Rita Fagan, PhD
Postdoctoral Scholar
Psychiatry
School of Medicine

Publications (9)

Top publication keywords:
EndocytosisDopamineProtein Kinase CDrosophila ProteinsGABA Plasma Membrane Transport ProteinsAmphetamineHedgehog ProteinsCorpus StriatumHEK293 CellsMonomeric GTP-Binding Proteinsras ProteinsProtein TransportDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsGTP Phosphohydrolases

• Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability.
  NPJ Parkinson's disease 2024 Kearney PJ, Zhang Y, Liang M, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shaffer SA, Yue Z, Melikian HE
• Rit2 silencing in dopamine neurons drives a Parkinsonian phenotype.
  bioRxiv : the preprint server for biology 2023 Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE
• Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype.
  Research square 2023 Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE
• Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster.
  Molecular psychiatry 2021 Fagan RR, Kearney PJ, Luethi D, Bolden NC, Sitte HH, Emery P, Melikian HE
• Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus.
  eNeuro 2020 Male I, Ozacar AT, Fagan RR, Loring MD, Shen MC, Pace VA, Devine CA, Lawson GE, Lutservitz A, Karlstrom RO

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• In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home.
  Neurochemical research 2020 Fagan RR, Kearney PJ, Melikian HE
• Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact.
  The Journal of biological chemistry 2020 Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE
• Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 Sweeney CG, Kearney PJ, Fagan RR, Smith LA, Bolden NC, Zhao-Shea R, Rivera IV, Kolpakova J, Xie J, Gao G, Tapper AR, Martin GE, Melikian HE
• The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Wu S, Fagan RR, Uttamapinant C, Lifshitz LM, Fogarty KE, Ting AY, Melikian HE