Robert Fletterick, PhD
Professor
Biochemistry and Biophysics
School of Medicine

Websites

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• Profile at www.msg.ucsf.edu (msg.ucsf.edu)

Grants and Projects

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• Structures of Protein Complexes Regulating Transcription in Enbryonic Stem Cells, NIH, 2010-2016
• A Synchroton Radiation Structural Biology Resource, NIH, 1980-2015
• Screening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells, NIH, 2012-2013
• Macromolecular Diffraction Resource: MacCHESS, NIH, 1983-2013
• Mechanisms of regulation of LRH-1, Nanog and SF-1 by DAX-1, NIH, 2007-2012
• Nuclear receptor LRH-1 in pancreatic cancer, NIH, 2010-2012
• Imaging Nuclear Receptor LRH-1 in Functional Transcriptional Assemblies, NIH, 2009-2011
• Structure and Function of Molecular Motors, NIH, 1994-2010
• Folding of Androgen Receptor-Coregulator Complex, NIH, 2006-2008
• A State-of-the-art BIACORE for UCSF Mission Bay, NIH, 2007-2008
• Conformational Changes in Actin, NIH, 2003-2007
• Crystal Farm Imaging System, NIH, 2006-2007
• Regulation of Orphan Nuclear Receptors Lrh-1 and Sf-1, NIH, 2004-2006
• Structure and Dynamics of Nuclear Receptors, NIH, 2000-2006
• Neutron Studies of Regulation of Vertebrate Muscle, NIH, 1999-2005
• Inhibition of Androgen Receptor Activation, NIH, 2002-2004
• Protease Specificity and Inhibition, NIH, 1988-2004
• Regulating Neurotransmitters through Monoamine Oxidases, NIH, 1999-2003
• Linking Structure to Response in Thyroid Receptor, NIH, 1998-2003
• Cns Degeneration Caused by Novel Pathogens, NIH, 1900-2002
• Evolution of Allosteric Regulation in Phosphorylase, NIH, 1984-2000
• Excellence in Molecular Biology, NIH, 1989-1997
• Structure-function Relationships in Phosphorylase a, NIH, 1979-1994
• Molecular Biology of Cellular Growth Control, NIH, 1983-1993
• Structure-function Relationships in Phosphorylase a, NIH, 1979-1989
• Primary and Tertiary Structures of Human Phosphorylases, NIH, 1984-1986

Publications (263)

Top publication keywords:
Receptors, Thyroid HormoneProtein Structure, TertiaryPhosphorylasesAmino Acid SequenceReceptors, Cytoplasmic and NuclearModels, MolecularCalmodulin-Binding ProteinsEscherichia coli ProteinsMolecular Motor ProteinsReceptors, AndrogenPeriplasmic ProteinsCrystallography, X-RayTrypsinProtein ConformationBinding Sites

• Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.
  Cell chemical biology 2019 Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM
• LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
  Nature communications 2018 Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA
• Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen.
  ACS chemical biology 2017 de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM
• NR5A2 discovering compounds that block tumor growth in PDAC.
  Journal of surgical oncology 2017 Fletterick R
• Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2).
  PloS one 2016 de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM

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• Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome.
  Journal of molecular biology 2016 Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P
• A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.
  eLife 2015 Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA
• Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.
  Journal of structural biology 2015 Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ
• The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling.
  PloS one 2015 Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson JÅ, Webb P, Cox MB
• Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick …
• Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
  Nature communications 2015 Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG
• Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ
• Advances in our structural understanding of orphan nuclear receptors.
  Trends in biochemical sciences 2014 Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E
• The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA
• Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients.
  Thyroid : official journal of the American Thyroid Association 2014 Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG
• The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.
  PloS one 2014 Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P
• Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P
• Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease.
  Thyroid : official journal of the American Thyroid Association 2013 Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE
• Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization.
  PloS one 2013 Vinogradova MV, Malanina GG, Waitzman JS, Rice SE, Fletterick RJ
• Structure-based discovery of antagonists of nuclear receptor LRH-1.
  The Journal of biological chemistry 2013 Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ
• Structure of a novel winged-helix like domain from human NFRKB protein.
  PloS one 2012 Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA
• Structural basis of coactivation of liver receptor homolog-1 by β-catenin.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ
• Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP
• A conserved surface on the ligand binding domain of nuclear receptors for allosteric control.
