Robert Stroud, MA, PhD
Professor
Biochemistry and Biophysics
School of Medicine
Education & Training
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- MA Physics and Chemistry University of Cambridge 09/1968
- Ph.D. Protein crystallography University of London 09/1968
- MS Protein crystallography University of London 09/1965
- BA Nat Science Physics University of Cambridge 1964
Websites
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- http://www.msg.ucsf.edu/stroud/index.htm (msg.ucsf.edu)
Grants and Projects
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- Molecular Basis for Transmembrane Conduction & Signaling, NIH, 1979-2024
- Structural Basis of Vesicular Neurotransmitter Transport, NIH, 2015-2024
- HARC Center: HIV Accessory and Regulatory Complexes, NIH, 2007-2022
- Mapping the conformational cycle of transmembrane transporters, NIH, 2015-2020
- Molecular Basis for Transmembrane Conduction & Signaling, NIH, 1979-2016
- Center for Structure of Membrane Proteins, NIH, 2010-2016
- Membrane Protein Expression Center, NIH, 2004-2015
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- A Synchroton Radiation Structural Biology Resource, NIH, 1980-2015
- 3 D Electron Microscopy of Macromolecules, NIH, 1985-2014
- 4th NIH Roadmap Meeting on Membrane Protein Structures and Complexes, NIH, 2012-2013
- RNA Modification Enzymes: Methyltransferase/PSI-synthase, NIH, 1996-2013
- Resource for Biocomputing, Visualization, and Informatics, NIH/NCRR, 1976-2012
- Anachem Lipidic Cubic Phase Crystallization Robot, NIH, 2010-2012
- Specialized Center for the Protein Structure Initiative, NIH, 2005-2011
- Signal Sequence Recognition and Protein Targeting, NIH, 2000-2009
- Structure Biology and Targeted Drug Design for AIDS, NIH, 1997-2007
- Structure Based Drug Design, NIH, 1995-2006
- 2005 Mechanisms of Membrane Transport Gordon Conference, NIH, 2005-2006
- THYMIDYLATE SYNTHASE, NIH, 1978-2002
- Structural Biology and Targeted Drug Design for Aids, NIH, 1987-1997
- Area Sensitive Detector for Protein Crystallography, NIH, 1991-1993
- Structure and Function of Bacteriorhodopsin, NIH, 1983-1993
- Light-energy and Signal-transducing Membranes, NIH, 1980-1991
- Area Sensitive Dectector for Protein Crystallography, NIH, 1985-1986
- The Crystallization of Membrane Proteins, NIH, 1985-1986
Publications (299)
Top publication keywords:
Escherichia coli ProteinsThymidylate SynthaseArabidopsis ProteinsDeoxyuracil NucleotidesMonosaccharide Transport ProteinsArabidopsisMembrane ProteinsSymportersCrystallography, X-RayAquaporinsEscherichia coliBinding SitesProtein ConformationModels, MolecularChromatography, Gel
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Kinetic Network Modeling with Molecular Simulation Inputs: A Proton-Coupled Phosphate Symporter.
Biophysical journal 2024 Liu Y, Li C, Gupta M, Stroud RM, Voth GA -
Structural basis of prostaglandin efflux by MRP4.
Nature structural & molecular biology 2024 Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM -
Vicia faba SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels.
eLife 2023 Lu J, Dreyer I, Dickinson MS, Panzer S, Jaslan D, Navarro-Retamal C, Geiger D, Terpitz U, Becker D, Stroud RM, Marten I, Hedrich R -
Substrate recognition and proton coupling by a bacterial member of solute carrier family 17.
The Journal of biological chemistry 2023 Batarni S, Nayak N, Chang A, Li F, Hareendranath S, Zhou L, Xu H, Stroud R, Eriksen J, Edwards RH -
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nature structural & molecular biology 2023 Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM
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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
bioRxiv : the preprint server for biology 2023 Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM -
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
eLife 2022 Costantino L, Ferrari S, Santucci M, Salo-Ahen OMH, Carosati E, Franchini S, Lauriola A, Pozzi C, Trande M, Gozzi G, Saxena P, Cannazza G, Losi L, Cardinale D, Venturelli A, Quotadamo A, Linciano P, … -
Diversity of function and mechanism in a family of organic anion transporters.
Current opinion in structural biology 2022 Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH -
Molecular basis of multistep voltage activation in plant two-pore channel 1.
Proceedings of the National Academy of Sciences of the United States of America 2022 Dickinson MS, Lu J, Gupta M, Marten I, Hedrich R, Stroud RM -
Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.
Biochemistry 2021 Dickinson MS, Pourmal S, Gupta M, Bi M, Stroud RM -
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody.
Biochemistry 2021 Eriksen J, Li F, Stroud RM, Edwards RH -
Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT.
Proceedings of the National Academy of Sciences of the United States of America 2021 Liu Y, Li C, Gupta M, Verma N, Johri AK, Stroud RM, Voth GA -
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, … -
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, … -
Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
Proceedings of the National Academy of Sciences of the United States of America 2021 Vecchio AJ, Rathnayake SS, Stroud RM -
Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog.
Biochemistry 2021 Kholodar SA, Finer-Moore JS, Swiderek K, Arafet K, Moliner V, Stroud RM, Kohen A -
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank.
The Journal of biological chemistry 2021 Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM -
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
eLife 2020 Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS -
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor… -
Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science (New York, N.Y.) 2020 Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM -
Diversity in kinetics correlated with structure in nano body-stabilized LacY.
