Robert Mahley, MD, PhD
Professor
Pathology
School of Medicine
Areas of Investigation
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The major focus of our laboratory is to elucidate the function of apolipoprotein (apo) E in both cardiovascular disease and neurobiology. We are especially interested in determining the basis of the differential effects of the apoE isoforms (apoE2, E3, and E4) in neuronal repair/remodeling, in neuroprotection, and in defining how apoE4 causes neuropathology.
Significance ApoE is produced in abundance in the brain and serves as the principal lipid transport vehicle in cerebrospinal fluid. ApoE4 is a major gene associated with 60–70% of cases of sporadic and familial Alzheimer’s disease. ApoE4 increases the occurrence and lowers the age of onset of Alzheimer’s disease and is also associated with poor clinical outcome in patients with traumatic brain injury. Defining the effects of the three apoE isoforms on the structure and function of the brain is providing crucial insights into the contribution of apoE4 to neurological disease, and providing a way forward for treating Alzheimer’s disease and other apoE4-associated neurodegenerative disorders.
Approaches We use biophysical techniques in combination with cell and molecular biology, and transgenic and gene knockout mice to study the molecular mechanisms involving apoE in normal development and disease, including Alzheimer’s disease and other neurodegenerative diseases. Medicinal chemistry is used to identify small molecules that modulate the structure of the apoE4.
Contributions My laboratory described apoE’s receptor ligand function, determined its protein and gene sequences, mapped the amino acid residues involved in receptor binding, and defined the three-dimensional structure of the ligand-binding domain. Understanding the structure and function of apoE laid the groundwork for the recent explosion of studies concerning apoE4 and Alzheimer’s disease. My laboratory was involved in describing the role of apoE in lipid transport in the nervous system, modulation of mitochondrial activity, and cytoskeletal stability involving normal and pathological CNS metabolism. By establishing brain-specific apoE transgenic mice, we demonstrated detrimental effects on apoE4 on the central nervous system in vivo and described a mechanism whereby apoE4 is involved in neuropathology.
Research Summary Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease. It has since emerged as a major risk factor (causative gene) for Alzheimer’s disease and other neurodegenerative disorders. Detailed understanding of the structural features of the three isoforms (apoE2, apoE3, and apoE4), which differ by only a single amino acid interchange, has elucidated their unique functions. ApoE2 and apoE4 increase the risk for heart disease: apoE2 increases atherogenic lipoprotein levels (it binds poorly to LDL receptors) and apoE4 increases LDL levels (it binds preferentially to triglyceride-rich, very low density lipoproteins, leading to downregulation of LDL receptors). ApoE4 also increases the risk for neurodegenerative diseases, decreases their age of onset, or alters their progression. ApoE4 likely causes neurodegeneration secondary to its abnormal structure, caused by an interaction between its carboxyl- and amino-terminal domains, called domain interaction. When neurons are stressed or injured, they synthesize apoE to redistribute cholesterol for neuronal repair or remodeling. However, because of its altered structure, neuronal apoE4 undergoes neuron-specific proteolysis, generating neurotoxic fragments (12–29-kDa) that escape the secretory pathway and cause mitochondrial dysfunction and cytoskeletal alterations, including tau phosphorylation. ApoE4-associated pathology can be prevented by small-molecule structure correctors that block domain interaction by converting apoE4 to a molecule that resembles apoE3 both structurally and functionally. Structure correctors are a potential therapeutic approach to reduce apoE4 pathology in both cardiovascular and neurological disorders.
Grants and Projects
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- Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms, NIH/NIA, 2019-2024
- Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms, NIH, 2019-2024
- Develop GABAergic Neuron Protectors for Treating ApoE4-Related Alzheimer's Disease, NIH, 2019-2021
- Somatostatin (SST)-GABAergic Interneuron Therapy for Alzheimer's Disease with ApoE4, NIH, 2018-2021
- Apolipoprotein E and Alzheimer's Disease: Mitochondrial Dysfunction and Neurodegeneration, NIH, 2018-2020
- ApoE2 and Alzheimer's Disease: Structural and Functional Roles in CNS Metabolism, NIH, 2018-2020
- Targeting ApoE4 as a Therapeutic Strategy for Alzheimer's Disease, NIH, 2012-2017
- ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease, NIH, 2012-2014
- Role of apoE structure and metabolism in neurodegeneration, NIH, 2008-2014
- Targeting Apolipoprotein E4-related Neuropathology, NIH, 2003-2006
- Extramular Research Facilities Construction, NIH, 2003-2005
- Lipoprotein Structure/function in Cholesterol Metabolism, NIH, 1989-2005
- Genetic Determinants: Low HDL, High Triglycerides, Obes*, NIH, 2002-2004
- Genetic Alterations on Lipoproteins and Atherosclerosis, NIH, 1992-2003
- Nhlbi Shared Research Facility for Molecular Biology, NIH, 1987-1993
- Small Instrumentation Grant, NIH, 1992-1993
- Biomedical Research Support Grant, NIH, 1983-1992
Publications (310)
Top publication keywords:
CholesterolReceptors, LDLApolipoprotein E4Cholesterol, HDLArteriosclerosisAlzheimer DiseaseLipoproteins, VLDLLipoproteins, LDLLipoproteins, HDLApolipoproteins EApolipoprotein E3ApolipoproteinsHyperlipoproteinemia Type IIILipaseLipoproteins
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nature neuroscience 2023 Nelson MR, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, Kim MJ, Koutsodendris N, Rao A, Grone B, Hao Y, Yoon SY, Xu Q, De Leon S, Choenyi T, Thomas R, Lopera F, Quiroz YT, Arboleda-Velasquez JF, … -
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Marino C, Perez-Corredor P, O'Hare M, Heuer A, Chmielewska N, Gordon H, Chandrahas AS, Gonzalez-Buendia L, Delgado-Tirado S, Doan TH, Vanderleest TE, Arevalo-Alquichire S, Obar RA, Ortiz-Cordero C, … -
Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.
