Qinheng Zheng, PhD
Postdoctoral Scholar
Cellular Molecular Pharmacology
School of Medicine

Education & Training

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• PhD Chemistry The Scripps Research Institute 05/2020
• BS Chemistry Peking University 07/2014

Publications (15)

Top publication keywords:
EthylenesWaterSulfhydryl CompoundsSerine Proteinase InhibitorsMolecular StructureSulfinic AcidsRadiopharmaceuticalsLeukocyte ElastaseSulfurSulfur CompoundsFluoridesClick ChemistryProto-Oncogene Proteins p21(ras)Pancreatic NeoplasmsSulfonic Acids

• Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
  Nature chemical biology 2024 Zheng Q, Zhang Z, Guiley KZ, Shokat KM
• Drugging the Next Undruggable KRAS Allele-Gly12Asp.
  Journal of medicinal chemistry 2022 Zheng Q, Peacock DM, Shokat KM
• Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.
  Journal of the American Chemical Society 2021 Zheng Q, Xu H, Wang H, Du WH, Wang N, Xiong H, Gu Y, Noodleman L, Sharpless KB, Yang G, Wu P
• Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry.
  Journal of the American Chemical Society 2020 Kitamura S, Zheng Q, Woehl JL, Solania A, Chen E, Dillon N, Hull MV, Kotaniguchi M, Cappiello JR, Kitamura S, Nizet V, Sharpless KB, Wolan DW
• SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB

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• The growing applications of SuFEx click chemistry
  Chem Soc Rev 2019 Barrow AS, Smedley CJ, Zheng Q, Li S, Dong J, Moses JE
• Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.
  Angewandte Chemie (International ed. in English) 2019 Smedley CJ, Zheng Q, Gao B, Li S, Molino A, Duivenvoorden HM, Parker BS, Wilson DJD, Sharpless KB, Moses JE
• Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.
  Chemistry (Weinheim an der Bergstrasse, Germany) 2018 Gahtory D, Sen R, Pujari S, Li S, Zheng Q, Moses JE, Sharpless KB, Zuilhof H
• Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.
  Nature chemistry 2017 Gao B, Zhang L, Zheng Q, Zhou F, Klivansky LM, Lu J, Liu Y, Dong J, Wu P, Sharpless KB
• SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts.
  Angewandte Chemie (International ed. in English) 2017 Wang H, Zhou F, Ren G, Zheng Q, Chen H, Gao B, Klivansky L, Liu Y, Wu B, Xu Q, Lu J, Sharpless KB, Wu P
• Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.
  Angewandte Chemie (International ed. in English) 2017 Zha GF, Zheng Q, Leng J, Wu P, Qin HL, Sharpless KB
• Aryl Fluorosulfate Trapped Staudinger Reduction.
  Organic letters 2017 Ren G, Zheng Q, Wang H
• Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.
  The Journal of organic chemistry 2016 Zheng Q, Dong J, Sharpless KB
• A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.
  Angewandte Chemie (International ed. in English) 2016 Qin HL, Zheng Q, Bare GA, Wu P, Sharpless KB
• Mild-condition synthesis of allenes from alkynes and aldehydes mediated by tetrahydroisoquinoline (THIQ).
  The Journal of organic chemistry 2013 Jiang GJ, Zheng QH, Dou M, Zhuo LG, Meng W, Yu ZX