PloS one 2020 Kumar H, Finer-Moore J, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM -
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, … -
Resting state structure of the hyperdepolarization activated two-pore channel 3.
Proceedings of the National Academy of Sciences of the United States of America 2020 Dickinson MS, Myasnikov A, Eriksen J, Poweleit N, Stroud RM -
Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proceedings of the National Academy of Sciences of the United States of America 2019 Vecchio AJ, Stroud RM -
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
eLife 2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P -
Structures suggest a mechanism for energy coupling by a family of organic anion transporters.
PLoS biology 2019 Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH -
High-pressure, high-temperature molecular doping of nanodiamond.
Science advances 2019 Crane MJ, Petrone A, Beck RA, Lim MB, Zhou X, Li X, Stroud RM, Pauzauskie PJ -
High-Throughput Nano-Scale Characterization of Membrane Proteins Using Fluorescence-Detection Size-Exclusion Chromatography.
Methods in molecular biology (Clifton, N.J.) 2019 Vecchio AJ, Stroud RM -
Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Proceedings of the National Academy of Sciences of the United States of America 2018 Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM -
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
The EMBO journal 2018 Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ -
Crystal Structure of a ligand-bound LacY-Nanobody Complex.
Proceedings of the National Academy of Sciences of the United States of America 2018 Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM -
A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer.
Biochemistry 2018 Finer-Moore JS, Lee TT, Stroud RM -
On the structure and mechanism of two-pore channels.
The FEBS journal 2017 Kintzer AF, Stroud RM -
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.
Proceedings of the National Academy of Sciences of the United States of America 2017 Nöll A, Thomas C, Herbring V, Zollmann T, Barth K, Mehdipour AR, Tomasiak TM, Brüchert S, Joseph B, Abele R, Oliéric V, Wang M, Diederichs K, Hummer G, Stroud RM, Pos KM, Tampé R -
The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Structure (London, England : 1993) 2016 Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A -
Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers.
Proceedings of the National Academy of Sciences of the United States of America 2016 Thurtle-Schmidt BH, Stroud RM -
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Proceedings of the National Academy of Sciences of the United States of America 2016 Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM -
Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana.
Nature 2016 Kintzer AF, Stroud RM -
Integral Membrane Protein Expression in Saccharomyces cerevisiae.
Methods in molecular biology (Clifton, N.J.) 2016 Boswell-Casteel RC, Johnson JM, Stroud RM, Hays FA -
Small-Scale Screening to Large-Scale Over-Expression of Human Membrane Proteins for Structural Studies.
Methods in molecular biology (Clifton, N.J.) 2016 Chaudhary S, Saha S, Thamminana S, Stroud RM -
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
Journal of molecular biology 2015 Finer-Moore J, Czudnochowski N, O'Connell JD, Wang AL, Stroud RM -
Fungal association and utilization of phosphate by plants: success, limitations, and future prospects.
Frontiers in microbiology 2015 Johri AK, Oelmüller R, Dua M, Yadav V, Kumar M, Tuteja N, Varma A, Bonfante P, Persson BL, Stroud RM -
Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site.
Proceedings of the National Academy of Sciences of the United States of America 2015 Kumar H, Finer-Moore JS, Kaback HR, Stroud RM -
Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.
Cell 2015 Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS -
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
Journal of medicinal chemistry 2015 Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC -
Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.
Journal of medicinal chemistry 2014 Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP -
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter.
Nature 2014 Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y -
General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays.
Current protocols in protein science 2014 Tomasiak TM, Pedersen BP, Chaudhary S, Rodriguez A, Colmanares YR, Roe-Zurz Z, Thamminana S, Tessema M, Stroud RM -
Tetra detector analysis of membrane proteins.
Current protocols in protein science 2014 Miercke LJW, Robbins RA, Stroud RM -
Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi.
Proceedings of the National Academy of Sciences of the United States of America 2014 Lohse MB, Rosenberg OS, Cox JS, Stroud RM, Finer-Moore JS, Johnson AD -
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
Proceedings of the National Academy of Sciences of the United States of America 2014 Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM -
Structure of sugar-bound LacY.
Proceedings of the National Academy of Sciences of the United States of America 2014 Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM -
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic acids research 2013 Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM -
Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter.
Proceedings of the National Academy of Sciences of the United States of America 2013 Pak JE, Ekendé EN, Kifle EG, O'Connell JD, De Angelis F, Tessema MB, Derfoufi KM, Robles-Colmenares Y, Robbins RA, Goormaghtigh E, Vandenbussche G, Stroud RM -
Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
Journal of medicinal chemistry 2013 Tochowicz A, Dalziel S, Eidam O, O'Connell JD, Griner S, Finer-Moore JS, Stroud RM -
In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities.
Journal of molecular biology 2013 Czudnochowski N, Wang AL, Finer-Moore J, Stroud RM -
Structural basis for alternating access of a eukaryotic calcium/proton exchanger.
Nature 2013 Waight AB, Pedersen BP, Schlessinger A, Bonomi M, Chau BH, Roe-Zurz Z, Risenmay AJ, Sali A, Stroud RM -
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.
Journal of the American Chemical Society 2013 Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A -
Crystal structure of a eukaryotic phosphate transporter.
Nature 2013 Pedersen BP, Kumar H, Waight AB, Risenmay AJ, Roe-Zurz Z, Chau BH, Schlessinger A, Bonomi M, Harries W, Sali A, Johri AK, Stroud RM -
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.
