Rik Derynck, PhD
Professor Emeritus
Cell and Tissue Biology
School of Dentistry

Websites

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• Profile at irm.ucsf.edu (irm.ucsf.edu)

Grants and Projects

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• Central role of ShcA in differential TGF-beta signaling, epithelial plasticity and carcinoma cell behavior, NIH, 2016-2021
• Regulatory non-Smad signaling in TGF-b-induced epithelial-mesenchymal transition, NIH, 2009-2019
• Functional crosstalk of TGF-beta/Smad signaling with methyl transferases, NIH, 1995-2017
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• TGF-b family signaling in cardiomyocyte differentiation from embryonic stem cells, NIH, 2009-2011
• Conversion of pre-adipose cells into muscle cells, NIH, 2008-2011
• Molecular Basis of Lung Morphogenesis Injury &Repair, NIH, 1998-2011
• TGF-beta receptor sumoylation and cell behavior, NIH, 2006-2008
• Adhesion and Proliferation in Oral Cancer Progression, NIH, 2001-2008
• New Strategies for Enhancing Tissue Integrity and Repair, NIH, 1999-2006
• Function of Transmembrane Tgf a Associated Proteins, NIH, 1992-2005
• TGF-Beta Superfamily: Signaling and Development, NIH, 2003-2004
• Faseb Conference on Tgf-beta Superfamily, NIH, 2001-2002
• Adhesion and Remodeling Mechanisms in Gingiva and Bone, NIH, 1992-1999
• Tgf-beta Family and Bone and Cartilage Formation, NIH, 1993-1998
• Role of the Tgf-b Family in Bone and Cartilage Formation, NIH, 1992-1993
• Conference on Growth and Differentiation Factors, NIH, 1992-1993

Publications (253)

Top publication keywords:
Receptors, Transforming Growth Factor betaTransforming Growth Factor alphaBone Morphogenetic ProteinsTransforming Growth Factor betaTransforming Growth FactorsSmad3 ProteinTrans-ActivatorsEpithelial-Mesenchymal TransitionSignal TransductionOsteoblastsArginineADAM ProteinsDNA-Binding ProteinsSmad ProteinsEpithelial Cells

• New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases.
  Cell regeneration (London, England) 2024 Gu S, Derynck R, Chen YG, Feng XH
• Expression of Concern: Association of tetraspanin CD9 with transmembrane TGFα confers alterations in cell-surface presentation of TGFα and cytoskeletal organization.
  Journal of cell science 2022 Imhof I, Gasper WJ, Derynck R
• Virtual screening for small-molecule pathway regulators by image-profile matching.
  Cell systems 2022 Rohban MH, Fuller AM, Tan C, Goldstein JT, Syangtan D, Gutnick A, DeVine A, Nijsure MP, Rigby M, Sacher JR, Corsello SM, Peppler GB, Bogaczynska M, Boghossian A, Ciotti GE, Hands AT, Mekareeya A, Doan…
• Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition.
  Nature reviews. Molecular cell biology 2021 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, …
• TGF-β as a driver of fibrosis: physiological roles and therapeutic opportunities.
  The Journal of pathology 2021 Budi EH, Schaub JR, Decaris M, Turner S, Derynck R

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• Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family.
  Developmental cell 2021 Katsuno Y, Derynck R
• TGFβ biology in cancer progression and immunotherapy.
  Nature reviews. Clinical oncology 2020 Derynck R, Turley SJ, Akhurst RJ
• Guidelines and definitions for research on epithelial-mesenchymal transition.
  Nature reviews. Molecular cell biology 2020 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, …
• Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells.
  Scientific reports 2019 Budi EH, Hoffman S, Gao S, Zhang YE, Derynck R
• EMT and Cancer: More Than Meets the Eye.
  Developmental cell 2019 Derynck R, Weinberg RA
• Transforming growth factor-β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response.
  The Journal of biological chemistry 2019 Duan D, Derynck R
• Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.
  Science signaling 2019 Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R
• Specificity, versatility, and control of TGF-β family signaling.
  Science signaling 2019 Derynck R, Budi EH
• Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells.
  iScience 2019 Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R
• Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation.
  The Journal of biological chemistry 2018 Katsuno Y, Qin J, Oses-Prieto J, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame A, Xu J, Derynck R
• Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition.