  Molecular and cellular endocrinology 2011 Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E
• Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
  Proceedings of the National Academy of Sciences of the United States of America 2011 De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB
• Decoration of microtubules in solution by the kinesin-14, Ncd.
  Acta crystallographica. Section D, Biological crystallography 2010 Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA
• Conformation switching of clathrin light chain regulates clathrin lattice assembly.
  Developmental cell 2010 Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM
• Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.
  The Journal of biological chemistry 2010 Pfaff SJ, Fletterick RJ
• Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.
  Acta crystallographica. Section D, Biological crystallography 2010 Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ
• Structure of the complex of a mitotic kinesin with its calcium binding regulator.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ
• Molecular basis for dimer formation of TRbeta variant D355R.
  Proteins 2009 Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ
• The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ
• Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.
  Molecular endocrinology (Baltimore, Md.) 2008 Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA
• 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.
  Journal of medicinal chemistry 2008 Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM
• Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
  The Journal of biological chemistry 2008 Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM
• Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein.
  Journal of structural biology 2008 Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ
• Interaction between the androgen receptor and a segment of its corepressor SHP.
  Acta crystallographica. Section D, Biological crystallography 2007 Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ
• Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.
  Journal of medicinal chemistry 2007 Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK
• A surface on the androgen receptor that allosterically regulates coactivator binding.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ
• Perspectives on designs of antiandrogens for prostate cancer.
  Expert opinion on drug discovery 2007 Estébanez-Perpiñá E, Jouravel N, Fletterick RJ
• Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
  Molecular endocrinology (Baltimore, Md.) 2007 Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ
• The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
  Structure (London, England : 1993) 2007 Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH
• Ca ion and the troponin switch.
  Advances in experimental medicine and biology 2007 Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ
• Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH
• Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
  Journal of molecular biology 2006 Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A
• A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.
  Science's STKE : signal transduction knowledge environment 2006 Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK
• An atomic model of the thin filament in the relaxed and Ca2+-activated states.
  Journal of molecular biology 2006 Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W
• Dynamics of the C-terminal region of TnI in the troponin complex in solution.
  Biophysical journal 2006 Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD
• Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer.
  BJU international 2005 Fletterick RJ
• Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.
  The Journal of biological chemistry 2005 Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK
• Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation.
  The Journal of biological chemistry 2005 Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P
• Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex.
  The Journal of biological chemistry 2005 Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD
• Ca(2+)-regulated structural changes in troponin.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ
• Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design.
  The Journal of steroid biochemistry and molecular biology 2005 Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD
• Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
  Cell 2005 Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM,…
• The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
  The Journal of biological chemistry 2004 Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK
• Thyroxine-thyroid hormone receptor interactions.
  The Journal of biological chemistry 2004 Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD
• Recognition and accommodation at the androgen receptor coactivator binding interface.
  PLoS biology 2004 Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ
• Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity.
  The Journal of biological chemistry 2004 Ruggles SW, Fletterick RJ, Craik CS
• Structure of a kinesin microtubule depolymerization machine.
  The EMBO journal 2004 Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R
• Crystal structure of kinesin regulated by Ca(2+)-calmodulin.
  The Journal of biological chemistry 2004 Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ
• Coordination between motor domains in processive kinesins.
  The Journal of biological chemistry 2004 Sablin EP, Fletterick RJ
• Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ
• The extended interactions and Gla domain of blood coagulation factor Xa.
  Biochemistry 2003 Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ
• The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
  Nature structural biology 2003 Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS
• Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.
  Molecular cell 2003 Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA
• Two resistance to thyroid hormone mutants with impaired hormone binding.
  Molecular endocrinology (Baltimore, Md.) 2003 Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ
• Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
  Molecular endocrinology (Baltimore, Md.) 2003 Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ
• Design of thyroid hormone receptor antagonists from first principles.
  The Journal of steroid biochemistry and molecular biology 2002 Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD
• How does ATP hydrolysis control actin's associations?
  Proceedings of the National Academy of Sciences of the United States of America 2002 Sablin EP, Dawson JF, VanLoock MS, Spudich JA, Egelman EH, Fletterick RJ
• The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding.
  The Journal of biological chemistry 2002 Walther M, Anton M, Wiedmann M, Fletterick R, Kuhn H
• Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.
  Endocrinology 2002 Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S
• TR surfaces and conformations required to bind nuclear receptor corepressor.
  Molecular endocrinology (Baltimore, Md.) 2002 Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson JL, Fletterick RJ, Baxter JD, West BL
• Nucleotide switches in molecular motors: structural analysis of kinesins and myosins.
  Current opinion in structural biology 2001 Sablin EP, Fletterick RJ
• Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study.