Nature structural & molecular biology 2013 Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A -
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
Journal of medicinal chemistry 2012 Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP -
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.
Journal of the American Chemical Society 2012 Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A -
LpxI structures reveal how a lipid A precursor is synthesized.
Nature structural & molecular biology 2012 Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM -
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.
Acta crystallographica. Section D, Biological crystallography 2012 Pozzi C, Ferrari S, Cortesi D, Luciani R, Stroud RM, Catalano A, Costi MP, Mangani S -
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter.
Annals of neurology 2012 Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BA, Zamvil SS -
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
PloS one 2012 Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F -
Fabs enable single particle cryoEM studies of small proteins.
Structure (London, England : 1993) 2012 Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y -
Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells.
Nature protocols 2012 Chaudhary S, Pak JE, Gruswitz F, Sharma V, Stroud RM -
Rapid identification of recombinant Fabs that bind to membrane proteins.
Methods (San Diego, Calif.) 2011 Kim J, Stroud RM, Craik CS -
Efficient expression screening of human membrane proteins in transiently transfected Human Embryonic Kidney 293S cells.
Methods (San Diego, Calif.) 2011 Chaudhary S, Pak JE, Pedersen BP, Bang LJ, Zhang LB, Ngaw SM, Green RG, Sharma V, Stroud RM -
Membranes.
Current opinion in structural biology 2011 Stroud RM, Schertler GF -
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins.
Proceedings of the National Academy of Sciences of the United States of America 2011 Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS -
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
BMC biology 2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P -
Structural and functional basis for RNA cleavage by Ire1.
BMC biology 2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P -
New tools in membrane protein determination.
F1000 biology reports 2011 Stroud RM -
Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.
PloS one 2010 Nelson PA, Khodadoust M, Prodhomme T, Spencer C, Patarroyo JC, Varrin-Doyer M, Ho JD, Stroud RM, Zamvil SS -
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes.
Proceedings of the National Academy of Sciences of the United States of America 2010 Egea PF, Stroud RM -
Structural context shapes the aquaporin selectivity filter.
Proceedings of the National Academy of Sciences of the United States of America 2010 Savage DF, O'Connell JD, Miercke LJ, Finer-Moore J, Stroud RM -
Unlocking the eukaryotic membrane protein structural proteome.
Current opinion in structural biology 2010 Lee JK, Stroud RM -
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems.
Proceedings of the National Academy of Sciences of the United States of America 2010 De Angelis F, Lee JK, O'Connell JD, Miercke LJ, Verschueren KH, Srinivasan V, Bauvois C, Govaerts C, Robbins RA, Ruysschaert JM, Stroud RM, Vandenbussche G -
Function of human Rh based on structure of RhCG at 2.1 A.
Proceedings of the National Academy of Sciences of the United States of America 2010 Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM -
Comparison of human solute carriers.
Protein science : a publication of the Protein Society 2010 Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A -
Overexpression and purification of integral membrane proteins in yeast.
Methods in enzymology 2010 Hays FA, Roe-Zurz Z, Stroud RM -
A survey of integral alpha-helical membrane proteins.
Journal of structural and functional genomics 2009 Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A -
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.
Proceedings of the National Academy of Sciences of the United States of America 2009 Alian A, Griner SL, Chiang V, Tsiang M, Jones G, Birkus G, Geleziunas R, Leavitt AD, Stroud RM -
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
Proceedings of the National Academy of Sciences of the United States of America 2009 Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM -
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
Journal of molecular biology 2009 Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM -
2007 annual progress report synopsis of the Center for Structures of Membrane Proteins.
Journal of structural and functional genomics 2009 Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W -
A general protocol for the crystallization of membrane proteins for X-ray structural investigation.
Nature protocols 2009 Newby ZE, O'Connell JD, Gruswitz F, Hays FA, Harries WE, Harwood IM, Ho JD, Lee JK, Savage DF, Miercke LJ, Stroud RM -
The unfolded protein response signals through high-order assembly of Ire1.
Nature 2008 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P -
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.
Journal of molecular biology 2008 Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM -
Ratiocinative screen of eukaryotic integral membrane protein expression and solubilization for structure determination.
Journal of structural and functional genomics 2008 Hays FA, Roe-Zurz Z, Li M, Kelly L, Gruswitz F, Sali A, Stroud RM -
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.
PloS one 2008 Egea PF, Tsuruta H, de Leon GP, Napetschnig J, Walter P, Stroud RM -
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
PloS one 2008 Egea PF, Napetschnig J, Walter P, Stroud RM -
Michael A. Raftery (1936-2007)--the first enzyme mechanism, sequential cooperativity, and the nicotinic acetylcholine receptor defined.
Protein science : a publication of the Protein Society 2008 Stroud RM -
Crystal structure of bovine mitochondrial factor B at 0.96-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2008 Lee JK, Belogrudov GI, Stroud RM -
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
Nature structural & molecular biology 2008 Newby ZE, O'Connell J, Robles-Colmenares Y, Khademi S, Miercke LJ, Stroud RM -
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proceedings of the National Academy of Sciences of the United States of America 2008 Alian A, Lee TT, Griner SL, Stroud RM, Finer-Moore J -
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2008 Du Z, Lee JK, Tjhen R, Stroud RM, James TL -
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Science (New York, N.Y.) 2007 Menuz K, Stroud RM, Nicoll RA, Hays FA -
X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.
