Qizhi Tang, PhD
Professor
Surgery
School of Medicine

Currently, two major areas of work are on therapeutic application of regulatory T cell therapy in type 1 diabetes and transplantation and immune modulation to enable immune suppression-free transplant of stem-cell-derived beta cells for treatment of type 1 diabetes.

Regulatory T cells are a small population of white blood cells that are essential for preventing tissue damages caused by over activation of the immune system. The Tang lab has shown that infusion of regulatory T cells in animal models can reverse type 1 diabetes, a disease caused by immune destruction of insulin-producing cells in the pancreatic islets. Similarly, regulatory T cell therapy can prevent rejection of transplanted organs in animal models. A joint team of researchers from the Tang and Bluestone labs is currently conducting 6 clinical trials evaluating the safety and efficacy of regulatory T cell therapy in patients. In the mean time, we are developing next generation regulatory T cell therapies in preclinical models to improve the safety and efficacy of the therapy.

In patients with chronic type 1 diabetes, transplanting of stem-cell-derived beta cells can potentially cure the disease, but patients have to commit to life-long immunosuppression to prevent rejection of the transplanted cells from rejection by the immune system. The Tang lab is currently investigating approaches to shield the transplanted cells from the immune systems using novel biomaterials developed in the Desai and Roy labs at UCSF. We are also applying genome-editing technologies to immunoengineer stem cells to evade immune rejection.

• Harnessing regulatory T cells to establish immune tolerance.
  Science translational medicine 2024 Ho P, Cahir-McFarland E, Fontenot JD, Lodie T, Nada A, Tang Q, Turka LA, Bluestone JA
• Precise surface functionalization of PLGA particles for human T cell modulation.
  Nature protocols 2023 Hadley P, Chen Y, Cline L, Han Z, Tang Q, Huang X, Desai T
• Epidermal Stem Cell Derived Exosomes Alleviate Excessive Autophagy Induced Endothelial Cell Apoptosis by Delivering miR200b-3p to Diabetic Wounds.
  The Journal of investigative dermatology 2023 Xu H, Yang H, Wang Z, Tang Q, Cao X, Chen C, Dong Y, Xu Z, Lv D, Rong Y, Chen M, Tang B, Deng W, Zhu J, Hu Z
• Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.
  Nature communications 2023 Kim EJ, Chen C, Gologorsky R, Santandreu A, Torres A, Wright N, Goodin MS, Moyer J, Chui BW, Blaha C, Brakeman P, Vartanian S, Tang Q, David Humes H, Fissell WH, Roy S
• Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes.
  Frontiers in immunology 2023 Obarorakpor N, Patel D, Boyarov R, Amarsaikhan N, Cepeda JR, Eastes D, Robertson S, Johnson T, Yang K, Tang Q, Zhang L
• Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Guinan EC, Contreras-Ruiz L, Crisalli K, Rickert C, Rosales I, Makar R, Colvin R, Geissler EK, Sawitzki B, Harden P, Tang Q, Blancho G, Turka LA, Markmann JF
• Regulatory T cells aid stem-cell therapy for Parkinson's disease.
  Nature 2023 Tang Q
• Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space.
  Bioengineering & translational medicine 2023 Chendke GS, Kharbikar BN, Ashe S, Faleo G, Sneddon JB, Tang Q, Hebrok M, Desai TA
• Impact of interleukin-6 on T cells in kidney transplant recipients.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022 Chandran S, Tang Q
• The dichotomous outcomes of TNFα signaling in CD4+ T cells.
  Frontiers in immunology 2022 Skartsis N, Ferreira LMR, Tang Q
• A Phase I/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients.
  Kidney international 2022 Moreau A, Kervella D, Bouchet-Delbos L, Braudeau C, Saïagh S, Guérif P, Limou S, Moreau A, Bercegeay S, Streitz M, Sawitzki B, James B, Harden PN, Game D, Tang Q, Markmann JF, Roberts ISD, Geissler EK…
• IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function.
  Frontiers in immunology 2021 Skartsis N, Peng Y, Ferreira LMR, Nguyen V, Ronin E, Muller YD, Vincenti F, Tang Q
• Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR
• Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.
  Frontiers in immunology 2021 Balcerek J, Shy BR, Putnam AL, Masiello LM, Lares A, Dekovic F, Acevedo L, Lee MR, Nguyen V, Liu W, Paruthiyil S, Xu J, Leinbach AS, Bluestone JA, Tang Q, Esensten JH
• The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes.
