Rajalingam Raja, PhD
Professor
Surgery
School of Medicine
Dr. Raja has over 30 years of experience in studying the basic and clinical aspects of Histocompatibility and Immunogenetics. During the Ph.D.
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program in the Department of Transplantation Immunology and Immunogenetics, All India Institute of Medical Sciences, Dr. Raja developed DNA-based HLA typing method and studied the diversity of HLA in Asian Indians, and the association between HLA alleles and infectious diseases. During 6 years of postdoctoral training in the Parham laboratory, Stanford University, Dr. Raja defined the KIR genomic diversity in several non-human species. In 2002, Dr. Raja joined as Associate Director of the University of California at Los Angeles (UCLA) Immunogenetics Center, which provides clinical histocompatibility testing. After 11 years of UCLA experience, Dr. Raja became the program director of the University of California San Francisco (UCSF) Immunogenetics and Transplantation Laboratory (ITL), which facilitates over 800 solid organ and bone marrow transplantations per year. As the CLIA-approved Laboratory Director, Clinical Consultant and Technical Supervisor, Dr. Raja provides leadership to all areas of clinical Histocompatibility and Immunogenetics testing including stem cell transplantation, various solid organ transplantations (kidney, pancreas, liver, heart, lung), testing for HLA-associated diseases, and testing for transfusion services. Dr. Raja's current research is focused on understanding the KIR-HLA genomic differences in human populations and their relevance in therapeutic transplantations and disease association. Dr. Raja involves in teaching and training in histocompatibility, immunogenetics and transplant immunology, and mentors post-doctoral research fellows, residents, and visiting scholars.
Awards
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- Prof. NK Mehra Oration Award 2016, Indian Society for Histocompatibility and Immunogenetics (ISHI), 2016
- Certificate of Qualification, Histocompatibility Laboratory Director, New York State Department of Health, 2012
- Histocompatibility Laboratory Director, Department of Public Health, State of California, 2009
- Clinical Immunology Training Award, FIMSA & IUIS, 1996
- Shakuntala Amir Chand prize for the best Ph.D. thesis in Biomedical Sciences in India, Indian Council of Medical Research (ICMR), 1996
- University First Rank in post-graduation (M.Sc.: Zoology, Biochemicstry, Molecular Biology), Bharathiyar University, Coimbatore, India, 1988
Education & Training
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- FRCPath Histocompatibility and Immunogenetics Royal College of Pathologists 2018
- D(ABHI) Histocompatibility Testing American Board of Histocompatibility and Immunogenetics (ABHI) 2008
- Post-Doctoral Research Immunogenetics Stanford University 2002
- Ph.D. Histocompatibility & Immunogenetics All India Institute of Medical Sciences 1996
- M.Phil. Endocrinology University of Madras 1989
- M.Sc. Zoology Bharathiyar University 1988
- B.Sc. Zoology University of Madras 1984
Interests
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- Major Histocompatibility Complex (MHC)
- Polymorphism and Population Diversity
- Disease Association
- Natural Killer (NK) cells
- Histocompatibility and Immunogenetics
- HLA antibodies
- Transplantation Immunology
- Hematopoietic Stem Cell Transplantation
- Killer cell Immunoglobulin-like receptors (KIR)
- Human Leukocyte Antigens (HLA)
- Solid Organ Transplantation
Websites
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- Transplant Site (transplantsurgery.ucsf.edu)
- Grand MMTI Team (cancer.ucsf.edu)
- My Lab Site (itl.ucsf.edu)
- Surgery Site (transplantsurgery.ucsf.edu)
Publications (102)
Top publication keywords:
Uveomeningoencephalitic SyndromeHistocompatibility Antigens Class IHistocompatibilityHLA AntigensHistocompatibility TestingHLA-B AntigensHLA-C AntigensHLA-DR AntigensReceptors, KIR3DL1Graft RejectionReceptors, ImmunologicIsoantibodiesKidney TransplantationReceptors, KIRKiller Cells, Natural
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A Scan of Pleiotropic Immune Mediated Disease Genes Identifies Novel Determinants of Baseline FVIII Inhibitor Status in Hemophilia-A.