Molecular & cellular proteomics : MCP 2023 Cakir Z, Lord SJ, Zhou Y, Jang GM, Polacco BJ, Eckhardt M, Jimenez-Morales D, Newton BW, Orr AL, Johnson JR, da Cruz A, Mullins RD, Krogan NJ, Mahley RW, Swaney DL -
Apolipoprotein E4 targets mitochondria and the mitochondria-associated membrane complex in neuropathology, including Alzheimer's disease.
Current opinion in neurobiology 2023 Mahley RW -
A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE.
Nucleic acids research 2022 Watts JA, Grunseich C, Rodriguez Y, Liu Y, Li D, Burdick JT, Bruzel A, Crouch RJ, Mahley RW, Wilson SH, Cheung VG
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Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.
Journal of Alzheimer's disease : JAD 2019 Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW -
Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases.
Clinical chemistry 2017 Mahley RW -
The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.
Nature 2016 Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo… -
Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.
Journal of molecular medicine (Berlin, Germany) 2016 Mahley RW -
Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.
Arteriosclerosis, thrombosis, and vascular biology 2016 Mahley RW -
Ancient human genomes suggest three ancestral populations for present-day Europeans.
Nature 2014 Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K, Sudmant PH, Schraiber JG, Castellano S, Lipson M, Berger B, Economou C, Bollongino R, Fu Q, Bos KI, Nordenfelt S, Li H, de Filippo… -
Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.
Neurobiology of disease 2014 Huang Y, Mahley RW -
Shinya Yamanaka, M.D., Ph.D. - 2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2013 Mahley RW -
Apolipoprotein e sets the stage: response to injury triggers neuropathology.
Neuron 2012 Mahley RW, Huang Y -
Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.
Journal of medicinal chemistry 2012 Mahley RW, Huang Y -
Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, Feinberg LF, … -
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
PLoS genetics 2012 Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L,… -
Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations.
Annals of human genetics 2012 Hodoglugil U, Mahley RW -
A genome-wide association search for type 2 diabetes genes in African Americans.
PloS one 2012 Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, DIAGRAM Consortium, MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale … -
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.
The Journal of biological chemistry 2011 Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW -
Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks.
Annals of human genetics 2011 Hodoglugil U, Williamson DW, Yu Y, Farrer LA, Mahley RW -
Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
The Journal of biological chemistry 2011 Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, … -
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.
The Journal of biological chemistry 2010 Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW -
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 2010 Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, Luan J, Ashford S, Wheeler E, Young EH, Hadley D, Thompson JR, Braund PS, Johnson T, Struchalin M,… -
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
Nature genetics 2010 Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJ, Barroso I, Khaw KT, Grundy S, … -
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Nature genetics 2010 Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, … -
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
PLoS genetics 2009 Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, Langenberg C, Prokopenko I, Saxena … -
GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.
Cell stem cell 2009 Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y -
Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.
Journal of lipid research 2009 Hodoglugil U, Williamson DW, Mahley RW -
Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.
Annals of neurology 2009 Mahley RW, Huang Y -
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
Obesity (Silver Spring, Md.) 2009 Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Cohen JC, Grundy SM, Mooser VE, Mitchell BD -
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research 2008 Mahley RW, Weisgraber KH, Huang Y -
Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.
Obesity (Silver Spring, Md.) 2008 Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID -
Genes contributing to prion pathogenesis.
The Journal of general virology 2008 Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz… -
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008 Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK -
LDL-cholesterol concentrations: a genome-wide association study.
Lancet (London, England) 2008 Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X, Johnson T, Ashford S, Inouye M, Luben R, Sims M, Hadley D, McArdle W, Barter P, Kesäniemi YA, Mahley RW, … -
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008 Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y -
Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.
Current Alzheimer research 2007 Mahley RW, Huang Y, Weisgraber KH -
Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study.
Atherosclerosis 2007 Stirnadel H, Lin X, Ling H, Song K, Barter P, Kesäniemi YA, Mahley R, McPherson R, Waeber G, Bersot T, Cohen J, Grundy S, Mitchell B, Mooser V, Waterworth D -
Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia.
The Journal of clinical endocrinology and metabolism 2007 Barter P, McPherson YR, Song K, Kesäniemi YA, Mahley R, Waeber G, Bersot T, Mooser V, Waterworth D, Grundy SM -
Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.
The Journal of clinical investigation 2007 Mahley RW, Huang Y -
Human prions and plasma lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2006 Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB -
Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).
The pharmacogenomics journal 2006 Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW -
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y -
Putting cholesterol in its place: apoE and reverse cholesterol transport.
The Journal of clinical investigation 2006 Mahley RW, Huang Y, Weisgraber KH -
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006 Huang Y, Mahley RW -
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006 Mahley RW, Weisgraber KH, Huang Y -
High density lipoprotein cholesterol in coronary artery patients: is it as low as expected?
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2006 Mahley RW, Bersot TP -
Smoking and obesity make a bad problem worse: genetics and lifestyle affect high density lipoprotein levels in Turks.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2006 Hodoglugil U, Mahley RW -
Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.
Acta neurologica Scandinavica. Supplementum 2006 Mahley RW, Huang Y -
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005 Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW -
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005 Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y -
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
The Journal of biological chemistry 2005 Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW -
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
Journal of lipid research 2005 Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW -
Modulation of high-density lipoproteins in a population in istanbul, Turkey, with low levels of high-density lipoproteins.
The American journal of cardiology 2005 Mahley RW, Can S, Ozbayrakçi S, Bersot TP, Tanir S, Palaoglu KE, Pépin GM -
An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.
Clinical genetics 2005 Hodoglugil U, Williamson DW, Huang Y, Mahley RW -
Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.
Journal of lipid research 2005 Yu Y, Wyszynski DF, Waterworth DM, Wilton SD, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Ma Q, Sharma SS, Montgomery DS, Middleton LT, Sundseth SS, Mooser V, Grundy SM, … -
Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks.