  EMBO reports 2017 Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R
• Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.
  The Journal of clinical investigation 2017 Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA
• Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility.
  Trends in cell biology 2017 Budi EH, Duan D, Derynck R
• Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K
• The Discovery and Early Days of TGF-β: A Historical Perspective.
  Cold Spring Harbor perspectives in biology 2016 Moses HL, Roberts AB, Derynck R
• TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology.
  Cold Spring Harbor perspectives in biology 2016 Morikawa M, Derynck R, Miyazono K
• Regulation of TGF-β Receptors.
  Methods in molecular biology (Clifton, N.J.) 2016 Budi EH, Xu J, Derynck R
• ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.
  PLoS biology 2015 Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R
• The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.
  Science signaling 2015 Budi EH, Muthusamy BP, Derynck R
• Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.
  Molecular cell 2014 Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R
• Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition.
  Current opinion in cell biology 2014 Derynck R, Muthusamy BP, Saeteurn KY
• Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS
• Does Smad6 methylation control BMP signaling in cancer?
  Cell cycle (Georgetown, Tex.) 2014 Xu J, Derynck R
• Molecular mechanisms of epithelial-mesenchymal transition.
  Nature reviews. Molecular cell biology 2014 Lamouille S, Xu J, Derynck R
• BMP-9 balances endothelial cell fate.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Derynck R, Akhurst RJ
• S-1 Complexity of cytokines in Treg function and stability.
  Cytokine 2013 Jeffrey A. Bluestone, Samantha Bailey-Bucktrout, Pinglong Xu, Rik Derynck, Elenora Trotta, Natasha Crellins, Isaac Rondon, Michael DuPage, Mark Travis, Dean Sheppard
• Abstract 323: Arginine Methylation Regulates Epicardial Cell Plasticity.
  Circulation Research 2013 Jian Xu, Juan Oses-Prieto, Alma Burlingame, Rik Derynck
• Arginine Methylation Initiates BMP-Induced Smad Signaling.
  Molecular cell 2013 Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R
• Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state.
  The Journal of biological chemistry 2013 Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R
• Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
  Current opinion in cell biology 2013 Lamouille S, Subramanyam D, Blelloch R, Derynck R
• TGF-β signaling and epithelial-mesenchymal transition in cancer progression.
  Current opinion in oncology 2013 Katsuno Y, Lamouille S, Derynck R
• 578 High Content Analysis of the Epithelial-Mesenchymal Transition to Identify Novel Targets in Cancer Progression.
  European Journal of Cancer 2012 S. Lamouille, R. Judson, R. Blelloch, R. Derynck
• TGF-β family signaling in stem cells.
  Biochimica et biophysica acta 2012 Sakaki-Yumoto M, Katsuno Y, Derynck R
• Post-translational regulation of TGF-β receptor and Smad signaling.
  FEBS letters 2012 Xu P, Liu J, Derynck R
• TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
  Development 2012 S. Lamouille, E. Connolly, J. W. Smyth, R. J. Akhurst, R. Derynck
• TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.
  Science signaling 2012 Xu P, Liu J, Sakaki-Yumoto M, Derynck R
• TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
  Journal of cell science 2012 Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R
• Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI
• Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
  Nature biotechnology 2011 Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R
• Stem cell antigen-1 (Sca-1) disrupts GDF10/TGF-ß signal transduction at the plasma membrane to regulate Smad2/3 nuclear signaling.
  The FASEB Journal 2011 Geeta Upadhyay, Yuzhi Yin, Hongyan Yuan, Levy Kopelovich, Rik Derynck, Robert I. Glazer
• Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition.
  Cells, tissues, organs 2010 Lamouille S, Derynck R
• Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing.
  EMBO reports 2010 Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T
• Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.
  Molecular cell 2010 Xu P, Derynck R
• Oncogene and tumour suppressor: the two faces of SnoN.
  The EMBO journal 2009 Lamouille S, Derynck R
• TGFbeta family signaling: novel insights in development and disease.
  Development (Cambridge, England) 2009 Wharton K, Derynck R
• Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter.
  The Journal of biological chemistry 2009 Piscopo DM, Johansen EB, Derynck R
• New regulatory mechanisms of TGF-beta receptor function.
  Trends in cell biology 2009 Kang JS, Liu C, Derynck R
• TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.