Research square 2023 Howard T, Almieda M, Diego V, Viel K, Luu B, Haack K, Raja R, Ameri A, Chitlur M, Rydz N, Lillicrap D, Watts R, Kessler C, Ramsey C, Dinh L, Kim B, Powell J, Peralta J, Bouls R, Abraham S, Shen YM, … -
COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort.
Human immunology 2023 Roll GR, Bray RA, Cooper M, Eagar TN, Gebel HM, Vranic GM, Hitchman KMK, Houp J, Kamoun M, Killian J, Kim J, Kumar V, Levine M, Lovasik BP, Lunow-Luke T, Parsons RF, Pattanayak V, Ranch D, Shah A, … -
Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations.
Scientific reports 2023 Raghav PK, Raghav A, Lathwal A, Saxena A, Mann Z, Sengar M, Rajalingam R -
Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses.
bioRxiv : the preprint server for biology 2023 Duan M, Nguyen DC, Joyner CJ, Saney CL, Tipton CM, Andrews J, Lonial S, Kim C, Hentenaar I, Kosters A, Ghosn E, Jackson A, Knechtle S, Maruthamuthu S, Chandran S, Martin T, Rajalingam R, Vincenti F, … -
CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR
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Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.
Nature biotechnology 2023 Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T -
KIR-HLA gene diversities and susceptibility to lung cancer.
Scientific reports 2022 Hematian Larki M, Ashouri E, Barani S, Ghayumi SMA, Ghaderi A, Rajalingam R -
Individualized Constellation of Killer Cell Immunoglobulin-Like Receptors and Cognate HLA Class I Ligands that Controls Natural Killer Cell Antiviral Immunity Predisposes COVID-19.
Frontiers in genetics 2022 Maruthamuthu S, Rajalingam K, Kaur N, Morvan MG, Soto J, Lee N, Kong D, Hu Z, Reyes K, Ng D, Butte AJ, Chiu C, Rajalingam R -
Concurrent use of two independent methods prevents erroneous HLA typing of deceased organ donors - An important strategy for patient safety and accurate virtual crossmatching for broader sharing.
Human immunology 2022 Cruz TD, Dames C, Pagaduan L, Cho Y, Kong D, Rajalingam R -
Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients.
Annals of transplantation 2021 Tatapudi VS, Kopchaliiska D, da Gente GJ, Buenaventura OF, Singh M, Laszik Z, Adey DB, Rajalingam R -
Individualized genetic makeup that controls natural killer cell function influences the efficacy of isatuximab immunotherapy in patients with multiple myeloma.
Journal for immunotherapy of cancer 2021 Sun H, Martin TG, Marra J, Kong D, Keats J, Macé S, Chiron M, Wolf JL, Venstrom JM, Rajalingam R -
Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts.
Human immunology 2021 Kong D, Lee N, Dela Cruz ID, Dames C, Maruthamuthu S, Golden T, Rajalingam R -
COVID-19 does not impact HLA antibody profile in a series of waitlisted renal transplant candidates.
Human immunology 2021 Roll GR, Lunow-Luke T, Braun HJ, Buenaventura O, Mallari M, Stock PG, Rajalingam R -
Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk.
Scientific reports 2021 Ashouri E, Rajalingam K, Barani S, Farjadian S, Ghaderi A, Rajalingam R -
A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.
Transplantation 2020 Roll GR, Webber AB, Gae DH, Laszik Z, Tavakol M, Mayen L, Cunniffe K, Syed S, Hirose R, Freise C, Feng S, Roberts JP, Ascher NL, Stock PG, Rajalingam R -
Allele-level HLA matching reduces early rejection in lung transplant recipients.
Annals of translational medicine 2020 Rajalingam R -
Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A.
Journal of thrombosis and haemostasis : JTH 2020 Diego VP, Luu BW, Hofmann M, Dinh LV, Almeida M, Powell JS, Rajalingam R, Peralta JM, Kumar S, Curran JE, Sauna ZE, Kellerman R, Park Y, Key NS, Escobar MA, Huynh H, Verhagen AM, Williams-Blangero S, … -
De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
Nature biotechnology 2019 Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, … -
Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.
Stem cell reports 2019 Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH -
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR.
