Prescott Woodruff, MD, MPH
Professor
Medicine
School of Medicine

Research Interests I. Mentoring in Translational Research II. The identification of molecular sub-phenotypes of asthma and COPD III. Mechanisms of airway inflammation and remodeling in lung diseases IV. Development of blood-based diagnostic tests for lung disease using genomic approaches V. Clinical Trials in asthma and COPD

Awards

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• Elected to the Association of American Physicians, 2022
• Elected to the American Society for Clinical Investigation, 2012
• AOA, 1993

Education & Training

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• MPH Harvard School of Public Health 1996
• MD Medicine Columbia College of Physicians and Surgeons 1993

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)
• SPIROMICS: an NIH COPD cohort (spiromics.net)
• Woodruff Lab website (woodrufflab.ucsf.edu)
• UCSF Airway Clinical Research Center (pulmonary.ucsf.edu)

Grants and Projects

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• Mentoring Precision Medicine in Lung Disease, NIH/NHLBI, 2017-2027
• Immunometabolic phenotypes in adult severe asthma and disease progression, NIH, 2019-2024
• Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study, NIH, 2019-2023
• Understanding Asthma Endotypes, NIH, 2008-2023
• SPIROMICS II: Biological underpinnings of COPD heterogeneity and progression, NIH, 2017-2022

Publications (307)

Top publication keywords:
LungEosinophiliaAdrenal Cortex HormonesBronchiAsthmaPulmonary Disease, Chronic ObstructiveSputumAirway RemodelingForced Expiratory VolumeGoblet CellsBronchitis, ChronicBronchodilator AgentsPulmonary EmphysemaSpirometryInterleukin-13

• Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function.
  The New England journal of medicine 2022 Han MK, Ye W, Wang D, White E, Arjomandi M, Barjaktarevic IZ, Brown SA, Buhr RG, Comellas AP, Cooper CB, Criner GJ, Dransfield MT, Drescher F, Folz RJ, Hansel NN, Kalhan R, Kaner RJ, Kanner RE, …
• Reconsidering the Utility of Race-Specific Lung Function Prediction Equations.
  American journal of respiratory and critical care medicine 2022 Baugh AD, Shiboski S, Hansel NN, Ortega V, Barjaktarevic I, Barr RG, Bowler R, Comellas AP, Cooper CB, Couper D, Criner G, Curtis JL, Dransfield M, Ejike C, Han MK, Hoffman E, Krishnan J, Krishnan JA,…
• Epithelial miR-141 regulates IL-13-induced airway mucus production.
  JCI insight 2021 Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG
• An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.
  The Journal of clinical investigation 2018 Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS,…
• Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function.
  The New England journal of medicine 2016 Woodruff PG, Barr RG, Bleecker E, Christenson SA, Couper D, Curtis JL, Gouskova NA, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Lazarus SC, Martinez FJ, Paine R, Rennard S, Tashkin DP, Han MK, …
• Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management.
  Lancet (London, England) 2015 Woodruff PG, Agusti A, Roche N, Singh D, Martinez FJ
• Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
  American journal of respiratory and critical care medicine 2015 Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG
• T-helper type 2-driven inflammation defines major subphenotypes of asthma.
  American journal of respiratory and critical care medicine 2009 Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV
• Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV

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• Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with COPD.
  Annals of the American Thoracic Society 2024 Baddour NA, Paulin LM, Gassett AJ, Woo H, Hoffman EA, Newell JD, Woodruff PG, Pirozzi CS, Barjaktarevic I, Barr RG, O'Neal W, Han MK, Martinez FJ, Peters SP, Hastie AT, Hansel NN, Ortega VE, Kaufman …
• Vessel and Airway Characteristics in One-Year CT-defined Rapid Emphysema Progression: SPIROMICS.
  Annals of the American Thoracic Society 2024 Gerard SE, Dougherty TM, Nagpal P, Jin D, Han MK, Newell JD, Saha PK, Comellas AP, Cooper CB, Couper D, Fortis S, Guo J, Hansel NN, Kanner RE, Kazeroni EA, Martinez FJ, Motahari A, Paine Iii R, …
• The Effect of Chronic Altitude Exposure on COPD Outcomes in the SPIROMICS Cohort.
  American journal of respiratory and critical care medicine 2024 Suri R, Markovic D, Woo H, Arjomandi M, Barr RG, Bowler RP, Criner G, Curtis JL, Dransfield MT, Drummond MB, Fortis S, Han MK, Hoffman EA, Kaner RJ, Kaufman JD, Krishnan JA, Martinez FJ, Ohar J, …
• Airway tree caliber heterogeneity and airflow obstruction among older adults.
  Journal of applied physiology (Bethesda, Md. : 1985) 2024 Vameghestahbanati M, Kingdom L, Hoffman EA, Kirby M, Allen NB, Angelini E, Bertoni A, Hamid Q, Hogg JC, Jacobs DR, Laine A, Maltais F, Michos ED, Sack C, Sin D, Watson KE, Wysoczanksi A, Couper D, …
• Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study.
  Nature communications 2024 Kim JS, Sun Y, Balte P, Cushman M, Boyle R, Tracy RP, Styer LM, Bell TD, Anderson MR, Allen NB, Schreiner PJ, Bowler RP, Schwartz DA, Lee JS, Xanthakis V, Doyle MF, Regan EA, Make BJ, Kanaya AM, …
• Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma.
  JCI insight 2024 Huang BK, Elicker BM, Henry TS, Kallianos KG, Hahn LD, Tang M, Heng F, McCulloch CE, Bhakta NR, Majumdar S, Choi J, Denlinger LC, Fain SB, Hastie AT, Hoffman EA, Israel E, Jarjour NN, Levy BD, Mauger …
• Lung Structure and Risk of Sleep Apnea in SPIROMICS.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2024 Koch AL, Shing TL, Namen A, Couper D, Smith B, Barr RG, Bhatt S, Putcha N, Baugh A, Saha AK, Ziedler M, Comellas A, Cooper CB, Barjaktarevic I, Bowler RP, Han MK, Kim V, Paine R, Kanner RE, Krishnan …
• Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in COPD.
  American journal of respiratory and critical care medicine 2024 Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie…
• A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.
  American journal of respiratory and critical care medicine 2023 Leung C, Tang M, Huang BK, Fain SB, Hoffman EA, Choi J, Dunican EM, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Levy BD, Wenzel SE, Sumino K, Hastie AT, Schirm J, McCulloch CE, Peters MC, Woodruff …
• Indoor Pollution and Lung Function Decline in Current and Former Smokers: SPIROMICS AIR.
  American journal of respiratory and critical care medicine 2023 Hansel NN, Woo H, Koehler K, Gassett A, Paulin LM, Alexis NE, Putcha N, Lorizio W, Fawzy A, Belz D, Sack C, Barr RG, Martinez FJ, Han MK, Woodruff P, Pirozzi C, Paine R, Barjaktarevic I, Cooper CB, …
• An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
  Cell reports 2023 Johansson K, Gagnon JD, Zhou SK, Fassett MS, Schroeder AW, Kageyama R, Bautista RA, Pham H, Woodruff PG, Ansel KM
• Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease.
  American journal of respiratory and critical care medicine 2023 Motahari A, Barr RG, Han MK, Anderson WH, Barjaktarevic I, Bleecker ER, Comellas AP, Cooper CB, Couper DJ, Hansel NN, Kanner RE, Kazerooni EA, Lynch DA, Martinez FJ, Newell JD, Schroeder JD, Smith BM,…
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Research square 2023 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• African American race is associated with worse sleep quality in heavy smokers.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2023 Baugh AD, Acho M, Arhin A, Barjaktarevic I, Couper D, Criner G, Han M, Hansel N, Krishnan J, Malcolm K, Namen A, Peters S, Schotland H, Sowho M, Zeidler M, Woodruff P, Thakur N
