Robert Blelloch, MD, PhD
Professor
Urology
School of Medicine

Websites

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• Profile at urology.ucsf.edu (urology.ucsf.edu)
• Blelloch Lab Website (blellochlab.ucsf.edu)

Grants and Projects

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• Mechanisms of Exosome Driven Immunoregulation of Cancer Progression, NIH, 2019-2024
• Predoctoral Training in Developmental Biology, NIH, 1994-2024
• Center for Research, Innovation and Training in Reproduction and Infertility, NIH, 2007-2023
• Iteratively redefining developmental potential through poised enhancers, NIH, 2017-2021
• Rewiring of the pluripotency enhancer network during early mammalian development, NIH, 2017-2021
• Emergence of divergent cell cycle programs during mammalian development, NIH, 2017-2020
• In Vivo Regulated Release and Function of Extracellular Small RNAs, NIH, 2013-2019
• MicroRNA Based Pathway Discovery in Cellular Reprogramming, NIH, 2012-2017
• Origins and Biological Consequences of Human Infertility, NIH, 2007-2017
• MiRNAs as prognostic markers for prostate cancer patients on active surveillance, NIH, 2011-2015
• California National Primate Research Center, NIH, 1975-2015
• Small RNAs in Stem Cell Differentiation and Neural Development, NIH, 2007-2014
• Determinants of Neural &Embryonic Stem Cell Potency, NIH, 2005-2012

Publications (100)

Top publication keywords:
NectinsDEAD-box RNA HelicasesSequence Analysis, RNAEmbryonic DevelopmentRibonuclease IIICellular ReprogrammingReverse Transcriptase Polymerase Chain ReactionPluripotent Stem CellsCell CycleMicroRNAsCell DifferentiationEmbryonic Stem CellsRNA-Binding ProteinsGerm CellsCell Lineage

• KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition.
  Cell reports 2025 Gökbuget D, Goehring L, Boileau RM, Lenshoek K, Huang TT, Blelloch R
• The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.
  bioRxiv : the preprint server for biology 2024 Ye J, Boileau RM, Parchem RJ, Judson-Torres RL, Blelloch R
• PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
  Cancer immunology research 2024 Yang J, Wang L, Byrnes JR, Kirkemo LL, Driks H, Belair CD, Aguilar OA, Lanier LL, Wells JA, Fong L, Blelloch R
• MLL3/MLL4 enzymatic activity shapes DNA replication timing.
  bioRxiv : the preprint server for biology 2023 Gökbuget D, Boileau RM, Lenshoek K, Blelloch R
• Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
  Nature structural & molecular biology 2023 Gökbuget D, Lenshoek K, Boileau RM, Bayerl J, Huang H, Wiita AP, Laird DJ, Blelloch R