  Annals of neurology 2001 Martín MA, Rubio JC, Buchbinder J, Fernández-Hojas R, del Hoyo P, Teijeira S, Gámez J, Navarro C, Fernández JM, Cabello A, Campos Y, Cervera C, Culebras JM, Andreu AL, Fletterick R, Arenas J
• Switch-based mechanism of kinesin motors.
  Nature 2001 Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N
• The role of ecotin dimerization in protease inhibition.
  Journal of molecular biology 2001 Eggers CT, Wang SX, Fletterick RJ, Craik CS
• Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
  The Journal of biological chemistry 2001 Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R
• Hormone selectivity in thyroid hormone receptors.
  Molecular endocrinology (Baltimore, Md.) 2001 Wagner RL, Huber BR, Shiau AK, Kelly A, Cunha Lima ST, Scanlan TS, Apriletti JW, Baxter JD, West BL, Fletterick RJ
• Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor.
  The Journal of biological chemistry 2001 Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD
• Selective modulation of thyroid hormone receptor action.
  The Journal of steroid biochemistry and molecular biology 2001 Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS
• Structural relationships among regulated and unregulated phosphorylases.
  Annual review of biophysics and biomolecular structure 2001 Buchbinder JL, Rath VL, Fletterick RJ
• Three-dimensional structural analysis of fibronectin heparin-binding domain mutations.
  Journal of cellular biochemistry. Supplement 2001 Kapila Y, Doan D, Tafolla E, Fletterick R
• The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity.
  Nature structural biology 2000 Waugh SM, Harris JL, Fletterick R, Craik CS
• A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
  Structure (London, England : 1993) 2000 Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ
• Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
  Journal of molecular biology 2000 Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ
• Searching for kinesin's mechanical amplifier.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000 Vale RD, Case R, Sablin E, Hart C, Fletterick R
• Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.
  The Journal of biological chemistry 1999 Borngräber S, Browner M, Gillmor S, Gerth C, Anton M, Fletterick R, Kühn H
• Visualizing a new binding site of ncd-motor domain on tubulin.
  Journal of structural biology 1999 Han Y, Sablin EP, Nogales E, Fletterick RJ, Downing KH
• Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
  Journal of molecular biology 1999 Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE
• Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3).
  Journal of cellular biochemistry 1999 Norman AW, Adams D, Collins ED, Okamura WH, Fletterick RJ
• Clathrin self-assembly is mediated by a tandemly repeated superhelix.
  Nature 1999 Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK
• Nuclear-receptor ligands and ligand-binding domains.
  Annual review of biochemistry 1999 Weatherman RV, Fletterick RJ, Scanlan TS
• Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
  Biochemistry 1998 Butte MJ, Hwang PK, Mobley WC, Fletterick RJ
• Molecular and structural biology of thyroid hormone receptors.
  Clinical and experimental pharmacology & physiology. Supplement 1998 Apriletti JW, Ribeiro RC, Wagner RL, Feng W, Webb P, Kushner PJ, West BL, Nilsson S, Scanlan TS, Fletterick RJ, Baxter JD
• Structure and specificity of nuclear receptor-coactivator interactions.
  Genes & development 1998 Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR
• The case for a common ancestor: kinesin and myosin motor proteins and G proteins.
  Journal of muscle research and cell motility 1998 Kull FJ, Vale RD, Fletterick RJ
• A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
  Biochemistry 1998 Focia PJ, Craig SP, Nieves-Alicea R, Fletterick RJ, Eakin AE
• Direction determination in the minus-end-directed kinesin motor ncd.
  Nature 1998 Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ
• A comparison of the crystallographic structures of two catalytic antibodies with esterase activity.
  Journal of molecular biology 1998 Buchbinder JL, Stephenson RC, Scanlan TS, Fletterick RJ
• A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone.
  The EMBO journal 1998 Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, Rajanayagam O, Agostini M, Fletterick RJ, Beck-Peccoz P, Reinhardt W, Binder G, Ranke MB, Hermus A, Hesch RD, Lazarus J, Newrick P, …
• Is the tubulin/FtsZ fold related to the G-protein fold?
  Trends in cell biology 1998 Kull FJ, Fletterick RJ
• Ecotin: a serine protease inhibitor with two distinct and interacting binding sites.
  Journal of molecular biology 1998 Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS
• Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors.
  Science (New York, N.Y.) 1998 Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL
• A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation.
