Renuka Nayak, MD, PhD
Assistant Professor
Medicine
School of Medicine
Dr. Renuka Nayak, MD, PhD, is a physician-scientist dedicated to advancing the care and treatment of patients with rheumatologic conditions such as rheumatoid arthritis, lupus, psoriatic arthritis, and other autoimmune diseases. She uses her unique backgrounds in Biology, Computer Science, and Clinical Rheumatology to investigate the role of the human gut microbiome in the treatment of rheumatoid arthritis.
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She uses an innovative combination of patient specimens, microbiology, next generation sequencing, and gnotobiotic mouse models to better understand how our microbiome, which many consider our "second genome," influences health and disease.
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 2022
- Rheumatology UCSF 2017
- Internal Medicine UCSF 2014
- MD, PhD Genomics University of Pennsylvania 2012
- BA Biology Swarthmore College 2004
- BA Computer Science Swarthmore College 2004
Grants and Projects
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Publications (17)
Top publication keywords:
MethotrexateEpistasis, GeneticAutoimmune DiseasesJoint DiseasesGastrointestinal MicrobiomeMicrobiotaGene Regulatory NetworksStress, PhysiologicalArthritis, RheumatoidMicrobial ConsortiaPsoriasisGastrointestinal TractBacteriaBacteriophage M13Rheumatic Diseases
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Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Wu KC, McCauley KE, Lynch SV, Nayak RR, King NJ, Patel S, Kim TY, Condra K, Fadrosh D, Nguyen D, Lin DL, Lynch K, Rogers SJ, Carter JT, Posselt AM, Stewart L, Schafer AL -
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
bioRxiv : the preprint server for biology 2023 Alexander M, Upadhyay V, Rock R, Ramirez L, Puchalska P, Orellana D, Ang QY, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ -
Simvastatin induces human gut bacterial cell surface genes.
Molecular microbiology 2023 Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ -
SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.
eLife 2023 Bustion AE, Nayak RR, Agrawal A, Turnbaugh PJ, Pollard KS -
Fanning the Flames of Autoimmunity: The Microbiome in Rheumatic Disease.
Arthritis & rheumatology (Hoboken, N.J.) 2022 Nayak RR
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Human gut bacterial metabolism drives Th17 activation and colitis.
Cell host & microbe 2021 Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, Upadhyay V, Pollard KS, Lynch SV, Turnbaugh PJ -
Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome.
Cell reports 2021 Lam KN, Spanogiannopoulos P, Soto-Perez P, Alexander M, Nalley MJ, Bisanz JE, Nayak RR, Weakley AM, Yu FB, Turnbaugh PJ -
Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota.
The Journal of investigative dermatology 2021 Nayak RR -
The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) 2021 Artacho A, Isaac S, Nayak R, Flor-Duro A, Alexander M, Koo I, Manasson J, Smith PB, Rosenthal P, Homsi Y, Gulko P, Pons J, Puchades-Carrasco L, Izmirly P, Patterson A, Abramson SB, Pineda-Lucena A, … -
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Cell host & microbe 2021 Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ -
Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response.
Nature reviews. Rheumatology 2020 Scher JU, Nayak RR, Ubeda C, Turnbaugh PJ, Abramson SB -
Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses.
Lupus science & medicine 2016 Mok A, Solomon O, Nayak RR, Coit P, Quach HL, Nititham J, Sawalha AH, Barcellos LF, Criswell LA, Chung SA -
Mirror, mirror on the wall: which microbiomes will help heal them all?
BMC medicine 2016 Nayak RR, Turnbaugh PJ -
Stress-induced changes in gene interactions in human cells.
Nucleic acids research 2013 Nayak RR, Bernal WE, Lee JW, Kearns MJ, Cheung VG -
Polymorphic cis- and trans-regulation of human gene expression.
PLoS biology 2010 Cheung VG, Nayak RR, Wang IX, Elwyn S, Cousins SM, Morley M, Spielman RS -
Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells.
American journal of human genetics 2010 Dombroski BA, Nayak RR, Ewens KG, Ankener W, Cheung VG, Spielman RS -
Coexpression network based on natural variation in human gene expression reveals gene interactions and functions.
Genome research 2009 Nayak RR, Kearns M, Spielman RS, Cheung VG