PloS one 2007 Reyes CL, Rutenber E, Walter P, Stroud RM -
X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2.
RNA (New York, N.Y.) 2007 Du Z, Lee JK, Fenn S, Tjhen R, Stroud RM, James TL -
Cell-free complements in vivo expression of the E. coli membrane proteome.
Protein science : a publication of the Protein Society 2007 Savage DF, Anderson CL, Robles-Colmenares Y, Newby ZE, Stroud RM -
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA.
Molecular cell 2007 Hur S, Stroud RM -
Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.
Nucleic acids research 2007 Fenn S, Du Z, Lee JK, Tjhen R, Stroud RM, James TL -
Structural basis of aquaporin inhibition by mercury.
Journal of molecular biology 2007 Savage DF, Stroud RM -
The crystal structure of E. coli rRNA pseudouridine synthase RluE.
Journal of molecular biology 2007 Pan H, Ho JD, Stroud RM, Finer-Moore J -
Transmembrane transporters: an open and closed case.
Proceedings of the National Academy of Sciences of the United States of America 2007 Stroud RM -
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A.
Proceedings of the National Academy of Sciences of the United States of America 2006 Gruswitz F, O'Connell J, Stroud RM -
The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction.
Physiology (Bethesda, Md.) 2006 Khademi S, Stroud RM -
Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective.
The Journal of biological chemistry 2006 Hur S, Stroud RM, Finer-Moore J -
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.
Journal of medicinal chemistry 2006 He X, Alian A, Stroud R, Ortiz de Montellano PR -
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
Biochemistry 2006 Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM -
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.
Structure (London, England : 1993) 2006 Keatinge-Clay AT, Stroud RM -
On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2005 Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P -
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.
Proceedings of the National Academy of Sciences of the United States of America 2005 Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM -
The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
Acta crystallographica. Section D, Biological crystallography 2005 Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM -
Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.
The Journal of biological chemistry 2005 Du Z, Lee JK, Tjhen R, Li S, Pan H, Stroud RM, James TL -
Targeting proteins to membranes: structure of the signal recognition particle.
Current opinion in structural biology 2005 Egea PF, Stroud RM, Walter P -
A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function.
Cell 2005 Lee TT, Agarwalla S, Stroud RM -
De novo design of an IL-4 antagonist and its structure at 1.9 A.
Proceedings of the National Academy of Sciences of the United States of America 2005 Laporte SL, Forsyth CM, Cunningham BC, Miercke LJ, Akhavan D, Stroud RM -
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2004 Chu F, Shan SO, Moustakas DT, Alber F, Egea PF, Stroud RM, Walter P, Burlingame AL -
Mechanism of association and reciprocal activation of two GTPases.
PLoS biology 2004 Shan SO, Stroud RM, Walter P -
The channel architecture of aquaporin 0 at a 2.2-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2004 Harries WE, Akhavan D, Miercke LJ, Khademi S, Stroud RM -
Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A.
Science (New York, N.Y.) 2004 Khademi S, O'Connell J, Remis J, Robles-Colmenares Y, Miercke LJ, Stroud RM -
An antibiotic factory caught in action.
Nature structural & molecular biology 2004 Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM -
Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies.
The Journal of biological chemistry 2004 Agarwalla S, Stroud RM, Gaffney BJ -
Mechanistic diversity of cytokine receptor signaling across cell membranes.
Science's STKE : signal transduction knowledge environment 2004 Stroud RM, Wells JA -
Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase.
Structure (London, England : 1993) 2004 Lee TT, Agarwalla S, Stroud RM -
Substrate twinning activates the signal recognition particle and its receptor.
Nature 2004 Egea PF, Shan SO, Napetschnig J, Savage DF, Walter P, Stroud RM -
Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
PLoS biology 2003 Savage DF, Egea PF, Robles-Colmenares Y, O'Connell JD, Stroud RM -
The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate.
Structure (London, England : 1993) 2003 Foster PG, Nunes CR, Greene P, Moustakas D, Stroud RM -
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis.
Journal of molecular biology 2003 Watanabe K, Khosla C, Stroud RM, Tsai SC -
Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family.
Journal of synchrotron radiation 2003 Lee JK, Khademi S, Harries W, Savage D, Miercke L, Stroud RM -
Selectivity and conductance among the glycerol and water conducting aquaporin family of channels.
FEBS letters 2003 Stroud RM, Savage D, Miercke LJ, Lee JK, Khademi S, Harries W -
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit.
Proceedings of the National Academy of Sciences of the United States of America 2003 Pan H, Agarwalla S, Moustakas DT, Finer-Moore J, Stroud RM -
Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase.
The Journal of biological chemistry 2003 O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC -
Glycerol facilitator GlpF and the associated aquaporin family of channels.
Current opinion in structural biology 2003 Stroud RM, Miercke LJ, O'Connell J, Khademi S, Lee JK, Remis J, Harries W, Robles Y, Akhavan D -
The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.
Protein engineering 2003 Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV -
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
Chemistry & biology 2003 Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV -
Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
Biochemistry 2003 Reiling KK, Krucinski J, Miercke LJ, Raymond WW, Caughey GH, Stroud RM -
The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity.
Protein engineering 2003 Birdsall DL, Finer-Moore J, Stroud RM -
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase.
Structure (London, England : 1993) 2003 Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM -
Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".
Biochemistry 2003 Stroud RM, Finer-Moore JS -
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.