  Molecular endocrinology (Baltimore, Md.) 1998 Clifton-Bligh RJ, de Zegher F, Wagner RL, Collingwood TN, Francois I, Van Helvoirt M, Fletterick RJ, Chatterjee VK
• Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan.
  Biochemistry 1998 Somoza JR, Skillman AG, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC
• Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family.
  Biochemistry 1998 Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ
• DAX1 mutations map to putative structural domains in a deduced three-dimensional model.
  American journal of human genetics 1998 Zhang YH, Guo W, Wagner RL, Huang BL, McCabe L, Vilain E, Burris TP, Anyane-Yeboa K, Burghes AH, Chitayat D, Chudley AE, Genel M, Gertner JM, Klingensmith GJ, Levine SN, Nakamoto J, New MI, Pagon RA, …
• X-ray crystallographic and functional studies of thyroid hormone receptor.
  The Journal of steroid biochemistry and molecular biology 1998 Ribeiro RC, Apriletti JW, Wagner RL, Feng W, Kushner PJ, Nilsson S, Scanlan TS, West BL, Fletterick RJ, Baxter JD
• Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.
  Recent progress in hormone research 1998 Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD
• The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
  Nature structural biology 1997 Gillmor SA, Villaseñor A, Fletterick R, Sigal E, Browner MF
• Distinct phosphorylation signals converge at the catalytic center in glycogen phosphorylases.
  Structure (London, England : 1993) 1997 Lin K, Hwang PK, Fletterick RJ
• Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.
  Biochemistry 1997 Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC
• Structural determinants of specificity in the cysteine protease cruzain.
  Protein science : a publication of the Protein Society 1997 Gillmor SA, Craik CS, Fletterick RJ
• A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis.
  Cell 1997 Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale RD, Milligan RA
• Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation.
  Biochemistry 1997 Buchbinder JL, Luong CB, Browner MF, Fletterick RJ
• Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
  Biochemistry 1997 Perona JJ, Tsu CA, Craik CS, Fletterick RJ
• Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.
  Biochemistry 1997 Tsu CA, Perona JJ, Fletterick RJ, Craik CS
• Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site.
  Biochimica et biophysica acta 1997 Craig SP, Focia PJ, Fletterick RJ
• A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Collingwood TN, Rajanayagam O, Adams M, Wagner R, Cavaillès V, Kalkhoven E, Matthews C, Nystrom E, Stenlof K, Lindstedt G, Tisell L, Fletterick RJ, Parker MG, Chatterjee VK
• The design plan of kinesin motors.
  Annual review of cell and developmental biology 1997 Vale RD, Fletterick RJ
• A protein phosphorylation switch at the conserved allosteric site in GP.
  Science (New York, N.Y.) 1996 Lin K, Rath VL, Dai SC, Fletterick RJ, Hwang PK
• Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding.
  The Journal of biological chemistry 1996 Buchbinder JL, Fletterick RJ
• Structure-based design of parasitic protease inhibitors.
  Bioorganic & medicinal chemistry 1996 Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL
• Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.
  Biochemistry 1996 Somoza JR, Chin MS, Focia PJ, Wang CC, Fletterick RJ
• Delocalizing trypsin specificity with metal activation.
  Biochemistry 1996 Willett WS, Brinen LS, Fletterick RJ, Craik CS
• X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
  Biochemistry 1996 Brinen LS, Willett WS, Craik CS, Fletterick RJ
• High-level expression and characterization of a purified 142-residue polypeptide of the prion protein.
  Biochemistry 1996 Mehlhorn I, Groth D, Stöckel J, Moffat B, Reilly D, Yansura D, Willett WS, Baldwin M, Fletterick R, Cohen FE, Vandlen R, Henner D, Prusiner SB
• The evolution of an allosteric site in phosphorylase.
  Structure (London, England : 1993) 1996 Rath VL, Lin K, Hwang PK, Fletterick RJ
• Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.
  Nature 1996 Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD
• Crystal structure of the motor domain of the kinesin-related motor ncd.
  Nature 1996 Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ
• A structural role for hormone in the thyroid hormone receptor.
  Nature 1995 Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ
• Mechanism of regulation in yeast glycogen phosphorylase.
  The Journal of biological chemistry 1995 Lin K, Hwang PK, Fletterick RJ
• Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain.
  Biochemistry 1995 Shimizu T, Sablin E, Vale RD, Fletterick R, Pechatnikova E, Taylor EW
• X-ray diffraction of scrapie prion rods and PrP peptides.