  Molecular cell 2009 Liu C, Xu P, Lamouille S, Xu J, Derynck R
• Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.
  Developmental cell 2009 Wu L, Derynck R
• TGF-beta-induced epithelial to mesenchymal transition.
  Cell research 2009 Xu J, Lamouille S, Derynck R
• TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.
  The EMBO journal 2008 Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF
• Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization.
  Journal of cell science 2008 Imhof I, Gasper WJ, Derynck R
• The type I TGF-beta receptor is covalently modified and regulated by sumoylation.
  Nature cell biology 2008 Kang JS, Saunier EF, Akhurst RJ, Derynck R
• Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.
  PloS one 2008 Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T
• Differentiation plasticity regulated by TGF-beta family proteins in development and disease.
  Nature cell biology 2007 Derynck R, Akhurst RJ
• TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.
  The EMBO journal 2007 Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R
• Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway.
  The Journal of cell biology 2007 Lamouille S, Derynck R
• Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.
  Journal of cell science 2007 Castro CP, Piscopo D, Nakagawa T, Derynck R
• Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone.
  Plastic and reconstructive surgery 2006 Wan DC, Aalami OO, Wang Z, Nacamuli RP, Lorget F, Derynck R, Longaker MT
• E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated Smad proteins and inhibit their transcriptional activity.
  Archives of virology 2006 Habig M, Smola H, Dole VS, Derynck R, Pfister H, Smola-Hess S
• Smads In Mesenchymal Differentiation.
  Smad Signal Transduction 2006 Rik Derynck, Lisa Choy, Tamara Alliston
• TGF-beta regulates the mechanical properties and composition of bone matrix.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T
• Transforming growth factor-beta signaling in stem cells and cancer.
  Science (New York, N.Y.) 2005 Mishra L, Derynck R, Mishra B
• Crystal structure of IRF-3 in complex with CBP.
  Structure (London, England : 1993) 2005 Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R, Lin K
• Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands.
  Developmental dynamics : an official publication of the American Association of Anatomists 2005 Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R
• Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
  The EMBO journal 2005 Kang JS, Alliston T, Delston R, Derynck R
• Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
  The Journal of biological chemistry 2005 Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R
• Signalling by TGF-ß.
  The Cancer Handbook 2005 Jing Qing, Rik Derynck
• Specificity and versatility in tgf-beta signaling through Smads.
  Annual review of cell and developmental biology 2005 Feng XH, Derynck R
• JNK regulates expression and autocrine signaling of TGF-beta1.
  Molecular cell 2004 Pardoux C, Derynck R
• TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation.
  The EMBO journal 2004 Liu D, Kang JS, Derynck R
• Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter.
  Molecular and cellular biology 2004 Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R
• Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation.
  Nature structural biology 2003 Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K
• Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Nature 2003 Derynck R, Zhang YE
• Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.
  The Journal of biological chemistry 2003 Lee PS, Chang C, Liu D, Derynck R
• Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.
  The Journal of biological chemistry 2003 Fan H, Turck CW, Derynck R
• Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function.
  The Journal of biological chemistry 2003 Choy L, Derynck R
• Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes.
  The Journal of cell biology 2002 Skillington J, Choy L, Derynck R
• Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
  The Journal of biological chemistry 2002 Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P
• Medicine: interfering with bone remodelling.
  Nature 2002 Alliston T, Derynck R
• Meeting report: signaling schemes for TGF-beta.
  Science's STKE : signal transduction knowledge environment 2001 Roberts AB, Derynck R
• TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.
  Genes & development 2001 Liu D, Black BL, Derynck R
• TGF-beta signaling in cancer--a double-edged sword.
  Trends in cell biology 2001 Akhurst RJ, Derynck R
• TGF-ß signaling in cancer — a double-edged sword.
  Trends in Cell Biology 2001 Rosemary J. Akhurst, Rik Derynck
• TGF-beta signaling in tumor suppression and cancer progression.
  Nature genetics 2001 Derynck R, Akhurst RJ, Balmain A
• Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes.
  Neoplasia (New York, N.Y.) 2001 Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT
• TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation.
  The EMBO journal 2001 Alliston T, Choy L, Ducy P, Karsenty G, Derynck R
• Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R
• Mammalian two-hybrid assays. Analyzing protein-protein interactions in transforming growth factor-beta signaling pathway.
