Rahul Kumar, PhD
Assistant Professor
Medicine
School of Medicine
Awards
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- Best Poster Award, UCSF-Pulmonary Retreat, 2022
- Jenesis Innovator Research Award, United Therapeutics, USA, 2022
- Young Investigator Award, 5th international Leh Symposium, India, 2018
- Postdoctoral Fellowship Award, American Heart Association, USA, 2017
- Distinction in scholarship, American Journal of Physiology-Lung Cellular and Molecular Physiology, 2015
- Certificate of Appreciation for Promoting diversity, University of Colorado, Denver, 2015
- Editorial Highlights: review article “Schistosomiasis and the pulmonary vasculature, Pulmonary Circulation, 2014
- Boehringer Ingelheim Young Investigator Travel Award, American Society of Hypertension, New York, USA, 2010
Grants and Projects
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- Activation, Phenotype, and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension, NIH, 2022-2027
- Role of Classical Monocytes in Hypoxic Pulmonary Hypertension, United Therapeutics, 2022-2023
- Transcriptomic and Proteomic Approaches to Identify Inflammatory Signatures in High Altitude Induced Pulmonary Hypertension and Pulmonary Edema, The Cardiovascular Medical Research and Education Fund (CMREF), USA, 2020-2022
- Crosstalk between Bone Marrow Compartment and Inflamed Lungs in Hypoxic Pulmonary Hypertension, American Thoracic Society (ATS), 2020-2022
- Hif2a Stabilization in Interstitial Macrophages causes Thrombospondin-1 Mediated Hypoxic Pulmonary Hypertension, American Heart Association USA, 2019-2022
- Role of Thrombospondin-1 in TGF-ß1 Activation in Hypoxic Pulmonary Hypertension, American Heart Association (AHA), USA, 2017-2019
Publications (56)
Top publication keywords:
Nitric Oxide Synthase Type IIIVascular RemodelingSchistosoma mansoniHypoxiaFamilial Primary Pulmonary HypertensionHypertension, PulmonaryAltitudeHypertensionSchistosomaEpistasis, GeneticVasoconstrictionSchistosomiasis mansoniTh2 CellsThrombospondin 1Schistosomiasis
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Experimental Schistosoma haematobium pulmonary hypertension.
Pulmonary circulation 2024 Kassa B, Fonseca-Balladares DC, Kumar R, Lee MH, Mickael C, Sanders L, Nolan K, Graham BB -
Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome.
Bioscience reports 2023 Kumar R, Chanana N, Sharma K, Palmo T, Lee MH, Mishra A, Nolan K, Fonseca Balladares DC, Mickael C, Gupta MD, Thinlas T, Pasha Q, Graham BB -
Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?
JHLT open 2023 Graham BB, Hilton JF, Lee MH, Kumar R, Balladares DF, Rahaghi FN, Estépar RSJ, Mickael C, Lima RLB, Loureiro CMC, Lucena J, Oliveira RKF, Corrêa RA -
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.
Clinical science (London, England : 1979) 2023 Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB -
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.
PLoS pathogens 2023 Kumar R, Aktay-Cetin Ö, Craddock V, Morales-Cano D, Kosanovic D, Cogolludo A, Perez-Vizcaino F, Avdeev S, Kumar A, Ram AK, Agarwal S, Chakraborty A, Savai R, de Jesus Perez V, Graham BB, Butrous G, …
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HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape.
Cells 2022 Medrano-Garcia S, Morales-Cano D, Barreira B, Vera-Zambrano A, Kumar R, Kosanovic D, Schermuly RT, Graham BB, Perez-Vizcaino F, Mathie A, Savai R, Pullamseti S, Butrous G, Fernández-Malavé E, … -
The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension.
Pulmonary circulation 2022 Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB -
Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2022 Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM -
Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2022 Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR -
Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure.
Frontiers in pharmacology 2022 Chanana N, Palmo T, Sharma K, Kumar R, Shah B, Mahajan S, Palleda GM, Gupta MD, Kukreti R, Faruq M, Thinlas T, Graham BB, Pasha Q -
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
The Journal of clinical investigation 2022 Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, … -
Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.
Pulmonary circulation 2022 Sinkala E, Ahmed HY, Sibomana JP, Lee MH, Kassa B, Kumar R, Mazimba S, Binegdie AB, Mpisa S, Wamundila K, Graham BB, Hilton JF -
Experimental Schistosoma japonicum-induced pulmonary hypertension.
PLoS neglected tropical diseases 2022 Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB -
Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2021 Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB -
Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension.
Cellular & molecular immunology 2021 Florentin J, Zhao J, Tai YY, Vasamsetti SB, O'Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P -
Schistosomiasis Pulmonary Arterial Hypertension.
Frontiers in immunology 2020 Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, … -
Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.
ERJ open research 2020 Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B -
Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.
Cardiovascular research 2020 Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB -
Sex-derived attributes contributing to SARS-CoV-2 mortality.
