surgery
School of Medicine

Education & Training

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• M.D. School of Medicine University of Minnesota 1980

Websites

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• Profile at UCSF Cancer Center (cancer.ucsf.edu)

Grants and Projects

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• General Clinical Research Center, NIH, 1974-2009
• Molecular Markers of Prognosis in Colon Cancer, NIH, 2000-2006
• Role of Cytokines in Cancer Patients Undergoing Surgery, NIH, 1993-1999

Publications (70)

Top publication keywords:
Loss of HeterozygosityAdenocarcinomaBinding, CompetitiveColorectal NeoplasmsPurinesMicrosatellite InstabilityNeuroendocrine TumorsLiver NeoplasmsNeoplasm StagingThymidylate SynthaseCoenzyme A LigasesPalliative CareColonic NeoplasmsBiomarkers, TumorChromosomes, Human, Pair 18

• Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.
  PloS one 2023 Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E
• STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.
  Journal of cellular and molecular medicine 2022 Antonia RJ, Karelehto E, Toriguchi K, Matli M, Warren RS, Pfeffer LM, Donner DB
• Synchronous Versus Metachronous Colorectal Liver Metastasis Yields Similar Survival in Modern Era.
  The Journal of surgical research 2020 Wisneski AD, Jin C, Huang CY, Warren R, Hirose K, Nakakura EK, Corvera CU
• RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon.
  Cancer discovery 2020 Yu J, Navickas A, Asgharian H, Culbertson B, Fish L, Garcia K, Olegario JP, Dermit M, Dodel M, Hänisch B, Luo Y, Weinberg EM, Dienstmann R, Warren RS, Mardakheh FK, Goodarzi H
• A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.
  Journal of surgical oncology 2020 Kasai Y, Mahuron K, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Warren RS, Bergsland EK, Nakakura EK