  Methods in molecular biology (Clifton, N.J.) 2001 Feng XH, Derynck R
• Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis.
  The Journal of biological chemistry 2000 Patil S, Wildey GM, Brown TL, Choy L, Derynck R, Howe PH
• Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.
  The Journal of biological chemistry 2000 Qing J, Zhang Y, Derynck R
• Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.
  The EMBO journal 2000 Kuo A, Zhong C, Lane WS, Derynck R
• Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta.
  The EMBO journal 2000 Feng XH, Lin X, Derynck R
• Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members.
  The Journal of biological chemistry 2000 Zhang Y, Derynck R
• Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation.
  The Journal of cell biology 2000 Choy L, Skillington J, Derynck R
• The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation.
  The Journal of cell biology 2000 Shi W, Fan H, Shum L, Derynck R
• Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades.
  The EMBO journal 1999 Fan H, Derynck R
• Skeletal development in the zebrafish.
  Nature genetics 1999 Derynck R
• Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.
  Development (Cambridge, England) 1999 Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R
• Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system.
  The European journal of neuroscience 1999 Kornblum HI, Zurcher SD, Werb Z, Derynck R, Seroogy KB
• Regulation of Smad signalling by protein associations and signalling crosstalk.
  Trends in cell biology 1999 Zhang Y, Derynck R
• Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure.
  Nature genetics 1999 Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler CF, Derynck R, Werb Z
• Smads: transcriptional activators of TGF-beta responses.
  Cell 1998 Derynck R, Zhang Y, Feng XH
• Erratum: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TFG-ß-induced transcription.
  Nature 1998 Ying Zhang, Xin-Hua Feng, Rik Derynck
• The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response.
  The Journal of biological chemistry 1998 Choy L, Derynck R
• Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.
  Molecular and cellular biology 1998 Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R
• Bone remodelling: a signalling system for osteoclast regulation.
  Current biology : CB 1998 Filvaroff E, Derynck R
• Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor.
  Journal of neuroscience research 1998 Kornblum HI, Hussain R, Wiesen J, Miettinen P, Zurcher SD, Chow K, Derynck R, Werb Z
• Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.
  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998 Sebastian J, Richards RG, Walker MP, Wiesen JF, Werb Z, Derynck R, Hom YK, Cunha GR, DiAugustine RP
• Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
  Nature 1998 Zhang Y, Feng XH, Derynck R
• The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.
  Genes & development 1998 Feng XH, Zhang Y, Wu RY, Derynck R
• Osteoblastic responses to TGF-beta during bone remodeling.
  Molecular biology of the cell 1998 Erlebacher A, Filvaroff EH, Ye JQ, Derynck R
• SMAD proteins and mammalian anatomy.
  Nature 1998 Derynck R
• Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.
  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998 Gorska AE, Joseph H, Derynck R, Moses HL, Serra R
• Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma.
  Endocrinology 1998 Hom YK, Young P, Wiesen JF, Miettinen PJ, Derynck R, Werb Z, Cunha GR
• Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation.
  The EMBO journal 1997 Verlhac MH, Chen RH, Hanachi P, Hershey JW, Derynck R
• Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads.
  Development (Cambridge, England) 1997 Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW
• TGF-beta receptor signaling.
  Biochimica et biophysica acta 1997 Derynck R, Feng XH
• Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.
  The Journal of cell biology 1997 Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL
• A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity.
  The EMBO journal 1997 Feng XH, Derynck R
• Impaired lung branching morphogenesis in the absence of functional EGF receptor.
  Developmental biology 1997 Miettinen PJ, Warburton D, Bu D, Zhao JS, Berger JE, Minoo P, Koivisto T, Allen L, Dobbs L, Werb Z, Derynck R
• The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.
  The Journal of biological chemistry 1997 Lawler S, Feng XH, Chen RH, Maruoka EM, Turck CW, Griswold-Prenner I, Derynck R
• Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.
  Molecular and cellular biology 1997 Wu RY, Zhang Y, Feng XH, Derynck R
• The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.
  Current biology : CB 1997 Zhang Y, Musci T, Derynck R
• Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR
• Structure and sequence of the mouse Bmp6 gene.
  Mammalian genome : official journal of the International Mammalian Genome Society 1997 Gitelman SE, Kobrin M, Lee A, Fet V, Lyons K, Hogan BL, Derynck R
• Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.