  Journal of molecular biology 1995 Nguyen JT, Inouye H, Baldwin MA, Fletterick RJ, Cohen FE, Prusiner SB, Kirschner DA
• When one and one are not two.
  Nature structural biology 1995 Fletterick RJ, Bazan JF
• Three-dimensional structure of a tubulin-motor-protein complex.
  Nature 1995 Hoenger A, Sablin EP, Vale RD, Fletterick RJ, Milligan RA
• The molecular biology of thyroid hormone action.
  Annals of the New York Academy of Sciences 1995 Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD
• Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation.
  The Journal of biological chemistry 1995 Crerar MM, Karlsson O, Fletterick RJ, Hwang PK
• Mutations in paired alpha-helices at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity.
  Biochemistry 1995 Buchbinder JL, Guinovart JJ, Fletterick RJ
• Crystallization and preliminary diffraction studies of thioesterase II from rat mammary gland.
  Proteins 1995 Buchbinder JL, Witkowski A, Smith S, Fletterick RJ
• The crystal structure of cruzain: a therapeutic target for Chagas' disease.
  Journal of molecular biology 1995 McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ
• Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Guo J, Huang W, Zhou GW, Fletterick RJ, Scanlan TS
• Engineered metal regulation of trypsin specificity.
  Biochemistry 1995 Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS
• Structural origins of substrate discrimination in trypsin and chymotrypsin.
  Biochemistry 1995 Perona JJ, Hedstrom L, Rutter WJ, Fletterick RJ
• Ecotin: lessons on survival in a protease-filled world.
  Protein science : a publication of the Protein Society 1995 McGrath ME, Gillmor SA, Fletterick RJ
• Crystallization and preliminary structural studies of the ncd motor domain.
  Proteins 1995 Sablin EP, Fletterick RJ
• Parallel evolution in two homologues of phosphorylase.
  Nature structural biology 1994 Rath VL, Fletterick RJ
• Crystal structure of a catalytic antibody with a serine protease active site.
  Science (New York, N.Y.) 1994 Zhou GW, Guo J, Huang W, Fletterick RJ, Scanlan TS
• A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA.
  Protein science : a publication of the Protein Society 1994 Guenot J, Fletterick RJ, Kollman PA
• Proposed three-dimensional structure for the cellular prion protein.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Huang Z, Gabriel JM, Baldwin MA, Fletterick RJ, Prusiner SB, Cohen FE
• Identification of the molecular trigger for allosteric activation in glycogen phosphorylase.
  Nature structural biology 1994 Browner MF, Hackos D, Fletterick R
• Structural clues to prion replication.
  Science (New York, N.Y.) 1994 Cohen FE, Pan KM, Huang Z, Baldwin M, Fletterick RJ, Prusiner SB
• Deconvoluting serpins.
  Nature structural biology 1994 Fletterick RJ, McGrath ME
• Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex.
  The EMBO journal 1994 McGrath ME, Erpel T, Bystroff C, Fletterick RJ
• Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994 Baldwin MA, Pan KM, Nguyen J, Huang Z, Groth D, Serban A, Gasset M, Mehlhorn I, Fletterick RJ, Cohen FE
• Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine.
  Journal of molecular biology 1994 McGrath ME, Wagner RL, Apriletti JW, West BL, Ramalingam V, Baxter JD, Fletterick RJ
• Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser.
  Biochemistry 1994 Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ
• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE
• PRISM: application to the solution of two protein structures.
  Acta crystallographica. Section D, Biological crystallography 1993 Bystroff C, Baker D, Fletterick RJ, Agard DA
• PRISM: topologically constrained phased refinement for macromolecular crystallography.
  Acta crystallographica. Section D, Biological crystallography 1993 Baker D, Bystroff C, Fletterick RJ, Agard DA
• Locating the catalytic water molecule in serine proteases.
  Science (New York, N.Y.) 1993 Perona JJ, Craik CS, Fletterick RJ
• Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
  Journal of molecular biology 1993 Perona JJ, Tsu CA, Craik CS, Fletterick RJ
• Relocating a negative charge in the binding pocket of trypsin.
  Journal of molecular biology 1993 Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ
• Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
  The Journal of biological chemistry 1993 Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS
• Structure of an engineered, metal-actuated switch in trypsin.
  Biochemistry 1993 McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ
• Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Gasset M, Baldwin MA, Fletterick RJ, Prusiner SB
• Purification of glycogen phosphorylase isozymes by metal-affinity chromatography.