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• Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis.
  Journal of surgical oncology 2019 Kasai Y, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Harun N, Kim MO, Warren RS, Bergsland EK, Nakakura EK
• Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors.
  Journal of surgical oncology 2019 Kasai Y, Mahuron K, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Warren RS, Bergsland EK, Nakakura EK
• Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer.
  Annals of oncology : official journal of the European Society for Medical Oncology 2019 Dienstmann R, Villacampa G, Sveen A, Mason MJ, Niedzwiecki D, Nesbakken A, Moreno V, Warren RS, Lothe RA, Guinney J
• High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma.
  PloS one 2019 Donner DB, Nakakura EK, Venook AP, Lenz HJ, Zhang W, Hwang J, Bergsland EK, Lin MH, Toriguchi K, Antonia RJ, Warren RS
• RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
  JCI insight 2019 Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P
• Mitogen Inducible Gene-6 Is a Prognostic Marker for Patients with Colorectal Liver Metastases.
  Translational oncology 2019 Donner DB, Ruan DT, Toriguchi K, Bergsland EK, Nakakura EK, Lin MH, Antonia RJ, Warren RS
• A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.
  Molecular cancer therapeutics 2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK
• Sampling strategies to capture single-cell heterogeneity.
  Nature methods 2017 Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ
• Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.
  Journal for immunotherapy of cancer 2017 Hege KM, Bergsland EK, Fisher GA, Nemunaitis JJ, Warren RS, McArthur JG, Lin AA, Schlom J, June CH, Sherwin SA
• Reply to L. Casadaban et al.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Niedzwiecki D, Frankel WL, Venook AP, Ye X, Friedman PN, Goldberg RM, Mayer RJ, Colacchio TA, Mulligan JM, Davison TS, O'Brien E, Kerr P, Johnston PG, Kennedy RD, Harkin DP, Schilsky RL, Bertagnolli …
• A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
  The oncologist 2016 Niedzwiecki D, Hasson RM, Lenz HJ, Ye C, Redston M, Ogino S, Fuchs CS, Compton CC, Mayer RJ, Goldberg RM, Colacchio TA, Saltz LB, Warren RS, Bertagnolli MM
• Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance).
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016 Niedzwiecki D, Frankel WL, Venook AP, Ye X, Friedman PN, Goldberg RM, Mayer RJ, Colacchio TA, Mulligan JM, Davison TS, O'Brien E, Kerr P, Johnston PG, Kennedy RD, Harkin DP, Schilsky RL, Bertagnolli …
• Unexpected insights for anti-EGFR cancer therapy.
  Oncotarget 2015 Depeille P, Warren RS, Roose JP
• RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
  Nature cell biology 2015 Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP
• CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.
  Gastroenterology 2014 Shiovitz S, Bertagnolli MM, Renfro LA, Nam E, Foster NR, Dzieciatkowski S, Luo Y, Lao VV, Monnat RJ, Emond MJ, Maizels N, Niedzwiecki D, Goldberg RM, Saltz LB, Venook A, Warren RS, Grady WM, Alliance …
• Prognostic impact of deficient DNA mismatch repair in patients with stage III colon cancer from a randomized trial of FOLFOX-based adjuvant chemotherapy.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Sinicrope FA, Mahoney MR, Smyrk TC, Thibodeau SN, Warren RS, Bertagnolli MM, Nelson GD, Goldberg RM, Sargent DJ, Alberts SR
• Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.
  PloS one 2013 Farkas C, Martins CP, Escobar D, Hepp MI, Castro AF, Evan G, Gutiérrez JL, Warren R, Donner DB, Pincheira R
• Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Warren RS, Atreya CE, Niedzwiecki D, Weinberg VK, Donner DB, Mayer RJ, Goldberg RM, Compton CC, Zuraek MB, Ye C, Saltz LB, Bertagnolli MM
• PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.
  Cancer medicine 2013 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS
• Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.
  Oncogene 2013 Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS
• Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Venook AP, Niedzwiecki D, Lopatin M, Ye X, Lee M, Friedman PN, Frankel W, Clark-Langone K, Millward C, Shak S, Goldberg RM, Mahmoud NN, Warren RS, Schilsky RL, Bertagnolli MM
• Imaging a functional tumorigenic biomarker in the transformed epithelium.
  Proceedings of the National Academy of Sciences of the United States of America 2012 LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS
• Lymph node sampling rates and predictors of nodal metastasis in pancreatic neuroendocrine tumor resections: the UCSF experience with 149 patients.
  Pancreas 2012 Parekh JR, Wang SC, Bergsland EK, Venook AP, Warren RS, Kim GE, Nakakura EK
• Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.
  Investigational new drugs 2012 Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM
• Is there currently an established role for the use of predictive or prognostic molecular markers in the management of colorectal cancer? A point/counterpoint.
  American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2012 Venook AP, Bendell JC, Warren RS
• Complete and safe resection of challenging retroperitoneal tumors: anticipation of multi-organ and major vascular resection and use of adjunct procedures.
  World journal of surgical oncology 2011 Tseng WW, Wang SC, Eichler CM, Warren RS, Nakakura EK
• Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Niedzwiecki D, Bertagnolli MM, Warren RS, Compton CC, Kemeny NE, Benson AB, Eckhardt SG, Alberts S, Porjosh GN, Kerr DJ, Fields A, Rougier P, Pipas JM, Schwartz JH, Atkins J, O'Rourke M, Perry MC, …
• Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Bertagnolli MM, Redston M, Compton CC, Niedzwiecki D, Mayer RJ, Goldberg RM, Colacchio TA, Saltz LB, Warren RS
• Pancreatic adenocarcinoma.
  Journal of the National Comprehensive Cancer Network : JNCCN 2010 Tempero MA, Arnoletti JP, Behrman S, Ben-Josef E, Benson AB, Berlin JD, Cameron JL, Casper ES, Cohen SJ, Duff M, Ellenhorn JD, Hawkins WG, Hoffman JP, Kuvshinoff BW, Malafa MP, Muscarella P, Nakakura …
• Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site.
  The Journal of surgical research 2010 Wang YC, Iezza G, Zuraek MB, Jablons DM, Theodore PR, Bergsland EK, Donner DB, Warren RS, Nakakura EK
• Identification of unknown primary tumors in patients with neuroendocrine liver metastases.