American journal of physiology. Endocrinology and metabolism 2020 Chanana N, Palmo T, Sharma K, Kumar R, Graham BB, Pasha Q -
Susceptibility to high-altitude pulmonary edema is associated with circulating miRNA levels under hypobaric hypoxia conditions.
American journal of physiology. Lung cellular and molecular physiology 2020 Alam P, Agarwal G, Kumar R, Mishra A, Saini N, Mohammad G, Pasha MAQ -
Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.
Scientific reports 2020 Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB -
Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.
Scientific reports 2020 Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB -
Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension.
Journal of the American Heart Association 2019 Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB -
IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.
American journal of respiratory cell and molecular biology 2019 Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB -
BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
Circulation 2019 Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE,… -
Common genetic variants in pulmonary arterial hypertension.
The Lancet. Respiratory medicine 2018 Gu S, Kumar R, Lee MH, Mickael C, Graham BB -
Paclitaxel blocks Th2-mediated TGF-β activation in Schistosoma mansoni-induced pulmonary hypertension.
Pulmonary circulation 2018 Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB -
Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.
American journal of respiratory cell and molecular biology 2018 Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM -
IL-33-HIF1α Axis in Hypoxic Pulmonary Hypertension.
EBioMedicine 2018 Kumar R, Graham B -
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Science translational medicine 2018 Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, … -
How does inflammation contribute to pulmonary hypertension?
The European respiratory journal 2018 Kumar R, Graham B -
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.
Nature communications 2017 Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, … -
Impact of interactions between risk alleles on clinical endpoints in hypertension.
Heart Asia 2016 Kohli S, Kumar R, Gupta M, Tyagi S, Pasha MA -
Unveiling the interactions among BMPR-2, ALK-1 and 5-HTT genes in the pathophysiology of HAPE.
Gene 2016 Ali Z, Waseem M, Kumar R, Pandey P, Mohammad G, Qadar Pasha MA -
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.
Cell reports 2015 Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas … -
The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.
American journal of respiratory and critical care medicine 2015 Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB -
Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.
American journal of physiology. Lung cellular and molecular physiology 2015 Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM -
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
EMBO molecular medicine 2015 White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF… -
CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes.
Hypertension research : official journal of the Japanese Society of Hypertension 2015 Kumar R, Kohli S, Ali Z, Duhan K, Ram R, Gupta M, Tyagi S, Mohammad G, Pasha MQ -
Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series).
Pulmonary circulation 2014 Graham BB, Kumar R -
Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension.
American journal of hypertension 2014 Kumar R, Kohli S, Mishra A, Garg R, Alam P, Stobdan T, Nejatizadeh A, Gupta M, Tyagi S, Pasha MA -
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
The Journal of clinical investigation 2014 Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, … -
β-T594M epithelial sodium channel gene polymorphism and essential hypertension in individuals of Indo-Aryan ancestry in Northern India.
Indian heart journal 2014 Gupta MD, Girish MP, Sikdar S, Ahuja R, Shah D, Kumar R, Rain M, Nejatizadeh A, Tyagi S, Pasha Q -
Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.
Pulmonary circulation 2014 Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB -
Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the North Indian population.
Coronary artery disease 2014 Gupta MD, Akkarappatty C, Girish MP, Kumar R, Rain M, Tyagi S, Qadar Pasha MA -
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.
American journal of respiratory cell and molecular biology 2013 Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM -
Pathology of pulmonary hypertension.
Clinics in chest medicine 2013 Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB -
Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension.
PloS one 2013 Kumar R, Kohli S, Alam P, Barkotoky R, Gupta M, Tyagi S, Jain SK, Pasha MA -
Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders.
PloS one 2012 Ali Z, Mishra A, Kumar R, Alam P, Pandey P, Ram R, Thinlas T, Mohammad G, Pasha MA -
CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema.
Clinical science (London, England : 1979) 2012 Mishra A, Ali Z, Vibhuti A, Kumar R, Alam P, Ram R, Thinlas T, Mohammad G, Pasha MA -
The epistasis between vascular homeostasis genes is apparent in essential hypertension.
Atherosclerosis 2011 Kumar R, Nejatizadeh A, Gupta M, Markan A, Tyagi S, Jain SK, Pasha MA -
Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension.
Genetics and molecular biology 2011 Nejatizadeh A, Kumar R, Stobdan T, Pasha MQ -
CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension.
Clinical biochemistry 2009 Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Tyagi S, Jain SK, Pasha MA -
Multi-locus interactions of vascular homeostasis genes in essential hypertension: a gender-based study.
Clinica chimica acta; international journal of clinical chemistry 2009 Kumar R, Nejatizadeh A, Arif E, Akhtar S, Gupta M, Tyagi S, Goyal AK, Jain SK, Qadar Pasha MA -
Significance of angiotensinogen gene haplotypes and genotypes combinations in hypertension.
Journal of hypertension 2008 Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Javed S, Pasha MQ -
Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension.
Free radical biology & medicine 2008 Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Sikdar S, Gupta M, Javed S, Pasha MA