  Journal of chromatography 1992 Luong CB, Browner MF, Fletterick RJ, Haymore BL
• Cooperative binding is not required for activation of muscle phosphorylase.
  Biochemistry 1992 Browner MF, Hwang PK, Fletterick RJ
• Tracking conformational states in allosteric transitions of phosphorylase.
  Biochemistry 1992 Browner MF, Fauman EB, Fletterick RJ
• The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution.
  Journal of molecular biology 1992 Goddette DW, Paech C, Yang SS, Mielenz JR, Bystroff C, Wilke ME, Fletterick RJ
• Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Gasset M, Baldwin MA, Lloyd DH, Gabriel JM, Holtzman DM, Cohen F, Fletterick R, Prusiner SB
• Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae.
  Journal of molecular biology 1992 Rath VL, Hwang PK, Fletterick RJ
• Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
  Biochemistry 1992 McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ
• Engineered metalloregulation in enzymes.
  Trends in biochemical sciences 1992 Higaki JN, Fletterick RJ, Craik CS
• Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin.
  Journal of bacteriology 1992 Erpel T, Hwang P, Craik CS, Fletterick RJ, McGrath ME
• Phosphorylase: a biological transducer.
  Trends in biochemical sciences 1992 Browner MF, Fletterick RJ
• Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate.
  Science (New York, N.Y.) 1991 Sprang SR, Withers SG, Goldsmith EJ, Fletterick RJ, Madsen NB
• Expression of the protease inhibitor ecotin and its co-crystallization with trypsin.
  Journal of molecular biology 1991 McGrath ME, Erpel T, Browner MF, Fletterick RJ
• An engineered liver glycogen phosphorylase with AMP allosteric activation.
  The Journal of biological chemistry 1991 Coats WS, Browner MF, Fletterick RJ, Newgard CB
• Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
  Journal of molecular biology 1991 Wilke ME, Higaki JN, Craik CS, Fletterick RJ
• Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis.
  Journal of molecular biology 1991 Wilke ME, Higaki JN, Craik CS, Fletterick RJ
• The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.
  The Journal of biological chemistry 1991 McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS
• Temperature-sensitive production of rabbit muscle glycogen phosphorylase in Escherichia coli.
  Protein engineering 1991 Browner MF, Rasor P, Tugendreich S, Fletterick RJ
• Hydrogen bonds involving sulfur atoms in proteins.
  Proteins 1991 Gregoret LM, Rader SD, Fletterick RJ, Cohen FE
• Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes.
  Biochemical and biophysical research communications 1990 Sloane DL, Browner MF, Dauter Z, Wilson K, Fletterick RJ, Sigal E
• Arginine 127 stabilizes the transition state in carboxypeptidase.
  The Journal of biological chemistry 1990 Phillips MA, Fletterick R, Rutter WJ
• Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
  Proceedings of the National Academy of Sciences of the United States of America 1990 Chambers TJ, Weir RC, Grakoui A, McCourt DW, Bazan JF, Fletterick RJ, Rice CM
• Rare McArdle disease locus polymorphic site on 11q13 contains CpG sequence.
  Human genetics 1990 Lebo RV, Anderson LA, DiMauro S, Lynch E, Hwang P, Fletterick R
• Regulation of serine protease activity by an engineered metal switch.
  Biochemistry 1990 Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS
• Electrical potentials in trypsin isozymes.
  Biochemistry 1989 Soman K, Yang AS, Honig B, Fletterick R
• Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Bazan JF, Fletterick RJ, Pilkis SJ
• Crystal structures of two engineered thiol trypsins.
  Biochemistry 1989 McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ
• Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989 Zhang WM, Browner MF, Fletterick RJ, DePaoli-Roach AA, Roach PJ
• Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase.
  Virology 1989 Dougherty WG, Parks TD, Cary SM, Bazan JF, Fletterick RJ
• Domain separation in the activation of glycogen phosphorylase a.
  Science (New York, N.Y.) 1989 Goldsmith EJ, Sprang SR, Hamlin R, Xuong NH, Fletterick RJ
• Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses.
  Virology 1989 Bazan JF, Fletterick RJ
• Comparative analysis of viral cysteine protease structural models.
  FEBS letters 1989 Bazan JF, Fletterick RJ
• Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiae.
