Randall Lee, MD, PhD
Professor
Medicine
School of Medicine

He utilizes catheter ablation, LAA ligation for embolic stroke associated with atrial fibrillation and implantable devices (pacemakers and defibrillators) for the treatment of arrhythmias.

RESEARCH INTERESTS: Cardiac tissue engineering for myocardial repair/regeneration. Cardiac engineering for the development of devices and monitoring of arrhythmias and embolic stroke prevention. His research focuses on cellular and molecular aspects of cardiac arrhythmias and vascular regeneration. Dr. Lee uses genetic engineering techniques to investigate derangements during cardiac arrhythmias and myocardial infarctions and as possible therapeutic tools. Dr. Lee also is interested in cardiac development of the conduction system and the means to alter conduction, which then may be applied to diseased states.

• Postoperative Coagulation Changes in Patients after Epicardial Left Atrial Appendage Occlusion Varies Based on the Left Atrial Appendage Size.
  Diseases (Basel, Switzerland) 2023 Batko J, Rusinek J, Slomka A, Litwinowicz R, Burysz M, Bartus M, Lakkireddy DR, Lee RJ, Natorska J, Zabczyk M, Kapelak B, Bartus K
• Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction.
  NPJ Regenerative medicine 2023 Mohindra P, Zhong JX, Fang Q, Cuylear DL, Huynh C, Qiu H, Gao D, Kharbikar BN, Huang X, Springer ML, Lee RJ, Desai TA
• Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction.
  Scientific reports 2023 Murtha LA, Hardy SA, Mabotuwana NS, Bigland MJ, Bailey T, Raguram K, Liu S, Ngo DT, Sverdlov AL, Tomin T, Birner-Gruenberger R, Hume RD, Iismaa SE, Humphreys DT, Patrick R, Chong JJH, Lee RJ, Harvey …
• Endocardial-to-Epicardial Wenckebach Conduction in the Left Atrium: Implications for 3-Dimensional Re-Entry During Atrial Fibrillation.
  JACC. Clinical electrophysiology 2023 Wong CX, Howell SJ, Lee RJ
• The Strengths and Weaknesses of Left Atrial Appendage Ligation or Exclusion (LARIAT, AtriaClip, Surgical Suture).
  Cardiac electrophysiology clinics 2023 Lee RJ, Hanke T
• A Randomized Trial of High vs Standard Power Radiofrequency Ablation for Pulmonary Vein Isolation: SHORT-AF.
  JACC. Clinical electrophysiology 2023 Lee AC, Voskoboinik A, Cheung CC, Yogi S, Tseng ZH, Moss JD, Dewland TA, Lee BK, Lee RJ, Hsia HH, Marcus GM, Vedantham V, Chieng D, Kistler PM, Dillon W, Vittinghoff E, Gerstenfeld EP
• Hybrid epicardial and endocardial sinus node-sparing ablation therapy for inappropriate sinus tachycardia: Rationale and design of the multicenter HEAL-IST IDE trial.
  Heart rhythm O2 2023 de Asmundis C, Pannone L, Lakkireddy D, Beaver TM, Brodt CR, Lee RJ, Frazier K, Chierchia GB, La Meir M
• Premature Atrial Contraction Location and Atrial Fibrillation Inducibility.
  Circulation. Arrhythmia and electrophysiology 2023 Howell SJ, Dukes JW, Vittinghoff E, Tang JJ, Moss JD, Lee RJ, Lee BK, Tseng ZH, Vedantham V, Olgin JE, Scheinman MM, Hsia H, Gerstenfeld EP, Marcus GM
• Log-Spectral Matching GAN: PPG-based Atrial Fibrillation Detection can be Enhanced by GAN-based Data Augmentation with Integration of Spectral Loss.
  IEEE journal of biomedical and health informatics 2023 Ding C, Xiao R, Do D, Lee DS, Lee RJ, Kalantarian S, Hu X
• Randomized Comparison of a Radiofrequency Wire Versus a Radiofrequency Needle System for Transseptal Puncture.
  JACC. Clinical electrophysiology 2022 Dewland TA, Gerstenfeld EP, Moss JD, Lee AC, Vedantham V, Lee RJ, Tseng ZH, Hsia HH, Lee BK, Wall GC, Chang KR, Yang MH, Marcus GM
• The Value of Programmed Ventricular Extrastimuli From the Right Ventricular Basal Septum During Supraventricular Tachycardia.
  JACC. Clinical electrophysiology 2022 Higuchi S, Ito H, Gerstenfeld EP, Lee AC, Lee BK, Marcus GM, Hsia HH, Moss JD, Lee RJ, Dewland TA, Vedantham V, Tseng ZH, Patel AR, Tanel RE, Badhwar N, Pellegrini CN, Kawamura M, Shoda M, Hwang C, …
• Impact of Label Noise on the Learning Based Models for a Binary Classification of Physiological Signal.