Blood 2019 Dehn J, Spellman S, Hurley CK, Shaw BE, Barker JN, Burns LJ, Confer DL, Eapen M, Fernandez-Vina M, Hartzman R, Maiers M, Marino SR, Mueller C, Perales MA, Rajalingam R, Pidala J -
Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.
Clinical transplantation 2019 Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD -
Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant.
JAMA dermatology 2019 Gao Y, Twigg AR, Hirose R, Roll GR, Nowacki AS, Maytin EV, Vidimos AT, Rajalingam R, Arron ST -
Diversity of Killer Cell Immunoglobulin-Like Receptors and Disease.
Clinics in laboratory medicine 2018 Rajalingam R -
Inhibitory natural killer cell receptor KIR3DL1 with its ligand Bw4 constraints HIV-1 disease among South Indians.
AIDS (London, England) 2018 Maruthamuthu S, Rajalingam R, Pandian K, Madasamy S, Manoharan M, Pitchai L, Murugesan A, Mariakuttikan J -
Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.
Clinical transplantation 2018 Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR -
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine 2017 Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, Mueller S, Pollack IF, Rajalingam R, … -
KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Boudreau JE, Giglio F, Gooley TA, Stevenson PA, Le Luduec JB, Shaffer BC, Rajalingam R, Hou L, Hurley CK, Noreen H, Reed EF, Yu N, Vierra-Green C, Haagenson M, Malkki M, Petersdorf EW, Spellman S, Hsu… -
HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R -
Short lung transplant donor telomere length is associated with decreased CLAD-free survival.
Thorax 2017 Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR -
The Impact of HLA Class I-Specific Killer Cell Immunoglobulin-Like Receptors on Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity and Organ Allograft Rejection.
Frontiers in immunology 2016 Rajalingam R -
Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
Transplantation 2016 Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q -
Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.
American journal of human genetics 2016 Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, … -
KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.
PloS one 2016 Levinson RD, Yung M, Meguro A, Ashouri E, Yu F, Mizuki N, Ohno S, Rajalingam R -
Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation.
PloS one 2016 Faridi RM, Kemp TJ, Dharmani-Khan P, Lewis V, Tripathi G, Rajalingam R, Daly A, Berka N, Storek J, Masood Khan F -
CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling.
Cancer research 2016 Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP -
HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis.
The Journal of clinical endocrinology and metabolism 2015 Heaney AP, Sumerel B, Rajalingam R, Bergsneider M, Yong WH, Liau LM -
Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function.
Journal of immunology (Baltimore, Md. : 1950) 2014 Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J -
Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis.
Human immunology 2014 Osman AE, Mubasher M, ElSheikh NE, AlHarthi H, Al Yami AS, Rajalingam R, Al-Dehaimi A, Middleton D, ElGhazali G -
Gene-specific PCR typing of killer cell immunoglobulin-like receptors.
Methods in molecular biology (Clifton, N.J.) 2013 Rajalingam R, Ashouri E -
Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.
PloS one 2012 Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M -
Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective.
Journal of thrombosis and haemostasis : JTH 2012 Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard TE -
Overview of the killer cell immunoglobulin-like receptor system.
Methods in molecular biology (Clifton, N.J.) 2012 Rajalingam R -
Human diversity of killer cell immunoglobulin-like receptors and disease.
The Korean journal of hematology 2011 Rajalingam R -
The shaping of modern human immune systems by multiregional admixture with archaic humans.
Science (New York, N.Y.) 2011 Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, … -
Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci.
Human immunology 2011 Solgi G, Ghafari H, Ashouri E, Alimoghdam K, Rajalingam R, Amirzargar A -
KIR-HLA mismatching in human renal allograft transplantation: emergence of a new concept.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011 Rajalingam R, Gebel HM -
Immunogenetics as a tool in anthropological studies.
Immunology 2011 Sanchez-Mazas A, Fernandez-Viña M, Middleton D, Hollenbach JA, Buhler S, Di D, Rajalingam R, Dugoujon JM, Mack SJ, Thorsby E -
HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone.
The British journal of ophthalmology 2010 Mackensen F, David F, Schwenger V, Smith LK, Rajalingam R, Levinson RD, Austin CR, Houghton D, Martin TM, Rosenbaum JT -
Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.
PLoS genetics 2010 Abi-Rached L, Moesta AK, Rajalingam R, Guethlein LA, Parham P -
Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.