  Molecular and cellular biology 1989 Hwang PK, Tugendreich S, Fletterick RJ
• Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Browner MF, Nakano K, Bang AG, Fletterick RJ
• Rapid preparation of proteins for crystallization trials.
  BioTechniques 1989 McGrath ME, Fletterick RJ, Craik CS
• The family of glycogen phosphorylases: structure and function.
  Critical reviews in biochemistry and molecular biology 1989 Newgard CB, Hwang PK, Fletterick RJ
• McArdle's disease: biochemical and molecular genetic studies.
  Annals of neurology 1988 Servidei S, Shanske S, Zeviani M, Lebo R, Fletterick R, DiMauro S
• Structural changes in glycogen phosphorylase induced by phosphorylation.
  Nature 1988 Sprang SR, Acharya KR, Goldsmith EJ, Stuart DI, Varvill K, Fletterick RJ, Madsen NB, Johnson LN
• Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Bazan JF, Fletterick RJ
• Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes.
  The Journal of biological chemistry 1988 Newgard CB, Littman DR, van Genderen C, Smith M, Fletterick RJ
• Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
  Critical reviews in biotechnology 1988 Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS
• The burden of proof in linking AIDS to scrapie.
  Nature 1987 Braun MJ, Gonda MA, George DG, Bazan JF, Fletterick RJ, Prusiner SB
• Primary sequence and structural analysis of sterol carrier protein 2 from rat liver: homology with immunoglobulins.
  The Journal of biological chemistry 1987 Pastuszyn A, Noland BJ, Bazan JF, Fletterick RJ, Scallen TJ
• Structure of the nucleotide activation switch in glycogen phosphorylase a.
  Science (New York, N.Y.) 1987 Sprang S, Goldsmith E, Fletterick R
• The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
  Science (New York, N.Y.) 1987 Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS
• Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.
  Biochemistry 1987 Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ
• The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14.
  American journal of human genetics 1987 Newgard CB, Fletterick RJ, Anderson LA, Lebo RV
• Redesigning trypsin via genetic engineering.
  Journal of cellular biochemistry 1987 Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W
• The three-dimensional structure of acarbose bound to glycogen phosphorylase.
  The Journal of biological chemistry 1987 Goldsmith EJ, Fletterick RJ, Withers SG
• AIDS virus and scrapie protein genes.
  Nature 1987 Fernando Bazan J, Fletterick RJ, Prusiner SB
• Predicted secondary structure and membrane topology of the scrapie prion protein.
  Protein engineering 1987 Bazan JF, Fletterick RJ, McKinley MP, Prusiner SB
• Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.
  Proteins 1987 Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R
• Modeling the biochemical differences between rabbit muscle and human liver phosphorylase.
  Proteins 1987 Rath VL, Newgard CB, Sprang SR, Goldsmith EJ, Fletterick RJ
• Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases.
  Nature 1986 Hwang PK, Fletterick RJ
• Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Newgard CB, Nakano K, Hwang PK, Fletterick RJ
• Complete cDNA sequence for rabbit muscle glycogen phosphorylase.
  FEBS letters 1986 Nakano K, Hwang PK, Fletterick RJ
• Turn prediction in proteins using a pattern-matching approach.
  Biochemistry 1986 Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ
• Structural relationships in glycogen phosphorylases.
  Annals of the New York Academy of Sciences 1986 Fletterick RJ, Burke JA, Hwang PK, Nakano K, Newgard CB
• Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs.
  European journal of biochemistry 1985 Hwang PK, See YP, Vincentini AM, Powers MA, Fletterick RJ, Crerar MM
• Redesigning trypsin: alteration of substrate specificity.
  Science (New York, N.Y.) 1985 Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ
• Measuring X-ray diffraction data from large proteins with X-ray diffractometry.
  Methods in enzymology 1985 Fletterick RJ, Sygusch J
• Purification and crystallization of bovine liver phosphorylase.
  Biochimica et biophysica acta 1984 Hwang P, Stern M, Fletterick RJ
• High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11.
  Science (New York, N.Y.) 1984 Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW
• Crystallization of the gene 45 protein from the DNA replication fork of bacteriophage T4.
  The Journal of biological chemistry 1984 Thaller C, Alberts B, Goldsmith E, Sprang S, Fletterick R
• Secondary structure assignment for alpha/beta proteins by a combinatorial approach.
  Biochemistry 1983 Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ
• Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site.
  Biochemistry 1983 Madsen NB, Shechosky S, Fletterick RJ
• Splice junctions: association with variation in protein structure.