  The Journal of biological chemistry 1996 Shum L, Turck CW, Derynck R
• Nomenclature: vertebrate mediators of TGFbeta family signals.
  Cell 1996 Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF
• Intracellular signalling: the mad way to do it.
  Current biology : CB 1996 Derynck R, Zhang Y
• Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation.
  Developmental biology 1996 Filvaroff EH, Derynck R
• Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
  Nature 1996 Zhang Y, Feng X, We R, Derynck R
• Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors.
  The Journal of biological chemistry 1996 Feng XH, Derynck R
• Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.
  The Journal of cell biology 1996 Erlebacher A, Derynck R
• Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors.
  The Journal of biological chemistry 1995 Feng XH, Filvaroff EH, Derynck R
• A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor.
  Nature 1995 Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R
• Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.
  Nature 1995 Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R
• Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells.
  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995 Gitelman SE, Kirk M, Ye JQ, Filvaroff EH, Kahn AJ, Derynck R
• Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors.
  The Journal of biological chemistry 1995 Chen RH, Moses HL, Maruoka EM, Derynck R, Kawabata M
• Toward a molecular understanding of skeletal development.
  Cell 1995 Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R
• TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.
  The Journal of cell biology 1994 Miettinen PJ, Ebner R, Lopez AR, Derynck R
• TGF-beta-receptor-mediated signaling.
  Trends in biochemical sciences 1994 Derynck R
• Homomeric interactions between type II transforming growth factor-beta receptors.
  The Journal of biological chemistry 1994 Chen RH, Derynck R
• Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.
  The Journal of cell biology 1994 Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R
• Association of the transmembrane TGF-alpha precursor with a protein kinase complex.
  The Journal of cell biology 1994 Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R
• Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor.
  Development (Cambridge, England) 1994 Filvaroff EH, Ebner R, Derynck R
• Transforming growth factor-beta activation in irradiated murine mammary gland.
  The Journal of clinical investigation 1994 Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA
• An emerging complexity of receptors for transforming growth factor-beta.
  Princess Takamatsu symposia 1994 Derynck R, Chen RH, Ebner R, Filvaroff EH, Lawler S
• The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1.
  Development (Cambridge, England) 1994 Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R
• Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Nabel EG, Shum L, Pompili VJ, Yang ZY, San H, Shu HB, Liptay S, Gold L, Gordon D, Derynck R
• Determination of type I receptor specificity by the type II receptors for TGF-beta or activin.
  Science (New York, N.Y.) 1993 Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R
• Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.
  Cancer research 1993 Chang HL, Gillett N, Figari I, Lopez AR, Palladino MA, Derynck R
• Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy.
  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993 Pittelkow MR, Cook PW, Shipley GD, Derynck R, Coffey RJ
• Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.
  Science (New York, N.Y.) 1993 Ebner R, Chen RH, Shum L, Lawler S, Zioncheck TF, Lee A, Lopez AR, Derynck R
• Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.
  Science (New York, N.Y.) 1993 Chen RH, Ebner R, Derynck R
• THE ROLE OF TGF-ß FAMILY MEMBERS IN MESENCHYMAL DIFFERENTIATION.
  Pediatric Research 1993 Rik Derynck, Ellen Filvaroff, Adrian Erlebacher, Stephen Gitelman
• VGR-1/BMP-6 INDUCES OSTEOGENIC DIFFERENTIATION IN MESEN-CHYMAL CELLS.
  Pediatric Research 1993 S E Gitelman, M Kirk, A J Kahn, R Derynck
• Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells.
  Molecular endocrinology (Baltimore, Md.) 1993 Gazit D, Ebner R, Kahn AJ, Derynck R
• Extracellular matrix regulates expression of the TGF-beta 1 gene.
  The Journal of cell biology 1993 Streuli CH, Schmidhauser C, Kobrin M, Bissell MJ, Derynck R
• Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.
  The Journal of cell biology 1992 Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R
• Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.
  Molecular and Cellular Biology 1992 A R Lopez, J Cook, P L Deininger, R Derynck
• Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.
  Molecular and cellular biology 1992 Lopez AR, Cook J, Deininger PL, Derynck R
• Growth regulation by transforming growth factor-beta.
  Cancer treatment and research 1992 Arrick BA, Derynck R
• The physiology of transforming growth factor-alpha.
