Priya Jaishankar, MS
Specialist
Pharmaceutical Chemistry
School of Pharmacy

Publications (40)

Top publication keywords:
Enzyme InhibitorsIndolesCysteine Proteinase InhibitorsSulfonic Acidsbeta-Lactamase InhibitorsTrypanocidal AgentsEthylenesUbiquitin-Specific Peptidase 7Eukaryotic Initiation Factor-2BAntiviral AgentsTrypanosomaStructure-Activity RelationshipEstrogen Receptor alphaCaspase 6Cyclohexylamines

• Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens.
  bioRxiv : the preprint server for biology 2025 Kim J, Correy GJ, Hall BW, Rachman MM, Mailhot O, Togo T, Gonciarz RL, Jaishankar P, Neitz RJ, Hantz ER, Doruk YU, Stevens MGV, Diolaiti ME, Reid R, Gopalkrishnan S, Krogan NJ, Renslo AR, Ashworth A, …
• Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain.
  bioRxiv : the preprint server for biology 2025 Seo L, Farran I, Aslam A, Li X, Jaishankar P, Ashworth A, Fraser JS, Renslo AR, Wankowicz SA
• Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo.
  Journal of medicinal chemistry 2025 Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, …
• The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
  eLife 2025 Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, …
• Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.
  bioRxiv : the preprint server for biology 2025 Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, …

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• The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.
  bioRxiv : the preprint server for biology 2025 Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, …
• Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance.
  Science advances 2025 Klope MT, Talukder P, Blank BR, Chelebieva S, Chen J, Fontaine SD, Gonciarz RL, Jaishankar P, Lee GJ, Legac J, Mathur V, Narayan A, Okitwi M, Orena S, Settineri NS, Tapia JA, Taremwa Y, Tumwebaze PK, …
• Expanding automated multiconformer ligand modeling to macrocycles and fragments.
  eLife 2025 Flowers J, Echols N, Correy GJ, Jaishankar P, Togo T, Renslo AR, van den Bedem H, Fraser JS, Wankowicz SA
• Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning.
  Science advances 2025 Correy GJ, Rachman MM, Togo T, Gahbauer S, Doruk YU, Stevens MGV, Jaishankar P, Kelley B, Goldman B, Schmidt M, Kramer T, Radchenko DS, Moroz YS, Ashworth A, Riley P, Shoichet BK, Renslo AR, Walters …
• Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments.
  bioRxiv : the preprint server for biology 2025 Flowers J, Echols N, Correy G, Jaishankar P, Togo T, Renslo AR, van den Bedem H, Fraser JS, Wankowicz SA
• Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains.
  ACS medicinal chemistry letters 2024 Klope MT, Tapia Cardona JA, Chen J, Gonciarz RL, Cheng K, Jaishankar P, Kim J, Legac J, Rosenthal PJ, Renslo AR
• Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning.
  bioRxiv : the preprint server for biology 2024 Correy GJ, Rachman M, Togo T, Gahbauer S, Doruk YU, Stevens M, Jaishankar P, Kelley B, Goldman B, Schmidt M, Kramer T, Ashworth A, Riley P, Shoichet BK, Renslo AR, Walters WP, Fraser JS
• Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.
  Journal of the American Chemical Society 2023 Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR
• From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
  Angewandte Chemie (International ed. in English) 2023 Visser EJ, Jaishankar P, Sijbesma E, Pennings MAM, Vandenboorn EMF, Guillory X, Neitz RJ, Morrow J, Dutta S, Renslo AR, Brunsveld L, Arkin MR, Ottmann C
• Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.
  Journal of the American Chemical Society 2023 Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR
• Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.
  Cell chemical biology 2022 Hulce KR, Jaishankar P, Lee GM, Bohn MF, Connelly EJ, Wucherer K, Ongpipattanakul C, Volk RF, Chuo SW, Arkin MR, Renslo AR, Craik CS
• Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.
  ACS chemical biology 2020 Bashore C, Jaishankar P, Skelton NJ, Fuhrmann J, Hearn BR, Liu PS, Renslo AR, Dueber EC
• Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.
  Journal of medicinal chemistry 2019 Pemberton OA, Jaishankar P, Akhtar A, Adams JL, Shaw LN, Renslo AR, Chen Y
• Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.
  Brain communications 2019 Griffin AL, Jaishankar P, Grandjean JM, Olson SH, Renslo AR, Baraban SC
• Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
  Cell chemical biology 2019 Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, …
• Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
  ACS infectious diseases 2019 Torelli NJ, Akhtar A, DeFrees K, Jaishankar P, Pemberton OA, Zhang X, Johnson C, Renslo AR, Chen Y
• Cilia-Associated Oxysterols Activate Smoothened.
  Molecular cell 2018 Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald …
• Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.
  Antimicrobial agents and chemotherapy 2018 Pemberton OA, Zhang X, Nichols DA, DeFrees K, Jaishankar P, Bonnet R, Adams J, Shaw LN, Renslo AR, Chen Y
• Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
  Science (New York, N.Y.) 2018 Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
• USP7 small-molecule inhibitors interfere with ubiquitin binding.
  Nature 2017 Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, …
• Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.
  Journal of the American Chemical Society 2017 Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS
• Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.
  eLife 2016 Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P
• Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.
  ChemMedChem 2016 Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR
• Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.
  Journal of the American Chemical Society 2015 Nichols DA, Hargis JC, Sanishvili R, Jaishankar P, Defrees K, Smith EW, Wang KK, Prati F, Renslo AR, Woodcock HL, Chen Y
• Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
  eLife 2015 Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P
• Broad-spectrum allosteric inhibition of herpesvirus proteases.
  Biochemistry 2014 Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS
• Tailoring small molecules for an allosteric site on procaspase-6.
  ChemMedChem 2013 Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR
• Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
  PloS one 2012 Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, …
• Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.
  Journal of medicinal chemistry 2012 Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y
• Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
  Bioorganic & medicinal chemistry letters 2009 Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR
• Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.
  Bioorganic & medicinal chemistry letters 2007 Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR
• A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials.
  Bioorganic & medicinal chemistry letters 2007 Renslo AR, Atuegbu A, Herradura P, Jaishankar P, Ji M, Leach KL, Huband MD, Dermyer MR, Wu L, Vara Prasad JV, Gordeev MF
• Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones.
  Bioorganic & medicinal chemistry letters 2006 Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gómez M, Blais J, Huband M, Vara Prasad JV, Gordeev MF
• Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones.
  Journal of medicinal chemistry 2005 Renslo AR, Jaishankar P, Venkatachalam R, Hackbarth C, Lopez S, Patel DV, Gordeev MF
• Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate.
  Organic letters 2005 Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gordeev MF