Qi Wen Fan, MD, PhD
Associate Professor
Neurology
School of Medicine

Publications (33)

Top publication keywords:
STAT5 Transcription FactorErbB ReceptorsFuransGliomaTOR Serine-Threonine KinasesProtein KinasesAutophagySTAT3 Transcription FactorMultiprotein ComplexesPyrimidinesGlioblastomaOncogene Protein v-aktBrain NeoplasmsProtein Kinase InhibitorsPyridines

• Brain-restricted mTOR inhibition with binary pharmacology.
  Nature 2022 Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM
• Betacellulin drives therapy resistance in glioblastoma.
  Neuro-oncology 2020 Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA
• Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.
  Cancer research 2019 Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW
• DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA.
  Neuro-Oncology 2019 Qi Wen Fan, Edward Lorenzana, Xujun Luo, Robin Lea, Ozlem Aksoy, Zhenyi An, Tomoko Ozawa, Douglas Wassarman, Kevan Shokat, James Aggen, Jaqueline A M Smith, Mallika Singh, Nicholas Butowski, David …
• THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA.
  Neuro-Oncology 2019 Xujun Luo, Qi-Wen Fan, Kevan M Shokat, William A Weiss

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• EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.
  Cancer research 2018 An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA
• Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
  Oncogene 2018 An Z, Aksoy O, Zheng T, Fan QW, Weiss WA
• CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA.
  Neuro-Oncology 2017 Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss
• Inhibiting 4EBP1 in Glioblastoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Fan QW, Nicolaides TP, Weiss WA
• Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma.
  Understanding and Targeting Oncogenic Translation Control in Different Human Cancers 2017 QiWen Fan, Ozlem Aksoy, Robyn Wong, Shirin Ilkhanizadeh, Chris Novotny, William Gustafson, Albert Tuong, Geraldine Cayanan, Erin Simonds, Daphne Haas-Kogan, Joanna Phillips, Theo Nicolaides, Theo …
• A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
  Cancer cell 2017 Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA
• Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas.
  Journal of neuro-oncology 2016 Zhang J, Yao TW, Hashizume R, Hariono S, Barkovich KJ, Fan QW, Prados M, James CD, Weiss WA, Nicolaides T
• ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA.
  Neuro-Oncology 2015 QiWen Fan, Robyn Wong, Chris Novotny, Masanori Okaniwa, Theodore Nicolaides, Kevan Shokat, William Weiss
• Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
  Cell reports 2014 Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, …
• MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA.
  Neuro-Oncology 2014 William A. Weiss, Robyn Wong, Qi-Wen Fan, Shirin Ilkhanizadeh, Mimi Lu, Janine Beyer, Nikhil Dube, John Forsayeth, Adrian Kells, Ting Xu, Krystof Bankiewicz, Greg Ducker, Morri Feldman, Kevan Shokat
• EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
  Cancer cell 2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA
• Abstract 5683: Blockade of glioma proliferation via allosteric inhibition of JAK2.
  Cancer Chemistry 2013 Kunyan He, Qi Qi, Chi-Bun Chan, Ge Xiao, Xia Liu, Carol Tucker-Burden, Liya Wang, Hui Mao, Xiang Lu, Frank E. McDonald, Hongbo Luo, Qi-wen Fan, William A. Weiss, Shi-yong Sun, Daniel J. Brat, Keqiang …
• Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.
  Methods in molecular biology (Clifton, N.J.) 2012 Fan QW, Weiss WA
• Autophagy and Akt promote survival in glioma.
  Autophagy 2011 Fan QW, Weiss WA
• Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy.
  Cancer Chemistry 2011 Krister J. Barkovich, Theodore Nicolaides, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss
• Akt and autophagy cooperate to promote survival of drug-resistant glioma.
  Science signaling 2010 Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA
• Pleiotropic role for MYCN in medulloblastoma.
  Genes & development 2010 Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg …
• Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy.
  Experimental and Molecular Therapeutics 2010 Theodore P. Nicolaides, Krister Barkovich, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss
• Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.
  Current topics in microbiology and immunology 2010 Fan QW, Weiss WA
• EGFR signals to mTOR through PKC and independently of Akt in glioma.
  Science signaling 2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA
• PI3K signaling in glioma--animal models and therapeutic challenges.
  Brain pathology (Zurich, Switzerland) 2009 Cheng CK, Fan QW, Weiss WA
• Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
  EMBO reports 2008 Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE
• A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
  Cancer research 2007 Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA
• 39 Glioma.
  Neurobiology of Disease 2007 Anders I. Persson, QiWen Fan, Joanna J. Phillips, William A. Weiss
• A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
  Cancer cell 2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA
• RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.
  Oncogene 2005 Fan QW, Weiss WA
• Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
  Cancer research 2003 Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA
• Tri-service physician's assistants programs.
  Military medicine 1977 Robinson HA, Thompson HW