Human immunology 2009 Levinson RD, Okada AA, Ashouri E, Keino H, Rajalingam R -
Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.
Human immunology 2009 Bonagura VR, Du Z, Ashouri E, Luo L, Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Gjertson DW, Reed EF, Rajalingam R -
Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.
Investigative ophthalmology & visual science 2009 Levinson RD, Martin TM, Luo L, Ashouri E, Rosenbaum JT, Smith JR, Austin CR, Lutt JR, Rajalingam R -
KIR gene content diversity in four Iranian populations.
Immunogenetics 2009 Ashouri E, Farjadian S, Reed EF, Ghaderi A, Rajalingam R -
A novel duplex SSP-PCR typing method for KIR gene profiling.
Tissue antigens 2009 Ashouri E, Ghaderi A, Reed EF, Rajalingam R -
A novel real-time PCR method for KIR genotyping.
Tissue antigens 2009 Alves LG, Rajalingam R, Canavez F -
Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.
International journal of immunogenetics 2008 Shastry A, Sedimbi SK, Rajalingam R, Nikitina-Zake L, Rumba I, Wigzell H, Sanjeevi CB -
Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.
Annals of the New York Academy of Sciences 2008 Shastry A, Sedimbi SK, Rajalingam R, Rumba I, Kanungo A, Sanjeevi CB -
Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants.
Current opinion in organ transplantation 2008 Rajalingam R -
KIR2DL5 alleles mark certain combination of activating KIR genes.
Genes and immunity 2008 Du Z, Sharma SK, Spellman S, Reed EF, Rajalingam R -
KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.
Human immunology 2008 Levinson RD, Du Z, Luo L, Holland GN, Rao NA, Reed EF, Rajalingam R -
Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations.
Immunogenetics 2008 Rajalingam R, Du Z, Meenagh A, Luo L, Kavitha VJ, Pavithra-Arulvani R, Vidhyalakshmi A, Sharma SK, Balazs I, Reed EF, Pitchappan RM, Middleton D -
Comparison of the rapidly evolving KIR locus in Parsis and natives of India.
Immunogenetics 2008 Kulkarni S, Single RM, Martin MP, Rajalingam R, Badwe R, Joshi N, Carrington M -
Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.
Genes and immunity 2008 Levinson RD, Du Z, Luo L, Monnet D, Tabary T, Brezin AP, Zhao L, Gjertson DW, Holland GN, Reed EF, Cohen JH, Rajalingam R -
Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3.
Immunogenetics 2007 Luo L, Du Z, Sharma SK, Cullen R, Spellman S, Reed EF, Rajalingam R -
Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses.
Iranian journal of immunology : IJI 2007 Rajalingam R -
Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans.
Immunogenetics 2006 Du Z, Gjertson DW, Reed EF, Rajalingam R -
HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California.
Human immunology 2004 Levinson RD, See RF, Rajalingam R, Reed EF, Park MS, Rao NA, Holland GN -
Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy.
American journal of ophthalmology 2004 Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson DW, Kappel PJ, See RF, Rao NA, Holland GN -
A sequencing-based typing method for HLA-DQA1 alleles.
Human immunology 2004 Rajalingam R, Ge P, Reed EF -
Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells.
Human immunology 2004 Jin YP, Fishbein MC, Said JW, Jindra PT, Rajalingam R, Rozengurt E, Reed EF -
Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 2004 Rajalingam R, Parham P, Abi-Rached L -
Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression.
Immunogenetics 2002 Yawata M, Yawata N, McQueen KL, Cheng NW, Guethlein LA, Rajalingam R, Shilling HG, Parham P -
Distinctive KIR and HLA diversity in a panel of north Indian Hindus.
Immunogenetics 2002 Rajalingam R, Krausa P, Shilling HG, Stein JB, Balamurugan A, McGinnis MD, Cheng NW, Mehra NK, Parham P -
Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.
Journal of immunology (Baltimore, Md. : 1950) 2002 Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P -
Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes.
Journal of immunology (Baltimore, Md. : 1950) 2001 Canavez F, Young NT, Guethlein LA, Rajalingam R, Khakoo SI, Shum BP, Parham P -
Molecular diversity of HLA-A*02 in Asian Indians: predominance of A*0211.