Atherosclerosis 2005 Hodoglugil U, Williamson DW, Huang Y, Mahley RW -
Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project).
The American journal of cardiology 2005 Wyszynski DF, Waterworth DM, Barter PJ, Cohen J, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Sharma SS, Nolan V, Middleton LT, Sundseth SS, Farrer LA, Mooser V, Grundy SM -
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
The Journal of biological chemistry 2004 Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y -
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry 2004 Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y -
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y -
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004 Huang Y, Weisgraber KH, Mucke L, Mahley RW -
Risk determination of dyslipidemia in populations characterized by low levels of high-density lipoprotein cholesterol.
American heart journal 2003 Bersot TP, Pépin GM, Mahley RW -
Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.
The Journal of biological chemistry 2003 Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y -
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003 Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y -
DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.
Clinical genetics 2002 Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV -
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry 2002 Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW -
Plasma lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL.
Journal of lipid research 2001 Mahley RW, Arslan P, Pekcan G, Pépin GM, Agaçdiken A, Karaagoglu N, Rakicioglu N, Nursal B, Dayanikli P, Palaoglu KE, Bersot TP -
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Proceedings of the National Academy of Sciences of the United States of America 2001 Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW -
Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice.
Journal of lipid research 2001 Dichek HL, Johnson SM, Akeefe H, Lo GT, Sage E, Yap CE, Mahley RW -
Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].
The Journal of clinical endocrinology and metabolism 2000 Nguyen TT, Kruckeberg KE, O'Brien JF, Ji ZS, Karnes PS, Crotty TB, Hay ID, Mahley RW, O'Brien T -
Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype.
Journal of lipid research 2000 Mahley RW, Pépin J, Palaoglu KE, Malloy MJ, Kane JP, Bersot TP -
Apolipoprotein E and cognitive performance.
Nature 2000 Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L -
Apolipoprotein E: far more than a lipid transport protein.
Annual review of genomics and human genetics 2000 Mahley RW, Rall SC -
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
Neuroscience 2000 Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L -
Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages.
Journal of molecular medicine (Berlin, Germany) 2000 Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A -
Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.
Arteriosclerosis, thrombosis, and vascular biology 1999 Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW -
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Journal of lipid research 1999 Mahley RW, Huang Y, Rall SC -
Is epsilon4 the ancestral human apoE allele?
Neurobiology of aging 1999 Mahley RW, Rall SC -
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW -
Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.
Current opinion in lipidology 1999 Mahley RW, Huang Y -
Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites.
Arteriosclerosis, thrombosis, and vascular biology 1999 Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW, Wieland H, Luley C -
Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population.
Journal of lipid research 1999 Bersot TP, Vega GL, Grundy SM, Palaoglu KE, Atagündüz P, Ozbayrakçi S, Gökdemir O, Mahley RW -
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.
Journal of lipid research 1999 Mahley RW, Ji ZS -
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
The Journal of biological chemistry 1998 Huang Y, Liu XQ, Rall SC, Taylor JM, von Eckardstein A, Assmann G, Mahley RW -
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
Proceedings of the National Academy of Sciences of the United States of America 1998 Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L -
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.
The Journal of biological chemistry 1998 Huang Y, Liu XQ, Rall SC, Mahley RW -
The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity.
Journal of lipid research 1998 Vega GL, Gao J, Bersot TP, Mahley RW, Verstraete R, Grundy SM, White A, Cohen JC -
Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma.
Proceedings of the National Academy of Sciences of the United States of America 1998 Zhu Y, Bellosta S, Langer C, Bernini F, Pitas RE, Mahley RW, Assmann G, von Eckardstein A -
Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.
The Journal of biological chemistry 1998 Ji ZS, Pitas RE, Mahley RW -
Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.
The Journal of clinical investigation 1998 Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM -
Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.
Biochemical Society transactions 1998 Pitas RE, Ji ZS, Weisgraber KH, Mahley RW -
Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake.
The Journal of biological chemistry 1998 Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW -
Heparan sulfate proteoglycans participate in hepatic lipaseand apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins.
The Journal of biological chemistry 1997 Ji ZS, Dichek HL, Miranda RD, Mahley RW -
Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.
Arteriosclerosis, thrombosis, and vascular biology 1997 Huang Y, Rall SC, Mahley RW -
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.
The Journal of biological chemistry 1997 Huang Y, Schwendner SW, Rall SC, Sanan DA, Mahley RW -
The J. David Gladstone Institutes.
Molecular medicine (Cambridge, Mass.) 1997 Mahley RW -
Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity.
Arteriosclerosis, thrombosis, and vascular biology 1997 Hussain MM, Goldberg IJ, Weisgraber KH, Mahley RW, Innerarity TL -
Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro.
Brain research 1997 McGeer PL, Walker DG, Pitas RE, Mahley RW, McGeer EG -
Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.
The Journal of biological chemistry 1996 Huang Y, Schwendner SW, Rall SC, Mahley RW -
Human apolipoprotein E: the Alzheimer's disease connection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996 Weisgraber KH, Mahley RW -
Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer's disease.
Israel journal of medical sciences 1996 Mahley RW -
Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996 Mahley RW, Nathan BP, Pitas RE -
Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth.
The Journal of biological chemistry 1995 Bellosta S, Nathan BP, Orth M, Dong LM, Mahley RW, Pitas RE -
Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.
The Journal of clinical investigation 1995 Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE -
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
Proceedings of the National Academy of Sciences of the United States of America 1995 Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL -
The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization.
The Journal of biological chemistry 1995 Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE -
Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits. Saturation of the sequestration step of the remnant clearance pathway.
The Journal of biological chemistry 1995 Hussain MM, Innerarity TL, Brecht WJ, Mahley RW -
Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.
Current opinion in lipidology 1995 Mahley RW, Nathan BP, Bellosta S, Pitas RE -
Turkish Heart Study: lipids, lipoproteins, and apolipoproteins.
Journal of lipid research 1995 Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V, Onat H, Fulks P, Mahley LL, Vakar F -
Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans.