  Archives of surgery (Chicago, Ill. : 1960) 2010 Wang SC, Parekh JR, Zuraek MB, Venook AP, Bergsland EK, Warren RS, Nakakura EK
• The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
  Endocrine-related cancer 2010 Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK
• p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Bertagnolli MM, Warren RS, Niedzwiecki D, Mueller E, Compton CC, Redston M, Hall M, Hahn HP, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Loda M
• Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009 Bertagnolli MM, Niedzwiecki D, Compton CC, Hahn HP, Hall M, Damas B, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Warren RS, Redston M
• Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers.
  Surgery 2008 Ruan DT, Warren RS, Moalem J, Chung KW, Griffin AC, Shen W, Duh QY, Nakakura E, Donner DB, Khanafshar E, Weng J, Clark OH, Kebebew E
• Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
  Endocrine-related cancer 2008 Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK
• Association of family history with cancer recurrence and survival among patients with stage III colon cancer.
  JAMA 2008 Chan JA, Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Thomas J, Schaefer P, Whittom R, Hantel A, Goldberg RM, Warren RS, Bertagnolli M, Fuchs CS
• Compound muscle action potentials and spontaneous electromyography can be used to identify and protect the femoral nerve during resection of large retroperitoneal tumors.
  Annals of surgical oncology 2008 Guo L, Clark JP, Warren RS, Nakakura EK
• Prognostic importance of superior diaphragmatic adenopathy at computed tomography in patients with resectable hepatic metastases from colorectal carcinoma.
  Journal of computer assisted tomography 2008 Aslam R, Coakley FV, Williams G, Yeh BM, Joe BN, Zuraek MB, Warren RS
• Introduction.
  Surgical oncology 2007 Warren RS, Nakakura EK
• Palliative care for patients with advanced pancreatic and biliary cancers.
  Surgical oncology 2007 Nakakura EK, Warren RS
• Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.
  Cancer research 2007 LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD
• Pancreatoblastoma in an adult: case report and review of the literature.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2006 Rajpal S, Warren RS, Alexander M, Yeh BM, Grenert JP, Hintzen S, Ljung BM, Bergsland EK
• Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481).
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006 Kemeny NE, Niedzwiecki D, Hollis DR, Lenz HJ, Warren RS, Naughton MJ, Weeks JC, Sigurdson ER, Herndon JE, Zhang C, Mayer RJ
• Pancreatic adenocarcinoma: Clinical Practice Guidelines in Oncology.
  Journal of the National Comprehensive Cancer Network : JNCCN 2005 Tempero MA, Behrman S, Ben-Josef E, Benson AB, Cameron JL, Casper ES, Hoffman JP, Karl RC, Kim P, Koh WJ, Kuvshinoff BW, Melvin WS, Muscarella P, Sasson AR, Shibata S, Shrieve DC, Talamonti MS, Tyler …
• [Liver metastases from colorectal cancer. Is the practice of surgery based on the best clinical evidence possible?].
  Cirugia espanola 2005 Durán Giménez-Rico H, García-Aguilar J, Warren RS, Iborra P, Guerrero V
• Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro.
  International journal of radiation oncology, biology, physics 2005 Arvold ND, Guha N, Wang D, Matli M, Deen DF, Warren RS, Haas-Kogan DA
• Fractional genomic alteration detected by array-based comparative genomic hybridization independently predicts survival after hepatic resection for metastatic colorectal cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Mehta KR, Nakao K, Zuraek MB, Ruan DT, Bergsland EK, Venook AP, Moore DH, Tokuyasu TA, Jain AN, Warren RS, Terdiman JP, Waldman FM
• Liver-directed therapies in colorectal cancer.
  Seminars in oncology 2005 Ruan DT, Warren RS
• Palliative techniques for hepatic cancer.
  Surgical oncology clinics of North America 2004 Ruan DT, Warren RS
• Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver.
  Journal of biochemical and molecular toxicology 2004 Vessey DA, Kelley M, Warren RS
• Aggressive surgery for metastatic liver neuroendocrine tumors.
  Surgery 2003 Norton JA, Warren RS, Kelly MG, Zuraek MB, Jensen RT
• beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
  Cancer research 2003 Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, Wiesmann M, Garcia PD, Fuller JH, Chan V, Randazzo F, Gundel R, Warren RS, Escobedo J, Aukerman SL, Taylor RN, Fantl WJ
• Distinguishing features of self-limiting adult small-bowel intussusception identified at CT.
  Radiology 2003 Lvoff N, Breiman RS, Coakley FV, Lu Y, Warren RS
• Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria.
  Journal of biochemical and molecular toxicology 2003 Vessey DA, Lau E, Kelley M, Warren RS
• Thorotrast-induced liver neoplasia: a collective review.
  Journal of the American College of Surgeons 2002 Lipshutz GS, Brennan TV, Warren RS
• Detection of hepatic metastases from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-analysis.
  Radiology 2002 Kinkel K, Lu Y, Both M, Warren RS, Thoeni RF
• Liver-directed viral therapy for cancer p53-targeted adenoviruses and beyond.
  Surgical oncology clinics of North America 2002 Warren RS, Kirn DH
• Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells.
  American journal of physiology. Gastrointestinal and liver physiology 2002 Wang D, Lehman RE, Donner DB, Matli MR, Warren RS, Welton ML
• Quantitative fractionation of alkaline phosphatase isoenzymes according to their thermostability.
  Clinical chemistry 1976 PetitClerc C
• Activity and longevity of insect growth regulators against mosquitoes.
  Journal of economic entomology 1975 Mulla MS, Darwazeh HA
• A double-blind controlled therapeutic trial of lorazepam vs medazepam in psychosomatic conditions in general practice.
  The British journal of clinical practice 1975 Sim M, Bindman E, Morrison I, Sandilands D
• Analyses of rumen fluid from "sudden death", lactic acidotic and healthy cattle fed high concentrate ration.
  Journal of animal science 1975 Wilson JR, Bartley EE, Anthony HD, Brent BE, Sapienza DA, Chapman TE, Dayton AD, Milleret RJ, Frey RA, Meyer RM
• Action of propranolol on mitochondrial functions--effects on energized ion fluxes in the presence of valinomycin.
  Biochemical pharmacology 1975 Järvisalo J, Saris NE
• Digitoxin metabolism by rat liver microsomes.
  Biochemical pharmacology 1975 Schmoldt A, Benthe HF, Haberland G