  JCI insight 2021 Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang …
• The Role of Regulatory T Cells in Pulmonary Arterial Hypertension.
  Frontiers in immunology 2021 Tian W, Jiang SY, Jiang X, Tamosiuniene R, Kim D, Guan T, Arsalane S, Pasupneti S, Voelkel NF, Tang Q, Nicolls MR
• A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells.
  Frontiers in immunology 2021 Lee LM, Zhang H, Lee K, Liang H, Merleev A, Vincenti F, Maverakis E, Thomson AW, Tang Q
• A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.
  The Journal of experimental medicine 2021 Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS
• The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.
  Frontiers in immunology 2021 Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q
• Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Chandran S, Leung J, Hu C, Laszik ZG, Tang Q, Vincenti FG
• Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes.
  Cell stem cell 2020 Bluestone JA, Tang Q
• Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.
  Nature immunology 2020 Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ,…
• CAR-Tregs as a Strategy for Inducing Graft Tolerance.
  Current transplantation reports 2020 Wagner JC, Tang Q
• Novel In Situ Hybridization and Multiplex Immunofluorescence Technology Combined With Whole-slide Digital Image Analysis in Kidney Transplantation.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2020 Junger H, Dobi D, Chen A, Lee L, Vasquez JJ, Tang Q, Laszik ZG
• Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
  Lancet (London, England) 2020 Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, …
• Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.
  Advanced biosystems 2019 Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA
• NextGen cell-based immunotherapies in cancer and other immune disorders.
  Current opinion in immunology 2019 Azimi CS, Tang Q, Roybal KT, Bluestone JA
• NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.
  Transplantation 2019 Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR
• Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus.
  Arthritis & rheumatology (Hoboken, N.J.) 2019 Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandova PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, Rosenblum MD, Autoimmunity Centers …
• Early expansion of donor-specific Tregs in tolerant kidney transplant recipients.
  JCI insight 2018 Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M
• Islet encapsulation therapy - racing towards the finish line?
  Nature reviews. Endocrinology 2018 Desai TA, Tang Q
• Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier.
  The Journal of allergy and clinical immunology 2018 Esensten JH, Muller YD, Bluestone JA, Tang Q
• Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.
  Transplantation 2018 Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, …
• Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.
  Cell stem cell 2018 Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M
• Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Greenland JR, Chong T, Wang AS, Martinez E, Shrestha P, Kukreja J, Hays SR, Golden JA, Singer JP, Tang Q
• Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.
  Science translational medicine 2018 Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC
• Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.
  Frontiers in immunology 2018 Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, …
• Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.
  ACS nano 2017 Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA
• Transplant trials with Tregs: perils and promises.
  The Journal of clinical investigation 2017 Tang Q, Vincenti F
• Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Klementowicz JE, Mahne AE, Spence A, Nguyen V, Satpathy AT, Murphy KM, Tang Q
• Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.
  ACS biomaterials science & engineering 2017 Song S, Yeung R, Park J, Posselt AM, Desai TA, Tang Q, Roy S
• Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
  Diabetes 2016 Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M
• Impact of Immune-Modulatory Drugs on Regulatory T Cell.
  Transplantation 2016 Furukawa A, Wisel SA, Tang Q
• Restoring Regulatory T Cells in Type 1 Diabetes.
  Current diabetes reports 2016 Spence A, Tang Q
• Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.
  Transplantation 2016 Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q
• Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage.
  Transplantation direct 2016 Higdon LE, Lee K, Tang Q, Maltzman JS
• Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device.
  Transplantation 2016 Faleo G, Lee K, Nguyen V, Tang Q
• Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC
• Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.
  Scientific reports 2016 Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S
• Approaching a cure for type 1 diabetes.
  Nature medicine 2016 Tang Q, Desai TA
• Manipulating IL-2 and IL-2R in autoimmune diseases and transplantation.
  Immunotherapy 2015 Zhang M, Tang Q
• Targeting Treg signaling for the treatment of autoimmune diseases.
  Current opinion in immunology 2015 Spence A, Klementowicz JE, Bluestone JA, Tang Q
• Therapeutic window of interleukin-2 for autoimmune diseases.
  Diabetes 2015 Tang Q
• Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices.
  ACS nano 2015 Nyitray CE, Chang R, Faleo G, Lance KD, Bernards DA, Tang Q, Desai TA
• Immunotherapy: making the case for precision medicine.
  Science translational medicine 2015 Bluestone JA, Tang Q
• Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice.