Journal of lipid research 1995 Ji ZS, Sanan DA, Mahley RW -
Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG.
Arteriosclerosis and thrombosis : a journal of vascular biology 1994 Ji ZS, Mahley RW -
Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).
Arteriosclerosis and thrombosis : a journal of vascular biology 1994 Fazio S, Sanan DA, Lee YL, Ji ZS, Mahley RW, Rall SC -
The epidemiology of hepatitis C in Turkey.
Infection 1994 Thomas DL, Mahley RW, Badur S, Palaoglu E, Quinn TC -
Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism.
Annals of the New York Academy of Sciences 1994 Mahley RW, Ji ZS, Brecht WJ, Miranda RD, He D -
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
The Journal of biological chemistry 1994 Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA -
Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1994 Fan J, Wang J, Bensadoun A, Lauer SJ, Dang Q, Mahley RW, Taylor JM -
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
Structure (London, England : 1993) 1994 Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA -
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
The Journal of clinical investigation 1994 Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD -
Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient.
Journal of lipid research 1994 Lüttmann S, von Eckardstein A, Wei W, Funke H, Köhler E, Mahley RW, Assmann G -
Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse.
Journal of lipid research 1994 de Silva HV, Más-Oliva J, Taylor JM, Mahley RW -
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.
Science (New York, N.Y.) 1994 Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE -
Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.
The Journal of biological chemistry 1994 Ji ZS, Lauer SJ, Fazio S, Bensadoun A, Taylor JM, Mahley RW -
Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia.
The Journal of biological chemistry 1994 Ji ZS, Fazio S, Mahley RW -
Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.
The Journal of biological chemistry 1994 Ji ZS, Fazio S, Lee YL, Mahley RW -
Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.
The Journal of biological chemistry 1994 de Silva HV, Lauer SJ, Wang J, Simonet WS, Weisgraber KH, Mahley RW, Taylor JM -
Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.
The Journal of biological chemistry 1993 Chiesa G, Johnson DF, Yao Z, Innerarity TL, Mahley RW, Young SG, Hammer RH, Hobbs HH -
Conformation of apolipoprotein E in lipoproteins.
The Journal of biological chemistry 1993 Lund-Katz S, Weisgraber KH, Mahley RW, Phillips MC -
A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder.
Journal of lipid research 1993 Bersot TP, Russell SJ, Thatcher SR, Pomernacki NK, Mahley RW, Weisgraber KH, Innerarity TL, Fox CS -
Epidemiology of hepatitis E virus infection in Turkey.
Lancet (London, England) 1993 Thomas DL, Mahley RW, Badur S, Palaoglu KE, Quinn TC -
Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.
The Journal of biological chemistry 1993 Ji ZS, Brecht WJ, Miranda RD, Hussain MM, Innerarity TL, Mahley RW -
Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice.
Biochemical Society transactions 1993 de Silva HV, Lauer SJ, Mahley RW, Weisgraber KH, Taylor JM -
Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100.
Metabolism: clinical and experimental 1993 Schmidt EB, Illingworth DR, Bacon S, Russell SJ, Thatcher SR, Mahley RW, Weisgraber KH -
Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100.
Atherosclerosis 1993 Schmidt EB, Illingworth DR, Bacon S, Mahley RW, Weisgraber KH -
Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.
Journal of lipid research 1992 Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE -
The role of apolipoprotein E genetic variants in lipoprotein disorders.
Journal of internal medicine 1992 Rall SC, Mahley RW -
Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100.
Lancet (London, England) 1992 Illingworth DR, Vakar F, Mahley RW, Weisgraber KH -
Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
The Journal of biological chemistry 1991 Hussain MM, Maxfield FR, Más-Oliva J, Tabas I, Ji ZS, Innerarity TL, Mahley RW -
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Science (New York, N.Y.) 1991 Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA -
Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism.
JAMA 1991 Mahley RW, Weisgraber KH, Innerarity TL, Rall SC -
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990 Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS -
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Journal of lipid research 1990 Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, Grundy SM, Friedl W, Davignon J, McCarthy BJ -
Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets.
Arteriosclerosis (Dallas, Tex.) 1990 Crook D, Weisgraber KH, Boyles JK, Mahley RW -
Isolation and characterization of several plasma apolipoproteins of common marmoset monkey.
Arteriosclerosis (Dallas, Tex.) 1990 Crook D, Weisgraber KH, Rall SC, Mahley RW -
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990 Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL -
Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E.
Annals of the New York Academy of Sciences 1990 Weisgraber KH, Innerarity TL, Rall SC, Mahley RW -
Chylomicron metabolism. Chylomicron uptake by bone marrow in different animal species.
The Journal of biological chemistry 1989 Hussain MM, Mahley RW, Boyles JK, Lindquist PA, Brecht WJ, Innerarity TL -
Lipoproteins and the pathogenesis of atherosclerosis.
Circulation 1989 Steinberg D, Carew TE, Fielding C, Fogelman AM, Mahley RW, Sniderman AD, Zilversmit DB -
Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake.
The Journal of biological chemistry 1989 Hussain MM, Mahley RW, Boyles JK, Fainaru M, Brecht WJ, Lindquist PA -
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.
The Journal of clinical investigation 1989 Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M -
Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletions.
The Journal of biological chemistry 1989 Lalazar A, Mahley RW -
Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.
The Journal of clinical investigation 1989 Rall SC, Newhouse YM, Clarke HR, Weisgraber KH, McCarthy BJ, Mahley RW, Bersot TP -
A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.
The Journal of clinical investigation 1989 Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ -
Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.
Arteriosclerosis (Dallas, Tex.) 1989 Weisgraber KH, Newhouse YM, Taylor JM, Tuan B, Nestruck AC, Davignon J, Mahley RW -
Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake.
Arteriosclerosis (Dallas, Tex.) 1989 Mahley RW, Hui DY, Innerarity TL, Beisiegel U -
Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes.