• Longitudinal Follow-Up of Participants With Tobacco Exposure and Preserved Spirometry.
  JAMA 2023 McKleroy W, Shing T, Anderson WH, Arjomandi M, Awan HA, Barjaktarevic I, Barr RG, Bleecker ER, Boscardin J, Bowler RP, Buhr RG, Criner GJ, Comellas AP, Curtis JL, Dransfield M, Doerschuk CM, Dolezal …
• Spirometry in Mixed-Race Civil War Veterans.
  Annals of the American Thoracic Society 2023 Baugh AD, Woodruff P, Shiboski S, Glidden DV, Ortega VE, Thakur N
• Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts.
  Annals of the American Thoracic Society 2023 Ngo D, Pratte KA, Flexeder C, Petersen H, Dang H, Ma Y, Keyes MJ, Gao Y, Deng S, Peterson BD, Farrell LA, Bhambhani VM, Palacios C, Quadir J, Gillenwater L, Xu H, Emson C, Gieger C, Suhre K, Graumann …
• Changes in Lung Volumes with Spirometric Disease Progression in COPD.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2023 Arjomandi M, Zeng S, Chen J, Bhatt SP, Abtin F, Barjaktarevic I, Barr RG, Bleecker ER, Buhr RG, Criner GJ, Comellas AP, Couper DJ, Curtis JL, Dransfield MT, Fortis S, Han MK, Hansel NN, Hoffman EA, …
• Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2023 Izquierdo M, Marion CR, Genese F, Newell JD, O'Neal WK, Li X, Hawkins GA, Barjaktarevic I, Barr RG, Christenson S, Cooper CB, Couper D, Curtis J, Han MK, Hansel NN, Kanner RE, Martinez FJ, Paine R, …
• Impact of Marijuana Smoking on COPD Progression in a Cohort of Middle-Aged and Older Persons.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2023 Barjaktarevic I, Cooper CB, Shing T, Buhr RG, Hoffman EA, Woodruff PG, Drummond MB, Kanner RE, Han MK, Hansel NN, Bowler RP, Kinney GL, Jacobson S, Morris MA, Martinez FJ, Ohar J, Couper D, Tashkin DP
• Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans.
  Thorax 2023 Angelini ED, Yang J, Balte PP, Hoffman EA, Manichaikul AW, Sun Y, Shen W, Austin JHM, Allen NB, Bleecker ER, Bowler R, Cho MH, Cooper CS, Couper D, Dransfield MT, Garcia CK, Han MK, Hansel NN, Hughes …
• A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD.
  Scientific reports 2023 DiLillo KM, Norman KC, Freeman CM, Christenson SA, Alexis NE, Anderson WH, Barjaktarevic IZ, Barr RG, Comellas AP, Bleecker ER, Boucher RC, Couper DJ, Criner GJ, Doerschuk CM, Wells JM, Han MK, …
• Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes.
  The Journal of asthma : official journal of the Association for the Care of Asthma 2023 Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers …
• Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS.
  Clinical immunology (Orlando, Fla.) 2023 LaFon DC, Woo H, Fedarko N, Azar A, Hill H, Tebo AE, Martins TB, Han MK, Krishnan JA, Ortega VE, Barjaktarevic I, Kaner RJ, Hastie A, O'Neal WK, Couper D, Woodruff PG, Curtis JL, Hansel NN, Nahm MH, …
• An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
  bioRxiv : the preprint server for biology 2023 Johansson K, Gagnon JD, Zhou S, Fassett MS, Schroeder AW, Kageyama R, Bautista RA, Pham H, Woodruff PG, Ansel KM
• Abstract P461: Changes in Cigarette Smoking Patterns During the COVID-19 Pandemic: The C4R Study.
  Circulation 2023 Pallavi Balte, Yifei Sun, Asma Sharaf, Akshaya Krishnaswamy, Alexander Arynchyn, Elizabeth A Regan, Vasan S Ramachandran, David Schwartz, Wendy S Post, Alka M Kanaya, Mitchell Elkind, Virginia J …
• Abstract P540: Cardiovascular Disease Risk Factors and Antibody Response to COVID-19 Vaccination: The C4R Study.
  Circulation 2023 John S Kim, Yifei Sun, Pallavi Balte, Mary Cushman, Russell P Tracy, Linda Styer, Michaela R Anderson, Norrina B Allen, Pamela Schreiner, Russell P Bowler, David Schwartz, Joyce Lee, Vanessa Xanthakis…
• Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
  American journal of respiratory and critical care medicine 2023 Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff…
• Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomes.
  The Journal of allergy and clinical immunology 2023 Ginebaugh SP, Hagner M, Ray A, Erzurum SC, Comhair SAA, Denlinger LC, Jarjour NN, Castro M, Woodruff PG, Christenson SA, Bleecker ER, Meyers DA, Hastie AT, Moore WC, Mauger DT, Israel E, Levy BD, …
