Raphael Trenker, PhD
Employee of Contracting Firm
Biochemistry and Biophysics
School of Medicine

Publications (28)

Top publication keywords:
Cryoelectron MicroscopyCell MembraneReceptor, ErbB-3Protein DomainsReceptors, Cell SurfaceSignal TransductionReceptor, ErbB-4Protein Interaction MapsLipid BilayersViral ProteinsUbiquitin-Protein LigasesReceptor Protein-Tyrosine KinasesLigandsB7-2 AntigenReceptor, ErbB-2

• Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
  eLife 2024 Raphael Trenker, Devan Diwanji, Tanner Bingham, Kliment A Verba, Natalia Jura
• Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
  eLife 2024 Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
• Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
  bioRxiv : the preprint server for biology 2024 Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
• De novo -designed transmembrane domains tune chimeric antigen receptor function.
  Acta Crystallographica Section A: Foundations and advances 2023 N. J. Chandler, A. S. Davey, A. Elazar, J. Y. Weinstein, J. V. Nguyen, R. Trenker, R. S. Cross, M. R. Jenkins, M. E. Call, S. J. Fleishman, M. J. Call
• De novo-designed transmembrane domains tune engineered receptor functions.
  eLife 2022 Elazar A, Chandler NJ, Davey AS, Weinstein JY, Nguyen JV, Trenker R, Cross RS, Jenkins MR, Call MJ, Call ME, Fleishman SJ

Show all (23 more) Hide

• An effective strategy for ligand-mediated pulldown of the HER2/HER3/NRG1β heterocomplex and cryo-EM structure determination at low sample concentrations.
  Methods in enzymology 2022 Trenker R, Diwanji D, Verba KA, Jura N
• Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3.
  Methods in enzymology 2022 Diwanji D, Trenker R, Jura N, Verba KA
• Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
  Nature 2022 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
• Cryo-EM structures of the near full-length HER2/HER3 heterodimer reveal a novel allosteric mechanism of activation.
  Biophysical Journal 2022 Devan C. Diwanji, Raphael Trenker, Tarjani M. Thaker, Feng Wang, David A. Agard, Kliment A. Verba, Natalia Jura
• Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
  Nature 2021 Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
• Mutant HER2 needs mutant HER3 to be an effective oncogene.
  Cell reports. Medicine 2021 Trenker R, Diwanji D, Jura N
• Human and viral membrane-associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression.
  The Journal of biological chemistry 2021 Trenker R, Wu X, Nguyen JV, Wilcox S, Rubin AF, Call ME, Call MJ
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• Receptor tyrosine kinase activation: From the ligand perspective.
  Current opinion in cell biology 2020 Trenker R, Jura N
• The serial millisecond crystallography instrument at the Australian Synchrotron incorporating the "Lipidico" injector.
  The Review of scientific instruments 2019 Berntsen P, Hadian Jazi M, Kusel M, Martin AV, Ericsson T, Call MJ, Trenker R, Roque FG, Darmanin C, Abbey B
• Protein-Eye View of the in Meso Crystallization Mechanism.
  Langmuir : the ACS journal of surfaces and colloids 2019 van T Hag L, de Campo L, Tran N, Sokolova A, Trenker R, Call ME, Call MJ, Garvey CJ, Leung AE, Darwish TA, Krause-Heuer A, Knott R, Meikle TG, Drummond CJ, Mezzenga R, Conn CE
• Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
  Nature communications 2019 Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N
• Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis.
  Crystal Growth & Design 2017 Alexandru Zabara, Thomas G. Meikle, Raphael Trenker, Shenggen Yao, Janet Newman, Thomas S. Peat, Frances Separovic, Charlotte E. Conn, Melissa J. Call, Matthew E. Call, Ehud M. Landau, Calum J. …
• Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.
  PLoS pathogens 2017 Cutts EE, Laasch N, Reiter DM, Trenker R, Slater LM, Stansfeld PJ, Vakonakis I
• Progress and prospects for structural studies of transmembrane interactions in single-spanning receptors.
  Current opinion in structural biology 2016 Trenker R, Call MJ, Call ME
• Cell-free synthesis of isotopically labelled peptide ligands for the functional characterization of G protein-coupled receptors.
  FEBS open bio 2015 Joedicke L, Trenker R, Langer JD, Michel H, Preu J
• Crystal Structure of the Glycophorin A Transmembrane Dimer in Lipidic Cubic Phase.
  Journal of the American Chemical Society 2015 Trenker R, Call ME, Call MJ