Biochemical and biophysical research communications 1988 Weisgraber KH, Newhouse YM, Mahley RW -
Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1988 Weisgraber KH, Innerarity TL, Newhouse YM, Young SG, Arnold KS, Krauss RM, Vega GL, Grundy SM, Mahley RW -
Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state.
The Journal of cell biology 1988 Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, Shooter EM, Gebicke-Haerter PJ -
Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins.
Journal of molecular biology 1988 Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA -
Apolipoprotein E-binding proteins isolated from dog and human liver.
Arteriosclerosis (Dallas, Tex.) 1988 Beisiegel U, Weber W, Havinga JR, Ihrke G, Hui DY, Wernette-Hammond ME, Turck CW, Innerarity TL, Mahley RW -
Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors.
The Journal of clinical investigation 1988 Koo C, Wernette-Hammond ME, Garcia Z, Malloy MJ, Uauy R, East C, Bilheimer DW, Mahley RW, Innerarity TL -
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
Science (New York, N.Y.) 1988 Mahley RW -
Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions.
The Journal of biological chemistry 1988 Lalazar A, Weisgraber KH, Rall SC, Giladi H, Innerarity TL, Levanon AZ, Boyles JK, Amit B, Gorecki M, Mahley RW -
Metabolism of canine beta-very low density lipoproteins in normal and cholesterol-fed dogs.
Arteriosclerosis (Dallas, Tex.) 1988 Fainaru M, Funke H, Boyles JK, Ludwig EH, Innerarity TL, Mahley RW -
Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.
Journal of lipid research 1987 Friedman G, Wernette-Hammond ME, Hui DY, Mahley RW, Innerarity TL -
Receptor binding activity of lipid recombinants of apolipoprotein B-100 thrombolytic fragments.
Journal of lipid research 1987 Corsini A, Spilman CH, Innerarity TL, Arnold KS, Rall SC, Boyles JK, Mahley RW -
Structural relationship of human apolipoprotein B48 to apolipoprotein B100.
The Journal of clinical investigation 1987 Innerarity TL, Young SG, Poksay KS, Mahley RW, Smith RS, Milne RW, Marcel YL, Weisgraber KH -
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.
Proceedings of the National Academy of Sciences of the United States of America 1987 Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, Grundy SM -
DNA sequence of the human apolipoprotein B gene.
DNA (Mary Ann Liebert, Inc.) 1987 Ludwig EH, Blackhart BD, Pierotti VR, Caiati L, Fortier C, Knott T, Scott J, Mahley RW, Levy-Wilson B, McCarthy BJ -
Lipoprotein uptake by neuronal growth cones in vitro.
Science (New York, N.Y.) 1987 Ignatius MJ, Shooter EM, Pitas RE, Mahley RW -
Human apolipoprotein B: complete cDNA sequence and identification of structural domains of the protein.
Biochemical Society transactions 1987 Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ -
Mapping of human apolipoprotein B antigenic determinants.
Arteriosclerosis (Dallas, Tex.) 1987 Marcel YL, Innerarity TL, Spilman C, Mahley RW, Protter AA, Milne RW -
Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis.
Experimental neurology 1987 Gebicke-Haerter PJ, Darby JK, Shooter EM, Riccardi VM, Weisgraber KH, Boyles JK, Mahley RW -
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins.
Biochimica et biophysica acta 1987 Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW -
Apolipoprotein B gene: plasma cholesterol and atherosclerosis.
Biochemical Society symposium 1987 Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ -
Functional domains of apolipoprotein E and apolipoprotein B.
Acta medica Scandinavica. Supplementum 1987 Innerarity TL, Weisgraber KH, Rall SC, Mahley RW -
The molecular basis of atherosclerosis: concepts derived from studies of lipoprotein metabolism and cell biology.
Clinical and investigative medicine. Medecine clinique et experimentale 1986 Mahley RW -
Complete cDNA and derived protein sequence of human apolipoprotein B-100.
Nucleic acids research 1986 Knott TJ, Wallis SC, Powell LM, Pease RJ, Lusis AJ, Blackhart B, McCarthy BJ, Mahley RW, Levy-Wilson B, Scott J -
Pathology: plasma cholesterol levels determined by lipoprotein interactions with cell surface receptors.
The Western journal of medicine 1986 Mahley RW, Innerarity TL, Hui DY, Weisgraber KH, Pitas RE -
Expression of the human apolipoprotein E gene in cultured mammalian cells.
The Journal of biological chemistry 1986 Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM -
Identification of homozygosity for a human apolipoprotein A-I variant.
Journal of lipid research 1986 Rall SC, Weisgraber KH, Mahley RW, Ehnholm C, Schamaun O, Olaisen B, Blomhoff JP, Teisberg P -
Isolation and characterization of the apolipoprotein E receptor from canine and human liver.
The Journal of biological chemistry 1986 Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW -
Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.
The Journal of biological chemistry 1986 Weisgraber KH, Rall SC, Mahley RW, Milne RW, Marcel YL, Sparrow JT -
Expression of apolipoprotein E during nerve degeneration and regeneration.
Proceedings of the National Academy of Sciences of the United States of America 1986 Ignatius MJ, Gebicke-Härter PJ, Skene JH, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM -
Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages.
The Journal of clinical investigation 1986 Bersot TP, Innerarity TL, Pitas RE, Rall SC, Weisgraber KH, Mahley RW -
Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages.
Arteriosclerosis (Dallas, Tex.) 1986 Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW -
Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions.
Cold Spring Harbor symposia on quantitative biology 1986 Mahley RW, Innerarity TL, Weisgraber KH, Rall SC, Hui DY, Lalazar A, Boyles JK, Taylor JM, Levy-Wilson B -
Characterization of apolipoprotein E-containing lipoproteins.
Methods in enzymology 1986 Weisgraber KH, Mahley RW -
Cloning and expression of the human apolipoprotein E gene.
Methods in enzymology 1986 Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM -
Cloning of the cDNA for rat and human apolipoprotein E mRNA.
