Randall Kramer, PhD
Professor Emeritus
Cell and Tissue Biology
School of Dentistry

Education & Training

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• Postdoctoral Fellow Tumor Biology University of California, Irvine 1980
• MS, PhD Pharmacology Yale University School of Medicine 1977
• BA Biochemistry University of California, Berkeley 1971

Websites

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• Profile at UCSF Cancer Center (cancer.ucsf.edu)

Grants and Projects

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• Cancer Center Support Grant, NIH, 1999-2023
• Mechanism regulating ErbB signaling network in head and neck cancer, NIH, 2012-2018
• Regulation of Survival in Head and Neck Cancer Progression, NIH, 1995-2013
• Regulation of Survival in Oral Squamous Cell Carcinoma, NIH, 1995-2009
• Skeletal Muscle Stem Cells for Tissue Repair, NIH, 2003-2009
• Adhesion and Proliferation in Oral Cancer Progression, NIH, 2001-2008
• New Strategies for Enhancing Tissue Integrity and Repair, NIH, 1999-2006
• Myotendinous Junction Formation in Skeletal Muscle, NIH, 1999-2005
• Molecular Mechanisms of Invasion in Oral Cancer, NIH, 1900-2004
• Adhesion and Remodeling Mechanisms in Gingiva and Bone, NIH, 1992-1999
• Oral Cancer--Adhesive Interactions During Progression, NIH, 1992-1997
• Integrin Receptor for Laminin in Malignant Melanoma, NIH, 1990-1995
• Tumor Cell Invasion of Microvessel Subendothelial Matrix, NIH, 1983-1994

Publications (19)

Top publication keywords:
CadherinsUp-RegulationIntegrin alpha ChainsSyndecan-1LamininCell DedifferentiationProto-Oncogene Proteins c-bcl-2Antigens, CDReceptor, ErbB-3Carcinoma, Squamous CellBone Morphogenetic Protein 7Head and Neck NeoplasmsGenes, NeoplasmCell SurvivalCell Adhesion

• One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer.
  Oncotarget 2019 Yang F, Xiao W, Liu Y, Liu R, Kramer R, Li X, Ajena Y, Baehr CM, Rojalin T, Zhang H, Lam KS
• ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth.
  Oncogene 2015 Humtsoe JO, Pham E, Louie RJ, Chan DA, Kramer RH
• Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics.
  Journal of the California Dental Association 2012 Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS
• Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells.
  Experimental cell research 2011 Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH
• Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis.
  Molecular cancer research : MCR 2010 Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH

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• Sdc1 negatively modulates carcinoma cell motility and invasion.
  Experimental cell research 2009 Ishikawa T, Kramer RH
• Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway.
  Oncogene 2009 Humtsoe JO, Kramer RH
• Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal.
  Developmental dynamics : an official publication of the American Association of Anatomists 2009 Pawlikowski B, Lee L, Zuo J, Kramer RH
• Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes.
  Journal of leukocyte biology 2008 Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M
• Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer.
  Technology in cancer research & treatment 2007 El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M
• STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells.
  Experimental cell research 2007 Onishi A, Chen Q, Humtsoe JO, Kramer RH
• Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis.
  The Journal of biological chemistry 2005 Jethanandani P, Kramer RH
• Tumor cell invasion and survival in head and neck cancer.
  Cancer metastasis reviews 2005 Kramer RH, Shen X, Zhou H
• Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1.
  The Journal of biological chemistry 2004 Zhou H, Kramer RH
• Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor.
  The American journal of pathology 2004 Shen X, Kramer RH
• Promoter methylation regulates cadherin switching in squamous cell carcinoma.
  Biochemical and biophysical research communications 2004 Chen Q, Lipkina G, Song Q, Kramer RH
• Regulation of alpha7 integrin expression during muscle differentiation.
  The Journal of biological chemistry 2003 Xiao J, Jethanandani P, Ziober BL, Kramer RH
• The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion.
  Cell and tissue research 2003 Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG
• The beta1 cytoplasmic domain regulates the laminin-binding specificity of the alpha7X1 integrin.
  Molecular biology of the cell 2003 Yeh MG, Ziober BL, Liu B, Lipkina G, Vizirianakis IS, Kramer RH