Robert Seed, PhD
Associate Researcher
Pathology
School of Medicine

Education & Training

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• Postdoc in prostate cancer aetiology University of York 09/2017
• Postdoc in pulmonary fibrosis UCSF Dept. of Pathology 05/2014
• PhD Experimental medicine University of Birmingham 01/2013
• MSc Biomedicine University of Lancaster 09/2008
• BSc Biochemistry University of Leeds 07/2007

Publications (19)

Top publication keywords:
Tumor EscapeProstateDown-RegulationT-Lymphocytes, RegulatoryGene Expression Regulation, NeoplasticIntegrinsNerve Tissue ProteinsSmall Ubiquitin-Related Modifier ProteinsConnexin 43Tumor Suppressor ProteinsNeoplasmsLatent TGF-beta Binding ProteinsProstatic NeoplasmsThyroid GlandProtein Inhibitors of Activated STAT

• The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy.
  Scientific reports 2019 Seed RI, Taurozzi AJ, Wilcock DJ, Nappo G, Erb HHH, Read ML, Gurney M, Archer LK, Ito S, Rumsby MG, Petrie JL, Clayton A, Maitland NJ, Collins AT
• Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.
  Frontiers in immunology 2022 Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M
• Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8.
  Bio-protocol 2022 Seed RI, Nishimura SL
• Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
  eLife 2022 Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT
• A Systematic Comparison of Antiandrogens Identifies Androgen Receptor Protein Stability as an Indicator for Treatment Response.
  Life (Basel, Switzerland) 2021 Siciliano T, Simons IH, Beier AK, Ebersbach C, Aksoy C, Seed RI, Stope MB, Thomas C, Erb HHH

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• A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
  Science immunology 2021 Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL
• Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β.
  Cell 2020 Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
• PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target.
  PloS one 2019 Erb HHH, Ebert M, Kuhn R, Donix L, Haferkamp A, Seed RI, Jüngel E
• Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.
  JCI insight 2018 Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron …
• Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program.
  PloS one 2017 Taurozzi AJ, Beekharry R, Wantoch M, Labarthe MC, Walker HF, Seed RI, Simms M, Rodrigues G, Bradford J, van der Horst G, van der Pluijm G, Collins AT
• The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling.
  Oncogenesis 2017 Nappo G, Handle F, Santer FR, McNeill RV, Seed RI, Collins AT, Morrone G, Culig Z, Maitland NJ, Erb HHH
• The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer.
  Molecular carcinogenesis 2014 Read ML, Seed RI, Modasia B, Kwan PP, Sharma N, Smith VE, Watkins RJ, Bansal S, Gagliano T, Stratford AL, Ismail T, Wakelam MJ, Kim DS, Ward ST, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ
• Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
  Science translational medicine 2014 Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ…
• The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells.
  Endocrinology 2014 Read ML, Seed RI, Fong JC, Modasia B, Ryan GA, Watkins RJ, Gagliano T, Smith VE, Stratford AL, Kwan PK, Sharma N, Dixon OM, Watkinson JC, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ
• Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells.
  Endocrinology 2013 Lewy GD, Ryan GA, Read ML, Fong JC, Poole V, Seed RI, Sharma N, Smith VE, Kwan PP, Stewart SL, Bacon A, Warfield A, Franklyn JA, McCabe CJ, Boelaert K
• PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.
  Endocrinology 2012 Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA, McCabe CJ
• The pituitary tumor transforming gene in thyroid cancer.
  Journal of endocrinological investigation 2012 Lewy GD, Sharma N, Seed RI, Smith VE, Boelaert K, McCabe CJ
• Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.
  Journal of virology 2011 Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PÓ, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS
• Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment.
  Cancer research 2011 Read ML, Lewy GD, Fong JC, Sharma N, Seed RI, Smith VE, Gentilin E, Warfield A, Eggo MC, Knauf JA, Leadbeater WE, Watkinson JC, Franklyn JA, Boelaert K, McCabe CJ