  Sensors (Basel, Switzerland) 2022 Ding C, Pereira T, Xiao R, Lee RJ, Hu X
• Targeted Treatment of Inappropriate Sinoatrial Node Tachycardia Based on Electrophysiological and Structural Mechanisms.
  The American journal of cardiology 2022 de Asmundis C, Pannone L, Lakkireddy D, Beaver TM, Brodt CR, Lee RJ, Sorgente A, Gauthey A, Monaco C, Overeinder I, Bala G, Almorad A, Ströker E, Sieira J, Brugada P, Chierchia GB, La Meir M, …
• Engineering stem cell therapeutics for cardiac repair.
  Journal of molecular and cellular cardiology 2022 Fang J, Li JJ, Zhong X, Zhou Y, Lee RJ, Cheng K, Li S
• The Strengths and Weaknesses of Left Atrial Appendage Ligation or Exclusion (LARIAT, AtriaClip, Surgical Suture).
  Interventional cardiology clinics 2022 Lee RJ, Hanke T
• Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis: LAA HOMEOSTASIS-2.
  Journal of clinical medicine 2022 Bartus K, Kanuri SH, Litwinowicz R, Ali Elbey M, Natorska J, Zabczyk M, Bartus M, Kapelak B, Gopinnathannair R, Garg J, Turagam MK, Malecki MT, Lee RJ, Lakkireddy D
• Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events.
  Annals of internal medicine 2021 Marcus GM, Vittinghoff E, Whitman IR, Joyce S, Yang V, Nah G, Gerstenfeld EP, Moss JD, Lee RJ, Lee BK, Tseng ZH, Vedantham V, Olgin JE, Scheinman MM, Hsia H, Gladstone R, Fan S, Lee E, Fang C, Ogomori…
• Epicardial Contrast Injection to Guide Left Atrial Appendage Closure.
  HeartRhythm case reports 2021 Dewland TA, Yoruk A, Lee RJ
• Unraveling the Gordian Knot!: Hospital Volume Threshold to Optimize Outcomes After Left Atrial Appendage Occlusion.
  JACC. Cardiovascular interventions 2021 Moussa ID, Lee RJ
• A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Alcohol to Assess Changes in Atrial Electrophysiology.
  JACC. Clinical electrophysiology 2021 Marcus GM, Dukes JW, Vittinghoff E, Nah G, Badhwar N, Moss JD, Lee RJ, Lee BK, Tseng ZH, Walters TE, Vedantham V, Gladstone R, Fan S, Lee E, Fang C, Ogomori K, Hue T, Olgin JE, Scheinman MM, Hsia H, …
• Explainability Metrics of Deep Convolutional Networks for Photoplethysmography Quality Assessment.
  IEEE access : practical innovations, open solutions 2021 Zhang O, Ding C, Pereira T, Xiao R, Gadhoumi K, Meisel K, Lee RJ, Chen Y, Hu X
• Giant Left Atrium Associated with Massive Thrombus Formation 14 Years after Orthotopic Heart Transplantation.
  Brazilian journal of cardiovascular surgery 2020 Bartus K, Litwinowicz R, Kapelak B, Filip G, Wierzbicki K, Lee RJ
• Endocardial versus epicardial left atrial appendage exclusion for stroke prevention in patients with atrial fibrillation: Midterm follow-up.
  Journal of cardiovascular electrophysiology 2020 Litwinowicz R, Burysz M, Mazur P, Kapelak B, Bartus M, Lakkireddy D, Lee RJ, Malec-Litwinowicz M, Bartus K
• Percutaneous epicardial approach for LAA ligation.
  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2020 Sanchez JM, Lee A, Bartus K, Lee RJ
• Incidence and outcomes of patients with atrial fibrillation and major bleeding complications: from the TREAT-AF study.
  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2020 Perino AC, Kaiser DW, Lee RJ, Fan J, Askari M, Schmitt SK, Turakhia MP
• Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results.
  JACC. Clinical electrophysiology 2020 Ellis CR, Badhwar N, Tschopp D, Danter M, Jackson GG, Kerendi F, Walters T, Fang Q, Deuse T, Beygui R, Lee RJ
• A collective European experience with left atrial appendage suture ligation using the LARIAT+ device.
  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2020 Tilz RR, Fink T, Bartus K, Wong T, Vogler J, Nentwich K, Panniker S, Fang Q, Piorkowski C, Liosis S, Gaspar T, Sawan N, Metzner A, Nietlispach F, Maisano F, Lee RJ, Foran JP, Ouyang F, Sievert H, …
• Photoplethysmography based atrial fibrillation detection: a review.