  Science (New York, N.Y.) 1983 Craik CS, Rutter WJ, Fletterick R
• Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications.
  Biochemistry 1982 Withers SG, Madsen NB, Sprang SR, Fletterick RJ
• Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose.
  Biochemistry 1982 Sprang SR, Goldsmith EJ, Fletterick RJ, Withers SG, Madsen NB
• Intron-exon splice junctions map at protein surfaces.
  Nature 1982 Craik CS, Sprang S, Fletterick R, Rutter WJ
• Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha.
  Biochemistry 1982 Sprang S, Fletterick R, Stern M, Yang D, Madsen N, Sturtevant J
• Structure of maltoheptaose by difference Fourier methods and a model for glycogen.
  Journal of molecular biology 1982 Goldsmith E, Sprang S, Fletterick R
• Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes.
  Canadian journal of biochemistry 1981 Kasvinsky PJ, Fletterick RJ, Madsen NB
• Subunit interactions and the allosteric response in phosphorylase.
  Biophysical journal 1980 Sprang S, Fletterick RJ
• Computer simulation of cellular self-sorting: a topological exchange model.
  Journal of theoretical biology 1980 Matela RJ, Fletterick RJ
• The structures and related functions of phosphorylase a.
  Annual review of biochemistry 1980 Fletterick RJ, Madsen NB
• Solvent accessibility properties of complex proteins.
  Nature 1979 Sprang S, Yang D, Fletterick RJ
• The structure of glycogen phosphorylase alpha at 2.5 A resolution.
  Journal of molecular biology 1979 Sprang S, Fletterick RJ
• Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms.
  Canadian journal of biochemistry 1979 Fletterick RJ, Sprang S, Madsen NB
• A systematic approach to isomorphous replacement using a series of simple charged mercurials.
  Biochemical and biophysical research communications 1979 Withers SG, Yang DS, Madsen NB, Fletterick RJ
• A topological exchange model for cell self-sorting.
  Journal of theoretical biology 1979 Matela RJ, Fletterick RJ
• Crystallographic analysis of phosphorylase alpha at 2.5 A resolution, a comment on the chemical sequence.
  Biochemistry 1978 Sprang S, Fletterick RJ
• Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism.
  The Journal of biological chemistry 1978 Madsen NB, Fletterick RJ
• Synergistic regulation of phosphorylase a by glucose and caffeine.
  The Journal of biological chemistry 1978 Kasvinsky PJ, Shechosky S, Fletterick RJ
• The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies.
  The Journal of biological chemistry 1978 Kasvinsky PJ, Madsen NB, Sygusch J, Fletterick RJ
• X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase.
  The Journal of biological chemistry 1978 Kasvinsky PJ, Madsen NB, Fletterick RJ, Sygusch J
• Location of pyridoxal phosphate in glycogen phosphorylase a.
  Proceedings of the National Academy of Sciences of the United States of America 1977 Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick RJ
• High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site.
  The Journal of biological chemistry 1977 Steitz TA, Anderson WF, Fletterick RJ, Anderson CM
• An essential arginine residue in the active-site pocket of glycogen phosporylase.
  Canadian journal of biochemistry 1977 Li EC, Fletterick RJ, Sygusch J, Madsen NB
• Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A.
  The Journal of biological chemistry 1976 Fletterick RJ, Sygusch J, Semple H, Madsen NB
• High resolution x-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits.
  Journal of molecular biology 1976 Steitz TA, Fletterick RJ, Anderson WF, Anderson CM
• Low-resolution structure of the glycogen phosphorylase alpha monomer and comparison with phosphorylase beta.
  Journal of molecular biology 1976 Fletterick RJ, Sygusch J, Murray N, Madsen NB
• The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution.
  Proceedings of the National Academy of Sciences of the United States of America 1975 Fletterick RJ, Bates DJ, Steitz TA
• Structure of yeast hexokinase. 3. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding.
  Journal of molecular biology 1974 Anderson WF, Fletterick RJ, Steitz TA
• Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits.
  Journal of molecular biology 1973 Steitz TA, Fletterick RJ, Hwang KJ
• The crystal and molecular structure of L-alanyl-L-alanine.
  The Journal of physical chemistry 1971 Fletterick RJ, Tsai C, Hughes RE
• The crystal and molecular structure of L-alanyl-L-alanine.
  The Journal of physical chemistry 1971 Fletterick RJ, Tsai CC, Hughes RE