Biochemistry 2003 Finer-Moore JS, Santi DV, Stroud RM -
The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme.
The Journal of eukaryotic microbiology 2003 O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC -
The glycerol facilitator GlpF its aquaporin family of channels, and their selectivity.
Advances in protein chemistry 2003 Stroud RM, Nollert P, Miercke L -
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.
Journal of molecular biology 2002 Ramirez UD, Minasov G, Focia PJ, Stroud RM, Walter P, Kuhn P, Freymann DM -
Structure-based studies on species-specific inhibition of thymidylate synthase.
Biochimica et biophysica acta 2002 Costi MP, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Soragni F, Venturelli A, Stroud RM -
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Biochemistry 2002 Fritz TA, Liu L, Finer-Moore JS, Stroud RM -
Encoding Selectivity of a Transmembrane Channel.
TheScientificWorldJournal 2002 Stroud RM, Nollert P, Miercke LJW, Harries WEC, O'Connell J -
Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure.
Biochemistry 2002 Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM -
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli.
The Journal of biological chemistry 2002 Agarwalla S, Kealey JT, Santi DV, Stroud RM -
The structure of GlpF, a glycerol conducting channel.
Novartis Foundation symposium 2002 Fu D, Libson A, Stroud R -
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proceedings of the National Academy of Sciences of the United States of America 2001 Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM -
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
Journal of molecular biology 2001 Sayre PH, Finer-Moore JS, Fritz TA, Biermann D, Gates SB, MacKellar WC, Patel VF, Stroud RM -
Structure of Cry2Aa suggests an unexpected receptor binding epitope.
Structure (London, England : 1993) 2001 Morse RJ, Yamamoto T, Stroud RM -
Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking.
Chemistry & biology 2001 Anderson AC, O'Neil RH, Surti TS, Stroud RM -
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.
Biochemical pharmacology 2001 Lackey DB, Groziak MP, Sergeeva M, Beryt M, Boyer C, Stroud RM, Sayre P, Park JW, Johnston P, Slamon D, Shepard HM, Pegram M -
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Biochemistry 2000 Reiling KK, Pray TR, Craik CS, Stroud RM -
Structure of a glycerol-conducting channel and the basis for its selectivity.
Science (New York, N.Y.) 2000 Fu D, Libson A, Miercke LJ, Weitzman C, Nollert P, Krucinski J, Stroud RM -
Site-directed ligand discovery.
Proceedings of the National Academy of Sciences of the United States of America 2000 Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA -
Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase.
Protein engineering 2000 Kawase S, Cho SW, Rozelle J, Stroud RM, Finer-Moore J, Santi DV -
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 2000 Chen JC, Krucinski J, Miercke LJ, Finer-Moore JS, Tang AH, Leavitt AD, Stroud RM -
Mesoscopic surfactant organization and membrane protein crystallization.
Protein science : a publication of the Protein Society 2000 Wiener MC, Verkman AS, Stroud RM, van Hoek AN -
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Journal of molecular biology 2000 Anderson AC, Perry KM, Freymann DM, Stroud RM -
Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants.
Biochemistry 2000 Variath P, Liu Y, Lee TT, Stroud RM, Santi DV -
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry 2000 Morse RJ, Kawase S, Santi DV, Finer-Moore J, Stroud RM -
Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.
Journal of molecular biology 2000 Cherbavaz DB, Lee ME, Stroud RM, Koshland DE -
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I.
Nature structural biology 2000 Foster PG, Huang L, Santi DV, Stroud RM -
Signal sequence recognition and protein targeting.
Current opinion in structural biology 1999 Stroud RM, Walter P -
Expression, purification, and structural characterization of the bacteriorhodopsin-aspartyl transcarbamylase fusion protein.
Protein expression and purification 1999 Turner GJ, Miercke LJ, Mitra AK, Stroud RM, Betlach MC, Winter-Vann A -
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
Biochemistry 1999 Anderson AC, O'Neil RH, DeLano WL, Stroud RM -
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nature structural biology 1999 Freymann DM, Keenan RJ, Stroud RM, Walter P -
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.
Journal of medicinal chemistry 1999 Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P -
Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin.
Protein engineering 1999 Zhan H, Liu B, Reid SW, Aoki KH, Li C, Syed RS, Karkaria C, Koe G, Sitney K, Hayenga K, Mistry F, Savel L, Dreyer M, Katz BA, Schreurs J, Matthews DJ, Cheetham JC, Egrie J, Giebel LB, Stroud RM -
Structure-based design of inhibitors specific for bacterial thymidylate synthase.
Biochemistry 1999 Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP -
Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
Journal of molecular biology 1998 Reyes CL, Sage CR, Rutenber EE, Nissen RM, Finer-Moore JS, Stroud RM -
Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.
Biochemistry 1998 Stout TJ, Schellenberger U, Santi DV, Stroud RM -
Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature 1998 Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM -
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry 1998 Sage CR, Michelitsch MD, Stout TJ, Biermann D, Nissen R, Finer-Moore J, Stroud RM -
Helical protein design.
Current opinion in biotechnology 1998 Schafmeister CE, Stroud RM -
Ion-channel-forming colicins.
Current opinion in structural biology 1998 Stroud RM, Reiling K, Wiener M, Freymann D -
Crystal structure of the signal sequence binding subunit of the signal recognition particle.
Cell 1998 Keenan RJ, Freymann DM, Walter P, Stroud RM -
The additivity of substrate fragments in enzyme-ligand binding.