  NPJ digital medicine 2020 Pereira T, Tran N, Gadhoumi K, Pelter MM, Do DH, Lee RJ, Colorado R, Meisel K, Hu X
• Anatomic Considerations for Epicardial and Endocardial Left Atrial Appendage Closure.
  Cardiac electrophysiology clinics 2019 Voskoboinik A, Lee RJ
• Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair.
  Advanced healthcare materials 2019 Henry JJD, Delrosario L, Fang J, Wong SY, Fang Q, Sievers R, Kotha S, Wang A, Farmer D, Janaswamy P, Lee RJ, Li S
• Coagulation factors and fibrinolytic activity in the left atrial appendage and other heart chambers in patients with atrial fibrillation: is there a local intracardiac prothrombotic state? (HEART-CLOT study).
  International journal of cardiology 2019 Bartus K, Litwinowicz R, Natorska J, Zabczyk M, Undas A, Kapelak B, Lakkireddy D, Lee RJ
• Reduction in risk of stroke and bleeding after left atrial appendage closure with LARIAT device in patients with increased risk of stroke and bleeding: Long term results.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2019 Litwinowicz R, Bartus M, Kapelak B, Suwalski P, Lakkireddy D, Lee RJ, Bartus K
• Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.
  PloS one 2019 Hardy SA, Mabotuwana NS, Murtha LA, Coulter B, Sanchez-Bezanilla S, Al-Omary MS, Senanayake T, Loering S, Starkey M, Lee RJ, Rainer PP, Hansbro PM, Boyle AJ
• Enhancement of human adipose-derived stem cell spheroid differentiation in an in situ enzyme-crosslinked gelatin hydrogel.
  Journal of materials chemistry. B 2019 Tsai CC, Hong YJ, Lee RJ, Cheng NC, Yu J
• Long term outcomes after left atrial appendage closure with the LARIAT device-Stroke risk reduction over five years follow-up.
  PloS one 2018 Litwinowicz R, Bartus M, Burysz M, Brzezinski M, Suwalski P, Kapelak B, Vuddanda V, Lakkireddy D, Lee RJ, Trabka R, Bartus K
• Rapid left atrial appendage thrombus formation before suture ligation with LARIAT.
  Postepy w kardiologii interwencyjnej = Advances in interventional cardiology 2018 Bartus K, Myc J, Bartus M, Lee RJ, Litwinowicz R, Dziewierz A, Kapelak B
• Combining Desorption Electrospray Ionization Mass Spectrometry Imaging and Machine Learning for Molecular Recognition of Myocardial Infarction.
  Analytical chemistry 2018 Margulis K, Zhou Z, Fang Q, Sievers RE, Lee RJ, Zare RN
• An overview of current and emerging devices for percutaneous left atrial appendage closure.
  Trends in cardiovascular medicine 2018 Chow DHF, Wong YH, Park JW, Lam YY, De Potter T, Rodés-Cabau J, Asmarats L, Sandri M, Sideris E, McCaw T, Lee RJ, Sievert H, Søndergaard L, De Backer O
• Subxiphoid Hybrid Approach for Epicardial/Endocardial Ablation and LAA Exclusion in Patients with Persistent and Longstanding Atrial Fibrillation.
  Journal of atrial fibrillation 2018 Badhwar N, Al-Dosari G, Dukes J, Lee RJ
• Use of Programmed Ventricular Extrastimulus During Supraventricular Tachycardia to Differentiate Atrioventricular Nodal Re-Entrant Tachycardia From Atrioventricular Re-Entrant Tachycardia.
  JACC. Clinical electrophysiology 2018 Ito H, Badhwar N, Patel AR, Hoffmayer KS, Moss JD, Pellegrini CN, Vedantham V, Tseng ZH, Tanel RE, Hsia HH, Lee RJ, Marcus GM, Gerstenfeld EP, Scheinman MM
• Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction.
  Biomaterials 2018 Le LV, Mohindra P, Fang Q, Sievers RE, Mkrtschjan MA, Solis C, Safranek CW, Russell B, Lee RJ, Desai TA
• Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation.
  Expert review of cardiovascular therapy 2018 Sanchez JM, Al-Dosari G, Chu S, Beygui R, Deuse T, Badhwar N, Lee RJ
• Pericardial Delivery of Biological Agents: The Next Frontier?
  JACC. Basic to translational science 2017 Govea A, Lee RJ
• Patients With Atrial Fibrillation Who Are Not on Anticoagulant Treatment Due to Increased Bleeding Risk Are Common and Have a High Risk of Stroke.