  Advances in cancer research 1992 Derynck R
• Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors.
  Molecular endocrinology (Baltimore, Md.) 1991 Lyons RM, Miller DA, Graycar JL, Moses HL, Derynck R
• Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.
  Molecular and cellular biology 1991 Arrick BA, Lee AL, Grendell RL, Derynck R
• Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.
  Molecular and Cellular Biology 1991 B A Arrick, A L Lee, R L Grendell, R Derynck
• Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.
  Cell regulation 1991 Ebner R, Derynck R
• Effects of MGSA/GRO alpha on melanocyte transformation.
  Oncogene 1991 Balentien E, Mufson BE, Shattuck RL, Derynck R, Richmond A
• Generation of antibodies and assays for transforming growth factor alpha.
  Methods in enzymology 1991 Lucas C, Bringman TS, Derynck R
• Purification and characterization of recombinant melanoma growth stimulating activity.
  Methods in enzymology 1991 Thomas HG, Han JH, Balentien E, Derynck R, Bordoni R, Richmond A
• Transforming growth factor-alpha.
  Molecular reproduction and development 1990 Derynck R
• Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.
  Journal of immunology (Baltimore, Md. : 1950) 1990 Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S
• Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol.
  Cancer research 1990 Arrick BA, Korc M, Derynck R
• Transforming growth factor-beta. A family of growth regulatory peptides.
  Annals of the New York Academy of Sciences 1990 Miller DA, Pelton RW, Derynck R, Moses HL
• Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues.
  Molecular endocrinology (Baltimore, Md.) 1989 Miller DA, Lee A, Matsui Y, Chen EY, Moses HL, Derynck R
• Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2.
  Molecular and cellular biology 1989 Bascom CC, Wolfshohl JR, Coffey RJ, Madisen L, Webb NR, Purchio AR, Derynck R, Moses HL
• Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2.
  Molecular and Cellular Biology 1989 C C Bascom, J R Wolfshohl, R J Coffey, L Madisen, N R Webb, A R Purchio, R Derynck, H L Moses
• Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2.
  Molecular endocrinology (Baltimore, Md.) 1989 Graycar JL, Miller DA, Arrick BA, Lyons RM, Moses HL, Derynck R
• Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos.
  Molecular endocrinology (Baltimore, Md.) 1989 Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R
• Expression and secretion of gro/MGSA by stimulated human endothelial cells.
  The EMBO journal 1989 Wen DZ, Rowland A, Derynck R
• Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BL, Derynck R
• Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters.
  The Journal of biological chemistry 1989 Pittelkow MR, Lindquist PB, Abraham RT, Graves-Deal R, Derynck R, Coffey RJ
• The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins.
  The Journal of biological chemistry 1989 Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD
• Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors.
  Cell 1989 Brachmann R, Lindquist PB, Nagashima M, Kohr W, Lipari T, Napier M, Derynck R
• Overexpression of transforming growth factor alpha in psoriatic epidermis.
  Science (New York, N.Y.) 1989 Elder JT, Fisher GJ, Lindquist PB, Bennett GL, Pittelkow MR, Coffey RJ, Ellingsworth L, Derynck R, Voorhees JJ
• 4742003 Human transforming growth factor.
  Progress in Growth Factor Research 1989 Rik M Derynck, David Goeddel
• Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA.
  Molecular carcinogenesis 1989 Shankar V, Ciardiello F, Kim N, Derynck R, Liscia DS, Merlo G, Langton BC, Sheer D, Callahan R, Bassin RH
• Transforming growth factors-alpha and -beta and their potential roles in neoplastic transformation.
  Cancer treatment and research 1989 Derynck R
• A new type of transforming growth factor-beta, TGF-beta 3.
  The EMBO journal 1988 Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ
• The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.
  Molecular and Cellular Biology 1988 E B Jakobovits, U Schlokat, J L Vannice, R Derynck, A D Levinson
• The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.
  Molecular and cellular biology 1988 Jakobovits EB, Schlokat U, Vannice JL, Derynck R, Levinson AD
• Transforming growth factor alpha.
  Cell 1988 Derynck R
• Developmental expression of transforming growth factors alpha and beta in mouse fetus.
  Molecular and Cellular Biology 1988 J N Wilcox, R Derynck
• Developmental expression of transforming growth factors alpha and beta in mouse fetus.