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• Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
  Genome biology 2023 Boileau RM, Chen KX, Blelloch R
• Regionally distinct trophoblast regulate barrier function and invasion in the human placenta.
  eLife 2022 Marsh B, Zhou Y, Kapidzic M, Fisher S, Blelloch R
• G1/S restriction point coordinates phasic gene expression and cell differentiation.
  Nature communications 2022 DeVeale B, Liu L, Boileau R, Swindlehurst-Chan J, Marsh B, Freimer JW, Abate A, Blelloch R
• Beyond Maternal Tolerance: Education of Uterine Natural Killer Cells by Maternal MHC Drives Fetal Growth.
  Frontiers in immunology 2022 Depierreux DM, Kieckbusch J, Shreeve N, Hawkes DA, Marsh B, Blelloch R, Sharkey A, Colucci F
• Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells.
  eLife 2022 Kirkemo LL, Elledge SK, Yang J, Byrnes JR, Glasgow JE, Blelloch R, Wells JA
• The roles of microRNAs in mouse development.
  Nature reviews. Genetics 2021 DeVeale B, Swindlehurst-Chan J, Blelloch R
• Single nuclei RNA-seq of mouse placental labyrinth development.
  eLife 2020 Marsh B, Blelloch R
• MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Sangokoya C, Blelloch R
• LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State.
  Stem cell reports 2019 Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R
• Epigenetic control of transcriptional regulation in pluripotency and early differentiation.
  Development (Cambridge, England) 2019 Gökbuget D, Blelloch R
• Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.
  Cell 2019 Poggio M, Hu T, Pai CC, Chu B, Belair CD, Chang A, Montabana E, Lang UE, Fu Q, Fong L, Blelloch R
• High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing.
  Scientific reports 2019 Belair CD, Hu T, Chu B, Freimer JW, Cooperberg MR, Blelloch RH
• FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
  Cell stem cell 2018 Krishnakumar R, Chen AF, Pantovich MG, Danial M, Parchem RJ, Labosky PA, Blelloch R
• Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells.
  eLife 2018 Freimer JW, Hu TJ, Blelloch R
• GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency.
  Cell stem cell 2018 Chen AF, Liu AJ, Krishnakumar R, Freimer JW, DeVeale B, Blelloch R
• Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes.
  Current biology : CB 2018 Freimer JW, Krishnakumar R, Cook MS, Blelloch R
• The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
  Development (Cambridge, England) 2017 Paikari A, D Belair C, Saw D, Blelloch R
• NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.
  RNA (New York, N.Y.) 2017 Ye J, Jin H, Pankov A, Song JS, Blelloch R
• Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.
  Integrative biology : quantitative biosciences from nano to macro 2017 Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE
• The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells.
  Nature communications 2017 Gambardella G, Carissimo A, Chen A, Cutillo L, Nowakowski TJ, di Bernardo D, Blelloch R
• Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum.
  Stem cell reports 2016 D'Aniello C, Habibi E, Cermola F, Paris D, Russo F, Fiorenzano A, Di Napoli G, Melck DJ, Cobellis G, Angelini C, Fico A, Blelloch R, Motta A, Stunnenberg HG, De Cesare D, Patriarca EJ, Minchiotti G
• miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.
  Cell reports 2016 Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, …
• A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
  Stem cells (Dayton, Ohio) 2016 Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH
• FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
  Cell stem cell 2016 Krishnakumar R, Chen AF, Pantovich MG, Danial M, Parchem RJ, Labosky PA, Blelloch R
• Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
  Current biology : CB 2015 Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA
• Biogenesis, delivery, and function of extracellular RNA.
  Journal of extracellular vesicles 2015 Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, …
• DGCR8 is essential for tumor progression following PTEN loss in the prostate.
  EMBO reports 2015 Belair CD, Paikari A, Moltzahn F, Shenoy A, Yau C, Dall'Era M, Simko J, Benz C, Blelloch R
• miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
  Cell reports 2015 Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R
• Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.
  The EMBO journal 2015 Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M
• CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
  Stem cell reports 2015 Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A
• Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.
  The EMBO journal 2015 Shenoy A, Danial M, Blelloch RH
• Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
  Osteoarthritis and cartilage 2015 Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW
• Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.
  Cell death and differentiation 2014 Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, Blelloch R, Wang Y
• Regulation of pluripotency by RNA binding proteins.
  Cell stem cell 2014 Ye J, Blelloch R
• Regulation of microRNA function in somatic stem cell proliferation and differentiation.
  Nature reviews. Molecular cell biology 2014 Shenoy A, Blelloch RH
• miR-19, miR-345, miR-519c-5p serum levels predict adverse pathology in prostate cancer patients eligible for active surveillance.
  PloS one 2014 Wang SY, Shiboski S, Belair CD, Cooperberg MR, Simko JP, Stoppler H, Cowan J, Carroll PR, Blelloch R
• Two miRNA clusters reveal alternative paths in late-stage reprogramming.
  Cell stem cell 2014 Parchem RJ, Ye J, Judson RL, LaRussa MF, Krishnakumar R, Blelloch A, Oldham MC, Blelloch R
• MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells.
  Nature structural & molecular biology 2013 Judson RL, Greve TS, Parchem RJ, Blelloch R
• Epigenetics of cellular reprogramming.
  Current opinion in genetics & development 2013 Krishnakumar R, Blelloch RH
• microRNA control of mouse and human pluripotent stem cell behavior.
  Annual review of cell and developmental biology 2013 Greve TS, Judson RL, Blelloch R
• miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms.
  Cell reports 2013 Wang Y, Melton C, Li YP, Shenoy A, Zhang XX, Subramanyam D, Blelloch R
• DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability.
  PloS one 2013 Jeker LT, Zhou X, Blelloch R, Bluestone JA
• Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions.
  Current opinion in cell biology 2013 Blelloch R, Gutkind JS
• Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
  Current opinion in cell biology 2013 Lamouille S, Subramanyam D, Blelloch R, Derynck R
• Small RNAs in germline development.
  Current topics in developmental biology 2013 Cook MS, Blelloch R
• An integrated nano-scale approach to profile miRNAs in limited clinical samples.
  American journal of clinical and experimental immunology 2012 Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM
• Sox1 marks an activated neural stem/progenitor cell in the hippocampus.
  Development (Cambridge, England) 2012 Venere M, Han YG, Bell R, Song JS, Alvarez-Buylla A, Blelloch R
• Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
  Molecular and cellular neurosciences 2012 Hsu R, Schofield CM, Dela Cruz CG, Jones-Davis DM, Blelloch R, Ullian EM
• Generation of induced pluripotent stem cells from the prairie vole.
  PloS one 2012 Manoli DS, Subramanyam D, Carey C, Sudin E, Van Westerhuyzen JA, Bales KL, Blelloch R, Shah NM
• Efficiency and specificity in microRNA biogenesis.
  Nature structural & molecular biology 2012 Barad O, Mann M, Chapnik E, Shenoy A, Blelloch R, Barkai N, Hornstein E
• microRNA induced transdifferentiation.
  F1000 biology reports 2012 Shenoy A, Blelloch R
• Dgcr8 controls neural crest cells survival in cardiovascular development.
  Developmental biology 2011 Chapnik E, Sasson V, Blelloch R, Hornstein E
• MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.
  Immunity 2011 Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM
• High throughput microRNA profiling: optimized multiplex qRT-PCR at nanoliter scale on the fluidigm dynamic arrayTM IFCs.
  Journal of visualized experiments : JoVE 2011 Moltzahn F, Hunkapiller N, Mir AA, Imbar T, Blelloch R
• A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.
  RNA (New York, N.Y.) 2011 Babiarz JE, Hsu R, Melton C, Thomas M, Ullian EM, Blelloch R
• From microRNAs to targets: pathway discovery in cell fate transitions.
  Current opinion in genetics & development 2011 Subramanyam D, Blelloch R
• Small RNAs in early mammalian development: from gametes to gastrulation.
  Development (Cambridge, England) 2011 Suh N, Blelloch R
• Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
  Nature biotechnology 2011 Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R
• Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.
  Neural development 2011 Schofield CM, Hsu R, Barker AJ, Gertz CC, Blelloch R, Ullian EM
• Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
  Genes & development 2011 Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M
• Cell cycle regulation by microRNAs in stem cells.
  Results and problems in cell differentiation 2011 Wang Y, Blelloch R
• Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.
  Cancer research 2010 Moltzahn F, Olshen AB, Baehner L, Peek A, Fong L, Stöppler H, Simko J, Hilton JF, Carroll P, Blelloch R
• On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.