  Chimerism 2015 Wegorzewska M, Le T, Tang Q, MacKenzie TC
• Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Mahne AE, Klementowicz JE, Chou A, Nguyen V, Tang Q
• Antigen recognition in the islets changes with progression of autoimmune islet infiltration.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS
• Interpretation of transplant biopsies and immune responses following Treg cell therapy.
  Current opinion in organ transplantation 2014 Tang Q, Kang SM
• Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC
• Regulatory T-cell therapy in transplantation: moving to the clinic.
  Cold Spring Harbor perspectives in medicine 2013 Tang Q, Bluestone JA
• Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
  Blood 2013 Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC
• Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients.
  Transplant international : official journal of the European Society for Organ Transplantation 2012 Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F
• IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
  Cell metabolism 2012 Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR
• Regulatory T-cell therapy for transplantation: how many cells do we need?
  Current opinion in organ transplantation 2012 Tang Q, Lee K
• CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.
  Journal of molecular cell biology 2011 Tang Q, Bluestone JA, Kang SM
• B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA
• Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Penaranda C, Tang Q, Bluestone JA
• Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
  The Journal of surgical research 2011 Brennan TV, Tang Q, Liu FC, Hoang V, Bi M, Bluestone JA, Kang SM
• The maternal immune response inhibits the success of in utero hematopoietic cell transplantation.
  Chimerism 2011 Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC
• Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
  The Journal of clinical investigation 2011 Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC
• IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells.
  The Journal of experimental medicine 2010 Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E
• Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.
  Diabetes 2010 Penaranda C, Tang Q, Ruddle NH, Bluestone JA
• Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
  Nature immunology 2009 Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA
• Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q
• T regulatory cells in autoimmune diabetes: past challenges, future prospects.
  Journal of clinical immunology 2008 Bluestone JA, Tang Q, Sedwick CE
• Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA
• Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.
  Nature 2007 Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D
• Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.
  Endocrinology 2007 Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC
• Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
  Clinical immunology (Orlando, Fla.) 2007 Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH
• Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
  The Journal of experimental medicine 2006 Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA
• Regulatory T-cell physiology and application to treat autoimmunity.
  Immunological reviews 2006 Tang Q, Bluestone JA
• Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI
• Imaging the function of regulatory T cells in vivo.
  Current opinion in immunology 2006 Tang Q, Krummel MF
• Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship?
  Nature immunology 2006 Tang Q, Bluestone JA
• Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.
  Seminars in immunology 2006 Masteller EL, Tang Q, Bluestone JA
• Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Trenado A, Sudres M, Tang Q, Maury S, Charlotte F, Grégoire S, Bonyhadi M, Klatzmann D, Salomon BL, Cohen JL
• How do CD4+CD25+ regulatory T cells control autoimmunity?
  Current opinion in immunology 2005 Bluestone JA, Tang Q
• Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA
• Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
  European journal of immunology 2004 Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA
• Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Bluestone JA, Tang Q
• Notch 1 signaling regulates peripheral T cell activation.
  Immunity 2004 Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA
• Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA
• CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA
• CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
  Nature immunology 2003 Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA
• The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
  Novartis Foundation symposium 2003 Boden E, Tang Q, Bour-Jordan H, Bluestone JA
• ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.
  Immunity 2001 Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI
• Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
  Journal of immunology (Baltimore, Md. : 1950) 2001 O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA
• Development and applications of surface-linked single chain antibodies against T-cell antigens.
  Journal of immunological methods 2001 Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA
• Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Smith JA, Tang Q, Bluestone JA
• T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.
  The Journal of experimental medicine 1997 Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA
• Proinflammatory functions of IL-2 in herpes simplex virus corneal infection.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Tang Q, Chen W, Hendricks RL
• Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas.
  The Journal of experimental medicine 1996 Tang Q, Hendricks RL
• Ex vivo model of leukocyte migration into herpes simplex virus-infected mouse corneas.
  Journal of leukocyte biology 1996 Chen W, Tang Q, Hendricks RL
• Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection.
  Journal of virology 1996 Liu T, Tang Q, Hendricks RL
• Involvement of LFA-1 and ICAM-1 in the herpetic disease resulting from HSV-1 corneal infection.
  Current eye research 1995 Dennis RF, Siemasko KF, Tang Q, Hendricks RL, Finnegan A
• Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells.
  Journal of virology 1994 Dingwell KS, Brunetti CR, Hendricks RL, Tang Q, Tang M, Rainbow AJ, Johnson DC
• IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes.
  Investigative ophthalmology & visual science 1993 Cubitt CL, Tang Q, Monteiro CA, Lausch RN, Oakes JE