Structure (London, England : 1993) 1998 Stout TJ, Sage CR, Stroud RM -
Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation.
Biochemistry 1998 Chen JC, Miercke LJ, Krucinski J, Starr JR, Saenz G, Wang X, Spilburg CA, Lange LG, Ellsworth JL, Stroud RM -
The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein engineering 1998 Birdsall DL, Huang W, Santi DV, Stroud RM, Finer-Moore J -
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry 1998 Rose RB, Craik CS, Stroud RM -
Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
Journal of molecular biology 1998 Finer-Moore JS, Liu L, Birdsall DL, Brem R, Apfeld J, Santi DV, Stroud RM -
Design of potent selective zinc-mediated serine protease inhibitors.
Nature 1998 Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM -
A novel dCMP methylase by engineering thymidylate synthase.
Biochemistry 1997 Agarwalla S, LaPorte S, Liu L, Finer-Moore J, Stroud RM, Santi DV -
A designed four helix bundle protein with native-like structure.
Nature structural biology 1997 Schafmeister CE, LaPorte SL, Miercke LJ, Stroud RM -
Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
Biochemistry 1997 Finer-Moore J, Tsutakawa SE, Cherbavaz DR, LaPorte DC, Koshland DE, Stroud RM -
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.
Bioorganic & medicinal chemistry 1997 Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR -
Crystal structure of colicin Ia.
Nature 1997 Wiener M, Freymann D, Ghosh P, Stroud RM -
Structure of the conserved GTPase domain of the signal recognition particle.
Nature 1997 Freymann DM, Keenan RJ, Stroud RM, Walter P -
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Biochemistry 1996 Sage CR, Rutenber EE, Stout TJ, Stroud RM -
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity.
Structure (London, England : 1993) 1996 Rutenber EE, Stroud RM -
Three-dimensional structures of HIV-1 and SIV protease product complexes.
Biochemistry 1996 Rose RB, Craik CS, Douglas NL, Stroud RM -
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.
Bioorganic & medicinal chemistry 1996 Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC, Craik CS, Stroud RM -
Balancing ATP in the cell.
Nature structural biology 1996 Stroud RM -
Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry 1996 Finer-Moore JS, Liu L, Schafmeister CE, Birdsall DL, Mau T, Santi DV, Stroud RM -
Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.
Biochemistry 1996 Costi PM, Liu L, Finer-Moore JS, Stroud RM, Santi DV -
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Journal of molecular biology 1996 Birdsall DL, Finer-Moore J, Stroud RM -
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Structure (London, England : 1993) 1996 Stout TJ, Stroud RM -
Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein engineering 1996 Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM -
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.
Biochemistry 1995 Schiffer CA, Clifton IJ, Davisson VJ, Santi DV, Stroud RM -
Significance of structural changes in proteins: expected errors in refined protein structures.
Protein science : a publication of the Protein Society 1995 Stroud RM, Fauman EB -
Topochemistry for preparing ligands that dimerize receptors.
Chemistry & biology 1995 Katz BA, Stroud RM, Collins N, Liu B, Arze R -
Ion channel forming colicins.
Current opinion in structural biology 1995 Stroud R -
Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry 1995 Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM -
Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
Biochemistry 1994 Finer-Moore JS, Maley GF, Maley F, Montfort WR, Stroud RM -
The domain structure of the ion channel-forming protein colicin Ia.
Nature structural biology 1994 Ghosh P, Mel SF, Stroud RM -
An electrostatic highway.
Nature structural biology 1994 Stroud RM -
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.
Biochemistry 1994 Fauman EB, Rutenber EE, Maley GF, Maley F, Stroud RM -
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.
Biochemistry 1993 Rose RB, Rosé JR, Salto R, Craik CS, Stroud RM -
Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins.
Science (New York, N.Y.) 1993 Schafmeister CE, Miercke LJ, Stroud RM -
Mapping a membrane-associated conformation of colicin Ia.
Biochemistry 1993 Mel SF, Falick AM, Burlingame AL, Stroud RM -
Two-dimensional crystallization of Escherichia coli-expressed bacteriorhodopsin and its D96N variant: high resolution structural studies in projection.
Biophysical journal 1993 Mitra AK, Miercke LJ, Turner GJ, Shand RF, Betlach MC, Stroud RM -
Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
Journal of molecular biology 1993 Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM -
Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.
Biochemistry 1993 Perry KM, Carreras CW, Chang LC, Santi DV, Stroud RM -
A carboxy-terminal fragment of colicin Ia forms ion channels.
The Journal of membrane biology 1993 Ghosh P, Mel SF, Stroud RM -
Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993 Stroud RM, Finer-Moore JS -
Structure-based discovery of inhibitors of thymidylate synthase.
Science (New York, N.Y.) 1993 Shoichet BK, Stroud RM, Santi DV, Kuntz ID, Perry KM -
Colicin Ia inserts into negatively charged membranes at low pH with a tertiary but little secondary structural change.
Biochemistry 1993 Mel SF, Stroud RM -
Bacteriorhodopsin D85N: three spectroscopic species in equilibrium.
Biochemistry 1993 Turner GJ, Miercke LJ, Thorgeirsson TE, Kliger DS, Betlach MC, Stroud RM -
Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
Biochemistry 1992 Kamb A, Finer-Moore JS, Stroud RM -
Structural basis for recognition of polyglutamyl folates by thymidylate synthase.