  Cell stem cell 2010 Elefanty AG, Blelloch R, Passegué E, Wernig M, Mummery CL
• miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
  Nature medicine 2010 Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, …
• PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
  Cancer research 2010 Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R
• Distinct requirements of microRNAs in NK cell activation, survival, and function.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Bezman NA, Cedars E, Steiner DF, Blelloch R, Hesslein DG, Lanier LL
• MicroRNAs control hepatocyte proliferation during liver regeneration.
  Hepatology (Baltimore, Md.) 2010 Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H
• Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
  Genes & development 2010 Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP
• MicroRNA function is globally suppressed in mouse oocytes and early embryos.
  Current biology : CB 2010 Suh N, Baehner L, Moltzahn F, Melton C, Shenoy A, Chen J, Blelloch R
• Opposing microRNA families regulate self-renewal in mouse embryonic stem cells.
  Nature 2010 Melton C, Judson RL, Blelloch R
• MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation.
  Advances in experimental medicine and biology 2010 Melton C, Blelloch R
• Journal club. A computational biologist looks at how mRNA length changes during development.
  Nature 2009 Blelloch R
• Watching reprogramming in real time.
  Nature biotechnology 2009 Subramanyam D, Blelloch R
• Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.
  PloS one 2009 Shenoy A, Blelloch R
• Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
  Circulation research 2009 Rao PK, Toyama Y, Chiang HR, Gupta S, Bauer M, Medvid R, Reinhardt F, Liao R, Krieger M, Jaenisch R, Lodish HF, Blelloch R
• Cell cycle regulation by MicroRNAs in embryonic stem cells.
  Cancer research 2009 Wang Y, Blelloch R
• Embryonic stem cell-specific microRNAs promote induced pluripotency.
  Nature biotechnology 2009 Judson RL, Babiarz JE, Venere M, Blelloch R
• Posttranscriptional crossregulation between Drosha and DGCR8.
  Cell 2009 Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH, Yang WY, Haussler D, Blelloch R, Kim VN
• Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation.
  Nature genetics 2008 Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R
• CompMoby: comparative MobyDick for detection of cis-regulatory motifs.
  BMC bioinformatics 2008 Chaivorapol C, Melton C, Wei G, Yeh RF, Ramalho-Santos M, Blelloch R, Li H
• Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.
  Genes & development 2008 Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R
• Regenerative medicine: short cut to cell replacement.
  Nature 2008 Blelloch R
• Generation of induced pluripotent stem cells in the absence of drug selection.
  Cell stem cell 2007 Blelloch R, Venere M, Yen J, Ramalho-Santos M
• DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
  Nature genetics 2007 Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R
• Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.
  Stem cells (Dayton, Ohio) 2006 Blelloch R, Wang Z, Meissner A, Pollard S, Smith A, Jaenisch R
• Nuclear cloning of embryonal carcinoma cells.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R
• TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.
  Development (Cambridge, England) 2004 Mathies LD, Schvarzstein M, Morphy KM, Blelloch R, Spence AM, Kimble J
• Reprogramming of a melanoma genome by nuclear transplantation.
  Genes & development 2004 Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R
• Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
  Cold Spring Harbor symposia on quantitative biology 2004 Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K
• Nuclear transplantation, embryonic stem cells and the potential for cell therapy.
  The hematology journal : the official journal of the European Haematology Association 2004 Hochedlinger K, Rideout WM, Kyba M, Daley GQ, Blelloch R, Jaenisch R
• The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.
  Developmental biology 1999 Blelloch R, Anna-Arriola SS, Gao D, Li Y, Hodgkin J, Kimble J
• Control of cell migration during Caenorhabditis elegans development.
  Current opinion in cell biology 1999 Blelloch R, Newman C, Kimble J
• Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans.
  Nature 1999 Blelloch R, Kimble J
• Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor.
  The EMBO journal 1996 Roehl H, Bosenberg M, Blelloch R, Kimble J
• A molecular genetic model of human bladder cancer pathogenesis.
  Seminars in oncology 1996 Reznikoff CA, Belair CD, Yeager TR, Savelieva E, Blelloch RH, Puthenveettil JA, Cuthill S