Qin Ma, PhD
Assistant Researcher
Neurology
School of Medicine

Awards

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• Educational Grant, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2023, 2023
• Educational Grant, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2022, 2022

Education & Training

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• Ph.D. Genetics Beijing Institute of Genomics, Chinese Academy of Sciences 01/2018
• bachelor’s degree Bioengineering Jilin University 06/2012

Grants and Projects

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• Integrated B cells epigenetic and transcriptome analysis in multiple sclerosis, National Multiple Sclerosis Society, 2022-2025

Publications (20)

Top publication keywords:
Spinocerebellar AtaxiasEncephalomyelitis, Autoimmune, ExperimentalDNA MethylationLymphocyte ActivationB-LymphocytesOligodendrogliaAtaxin-1Genome-Wide Association StudyEpigenesis, Genetic5-MethylcytosineReceptors, Antigen, B-CellArgonaute ProteinsGenomeMultiple SclerosisOlfactory Bulb

• High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis.
  Frontiers in neurology 2023 Ma Q, Augusto DG, Montero-Martin G, Caillier SJ, Osoegawa K, Cree BAC, Hauser SL, Didonna A, Hollenbach JA, Norman PJ, Fernandez-Vina M, Oksenberg JR
• Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes.
  Communications biology 2023 Ma Q, Shams H, Didonna A, Baranzini SE, Cree BAC, Hauser SL, Henry RG, Oksenberg JR
• Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
  Brain : a journal of neurology 2023 Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N, University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, …
• Ataxin-1 controls the expression of specific noncoding RNAs in B cells upon autoimmune demyelination.
  Immunology and cell biology 2023 Ma Q, Didonna A
• Epigenetic control of ataxin-1 in multiple sclerosis.
  Annals of clinical and translational neurology 2022 Ma Q, Oksenberg JR, Didonna A

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• Methylation at a conserved lysine residue modulates tau assembly and cellular functions.
  Molecular and cellular neurosciences 2022 Shams H, Matsunaga A, Ma Q, Mofrad MRK, Didonna A
• Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Ma Q, Caillier SJ, Muzic S, University of California San Francisco MS-EPIC Team, Wilson MR, Henry RG, Cree BAC, Hauser SL, Didonna A, Oksenberg JR
• The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells.
  Molecular brain 2021 Ma Q, Didonna A
• Increased chromosomal instability characterizes metastatic renal cell carcinoma.
  Translational oncology 2020 Ma Q, Wang J, Qi J, Peng D, Guan B, Zhang J, Li Z, Zhang H, Li T, Shi Y, Li X, Zhou L, Chen K, Ci W
• Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis.
  Journal of neuroinflammation 2020 Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A
• Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR
• Genetic Load and Potential Mutational Meltdown in Cancer Cell Populations.
  Molecular biology and evolution 2019 Zhang Y, Li Y, Li T, Shen X, Zhu T, Tao Y, Li X, Wang D, Ma Q, Hu Z, Liu J, Ruan J, Cai J, Wang HY, Lu X
• Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain.
  Epigenetics & chromatin 2018 Ma Q, Xu Z, Lu H, Xu Z, Zhou Y, Yuan B, Ci W
• Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation.
  Epigenomics 2018 Peng D, Ge G, Xu Z, Ma Q, Shi Y, Zhou Y, Gong Y, Xiong G, Zhang C, He S, He Z, Li X, Ci W, Zhou L
• Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity.
  eLife 2017 Xu J, Peng X, Chen Y, Zhang Y, Ma Q, Liang L, Carter AC, Lu X, Wu CI
• Mouse olfactory bulb methylome and hydroxymethylome maps reveal noncanonical active turnover of DNA methylation.
  Epigenetics 2017 Ma Q, Lu H, Xu Z, Zhou Y, Ci W
• Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress.
  Nature communications 2017 Zhang C, Yang L, Ding Y, Wang Y, Lan L, Ma Q, Chi X, Wei P, Zhao Y, Steinbüchel A, Zhang H, Liu P
• Ultra-precise detection of mutations by droplet-based amplification of circularized DNA.
  BMC genomics 2016 Wang K, Ma Q, Jiang L, Lai S, Lu X, Hou Y, Wu CI, Ruan J
• Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer.
  Cell research 2015 Chen K, Zhang J, Guo Z, Ma Q, Xu Z, Zhou Y, Xu Z, Li Z, Liu Y, Ye X, Li X, Yuan B, Ke Y, He C, Zhou L, Liu J, Ci W
• Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis.
  Scientific reports 2015 Cheng QY, Xiong J, Huang W, Ma Q, Ci W, Feng YQ, Yuan BF