Biochemistry 1992 Kamb A, Finer-Moore J, Calvert AH, Stroud RM -
Reversible dissociation and unfolding of the dimeric protein thymidylate synthase.
Protein science : a publication of the Protein Society 1992 Perry KM, Pookanjanatavip M, Zhao J, Santi DV, Stroud RM -
Inclusion of solvation free energy with molecular mechanics energy: alanyl dipeptide as a test case.
Protein science : a publication of the Protein Society 1992 Schiffer CA, Caldwell JW, Stroud RM, Kollman PA -
Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
Proteins 1992 Finer-Moore JS, Kossiakoff AA, Hurley JH, Earnest T, Stroud RM -
Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin.
Biochemistry 1991 Thorgeirsson TE, Milder SJ, Miercke LJ, Betlach MC, Shand RF, Stroud RM, Kliger DS -
Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.
Biochemistry 1991 Hurley JH, Dean AM, Koshland DE, Stroud RM -
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.
The Journal of biological chemistry 1991 Lax I, Mitra AK, Ravera C, Hurwitz DR, Rubinstein M, Ullrich A, Stroud RM, Schlessinger J -
Crystallization of human thymidylate synthase.
Journal of molecular biology 1991 Schiffer CA, Davisson VJ, Santi DV, Stroud RM -
Ion channels formed by a highly charged peptide.
Biochemistry 1991 Ghosh P, Stroud RM -
Wild-type and mutant bacterioopsins D85N, D96N, and R82Q: high-level expression in Escherichia coli.
Biochemistry 1991 Shand RF, Miercke LJ, Mitra AK, Fong SK, Stroud RM, Betlach MC -
Wild-type and mutant bacteriorhodopsins D85N, D96N, and R82Q: purification to homogeneity, pH dependence of pumping, and electron diffraction.
Biochemistry 1991 Miercke LJ, Betlach MC, Mitra AK, Shand RF, Fong SK, Stroud RM -
Resonance Raman spectra of bacteriorhodopsin mutants with substitutions at Asp-85, Asp-96, and Arg-82.
Photochemistry and photobiology 1991 Lin SW, Fodor SP, Miercke LJ, Shand RF, Betlach MC, Stroud RM, Mathies RA -
Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin.
Biochemistry 1991 Milder SJ, Thorgeirsson TE, Miercke LJ, Stroud RM, Kliger DS -
1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
Proteins 1991 Earnest T, Fauman E, Craik CS, Stroud R -
Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels.
Biochemistry 1990 Stroud RM, McCarthy MP, Shuster M -
Saturation site-directed mutagenesis of thymidylate synthase.
The Journal of biological chemistry 1990 Climie S, Ruiz-Perez L, Gonzalez-Pacanowska D, Prapunwattana P, Cho SW, Stroud R, Santi DV -
Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin.
Biochemistry 1990 Mangel WF, Singer PT, Cyr DM, Umland TC, Toledo DL, Stroud RM, Pflugrath JW, Sweet RM -
Regulation of an enzyme by phosphorylation at the active site.
Science (New York, N.Y.) 1990 Hurley JH, Dean AM, Sohl JL, Koshland DE, Stroud RM -
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
Biochemistry 1990 Finer-Moore JS, Montfort WR, Stroud RM -
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Biochemistry 1990 Montfort WR, Perry KM, Fauman EB, Finer-Moore JS, Maley GF, Hardy L, Maley F, Stroud RM -
Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.
The Journal of biological chemistry 1990 Hurley JH, Dean AM, Thorsness PE, Koshland DE, Stroud RM -
High sensitivity electron diffraction analysis. A study of divalent cation binding to purple membrane.
Biophysical journal 1990 Mitra AK, Stroud RM -
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Proteins 1990 Perry KM, Fauman EB, Finer-Moore JS, Montfort WR, Maley GF, Maley F, Stroud RM -
Prediction of homologous protein structures based on conformational searches and energetics.
Proteins 1990 Schiffer CA, Caldwell JW, Kollman PA, Stroud RM -
Preparative purification of functional bacteriorhodopsin by high-performance size-exclusion chromatography.
Journal of chromatography 1989 Miercke LJ, Stroud RM, Dratz EA -
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 1989 Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE, Stroud RM -
Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1989 Poulter L, Earnest JP, Stroud RM, Burlingame AL -
Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A.
The Journal of cell biology 1989 Mitra AK, McCarthy MP, Stroud RM -
Changes in conformation upon agonist binding, and nonequivalent labeling, of the membrane-spanning regions of the nicotinic acetylcholine receptor subunits.
The Journal of biological chemistry 1989 McCarthy MP, Stroud RM -
Purification of bacteriorhodopsin and characterization of mature and partially processed forms.
The Journal of biological chemistry 1989 Miercke LJ, Ross PE, Stroud RM, Dratz EA -
Conformational states of the nicotinic acetylcholine receptor from Torpedo californica induced by the binding of agonists, antagonists, and local anesthetics. Equilibrium measurements using tritium-hydrogen exchange.
Biochemistry 1989 McCarthy MP, Stroud RM -
Cesium ion liquid secondary ion mass spectrometry of membrane-bound glycoproteins: structural and topological considerations of acetylcholine receptor from Torpedo californica.
Biomedical & environmental mass spectrometry 1988 Poulter L, Earnest JP, Stroud RM, Burlingame AL -
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.
Molecular and cellular biology 1988 Basson ME, Thorsness M, Finer-Moore J, Stroud RM, Rine J -
Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments.