Methods in enzymology 1986 Taylor JM, Mahley RW, Fukazawa C -
Isolation and characterization of apolipoprotein E.
Methods in enzymology 1986 Rall SC, Weisgraber KH, Mahley RW -
Lipoprotein-receptor interactions.
Methods in enzymology 1986 Innerarity TL, Pitas RE, Mahley RW -
Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions.
Advances in experimental medicine and biology 1986 Innerarity TL, Hui DY, Bersot TP, Mahley RW -
Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels.
Analytical biochemistry 1985 Weisgraber KH, Newhouse YM, Seymour JL, Rall SC, Mahley RW -
Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology.
Circulation 1985 Mahley RW -
Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins.
The Journal of biological chemistry 1985 Koo C, Innerarity TL, Mahley RW -
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.
The Journal of clinical investigation 1985 Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM -
Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis.
Arteriosclerosis (Dallas, Tex.) 1985 Cornhill JF, Barrett WA, Herderick EE, Mahley RW, Fry DL -
Receptor interactions controlling lipoprotein metabolism.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1985 Weisgraber KH, Innerarity TL, Rall SC, Mahley RW -
Nucleotide sequence and structure of the human apolipoprotein E gene.
Proceedings of the National Academy of Sciences of the United States of America 1985 Paik YK, Chang DJ, Reardon CA, Davies GE, Mahley RW, Taylor JM -
Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.
Proceedings of the National Academy of Sciences of the United States of America 1985 Elshourbagy NA, Liao WS, Mahley RW, Taylor JM -
Apolipoprotein E: receptor binding properties.
Advances in experimental medicine and biology 1985 Weisgraber KH, Innerarity TL, Rall SC, Mahley RW -
Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia.
Annals of the New York Academy of Sciences 1985 Mahley RW, Innerarity TL, Rall SC, Weisgraber KH -
Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.
The Journal of cell biology 1985 Pitas RE, Boyles J, Mahley RW, Bissell DM -
Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. A process independent of apolipoprotein B48.
The Journal of biological chemistry 1984 Hui DY, Innerarity TL, Milne RW, Marcel YL, Mahley RW -
Plasma lipoproteins: apolipoprotein structure and function.
Journal of lipid research 1984 Mahley RW, Innerarity TL, Rall SC, Weisgraber KH -
Apolipoprotein A-IGiessen (Pro143----Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase.
European journal of biochemistry 1984 Utermann G, Haas J, Steinmetz A, Paetzold R, Rall SC, Weisgraber KH, Mahley RW -
Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia.
Proceedings of the National Academy of Sciences of the United States of America 1984 Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL -
Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells.
Arteriosclerosis (Dallas, Tex.) 1984 Funke H, Boyles J, Weisgraber KH, Ludwig EH, Hui DY, Mahley RW -
Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.
The Journal of biological chemistry 1984 Rall SC, Weisgraber KH, Mahley RW, Ogawa Y, Fielding CJ, Utermann G, Haas J, Steinmetz A, Menzel HJ, Assmann G -
Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.
The Journal of biological chemistry 1984 Innerarity TL, Weisgraber KH, Arnold KS, Rall SC, Mahley RW -
Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.
The Journal of biological chemistry 1984 McLean JW, Elshourbagy NA, Chang DJ, Mahley RW, Taylor JM -
A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1.
The Journal of clinical investigation 1984 Weisgraber KH, Rall SC, Innerarity TL, Mahley RW, Kuusi T, Ehnholm C -
Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.
Journal of lipid research 1984 Utermann G, Weisgraber KH, Weber W, Mahley RW -
Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type.
The Journal of biological chemistry 1984 Menzel HJ, Assmann G, Rall SC, Weisgraber KH, Mahley RW -
Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma.
Metabolism: clinical and experimental 1984 Innerarity TL, Bersot TP, Arnold KS, Weisgraber KH, Davis PA, Forte TM, Mahley RW -
Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E.
The Journal of biological chemistry 1984 Hui DY, Innerarity TL, Mahley RW -
Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase.
Agents and actions. Supplements 1984 Steinmetz A, Utermann G, Haas J, Menzel HJ, Rall SC, Weisgraber KH, Mahley RW -
Type III hyperlipoproteinemia: recent insights into the genetic defect of familial dysbetalipoproteinemia.
Advances in internal medicine 1984 Mahley RW, Angelin B -
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
The Journal of biological chemistry 1983 Innerarity TL, Friedlander EJ, Rall SC, Weisgraber KH, Mahley RW -
The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.
The Journal of biological chemistry 1983 Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT -
Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.
The Journal of clinical investigation 1983 Rall SC, Weisgraber KH, Innerarity TL, Bersot TP, Mahley RW, Blum CB -
Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-i) with high density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1983 Schmitz G, Assmann G, Rall SC, Mahley RW -
Cholesteryl ester accumulation in mouse peritoneal macrophages induced by beta-migrating very low density lipoproteins from patients with atypical dysbetalipoproteinemia.
The Journal of clinical investigation 1983 Bersot TP, Innerarity TL, Mahley RW, Havel RJ -
Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies.
Archives of pathology & laboratory medicine 1983 Mahley RW -
Verapamil suppresses atherosclerosis in cholesterol-fed rabbits.
Journal of the American College of Cardiology 1983 Rouleau JL, Parmley WW, Stevens J, Wikman-Coffelt J, Sievers R, Mahley RW, Havel RJ -
Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro.
The Journal of biological chemistry 1983 Gordon V, Innerarity TL, Mahley RW -
Lipoprotein receptors and cholesterol homeostasis.
Biochimica et biophysica acta 1983 Mahley RW, Innerarity TL -
Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.
The Journal of clinical investigation 1983 Rall SC, Weisgraber KH, Innerarity TL, Mahley RW -
Regulation of hepatic lipoprotein receptors in the dog. Rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids.
The Journal of clinical investigation 1983 Angelin B, Raviola CA, Innerarity TL, Mahley RW -
Apolipoprotein E and cholesterol metabolism.