  JACC. Clinical electrophysiology 2017 Redfors B, Gray WA, Lee RJ, Ellenbogen KA, Bonafede M, Ben-Yehuda O
• Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable?
  Journal of cardiovascular electrophysiology 2017 Szilágyi J, Marcus GM, Badhwar N, Lee BK, Lee RJ, Vedantham V, Tseng ZH, Walters T, Scheinman M, Olgin J, Gerstenfeld EP
• Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling.
  American journal of cardiovascular disease 2017 Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ
• The QT Interval as a Noninvasive Marker of Atrial Refractoriness.
  Pacing and clinical electrophysiology : PACE 2016 Nguyen KT, Gladstone RA, Dukes JW, Nazer B, Vittinghoff E, Badhwar N, Vedantham V, Gerstenfeld EP, Lee BK, Lee RJ, Tseng ZH, Olgin JE, Scheinman MM, Marcus GM
• Conversion of persistent atrial fibrillation to sinus rhythm after LAA ligation with the LARIAT device.
  International journal of cardiology 2016 Badhwar N, Mittal S, Rasekh A, Vasaiwala S, Musat D, S Naeini P, Fang Q, Nentwich K, Deneke T, Chang J, Lakkireddy D, Wilber D, Lee RJ
• Current Treatment Strategies for Heart Failure: Role of Device Therapy and LV Reconstruction.
  Current treatment options in cardiovascular medicine 2016 Janaswamy P, Walters TE, Nazer B, Lee RJ
• Clinical Significance of Leaks Following Left Atrial Appendage Ligation With the LARIAT Suture Delivery Device.
  JACC. Cardiovascular interventions 2016 Lee RJ
• Left atrial appendage ligation with the next generation LARIAT(+) suture delivery device: Early clinical experience.
  International journal of cardiology 2016 Bartus K, Gafoor S, Tschopp D, Foran JP, Tilz R, Wong T, Lakkireddy D, Sievert H, Lee RJ
• Short and long-term outcomes of percutaneous left atrial appendage suture ligation: Results from a US multicenter evaluation.
  Heart rhythm 2016 Lakkireddy D, Afzal MR, Lee RJ, Nagaraj H, Tschopp D, Gidney B, Ellis C, Altman E, Lee B, Kar S, Bhadwar N, Sanchez M, Gadiyaram V, Evonich R, Rasekh A, Cheng J, Cuoco F, Chandhok S, Gunda S, Reddy M,…
• Impact of Periprocedural Colchicine on Postprocedural Management in Patients Undergoing a Left Atrial Appendage Ligation Using LARIAT.
  Journal of cardiovascular electrophysiology 2015 Gunda S, Reddy M, Nath J, Nagaraj H, Atoui M, Rasekh A, Ellis CR, Badhwar N, Lee RJ, DI Biase L, Mansour M, Ruskin JN, Natale A, Earnest M, Lakkireddy DR
• Reversible High-Grade Atrioventricular Block Associated With Cocaine Use.
  JAMA internal medicine 2015 Hall PS, Nazer B, Lee RJ
• One-year follow-up results from AUGMENT-HF: a multicentre randomized controlled clinical trial of the efficacy of left ventricular augmentation with Algisyl in the treatment of heart failure.
  European journal of heart failure 2015 Mann DL, Lee RJ, Coats AJ, Neagoe G, Dragomir D, Pusineri E, Piredda M, Bettari L, Kirwan BA, Dowling R, Volterrani M, Solomon SD, Sabbah HN, Hinson A, Anker SD
• Left Atrial Appendage Ligation in Nonvalvular Atrial Fibrillation Patients at High Risk for Embolic Events With Ineligibility for Oral Anticoagulation: Initial Report of Clinical Outcomes.
  JACC. Clinical electrophysiology 2015 Sievert H, Rasekh A, Bartus K, Morelli RL, Fang Q, Kuropka J, Le D, Gafoor S, Heuer L, Safavi-Naeini P, Hue TF, Marcus GM, Badhwar N, Massumi A, Lee RJ
• Percutaneous alternative to the Maze procedure for the treatment of persistent or long-standing persistent atrial fibrillation (aMAZE trial): Rationale and design.
  American heart journal 2015 Lee RJ, Lakkireddy D, Mittal S, Ellis C, Connor JT, Saville BR, Wilber D
• The Effect of Direct Current Stimulation versus T-Wave Shock on Defibrillation Threshold Testing.
  Pacing and clinical electrophysiology : PACE 2015 Ito H, Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Gerstenfeld EP, Scheinman MM
• The feasibility and safety of Algisyl-LVR™ as a method of left ventricular augmentation in patients with dilated cardiomyopathy: initial first in man clinical results.
