Rachel Rutishauser, MD, PhD
Associate Professor
Medicine
School of Medicine
I am an infectious disease-trained Associate Professor of Medicine in the Division of Experimental Medicine at the University of California, San Francisco. My laboratory focuses on understanding the mechanisms that promote the formation of effective and durable CD8+ T cell immunity to viral pathogens (e.g., HIV, SARS-CoV-2) and vaccination at different stages of human development.
Awards
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- CROI New Investigator Scholarship, CROI, 2019
- CROI New Investigator Scholarship, CROI, 2018
- HVTN Translational Early Stage Investigator Conference Travel Award, HVTN, 2018
- HVTN Translational Early Stage Investigator Conference Travel Award, HVTN, 2017
- CFAR Early Career Award for Excellence in Basic Research, UCSF, 2017
- AIDS Research Institute Clinical Fellow, UCSF, 2016
- IDWeek Trainee Travel Award, IDSA, 2015
- SFGH Department of Medicine Clinical Fellow Award, UCSF, 2015
- UCSF Infectious Diseases Division Clinical Fellow Award, UCSF, 2015
- Norma Bailey Berniker Prize, Yale University, 2011
- The MD/PhD Award, Yale University, 2011
Education & Training
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- Fellowship Infectious Disease University of California, San Francisco 2018
- Residency Internal Medicine University of California, San Francisco 2014
- M.D. School of Medicine Yale University 2011
- Ph.D. Immunobiology Yale University 2010
- B.A. Biology Harvard University 2003
Websites
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- Rutishauser Lab (UCSF) website (experimentalmedicine.ucsf.edu)
Grants and Projects
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- Targeting HIV-specific T cell differentiation programs to enhance post-treatment control of HIV, NIH/NIAID, 2022-2026
- Genetic modification of HIV-specific T cell differentiation state to promote control of HIV, California HIV Research Program (CHRP), 2022-2024
- Dissecting the signals that maintain HIV-specific CD8+ T cell exhaustion, NIH, 2018-2023
- Exploring the role of TCF-7 in the regulation of HIV-specific CD8+ T cell regenerative capacity, UCSF AIDS Research, Gilead HIV Cure Mentored Scientist Award, 2018
- Optimizing methods to stain tetramer+ HIV-specific CD8+ T cells from frozen gut biopsy samples, amfAR Institute for HIV Cure Research, 2018
- Assessing HIV-specific CD8+ T cell Exhaustion during Antiretroviral Therapy, UCSF-Gladstone CFAR, 2017
Publications (41)
Top publication keywords:
T Cell Transcription Factor 1Zika VirusReactive Oxygen SpeciesImmunologic MemoryAIDS VaccinesZika Virus InfectionCD8-Positive T-LymphocytesHIV InfectionsSimian Immunodeficiency VirusTuberculosis, UrogenitalSecondary PreventionViremiaImmunophenotypingSimian Acquired Immunodeficiency SyndromeHIV-1
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Author Correction: Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report.
NPJ vaccines 2024 Maciel M, Amara RR, Bar KJ, Crotty S, Deeks SG, Duplessis C, Gaiha G, McElrath MJ, McMichael A, Palin A, Rutishauser R, Shapiro S, Smiley ST, D'Souza MP -
Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report.
NPJ vaccines 2024 Maciel M, Amara RR, Bar KJ, Crotty S, Deeks SG, Duplessis C, Gaiha G, McElrath MJ, McMichael A, Palin A, Rutishauser R, Shapiro S, Smiley ST, D'Souza MP -
Generating and measuring effective vaccine-elicited HIV-specific CD8 + T cell responses.
Current opinion in HIV and AIDS 2023 Borgo GM, Rutishauser RL -
PP 8.3 – 00049 Reduction in Markers of HIV Persistence with Gag/Pol/Il-12 DNA Therapeutic Vaccination.
Journal of Virus Eradication 2022 K. Chew, D. Glidden, R. Fromentin, J. Jacobs, G. Laird, N. Chomont, J. Mellors, D. Weiner, S. Deeks, R. Rutishauser -
In vivo killing of primary HIV-infected cells by peripheral-injected early memory-enriched anti-HIV duoCAR T cells.
JCI insight 2022 Anthony-Gonda K, Ray A, Su H, Wang Y, Xiong Y, Lee D, Block A, Chilunda V, Weiselberg J, Zemelko L, Wang YY, Kleinsorge-Block S, Reese JS, de Lima M, Ochsenbauer C, Kappes JC, Dimitrov DS, Orentas R, …
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Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection.
AIDS (London, England) 2022 Peluso MJ, Spinelli MA, Deveau TM, Forman CA, Munter SE, Mathur S, Tang AF, Lu S, Goldberg SA, Arreguin MI, Hoh R, Tai V, Chen JY, Martinez EO, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Sette A, … -
CD8 + T-cell responses in HIV controllers: potential implications for novel HIV remission strategies.
Current opinion in HIV and AIDS 2022 Rutishauser RL, Trautmann L -
A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection.
Cell reports 2022 McCarthy EE, Odorizzi PM, Lutz E, Smullin CP, Tenvooren I, Stone M, Simmons G, Hunt PW, Feeney ME, Norris PJ, Busch MP, Spitzer MH, Rutishauser RL -
HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions.
The Journal of Immunology 2022 Adolfo B Frias, Rachel L Rutishauser, Ashish Arunkumar Sharma, Tian Mi, Hossam Aly Abdelsamed, Caitlin Zebley, Christian M Constantz, Mars Stone, Michael Busch, Steven Deeks, Rafick Sekaly, Ben A … -
Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study.