Klinische Wochenschrift 1983 Mahley RW -
Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I.
The Journal of biological chemistry 1983 Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR -
Foam cells in explants of atherosclerotic rabbit aortas have receptors for beta-very low density lipoproteins and modified low density lipoproteins.
Arteriosclerosis (Dallas, Tex.) 1983 Pitas RE, Innerarity TL, Mahley RW -
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.
Journal of lipid research 1982 Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C -
Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.
Proceedings of the National Academy of Sciences of the United States of America 1982 Rall SC, Weisgraber KH, Innerarity TL, Mahley RW -
Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.
Journal of lipid research 1982 Fainaru M, Mahley RW, Hamilton RL, Innerarity TL -
Yucatan miniature swine as a model for diet-induced atherosclerosis.
Atherosclerosis 1982 Reitman JS, Mahley RW, Fry DL -
Human apolipoprotein E. The complete amino acid sequence.
The Journal of biological chemistry 1982 Rall SC, Weisgraber KH, Mahley RW -
Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site.
The Journal of biological chemistry 1982 Weisgraber KH, Innerarity TL, Mahley RW -
Atherogenic hyperlipoproteinemia. The cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol.
The Medical clinics of North America 1982 Mahley RW -
Modulating effects of canine high density lipoproteins on cholesteryl ester synthesis induced by beta-very low density lipoproteins in macrophages. Possible in vitro correlates with atherosclerosis.
Arteriosclerosis (Dallas, Tex.) 1982 Innerarity TL, Pitas RE, Mahley RW -
Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
The Journal of clinical investigation 1981 Mahley RW, Hui DY, Innerarity TL, Weisgraber KH -
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
The Journal of clinical investigation 1981 Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW -
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.
The Journal of biological chemistry 1981 Weisgraber KH, Rall SC, Mahley RW -
Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites.
Proceedings of the National Academy of Sciences of the United States of America 1981 Innerarity TL, Kempner ES, Hui DY, Mahley RW -
Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
The Journal of biological chemistry 1981 Hui DY, Innerarity TL, Mahley RW -
Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.
Arteriosclerosis (Dallas, Tex.) 1981 Pitas RE, Innerarity TL, Weinstein JN, Mahley RW -
Chylomicron metabolism during dietary-induced hypercholesterolemia in dogs.
Journal of lipid research 1981 Melchior GW, Mahley RW, Buckhold DK -
Effect of arterial stretch on transmural albumin and Evan's blue dye transport.
The American journal of physiology 1981 Fry DL, Mahley RW, Oh SY -
Aortic transmural serum protein transport: effect of concentration, time, and location.
The American journal of physiology 1981 Fry DL, Mahley RW, Oh SY, Swyt CR -
Cellular and molecular biology of lipoprotein metabolism in atherosclerosis.
Diabetes 1981 Mahley RW -
The role of dietary fat and cholesterol in atherosclerosis and lipoprotein metabolism.
The Western journal of medicine 1981 Mahley RW -
Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.
The Journal of biological chemistry 1980 Hui DY, Harmony JA, Innerarity TL, Mahley RW -
Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity.
The Journal of biological chemistry 1980 Innerarity TL, Pitas RE, Mahley RW -
A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.
The Journal of clinical investigation 1980 Franceschini G, Sirtori CR, Capurso A, Weisgraber KH, Mahley RW -
A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins.
The Journal of clinical investigation 1980 Weisgraber KH, Bersot TP, Mahley RW, Franceschini G, Sirtori CR -
Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species.
Journal of lipid research 1980 Mahley RW, Innerarity TL, Brown MS, Ho YK, Goldstein JL -
Effect of cholesterol supplementation of diets of thyroidectomized dogs on the fatty acid composition of erythrocyte phospholipids and plasma phosphatidylcholine.
Biochimica et biophysica acta 1980 Pitas RE, Nelson GJ, Mahley RW -
Receptor binding of cholesterol-induced high-density lipoproteins containing predominantly apoprotein E to cultured fibroblasts with mutations at the low-density lipoprotein receptor locus.
Biochemistry 1980 Innerarity TL, Pitas RE, Mahley RW -
Quantitative microautoradiography of arteries: comparison of radioactivity to silver.
The American journal of physiology 1980 Fry DL, Mahley RW, Oh SY, Lewis SJ, Plowman F, Swyt CR -
Comparison of the human, canine and swine E apoproteins.
Biochemical and biophysical research communications 1980 Weisgraber KH, Troxler RF, Rall SC, Mahley RW -
Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein.
The Journal of biological chemistry 1980 Pitas RE, Innerarity TL, Mahley RW -
Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.
The Journal of biological chemistry 1980 Goldstein JL, Ho YK, Brown MS, Innerarity TL, Mahley RW -
Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.
The Journal of biological chemistry 1980 Sherrill BC, Innerarity TL, Mahley RW -
Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography.
Journal of lipid research 1980 Weisgraber KH, Mahley RW -
Atherosclerosis in the Erythrocebus patas, an old world monkey.
The American journal of pathology 1980 Mahley RW, Johnson DK, Pucak GJ, Fry DL -
Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins.
Annals of the New York Academy of Sciences 1980 Mahley RW, Innerarity TL, Weisgraber KH -
Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1980 Mahley RW, Weisgraber KH, Melchior GW, Innerarity TL, Holcombe KS -
Changes induced in the lipoproteins of Yucatan miniature swine by cholesterol feeding.
Biochimica et biophysica acta 1979 Reitman JS, Mahley RW -
Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors.
Biochimica et biophysica acta 1979 Mahley RW, Weisgraber KH, Innerarity TL -
Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins.
The Journal of clinical investigation 1979 Mahley RW, Innerarity TL, Weisgraber KB, Oh SY -
Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.
The Journal of biological chemistry 1979 Innerarity TL, Pitas RE, Mahley RW -
Effects of diets high in saturated fat and cholesterol on the lipid composition of canine platelets.