  International journal of cardiology 2015 Lee RJ, Hinson A, Bauernschmitt R, Matschke K, Fang Q, Mann DL, Dowling R, Schiller N, Sabbah HN
• A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial).
  European heart journal 2015 Anker SD, Coats AJ, Cristian G, Dragomir D, Pusineri E, Piredda M, Bettari L, Dowling R, Volterrani M, Kirwan BA, Filippatos G, Mas JL, Danchin N, Solomon SD, Lee RJ, Ahmann F, Hinson A, Sabbah HN, …
• Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation.
  Expert review of cardiovascular therapy 2015 Le D, Morelli R, Badhwar N, Lee RJ
• Left atrial appendage ligation in patients with atrial fibrillation leads to a decrease in atrial dispersion.
  Journal of the American Heart Association 2015 Kawamura M, Scheinman MM, Lee RJ, Badhwar N
• Sequential Percutaneous LAA Ligation and Pulmonary Vein Isolation in Patients with Persistent AF: Initial Results of a Feasibility Study.
  Journal of cardiovascular electrophysiology 2015 Badhwar N, Lakkireddy D, Kawamura M, Han FT, Iyer SK, Moyers BS, Dewland TA, Woods C, Ferrell R, Nath J, Earnest M, Lee RJ
• Immuno-modification of enhancing stem cells targeting for myocardial repair.
  Journal of cellular and molecular medicine 2015 Yu J, Wu YK, Gu Y, Fang Q, Sievers R, Ding CH, Olgin JE, Lee RJ
• Delivery of lipid micelles into infarcted myocardium using a lipid-linked matrix metalloproteinase targeting peptide.
  Molecular pharmaceutics 2015 Nguyen J, Sievers R, Motion JP, Kivimäe S, Fang Q, Lee RJ
• Surgical and concomitant epicardial-endocardial (hybrid) ablation of persistent and long-standing persistent atrial fibrillation.
  Current problems in cardiology 2015 Badhwar N, Tschopp DR, Lee RJ
• Impact of left atrial appendage exclusion using an epicardial ligation system (LARIAT) on atrial fibrillation burden in patients with cardiac implantable electronic devices.
  Heart rhythm 2014 Afzal MR, Kanmanthareddy A, Earnest M, Reddy M, Atkins D, Bommana S, Bartus K, Rasekh A, Han F, Badhwar N, Cheng J, Dibiase L, Ellis CR, Dawn B, Natale A, Lee RJ, Lakkireddy D
• Anatomic analysis of the left atrial appendage after closure with the LARIAT device.
  Circulation. Arrhythmia and electrophysiology 2014 Bartus K, Morelli RL, Szczepanski W, Kapelak B, Sadowski J, Lee RJ
• Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction.
  Biomaterials 2014 Pinney JR, Du KT, Ayala P, Fang Q, Sievers RE, Chew P, Delrosario L, Lee RJ, Desai TA
• Evolution of stroke prevention in nonvalvular atrial fibrillation patients.
  Journal of the American College of Cardiology 2014 Lee RJ
• His overdrive pacing during supraventricular tachycardia: a novel maneuver for distinguishing atrioventricular nodal reentrant tachycardia from atrioventricular reciprocating tachycardia.
  Heart rhythm 2014 Singh DK, Viswanathan MN, Tanel RE, Lee RJ, Lee BK, Marcus GM, Olgin JE, Han F, Vedantham V, Tseng ZH, Pellegrini C, Kawamura M, Gerstenfeld EP, Badhwar N, Scheinman M
• Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy.
  Journal of cardiovascular electrophysiology 2014 Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Olgin JE, Gerstenfeld EP, Scheinman MM
• Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation.
  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2014 Stepanyan G, Badhwar N, Lee RJ, Marcus GM, Lee BK, Tseng ZH, Vedantham V, Olgin J, Scheinman M, Gerstenfeld EP
• LAA ligation using the LARIAT suture delivery device: tips and tricks for a successful procedure.
  Heart rhythm 2014 Koneru JN, Badhwar N, Ellenbogen KA, Lee RJ
• The effects of LAA ligation on LAA electrical activity.
  Heart rhythm 2014 Han FT, Bartus K, Lakkireddy D, Rojas F, Bednarek J, Kapelak B, Bartus M, Sadowski J, Badhwar N, Earnest M, Valderrabano M, Lee RJ
• The effects of aging on apoptosis following myocardial infarction.
  Cardiovascular therapeutics 2013 Boyle AJ, Hwang J, Ye J, Shih H, Jun K, Zhang Y, Fang Q, Sievers R, Yeghiazarians Y, Lee RJ
• Aging Impairs the Proliferative Capacity of Cardiospheres, Cardiac Progenitor Cells and Cardiac Fibroblasts: Implications for Cell Therapy.
