Rachael Jackman, PhD
Associate Professor
Laboratory Medicine
School of Medicine

Grants and Projects

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• The impact of illness and medical treatments on the alloantibody response to platelet transfusion, NIH, 2019-2023
• Mechanisms regulating alloimmunization and tolerance with pathogen reduction and transfusion of allogeneic platelets, NIH, 2016-2020

Publications (28)

Top publication keywords:
Histocompatibility AntigensBlood PlateletsPhotosensitizing AgentsTransfusion ReactionImmunomodulationUltraviolet RaysRiboflavinChimerismBlood TransfusionIsoantibodiesPlatelet TransfusionBlood PreservationImmune ToleranceHistocompatibility Antigens Class IPlatelet-Rich Plasma

• Testosterone supplementation increases red blood cell susceptibility to oxidative stress, decreases membrane deformability, and decreases survival after cold storage and transfusion.
  Transfusion 2024 Tran J, Jackman RP, Muench MO, Hazegh K, Bean SW, Thomas KA, Fang F, Page G, O'Connor K, Roubinian NH, Anawalt BD, Kanias T
• Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice.
  Frontiers in immunology 2023 Tran JQ, Muench MO, Gaillard B, Darst O, Tomayko MM, Jackman RP
• Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice.
  Frontiers in immunology 2023 Jackman RP, Darst O, Gaillard B, Tran JQ, Tomayko MM, Muench MO
• Bidirectionality between Cardiometabolic Diseases and COVID-19: Role of Humoral Immunity.
  Advances in nutrition (Bethesda, Md.) 2023 Yu EA, Jackman RP, Glesby MJ, Narayan KV
• Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasma.
  The Journal of clinical investigation 2022 Saá P, Fink RV, Bakkour S, Jin J, Simmons G, Muench MO, Dawar H, Di Germanio C, Hui AJ, Wright DJ, Krysztof DE, Kleinman SH, Cheung A, Nester T, Kessler DA, Townsend RL, Spencer BR, Kamel H, Vannoy JM…

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• Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-β expression by cDCs and monocytes in mice.
  Blood advances 2020 Tran JQ, Muench MO, Jackman RP
• Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress.
  Transfusion 2020 Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T
• Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice.
  PloS one 2020 Blessinger SA, Tran JQ, Jackman RP, Gilfanova R, Rittenhouse J, Gutierrez AG, Heitman JW, Hazegh K, Kanias T, Muench MO
• A small allelic variant in donor class I MHC is sufficient to induce alloantibodies following transfusion of standard or pathogen-reduced platelets in mice.
  Vox sanguinis 2020 Jackman RP, Heitman JW, Muench MO
• Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes.
  Transfusion 2019 Tran JQ, Muench MO, Heitman JW, Jackman RP
• Lack of persistent microchimerism in contemporary transfused trauma patients.
  Transfusion 2019 Jackman RP, Utter GH, Lee TH, Montalvo L, Wen L, Chafets D, Rivers RM, Kopko PM, Norris PJ, Busch MP
• Potential of Membranes Surrounding the Fetus as Immunoprotective Cell-Carriers for Allogeneic Transplantations.
  Transplantation direct 2019 Togarrati PP, Dinglasan N, Yee E, Heitman JW, Jackman RP, Geisberg M, Norris PJ, Bárcena A, Muench MO
• Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice.
  Vox sanguinis 2019 Tran JQ, Muench MO, Heitman JW, Jackman RP
• Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis.
  Lupus science & medicine 2018 Jackman RP, Cruz GI, Nititham J, Triulzi DJ, Barcellos LF, Criswell LA, Norris PJ, Busch MP
• Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood.
  Transfusion 2016 Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ
• C1q-binding anti-HLA antibodies do not predict platelet transfusion failure in Trial to Reduce Alloimmunization to Platelets study participants.
  Transfusion 2016 Jackman RP, Lee JH, Pei R, Bolgiano D, Lebedeva M, Slichter SJ, Norris PJ
• Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets.
  Transfusion 2016 Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP
• Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro.
  Blood 2013 Danesh A, Inglis HC, Jackman RP, Wu S, Deng X, Muench MO, Heitman JW, Norris PJ
• Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response.
  Transfusion 2013 Jackman RP, Deng X, Bolgiano D, Utter GH, Schechterly C, Lebedeva M, Operskalski E, Luban NL, Alter H, Busch MP, Slichter SJ, Norris PJ
• Immunomodulation in transfused trauma patients.
  Current opinion in anaesthesiology 2013 Jackman RP
• Immune modulation and lack of alloimmunization following transfusion with pathogen-reduced platelets in mice.
  Transfusion 2013 Jackman RP, Muench MO, Heitman JW, Inglis HC, Law JP, Marschner S, Goodrich RP, Norris PJ
• Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants.
  Blood 2013 Jackman RP, Deng X, Bolgiano D, Lebedeva M, Heitman JW, Busch MP, Slichter SJ, Norris PJ
• Transfusion-associated microchimerism: the hybrid within.
  Transfusion medicine reviews 2012 Bloch EM, Jackman RP, Lee TH, Busch MP
• Distinct roles of trauma and transfusion in induction of immune modulation after injury.
  Transfusion 2012 Jackman RP, Utter GH, Muench MO, Heitman JW, Munz MM, Jackman RW, Biswas HH, Rivers RM, Tobler LH, Busch MP, Norris PJ
• Effects of blood sample age at time of separation on measured cytokine concentrations in human plasma.
  Clinical and vaccine immunology : CVI 2010 Jackman RP, Utter GH, Heitman JW, Hirschkorn DF, Law JP, Gefter N, Busch MP, Norris PJ
• Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment.
  Transfusion 2009 Jackman RP, Heitman JW, Marschner S, Goodrich RP, Norris PJ
• CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Jackman RP, Balamuth F, Bottomly K
• Mycobacterium tuberculosis/HIV-1 coinfection and disease: role of human leukocyte antigen variation.
  The Journal of infectious diseases 2004 Louie LG, Hartogensis WE, Jackman RP, Schultz KA, Zijenah LS, Yiu CH, Nguyen VD, Sohsman MY, Katzenstein DK, Mason PR