Lipids 1979 Pitas RE, Nelson GJ, Jaffe RM, Mahley RW -
Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc.
Proceedings of the National Academy of Sciences of the United States of America 1979 Pitas RE, Innerarity TL, Arnold KS, Mahley RW -
Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues.
Proceedings of the National Academy of Sciences of the United States of America 1979 Mahley RW, Weisgraber KH, Innerarity TL, Windmueller HG -
Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.
The Journal of biological chemistry 1978 Weisgraber KH, Innerarity TL, Mahley RW -
Isolation and characterization of an apoprotein from the d less than 1.006 lipoproteins of human and canine lymph homologous with the rat A-IV apoprotein.
Biochemical and biophysical research communications 1978 Weisgraber KH, Bersot TP, Mahley RW -
Alterations in human high-density lipoproteins, with or without increased plasma-cholesterol, induced by diets high in cholesterol.
Lancet (London, England) 1978 Mahley RW, Innerarity TL, Bersot TP, Lipson A, Margolis S -
Structural organization of the lipoprotein HDLc from atherosclerotic swine. Structural features relating the particle surface and core.
Biochemistry 1978 Atkinson D, Tall AR, Small DM, Mahley RW -
Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction.
The Journal of biological chemistry 1978 Weisgraber KH, Mahley RW -
Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex.
The Journal of biological chemistry 1978 Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP -
delta 15,18-tetracosadienoic acid content of sphingolipids from platelets and erythrocytes of animals fed diets high in saturated or polyunsaturated fats.
Lipids 1978 Pitas RE, Nelson GJ, Jaffe RM, Mahley RW -
Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins.
Biochemistry 1978 Innerarity TL, Mahley RW -
Characterization of the lipoproteins of atherosclerotic swine.
The Journal of biological chemistry 1977 Tall AR, Atkinson D, Small DM, Mahley RW -
Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.
The Journal of biological chemistry 1977 Mahley RW, Innerarity TL, Pitas RE, Weisgraber KH, Brown JH, Gross E -
The rat arginine-rich apoprotein and its redistribution following injection of iodinated lipoproteins into normal and hypercholesterolemic rats.
Atherosclerosis 1977 Weisgraber KH, Mahley RW, Assmann G -
Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall.
The American journal of physiology 1977 Fry DL, Mahley RW, Weisgraber KH, Oh SY -
Interaction of canine and swine lipoproteins with the low density lipoprotein receptor of fibroblasts as correlated with heparin/manganese precipitability.
The Journal of biological chemistry 1977 Mahley RW, Innerarity TL -
Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat.
Journal of lipid research 1977 Mahley RW, Holcombe KS -
Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.
The American journal of pathology 1977 Mahley RW, Innerarity TL, Weisgraber KH, Fry DL -
Lipoproteins and arterial smooth muscle cells: regulation of cellular metabolism by swine lipoproteins.
Advances in experimental medicine and biology 1977 Mahley RW -
Swine aortic smooth muscle in tissue culture. Some effects of purified swine lipoproteins on cell growth and morphology.
Circulation research 1976 Brown BG, Mahley R, Assmann G -
Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey.
Biochemistry 1976 Mahley RW, Weisgraber KH, Innerarity T -
Thrombosis in association with atherosclerosis induced by dietary perturbations in dogs.
Science (New York, N.Y.) 1976 Mahley R, Nelson AW, Ferrans VJ, Fry DL -
Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey.
Biochemistry 1976 Mahley RW, Weisgraber KH, Innerarity T, Brewer HB -
Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.
The Journal of biological chemistry 1976 Bersot TP, Mahley RW, Brown MS, Goldstein JL -
Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding.
Biochemistry 1975 Mahley RW, Weisgraber KH, Innerarity T, Brewer HB, Assmann G -
Canine lipoproteins and atherosclerosis. I. Isolation and characterization of plasma lipoproteins from control dogs.
Circulation research 1974 Mahley RW, Weisgraber KH -
Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia.
Circulation research 1974 Mahley RW, Weisgraber KH, Innerarity T -
Incorporation of sialic acid into sialidase-treated apolipoprotein of human, very low density lipoprotein by a pork liver sialytransferase.
Canadian journal of biochemistry 1974 Wetmore S, Mahley RW, Brown WV, Schachter H -
An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins.
Biochemistry 1974 Mahley RW, Weisgraber KH -
Cholesterol esterification by the rat liver Golgi apparatus.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1974 Assmann G, Mahley RW, Davis B, Holcombe KS -
Role of plasma lipoproteins in cortisone-induced fat embolism.
The American journal of pathology 1972 Mahley RW, Gray ME, LeQuire VS -
Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine.
Laboratory investigation; a journal of technical methods and pathology 1971 Mahley RW, Bennett BD, Morré DJ, Gray ME, Thistlethwaite W, LeQuire VS -
Identity of very low density lipoprotein apoproteins of plasma and liver Golgi apparatus.
Science (New York, N.Y.) 1970 Mahley RW, Bersot TP, LeQuire VS, Levy RI, Windmueller HG, Brown WV -
Barr body studies from the hair.
Lancet (London, England) 1970 Engel E, Culbertson JC, Mahley RW, Fenichel GM -
Isolation of a Golgi apparatus-rich fraction from rat liver. I. Method and morphology.
The Journal of cell biology 1970 Morré DJ, Hamilton RL, Mollenhauer HH, Mahley RW, Cunningham WP, Cheetham RD, Lequire VS -
Characterization of lipoprotein particles isolated from the Golgi apparatus of rat liver.
Journal of lipid research 1969 Mahley RW, Hamilton RL, Lequire VS -
Lipid transport in liver. II. Electron microscopic and biochemical studies of alterations in lipoprotein transport induced by cortisone in the rabbit.
Laboratory investigation; a journal of technical methods and pathology 1968 Mahley RW, Gray ME, Hamilton RL, LeQuire VS