Reza Kheirkhahi Oqani, PhD
Specialist
Pediatrics
School of Medicine

Education & Training

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• Ph.D Reproductive Biology Chungnam National University 2013

Publications (24)

Top publication keywords:
Tissue Inhibitor of Metalloproteinase-2PlacentaIn Vitro Oocyte Maturation TechniquesSwineCloning, OrganismOocytesOogenesisInfertilityNuclear Transfer TechniquesNicotinamide PhosphoribosyltransferaseEmbryo Culture TechniquesFertilization in VitroPositive Transcriptional Elongation Factor BBlastocystEmbryo Transfer

• Revisiting placental hypoxia in assisted reproduction: from molecular signatures to functional consequences.
  Human reproduction update 2026 Oqani RK, Maltepe E, Rinaudo P
• Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses, and reduced fitness†.
  Biology of reproduction 2026 Oqani RK, Maltepe E, Rinaudo P, Wagner DE
• Impact of embryo culture and day of embryo transfer on the cardiometabolic health of adult mice†.
  Biology of reproduction 2025 Simbulan RK, Lee SH, Oqani RK, Liu X, Lantier L, McGuinness OP, Brooks GA, Rinaudo PF
• Artificial Oocyte: Development and Potential Application.
  Cells 2022 Oqani RK, So S, Lee Y, Ko JJ, Kang E
• Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
  Scientific reports 2019 Oqani RK, Lin T, Lee JE, Kang JW, Shin HY, Il Jin D

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• Melatonin supplementation during prolonged in vitro maturation improves the quality and development of poor-quality porcine oocytes via anti-oxidative and anti-apoptotic effects.
  Molecular reproduction and development 2018 Lin T, Lee JE, Kang JW, Oqani RK, Cho ES, Kim SB, Il Jin D
• Dynamic changes of SETD2, a histone H3K36 methyltransferase, in porcine oocytes, IVF and SCNT embryos.
  PloS one 2018 Diao YF, Lin T, Li X, Oqani RK, Lee JE, Kim SY, Jin DI
• α-Solanine impairs oocyte maturation and quality by inducing autophagy and apoptosis and changing histone modifications in a pig model.
  Reproductive toxicology (Elmsford, N.Y.) 2017 Lin T, Oqani RK, Lee JE, Kang JW, Kim SY, Cho ES, Jeong YD, Baek JJ, Jin DI
• Effects of CDK inhibitors on the maturation, transcription, and MPF activity of porcine oocytes.
  Reproductive biology 2017 Oqani RK, Lin T, Lee JE, Kim SY, Kang JW, Jin DI
• Delayed blastocyst formation or an extra day culture increases apoptosis in pig blastocysts.
  Animal reproduction science 2017 Lin T, Lee JE, Oqani RK, Kim SY, Cho ES, Jeong YD, Baek JJ, Jin DI
• Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error.
  PloS one 2016 Kim HR, Lee JE, Oqani RK, Kim SY, Wakayama T, Li C, Sa SJ, Woo JS, Jin DI
• Tauroursodeoxycholic acid improves pre-implantation development of porcine SCNT embryo by endoplasmic reticulum stress inhibition.
  Reproductive biology 2016 Lin T, Lee JE, Oqani RK, Kim SY, Cho ES, Jeong YD, Baek JJ, Jin DI
• Inhibition of P-TEFb disrupts global transcription, oocyte maturation, and embryo development in the mouse.
  Genesis (New York, N.Y. : 2000) 2016 Oqani RK, Lin T, Lee JE, Kim SY, Sa SJ, Woo JS, Jin DI
• P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig.
  PloS one 2016 Oqani RK, Lin T, Lee JE, Choi KM, Shin HY, Jin DI
• Coculture with good-quality COCs enhances the maturation and development rates of poor-quality COCs.
  Theriogenology 2015 Lin T, Oqani RK, Lee JE, Shin HY, Jin DI
• Procedure used for denuding pig oocytes influences oocyte damage, and development of in vitro and nuclear transfer embryos.
  Animal reproduction science 2014 Lin T, Diao YF, Choi HS, Oqani RK, Kang JW, Lee JE, Jin DI
• Changes in histone H3 lysine 36 methylation in porcine oocytes and preimplantation embryos.
  PloS one 2014 Diao YF, Oqani RK, Li XX, Lin T, Kang JW, Jin DI
• Distinct roles of ROCK1 and ROCK2 during development of porcine preimplantation embryos.
  Reproduction (Cambridge, England) 2014 Zhang JY, Dong HS, Oqani RK, Lin T, Kang JW, Jin DI
• Treatment of fetal fibroblasts with DNA methylation inhibitors and/or histone deacetylase inhibitors improves the development of porcine nuclear transfer-derived embryos.
  Animal reproduction science 2013 Diao YF, Naruse KJ, Han RX, Li XX, Oqani RK, Lin T, Jin DI
• Halogenated nucleotide labeling of nascent RNAs reveals dynamic transcription in growing pig oocytes.
  Developmental dynamics : an official publication of the American Association of Anatomists 2012 Oqani RK, Lee MG, Diao YF, Han RX, Jin DI
• Phosphorylation Status of RNA Polymerase II Carboxyl-terminal Domain in Porcine Oocytes and Early Embryos.
  Asian-Australasian journal of animal sciences 2012 Oqani RK, Zhang JY, Lee MG, Diao YF, Jin DI
• Effect of endoplasmic reticulum stress on porcine oocyte maturation and parthenogenetic embryonic development in vitro.
  Biology of reproduction 2012 Zhang JY, Diao YF, Oqani RK, Han RX, Jin DI
• Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model.
  Journal of applied toxicology : JAT 2011 Lee SH, Kim HR, Han RX, Oqani RK, Jin DI
• The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
  BMC developmental biology 2011 Oqani RK, Kim HR, Diao YF, Park CS, Jin DI