  Journal of clinical medicine 2013 Ye J, Hom DS, Hwang J, Yeghiazarians Y, Lee RJ, Boyle AJ
• Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study).
  Journal of the American Heart Association 2013 Hsu JC, Badhwar N, Gerstenfeld EP, Lee RJ, Mandyam MC, Dewland TA, Imburgia KE, Hoffmayer KS, Vedantham V, Lee BK, Tseng ZH, Scheinman MM, Olgin JE, Marcus GM
• Shox2 regulates the pacemaker gene program in embryoid bodies.
  Stem cells and development 2013 Hashem SI, Lam ML, Mihardja SS, White SM, Lee RJ, Claycomb WC
• The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model.
  Biomaterials 2013 Mihardja SS, Gonzales JA, Gao D, Sievers RE, Fang Q, Stillson CA, Yu J, Peng M, Lee RJ
• Augmentation of left ventricular wall thickness with alginate hydrogel implants improves left ventricular function and prevents progressive remodeling in dogs with chronic heart failure.
  JACC. Heart failure 2013 Sabbah HN, Wang M, Gupta RC, Rastogi S, Ilsar I, Sabbah MS, Kohli S, Helgerson S, Lee RJ
• Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.
  PloS one 2013 Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML
• Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart.
  International journal of cardiology 2013 Lee LC, Wall ST, Klepach D, Ge L, Zhang Z, Lee RJ, Hinson A, Gorman JH, Gorman RC, Guccione JM
• Percutaneous left atrial appendage suture ligation using the LARIAT device in patients with atrial fibrillation: initial clinical experience.
  Journal of the American College of Cardiology 2012 Bartus K, Han FT, Bednarek J, Myc J, Kapelak B, Sadowski J, Lelakowski J, Bartus S, Yakubov SJ, Lee RJ
• Using extracellular matrix-derived peptides to alter the microenvironment for myocardial repair.
  Current vascular pharmacology 2012 Mihardja SS, Lee RJ
• Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation.
  The American journal of cardiology 2012 Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Gerstenfeld EP, Olgin JE, Marcus GM
• Polymer-based restoration of left ventricular mechanics.
  Cell transplantation 2012 Lee RJ, Hinson A, Helgerson S, Bauernschmitt R, Sabbah HN
• Predictors of axillary vein location for vascular access during pacemaker and defibrillator lead implantation.
  Pacing and clinical electrophysiology : PACE 2011 Hsu JC, Friday J, Lee BK, Azadani PN, Lee RJ, Badhwar N, Tseng ZH, Olgin JE, Marcus GM
• Predictors of unusual ECG characteristics in cavotricuspid isthmus-dependent atrial flutter ablation.
  Pacing and clinical electrophysiology : PACE 2011 Hoffmayer KS, Yang Y, Joseph S, McCabe JM, Bhave P, Hsu J, Ng RK, Lee BK, Badhwar N, Lee RJ, Tseng ZH, Olgin JE, Narayan SM, Marcus GM, Scheinman MM
• Electrophysiologic properties of para-Hisian atrial tachycardia.
  Heart rhythm 2011 Iwai S, Badhwar N, Markowitz SM, Stambler BS, Keung E, Lee RJ, Chung JH, Olgin JE, Scheinman MM, Lerman BB
• Extracellular matrix-derived peptides and myocardial repair.
  Cell adhesion & migration 2011 Mihardja SS, Yu J, Lee RJ
• An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors.
  PloS one 2011 Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS
• The aging heart and post-infarction left ventricular remodeling.
  Journal of the American College of Cardiology 2011 Shih H, Lee B, Lee RJ, Boyle AJ
• Proteomic identification of biomarkers of vascular injury.
  American journal of translational research 2010 Huang NF, Kurpinski K, Fang Q, Lee RJ, Li S
• Feasibility of closed-chest ligation of the left atrial appendage in humans.
  Heart rhythm 2010 Bartus K, Bednarek J, Myc J, Kapelak B, Sadowski J, Lelakowski J, Yakubov SJ, Lee RJ
• Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentry.
  Journal of cardiovascular electrophysiology 2010 Yang Y, Varma N, Badhwar N, Tanel RE, Sundara S, Lee RJ, Lee BK, Tseng ZH, Marcus GM, Kim AM, Olgin JE, Scheinman MM
• The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat.
  Biomaterials 2010 Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ
• Biophysical and chemical effects of fibrin on mesenchymal stromal cell gene expression.
  Acta biomaterialia 2010 Huang NF, Chu J, Lee RJ, Li S
• Catheter-based left atrial appendage (LAA) ligation for the prevention of embolic events arising from the LAA: initial experience in a canine model.
  Circulation. Cardiovascular interventions 2010 Lee RJ, Bartus K, Yakubov SJ
• Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction.