Tissue antigens 2001 Mehra NK, Jaini R, Rajalingam R, Balamurugan A, Kaur G -
Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.
Journal of immunology (Baltimore, Md. : 1950) 2001 Gardiner CM, Guethlein LA, Shilling HG, Pando M, Carr WH, Rajalingam R, Vilches C, Parham P -
Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.
Tissue antigens 2001 Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P -
Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes.
The Journal of experimental medicine 2001 Rajalingam R, Hong M, Adams EJ, Shum BP, Guethlein LA, Parham P -
Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes.
Tissue antigens 2000 Vilches C, Pando MJ, Rajalingam R, Gardiner CM, Parham P -
Cold reactive lymphocytotoxic antibodies in pulmonary tuberculosis: correlation with disease activity and HLA.
Indian journal of experimental biology 2000 Rajalingam R, Mehra NK, Jain RC -
Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
Indian journal of experimental biology 2000 Rajalingam R, Mehra NK, Singal DP -
KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.
Journal of immunology (Baltimore, Md. : 1950) 2000 Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young NT, Parham P -
Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans.
Immunity 2000 Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P -
A divergent non-classical class I gene conserved in salmonids.
Immunogenetics 1999 Shum BP, Rajalingam R, Magor KE, Azumi K, Carr WH, Dixon B, Stet RJ, Adkison MA, Hedrick RP, Parham P -
Polymorphic MHC molecules dictate cytokine profile and clinical disease in mycobacterial diseases.
Indian journal of clinical biochemistry : IJCB 1997 Mehra NK, Mitra DK, Rajalingam R -
HLA class I profile in Asian Indian patients with pulmonary tuberculosis.
Indian journal of experimental biology 1997 Rajalingam R, Mehra NK, Mehra RD, Neolia S, Jain RC, Pande JN -
HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis.
The American journal of gastroenterology 1997 Habeeb MA, Rajalingam R, Dhar A, Kumar A, Sharma MP, Mehra NK -
Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis.
Tissue antigens 1997 Rajalingam R, Singal DP, Mehra NK -
HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells.
Clinical immunology and immunopathology 1997 Mitra DK, Rajalingam R, Taneja V, Bhattacharyya BC, Mehra NK -
Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients with pulmonary tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1996 Rajalingam R, Mehra NK, Chopra GS, Puri MM, Jain RC -
Correlation of serum interleukin-2 receptor-alpha levels with clinical manifestations in pulmonary tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1996 Rajalingam R, Mehra NK, Pande JN, Jain RC, Singla R -
Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis.
International journal of cardiology 1996 Mehra NK, Rajalingam R, Sagar S, Jain S, Sharma BK -
Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity.
The Journal of infectious diseases 1996 Rajalingam R, Mehra NK, Jain RC, Myneedu VP, Pande JN -
Generation of DR51-associated DQA1, DQB1 haplotypes in Asian Indians.
Tissue antigens 1996 Mehra NK, Rajalingam R, Giphart MJ -
CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1995 Mitra DK, Mehra NK, Maiti TK, Banerjee A, Taneja V, Rajalingam R, Ahuja RK, Bhattacharya BC -
Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1995 Mehra NK, Rajalingam R, Mitra DK, Taneja V, Giphart MJ -
Dorsolateral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid rats.
Indian journal of experimental biology 1994 Sidharthan V, Rose PJ, Rajalingam R, Udhayakumar RC, Aruldhas MM, Govindarajulu P -
Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing. Unique haplotypes and a novel DR4 subtype.
Human immunology 1994 Mehra NK, Bouwens AG, Naipal A, Rajalingam R, Grubic Z, Taneja V, Tilanus MG, Giphart MJ -
Effects of alloxan induced diabetes on lipid profiles in renal cortex and medulla of mature albino rats.
Indian journal of experimental biology 1993 Rajalingam R, Srinivasan N, Govindarajulu P -
Ventral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid albino rats.
Indian journal of experimental biology 1993 Sidharthan V, Rajalingam R, Aruldhas MM, Govindarajulu P -
Human leukocyte antigen (HLA) in respiratory allergy.
Asian Pacific journal of allergy and immunology 1992 Mehra NK, Rajalingam R, Bovornkitti S