Biochemistry 1988 Basus VJ, Billeter M, Love RA, Stroud RM, Kuntz ID -
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Science (New York, N.Y.) 1987 Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS -
Independent mutations at the amino terminus of a protein act as surrogate signals for mitochondrial import.
The EMBO journal 1987 Vassarotti A, Stroud R, Douglas M -
Atomic structure of thymidylate synthase: target for rational drug design.
Science (New York, N.Y.) 1987 Hardy LW, Finer-Moore JS, Montfort WR, Jones MO, Santi DV, Stroud RM -
An archetypal molecular transducer of the nervous system: the acetylcholine receptor.
Research publications - Association for Research in Nervous and Mental Disease 1987 Stroud RM -
Topological mapping and the ionic channel in an acetylcholine receptor.
Society of General Physiologists series 1987 Stroud RM -
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains.
Protein engineering 1986 Masters SB, Stroud RM, Bourne HR -
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor.
Protein engineering 1986 Love RA, Stroud RM -
Cation binding sites on the projected structure of bacteriorhodopsin.
Biophysical journal 1986 Katre NV, Kimura Y, Stroud RM -
Location of terbium binding sites on acetylcholine receptor-enriched membranes.
Journal of molecular biology 1986 Fairclough RH, Miake-Lye RC, Stroud RM, Hodgson KO, Doniach S -
Purification and crystallization of creatine kinase from rabbit skeletal muscle.
The Journal of biological chemistry 1986 Hershenson S, Helmers N, Desmueles P, Stroud R -
The molecular neurobiology of the acetylcholine receptor.
Annual review of neuroscience 1986 McCarthy MP, Earnest JP, Young EF, Choe S, Stroud RM -
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.
The Journal of biological chemistry 1985 Liscum L, Finer-Moore J, Stroud RM, Luskey KL, Brown MS, Goldstein JL -
Acetylcholine receptor structure, function, and evolution.
Annual review of cell biology 1985 Stroud RM, Finer-Moore J -
Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide.
Proceedings of the National Academy of Sciences of the United States of America 1985 Young EF, Ralston E, Blake J, Ramachandran J, Hall ZW, Stroud RM -
Location of an extrinsic label in the primary and tertiary structure of bacteriorhodopsin.
Biophysical journal 1984 Katre NV, Finer-Moore J, Stroud RM, Hayward SB -
Subunit secondary structure in filamentous viruses: predictions and observations.
Journal of biomolecular structure & dynamics 1984 Finer-Moore J, Stroud RM, Prescott B, Thomas GJ -
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1984 Finer-Moore J, Stroud RM -
Subunit organization and structure of an acetylcholine receptor.
Cold Spring Harbor symposia on quantitative biology 1983 Fairclough RH, Finer-Moore J, Love RA, Kristofferson D, Desmeules PJ, Stroud RM -
Linking regions between helices in bacteriorhodopsin revealed.
Biophysical journal 1982 Agard DA, Stroud RM -
Structure and function of an acetylcholine receptor.
Biophysical journal 1982 Kistler J, Stroud RM, Klymkowsky MW, Lalancette RA, Fairclough RH -
Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids.
Biophysical journal 1981 Stroud RM, Serwer P, Ross MJ -
Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy.
Journal of molecular biology 1981 Hayward SB, Stroud RM -
Attachment site(s) of retinal in bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1981 Katre NV, Wolber PK, Stoeckenius W, Stroud RM -
Crystalline arrays of membrane-bound acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1981 Kistler J, Stroud RM -
Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution.
Analytical biochemistry 1981 Agard DA, Steinberg RA, Stroud RM -
Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma.
Molecular immunology 1980 Nagasawa S, Stroud RM -
Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.
The Journal of cell biology 1980 Klymkowsky MW, Heuser JE, Stroud RM -
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica.
Journal of molecular biology 1979 Klymkowsky MW, Stroud RM -
Structure determination of asymmetric membrane profiles using an iterative Fourier method.
Biophysical journal 1979 Stroud RM, Agard DA -
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica.
Journal of molecular biology 1977 Ross MJ, Klymkowsky MW, Agard DA, Stroud RM -
Structure of bovine trypsinogen at 1.9 A resolution.
Biochemistry 1977 Kossiakoff AA, Chambers JL, Kay LM, Stroud RM -
Mechanism of hydrolysis by serine proteases: direct determination of the pKa's of aspartyl-102 and aspartyl-194 in bovine trypsin using difference infrared spectroscopy.
Biochemistry 1976 Koeppe RE, Stroud RM -
A pulsed diffusion technique for the growth of protein crystals for x-ray diffraction.
Journal of molecular biology 1975 Koeppe RE, Stroud RM -
The structural basis for binding of complement by immunoglobulin M.
The Journal of experimental medicine 1974 Hurst MM, Volanakis JE, Hester RB, Stroud RM, Bennett JC -
Silver ion inhibition of serine proteases: crystallographic study of silver-trypsin.
Biochemical and biophysical research communications 1974 Chambers JL, Christoph GG, Krieger M, Kay L, Stroud RM -
Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding.
Journal of molecular biology 1974 Krieger M, Kay LM, Stroud RM -
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution.
Journal of molecular biology 1974 Stroud RM, Kay LM, Dickerson RE -
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution.
Cold Spring Harbor symposia on quantitative biology 1972 Stroud RM, Kay LM, Dickerson RE