  PloS one 2010 Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ
• High-resolution optical mapping of ventricular tachycardia in rats with chronic myocardial infarction.
  Pacing and clinical electrophysiology : PACE 2010 Ding C, Gepstein L, Nguyen DT, Wilson E, Hulley G, Beaser A, Lee RJ, Olgin J
• Engineering of aligned skeletal muscle by micropatterning.
  American journal of translational research 2010 Huang NF, Lee RJ, Li S
• Stem cells for myocardial repair and regeneration: where are we today?
  Methods in molecular biology (Clifton, N.J.) 2010 Lee RJ
• Intracardiac and extracardiac markers of inflammation during atrial fibrillation.
  Heart rhythm 2009 Marcus GM, Smith LM, Ordovas K, Scheinman MM, Kim AM, Badhwar N, Lee RJ, Tseng ZH, Lee BK, Olgin JE
• Differences in accessory pathway location by sex and race.
  Heart rhythm 2009 Hsu JC, Tanel RE, Lee BK, Scheinman MM, Badhwar N, Lee RJ, Tseng ZH, Olgin JE, Marcus GM
• Test characteristics of neck fullness and witnessed neck pulsations in the diagnosis of typical AV nodal reentrant tachycardia.
  Clinical cardiology 2009 Sakhuja R, Smith LM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE, Marcus GM
• Bone marrow-derived mesenchymal stem cells in fibrin augment angiogenesis in the chronically infarcted myocardium.
  Regenerative medicine 2009 Huang NF, Lam A, Fang Q, Sievers RE, Li S, Lee RJ
• Comparison of gene-transfer efficiency in human embryonic stem cells.
  Molecular imaging and biology 2009 Cao F, Xie X, Gollan T, Zhao L, Narsinh K, Lee RJ, Wu JC
• Remote navigation guided ablation of incessant atrial tachycardia in a patient with restricted venous access.
  Journal of cardiovascular electrophysiology 2009 Kim AM, Badhwar N, Lee RJ
• Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy.
  The Journal of thoracic and cardiovascular surgery 2009 Yu J, Christman KL, Chin E, Sievers RE, Saeed M, Lee RJ
• The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model.
  Biomaterials 2008 Yu J, Gu Y, Du KT, Mihardja S, Sievers RE, Lee RJ
• Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time.
  Pacing and clinical electrophysiology : PACE 2008 Kim AM, Turakhia M, Lu J, Badhwar N, Lee BK, Lee RJ, Marcus GM, Tseng ZH, Scheinman M, Olgin JE
• Protracted CRP elevation after atrial fibrillation ablation.
  Pacing and clinical electrophysiology : PACE 2008 McCabe JM, Smith LM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE, Marcus GM
• The effect of polypyrrole on arteriogenesis in an acute rat infarct model.
  Biomaterials 2008 Mihardja SS, Sievers RE, Lee RJ
• Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells.
  Journal of cellular physiology 2008 Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML
• Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory period.
  Pacing and clinical electrophysiology : PACE 2008 Marcus GM, Smith LM, Whiteman D, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE
• Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction.
  Journal of applied physiology (Bethesda, Md. : 1985) 2008 Zhao TC, Tseng A, Yano N, Tseng Y, Davol PA, Lee RJ, Lum LG, Padbury JF
• A first-degree family history in lone atrial fibrillation patients.
  Heart rhythm 2008 Marcus GM, Smith LM, Vittinghoff E, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE
• Markers of inflammation before and after curative ablation of atrial flutter.
  Heart rhythm 2007 Marcus GM, Smith LM, Glidden DV, Wilson E, McCabe JM, Whiteman D, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE
• Tissue engineering and stem cell therapy for myocardial repair.
  Frontiers in bioscience : a journal and virtual library 2007 Gu Y, Yu J, Lum LG, Lee RJ
• Chemical and physical regulation of stem cells and progenitor cells: potential for cardiovascular tissue engineering.
  Tissue engineering 2007 Huang NF, Lee RJ, Li S
• Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches.
  Journal of applied physiology (Bethesda, Md. : 1985) 2007 Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML
• Antibody targeting of stem cells to infarcted myocardium.
  Stem cells (Dayton, Ohio) 2006 Lee RJ, Fang Q, Davol PA, Gu Y, Sievers RE, Grabert RC, Gall JM, Tsang E, Yee MS, Fok H, Huang NF, Padbury JF, Larrick JW, Lum LG
• Repeat transseptal catheterization after ablation for atrial fibrillation.
  Journal of cardiovascular electrophysiology 2006 Marcus GM, Ren X, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Foster E, Olgin JE
• Regional left atrial voltage in patients with atrial fibrillation.
