Rachel Zwick, PhD
Postdoctoral Scholar
Orofacial Sciences
School of Dentistry

Grants and Projects

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• Intestinal stem cell control of regional secretory cell specialization, NIH, 2020-2022
• Cellular mechanisms and function of adipocyte repopulation in the mammary gland, NIH, 2015-2017

Publications (15)

Top publication keywords:
Lipid MetabolismEnterocytesCell ProliferationJejunumDuodenumAdipose TissueIleumIntestine, SmallStem CellsMammary Glands, AnimalAdipocytesRegenerationMammary Glands, HumanIntestinal MucosaIntestines

• Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
  Nature cell biology 2024 Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz …
• Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.
  The Journal of clinical investigation 2023 Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD
• Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
  bioRxiv : the preprint server for biology 2023 Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz …
• EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids.
  JCI insight 2023 Childs CJ, Holloway EM, Sweet CW, Tsai YH, Wu A, Vallie A, Eiken MK, Capeling MM, Zwick RK, Palikuqi B, Trentesaux C, Wu JH, Pellón-Cardenas O, Zhang CJ, Glass I, Loebel C, Yu Q, Camp JG, Sexton JZ, …
• γδ T cells regulate the intestinal response to nutrient sensing.
  Science (New York, N.Y.) 2021 Sullivan ZA, Khoury-Hanold W, Lim J, Smillie C, Biton M, Reis BS, Zwick RK, Pope SD, Israni-Winger K, Parsa R, Philip NH, Rashed S, Palm N, Wang A, Mucida D, Regev A, Medzhitov R

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• Lgr5+ telocytes are a signaling source at the intestinal villus tip.
  Nature communications 2020 Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel…
• Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.
  American journal of physiology. Gastrointestinal and liver physiology 2018 Zwick RK, Ohlstein B, Klein OD
• Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair.
  Science (New York, N.Y.) 2018 Shook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, López-Giráldez F, Dash BC, Muñoz-Rojas AR, Aultman KD, Zwick RK, Lei V, Arbiser JL, Miller-Jensen K, Clark DA, Hsia HC, Horsley V
• Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.
  Nature communications 2018 Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V
• Anatomical, Physiological, and Functional Diversity of Adipose Tissue.
  Cell metabolism 2018 Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV
• The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches.
  Annual review of cell and developmental biology 2016 Shook B, Rivera Gonzalez G, Ebmeier S, Grisotti G, Zwick R, Horsley V
• Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis.
  Molecular biology of the cell 2015 Goldstein J, Roth E, Roberts N, Zwick R, Lin S, Fletcher S, Tadeu A, Wu C, Beck A, Zeiss C, Suárez-Fariñas M, Horsley V
• Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer.
  Stem cells (Dayton, Ohio) 2013 Shaykhiev R, Wang R, Zwick RK, Hackett NR, Leung R, Moore MA, Sima CS, Chao IW, Downey RJ, Strulovici-Barel Y, Salit J, Crystal RG
• RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium.
  Respiratory research 2013 Didon L, Zwick RK, Chao IW, Walters MS, Wang R, Hackett NR, Crystal RG
• The human airway epithelial basal cell transcriptome.
  PloS one 2011 Hackett NR, Shaykhiev R, Walters MS, Wang R, Zwick RK, Ferris B, Witover B, Salit J, Crystal RG