The Lancet. Microbe 2022 Spottiswoode N, Bloomstein JD, Caldera S, Sessolo A, McCauley K, Byanyima P, Zawedde J, Kalantar K, Kaswabuli S, Rutishauser RL, Lieng MK, Davis JL, Moore J, Jan A, Iwai S, Shenoy M, Sanyu I, DeRisi … -
Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
Open forum infectious diseases 2021 Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Ngo LH, Deswal M, Munter SE, … -
Impact of Anti-PD-1 and Anti-CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Rasmussen TA, Rajdev L, Rhodes A, Dantanarayana A, Tennakoon S, Chea S, Spelman T, Lensing S, Rutishauser R, Bakkour S, Busch M, Siliciano JD, Siliciano RF, Einstein MH, Dittmer DP, Chiao E, Deeks SG,… -
Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.
Cell reports 2021 Peluso MJ, Deitchman AN, Torres L, Iyer NS, Munter SE, Nixon CC, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman EA, Spinelli MA, Gandhi M, Trinh L,… -
SARS-CoV-2 Vaccination in the Context of Ongoing HIV Cure-Related Research Studies.
Journal of acquired immune deficiency syndromes (1999) 2021 Peluso MJ, Dee L, Taylor J, Campbell DM, Ehm A, Agosto-Rosario M, Shao S, Williams MC, Hoh R, Rutishauser RL, Deeks SG, Sauceda JA, Dubé K -
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
Science advances 2021 Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Donatelli J, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, … -
Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
Open forum infectious diseases 2021 Peluso MJ, Munter SE, Lynch KL, Yun C, Torres L, Iyer NS, Donatelli J, Ryan L, Deitchman AN, Deeks SG, Rutishauser RL, Henrich TJ -
Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.
medRxiv : the preprint server for health sciences 2021 Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Bautista JA, Ngo LH, Deswal M, … -
Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.
medRxiv : the preprint server for health sciences 2021 Peluso MJ, Deitchman AN, Torres L, Iyer NS, Nixon CC, Munter SE, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman E, Spinelli MA, Gandhi M, Trinh L, … -
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations.
Cells 2021 Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L -
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.
JCI insight 2021 Rutishauser RL, Deguit CDT, Hiatt J, Blaeschke F, Roth TL, Wang L, Raymond KA, Starke CE, Mudd JC, Chen W, Smullin C, Matus-Nicodemos R, Hoh R, Krone M, Hecht FM, Pilcher CD, Martin JN, Koup RA, Douek… -
Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.
Cell reports 2021 Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD -
Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Henrich TJ, Schreiner C, Cameron C, Hogan LE, Richardson B, Rutishauser RL, Deitchman AN, Chu S, Rogers R, Thanh C, Gibson EA, Zarinsefat A, Bakkour S, Aweeka F, Busch MP, Liegler T, Baker C, Milush J… -
Clinical Utility of Universal Broad-Range Polymerase Chain Reaction Amplicon Sequencing for Pathogen Identification: A Retrospective Cohort Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 Kerkhoff AD, Rutishauser RL, Miller S, Babik JM -
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.
Nature immunology 2020 Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone… -
A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.
Journal of virus eradication 2020 Peluso MJ, Dee L, Campbell D, Taylor J, Hoh R, Rutishauser RL, Sauceda J, Deeks SG, Dubé K -
OP 4.2 Characterising ‘exceptional’ control among HIV elite controllers.
Journal of virus eradication 2019 M. Peluso, P. Burbelo, S. Kumar, S. Munter, R. Hoh, S. Lee, P. Hunt, R. Rutishauser, T. Henrich, S. Deeks -
Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection.
Journal of acquired immune deficiency syndromes (1999) 2019 Deguit CDT, Hough M, Hoh R, Krone M, Pilcher CD, Martin JN, Deeks SG, McCune JM, Hunt PW, Rutishauser RL -
Rapid development of HIV elite control in a patient with acute infection.
BMC infectious diseases 2019 Morley D, Lambert JS, Hogan LE, De Gascun C, Redmond N, Rutishauser RL, Thanh C, Gibson EA, Hobbs K, Bakkour S, Busch MP, Farrell J, McGetrick P, Henrich TJ -
Inconsistent HIV reservoir dynamics and immune responses following anti-PD-1 therapy in cancer patients with HIV infection.
Annals of oncology : official journal of the European Society for Medical Oncology 2018 Scully EP, Rutishauser RL, Simoneau CR, Delagrèverie H, Euler Z, Thanh C, Li JZ, Hartig H, Bakkour S, Busch M, Alter G, Marty FM, Wang CC, Deeks SG, Lorch J, Henrich TJ -
HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
PLoS medicine 2017 Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, … -
Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals.
Gut microbes 2017 Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M -
Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.
AIDS research and human retroviruses 2017 Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM -
Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature.
Transplant infectious disease : an official journal of the Transplantation Society 2017 Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM -
Antimicrobial Resistance: A Call to Action!
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Brown L, Langelier C, Reid MJ, Rutishauser RL, Strnad L -
Broad-range PCR for early diagnosis of nosocomial Enterococcus gallinarum meningitis.
Infectious diseases (London, England) 2016 Su PY, Miller S, Rutishauser RL, Babik J -
Think global, act local: chronic dysuria and sterile pyuria in an Eritrean-American woman.
BMJ case reports 2014 Rutishauser RL, Langelier C, Baxi SM, Hanks D, Chin-Hong P -
Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection.
Immunity 2011 Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM -
Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2010 Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM -
Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation.
Immunological reviews 2010 Rutishauser RL, Kaech SM -
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.
Immunity 2009 Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Meffre E, Jacob J, Calame K, Kaech SM -
Long-term consequences of agonistic interactions between socially naive juvenile American lobsters (Homarus americanus).
The Biological bulletin 2004 Rutishauser RL, Basu AC, Cromarty SI, Kravitz EA