  Heart rhythm 2006 Marcus GM, Yang Y, Varosy PD, Ordovas K, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE
• Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery.
  Cardiology 2006 Nakai T, Chandy J, Nakai K, Bellows WH, Flachsbart K, Lee RJ, Leung JM
• Biomaterials for the treatment of myocardial infarction.
  Journal of the American College of Cardiology 2006 Christman KL, Lee RJ
• MR guidance of targeted injections into border and core of scarred myocardium in pigs.
  Radiology 2006 Saeed M, Martin AJ, Lee RJ, Weber O, Revel D, Saloner D, Higgins CB
• Myotube assembly on nanofibrous and micropatterned polymers.
  Nano letters 2006 Huang NF, Patel S, Thakar RG, Wu J, Hsiao BS, Chu B, Lee RJ, Li S
• A rodent model of myocardial infarction for testing the efficacy of cells and polymers for myocardial reconstruction.
  Nature protocols 2006 Huang NF, Sievers RE, Park JS, Fang Q, Li S, Lee RJ
• The new face of bispecific antibodies: targeting cancer and much more.
  Experimental hematology 2006 Lum LG, Davol PA, Lee RJ
• Scarred myocardium imposes additional burden on remote viable myocardium despite a reduction in the extent of area with late contrast MR enhancement.
  European radiology 2005 Saeed M, Lee RJ, Weber O, Do L, Martin A, Ursell P, Saloner D, Higgins CB
• Injectable biopolymers enhance angiogenesis after myocardial infarction.
  Tissue engineering 2005 Huang NF, Yu J, Sievers R, Li S, Lee RJ
• Atrial tachycardia arising from the coronary sinus musculature: electrophysiological characteristics and long-term outcomes of radiofrequency ablation.
  Journal of the American College of Cardiology 2005 Badhwar N, Kalman JM, Sparks PB, Kistler PM, Attari M, Berger M, Lee RJ, Sra J, Scheinman MM
• Virtual reality of stem cell transplantation to repair injured myocardium.
  Journal of cellular biochemistry 2005 Lum LG, Padbury JF, Davol PA, Lee RJ
• Pleiotrophin induces formation of functional neovasculature in vivo.
  Biochemical and biophysical research communications 2005 Christman KL, Fang Q, Kim AJ, Sievers RE, Fok HH, Candia AF, Colley KJ, Herradon G, Ezquerra L, Deuel TF, Lee RJ
• Protected circumferential conduction in the posterior atrioventricular vestibule of the left atrium: electrophysiologic and anatomic correlates.
  Pacing and clinical electrophysiology : PACE 2005 Cheng J, Yang Y, Ursell PC, Lee RJ, Dorostkar PC, Boahene KA, Scheinman MM
• Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer.
  Biomaterials 2005 Christman KL, Fang Q, Yee MS, Johnson KR, Sievers RE, Lee RJ
• Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium.
  Journal of the American College of Cardiology 2004 Christman KL, Vardanian AJ, Fang Q, Sievers RE, Fok HH, Lee RJ
• Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction.
  Tissue engineering 2004 Christman KL, Fok HH, Sievers RE, Fang Q, Lee RJ
• Usefulness of a ventricular extrastimulus from the summit of the ventricular septum in diagnosis of septal accessory pathway in patients with supraventricular tachycardia.
  The American journal of cardiology 2004 Matsushita T, Badhwar N, Collins KK, Van Hare GF, Barbato G, Lee BK, Lee RJ, Scheinman MM
• Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery.
  Anesthesia and analgesia 2004 Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung JM
• Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium.
  Blood cells, molecules & diseases 2004 Lum LG, Fok H, Sievers R, Abedi M, Quesenberry PJ, Lee RJ
• Tissue engineering of muscle on micropatterned polymer films.
  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004 Huang NF, Thakar RG, Wong M, Kim D, Lee RJ, Li S
• Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice.
  Journal of the American College of Cardiology 2003 Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW
• Surface electrocardiographic characteristics of right and left atrial flutter.
  Circulation 2003 Bochoeyer A, Yang Y, Cheng J, Lee RJ, Keung EC, Marrouche NF, Natale A, Scheinman MM
• Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
  Journal of the renin-angiotensin-aldosterone system : JRAAS 2003 Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW
• Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine model.
  Circulation 2002 Nakai T, Lesh MD, Gerstenfeld EP, Virmani R, Jones R, Lee RJ
• The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke.
  Journal of the renin-angiotensin-aldosterone system : JRAAS 2002 Zhu BQ, Sievers RE, Browne AE, Hillman RT, Chair K, Lee RJ, Chatterjee K, Glantz SA, Parmley WW
• The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery.
  American heart journal 2002 Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung JM