  Molecular and cellular biology 1988 Wilcox JN, Derynck R
• Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.
  The EMBO journal 1988 Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R
• Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1988 Wilcox JN, Derynck R
• Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family.
  Oncogene research 1988 Barton DE, Foellmer BE, Du J, Tamm J, Derynck R, Francke U
• TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression.
  Molecular carcinogenesis 1988 Finzi E, Kilkenny A, Strickland JE, Balaschak M, Bringman T, Derynck R, Aaronson S, Yuspa SH
• Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
  The Journal of biological chemistry 1987 Gutierrez GE, Mundy GR, Derynck R, Hewlett EL, Katz MS
• Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Smith JJ, Derynck R, Korc M
• Expression of transforming growth factor alpha (TGF alpha) in differentiated rat mammary tumors: estrogen induction of TGF alpha production.
  Molecular endocrinology (Baltimore, Md.) 1987 Liu SC, Sanfilippo B, Perroteau I, Derynck R, Salomon DS, Kidwell WR
• Production and auto-induction of transforming growth factor-alpha in human keratinocytes.
  Nature 1987 Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR
• Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha.
  The Journal of pharmacology and experimental therapeutics 1987 Gan BS, Hollenberg MD, MacCannell KL, Lederis K, Winkler ME, Derynck R
• The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Finzi E, Fleming T, Segatto O, Pennington CY, Bringman TS, Derynck R, Aaronson SA
• Intron-exon structure of the human transforming growth factor-beta precursor gene.
  Nucleic acids research 1987 Derynck R, Rhee L, Chen EY, Van Tilburg A
• Sequence of the porcine transforming growth factor-beta precursor.
  Nucleic acids research 1987 Derynck R, Rhee L
• Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells.
  Journal of cellular physiology 1987 Salomon DS, Perroteau I, Kidwell WR, Tam J, Derynck R
• Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor.
  Cell 1987 Bringman TS, Lindquist PB, Derynck R
• Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells.
  Cell 1987 Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R, Dickson RB
• Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.
  Cancer research 1987 Derynck R, Goeddel DV, Ullrich A, Gutterman JU, Williams RD, Bringman TS, Berger WH
• Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice.
  The Journal of clinical investigation 1986 Tashjian AH, Voelkel EF, Lloyd W, Derynck R, Winkler ME, Levine L
• Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures.
  The Journal of clinical investigation 1986 Takahashi N, MacDonald BR, Hon J, Winkler ME, Derynck R, Mundy GR, Roodman GD
• Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.
  European journal of biochemistry 1986 Haegeman G, Content J, Volckaert G, Derynck R, Tavernier J, Fiers W
• Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation.
  Cell 1986 Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV, Derynck R
• Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor.
  Science (New York, N.Y.) 1986 Schreiber AB, Winkler ME, Derynck R
• Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.
  The Journal of experimental medicine 1986 Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS
• Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7.
  Somatic cell and molecular genetics 1986 Fujii D, Brissenden JE, Derynck R, Francke U
• The murine transforming growth factor-beta precursor.
  The Journal of biological chemistry 1986 Derynck R, Jarrett JA, Chen EY, Goeddel DV
• Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Ibbotson KJ, Harrod J, Gowen M, D'Souza S, Smith DD, Winkler ME, Derynck R, Mundy GR
• Endogenous and heterologous expression of transforming growth factor-alpha in mammalian cells.
  Cold Spring Harbor symposia on quantitative biology 1986 Derynck R, Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV
• Transforming Growth Factor-a.
  Oncogenes and Growth Control 1986 Rik Derynck
• Transforming growth factor-alpha: structure and biological activities.
  Journal of cellular biochemistry 1986 Derynck R
• Human transforming growth factor-alpha stimulates bone resorption in vitro.
  The Journal of clinical investigation 1985 Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ
• Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation.
  Cancer research 1985 Brissenden JE, Derynck R, Francke U
• Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.
  Nature 1985 Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV
• Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.
  Proceedings of the National Academy of Sciences of the United States of America 1985 Tashjian AH, Voelkel EF, Lazzaro M, Singer FR, Roberts AB, Derynck R, Winkler ME, Levine L
• Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice.
  Nature 1985 Smith JM, Sporn MB, Roberts AB, Derynck R, Winkler ME, Gregory H
• Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
  Nature 1984 Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV
• Human transforming growth factor-alpha: precursor structure and expression in E. coli.
  Cell 1984 Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV
• Expression of the human interferon-gamma cDNA in yeast.
  Nucleic acids research 1983 Derynck R, Singh A, Goeddel DV
• CHAPTER 13 Expression of Human Interferon-? in Heterologous Systems Genentech, Inc. Contribution no. 134.
  Experimental Manipulation of Gene Expression 1983 RIK DERYNCK, RONALD A. HITZEMAN, PATRICK W. GRAY, DAVID V. GOEDDEL
• More about interferon cloning.
  Interferon 1983 Derynck R
• The primary structure of the Saccharomyces cerevisiae gene for 3-phosphoglycerate kinase.
  Nucleic acids research 1982 Hitzeman RA, Hagie FE, Hayflick JS, Chen CY, Seeburg PH, Derynck R
• In vitro cotranslational processing of human pre-interferon beta 1 enhances its biological activity.
  Virology 1982 Content J, De Wit L, Derynck R, De Clercq E, Fiers W
• Human interferon gamma is encoded by a single class of mRNA.
  Nucleic acids research 1982 Derynck R, Leung DW, Gray PW, Goeddel DV
• Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta.
  Proceedings of the National Academy of Sciences of the United States of America 1982 Content J, De Wit L, Pierard D, Derynck R, De Clercq E, Fiers W
• Expression of human immune interferon cDNA in E. coli and monkey cells.
  Nature 1982 Gray PW, Leung DW, Pennica D, Yelverton E, Najarian R, Simonsen CC, Derynck R, Sherwood PJ, Wallace DM, Berger SL, Levinson AD, Goeddel DV
• PLASMID-DIRECTED SYNTHESIS OF HUMAN IMMUNE INTERFERON IN E. COLI AND MONKEY CELLS.
  Interferons 1982 Christian C. Simonsen, H. Michael Shepard, Patrick W. Gray, David W. Leung, Diane Pennica, Elizabeth Yelverton, Rik Derynck, Pamela J. Sherwood, Arthur D. Levinson, David V. Goeddel
• SYNTHESIS OF HUMAN INTERFERONS AND ANALOGS IN HETEROLOGOUS CELLS.
  From Gene to Protein: Translation Into Biotechnology 1982 R. Derynck, P.W. Gray, E. Yelverton, D.W. Leung, H.M. Shepard, R.M. Lawn, A. Ullrich, R. Najarian, D. Pennica, F.E. Hagie, R.A. Hitzeman, P.J. Sherwood, A.D. Levinson, D.V. Goeddel
• The human fibroblast interferon gene(s) and their expression in heterologous cells.
  Princess Takamatsu symposia 1982 Fiers W, Degrave W, Derynck R, Devos R, Gheysen D, Remaut E, Stanssens P, Tavernier J, Content J, De Clercq E
• Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli.
  Reviews of infectious diseases 1981 Derynck R, Devos R, Remaut E, Saman E, Stanssens P, Tavernier J, Volckaert G, Content J, De Clercq E, Fiers W
• Molecular mechanisms of nucleotide-sequence rearrangements in cDNA clones of human fibroblast interferon mRNA.
  Gene 1981 Volckaert G, Tavernier J, Derynck R, Devos R, Fiers W
• Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions.
  Gene 1981 Degrave W, Derynck R, Tavernier J, Haegeman G, Fiers W
• Evidence for a unique human fibroblast interferon (IFN-beta 1) chromosomal gene, devoid of intervening sequences.
  Nucleic acids research 1981 Tavernier J, Derynck R, Fiers W
• Expression of human fibroblast interferon gene in Escherichia coli.
  Nature 1980 Derynck R, Remaut E, Saman E, Stanssens P, De Clercq E, Content J, Fiers W
• Isolation and structure of a human fibroblast interferon gene.
  Nature 1980 Derynck R, Content J, DeClercq E, Volckaert G, Tavernier J, Devos R, Fiers W
• A two-dimensional electrophoretic procedure for the separation of DNA restriction fragments.
  Journal of molecular biology 1977 Derynck R, Fiers W
• Two dimensional electrophoretic separation of restriction fragments.
  Archives internationales de physiologie et de biochimie 1977 Derynck R, Fiers W