• Predicting severe chronic obstructive pulmonary disease exacerbations using quantitative CT: a retrospective model development and external validation study.
  The Lancet. Digital health 2023 Chaudhary MFA, Hoffman EA, Guo J, Comellas AP, Newell JD, Nagpal P, Fortis S, Christensen GE, Gerard SE, Pan Y, Wang D, Abtin F, Barjaktarevic IZ, Barr RG, Bhatt SP, Bodduluri S, Cooper CB, Gravens-…
• Ambient Air Pollution Exposure and Sleep Quality in COPD.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2023 Sowho MO, Koch AL, Putcha N, Woo H, Gassett A, Paulin LM, Koehler K, Barr RG, Comellas AP, Cooper CB, Barjaktarevic I, Zeidler MR, Billings ME, Bowler RP, Han MK, Kim V, Paine Iii R, Parekh TM, …
• Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.
  Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation 2023 Manuel Izquierdo, Chad R. Marion, Frank Genese, John D. Newell, Wanda K. O'Neal, Xingnan Li, Gregory A. Hawkins, Igor Barjaktarevic, R. Graham Barr, Stephanie Christenson, Christopher B. Cooper, David…
• Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD.
  Chest 2022 Fortis S, Quibrera PM, Comellas AP, Bhatt SP, Tashkin DP, Hoffman EA, Criner GJ, Han MK, Barr RG, Arjomandi M, Dransfield MB, Peters SP, Dolezal BA, Kim V, Putcha N, Rennard SI, Paine R, Kanner RE, …
• Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS.
  Respiratory research 2022 Tejwani V, Woo H, Liu C, Tillery AK, Gassett AJ, Kanner RE, Hoffman EA, Martinez FJ, Woodruff PG, Barr RG, Fawzy A, Koehler K, Curtis JL, Freeman CM, Cooper CB, Comellas AP, Pirozzi C, Paine R, …
• Clinical Implications of Low Absolute Blood Eosinophil Count in the SPIROMICS COPD Cohort.
  Chest 2022 LeMaster WB, Quibrera PM, Couper D, Tashkin DP, Bleecker ER, Doerschuk CM, Ortega VE, Cooper C, Han MK, Woodruff PG, O'Neal WK, Anderson WH, Alexis NE, Bowler RP, Barr RG, Kaner RJ, Dransfield MT, …
• The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.
  American journal of respiratory and critical care medicine 2022 Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips…
• COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
  American journal of respiratory and critical care medicine 2022 Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID…
• Effect of marijuana smoking on lung function change in older ever tobacco smokers.
  The European respiratory journal 2022 Barjaktarevic I, Cooper CB, Shing T, Buhr RG, Hoffman EA, Woodruff PG, Drummond MB, Kanner RE, Han MK, Hansel NN, Bowler RP, Kinney GL, Jacobson S, Morris MA, Martinez FJ, Ohar J, Couper D, Tashkin DP
• Reply to Townsend and Cowl.
  American journal of respiratory and critical care medicine 2022 Baugh AD, Thakur N, Woodruff PG
• Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
  Critical care (London, England) 2022 Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, …
• Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.
  American journal of respiratory and critical care medicine 2022 Buhr RG, Barjaktarevic IZ, Quibrera PM, Bateman LA, Bleecker ER, Couper DJ, Curtis JL, Dolezal BA, Han MK, Hansel NN, Krishnan JA, Martinez FJ, McKleroy W, Paine R, Rennard SI, Tashkin DP, Woodruff PG…
• Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease.
  American journal of respiratory and critical care medicine 2022 Madapoosi SS, Cruickshank-Quinn C, Opron K, Erb-Downward JR, Begley LA, Li G, Barjaktarevic I, Barr RG, Comellas AP, Couper DJ, Cooper CB, Freeman CM, Han MK, Kaner RJ, Labaki W, Martinez FJ, Ortega …
• Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity.
  Sleep 2022 Baugh A, Buhr RG, Quibrera P, Barjaktarevic I, Barr RG, Bowler R, Han MK, Kaufman JD, Koch AL, Krishnan J, Labaki W, Martinez FJ, Mkorombindo T, Namen A, Ortega V, Paine R, Peters SP, Schotland H, …
• Association Among Chronic Obstructive Pulmonary Disease Severity, Exacerbation Risk, and Anxiety and Depression Symptoms in the SPIROMICS Cohort.
  Journal of the Academy of Consultation-Liaison Psychiatry 2022 Weiss JR, Serdenes R, Madtha U, Zhao H, Kim V, Lopez-Pastrana J, Eakin MN, O'Toole J, Cooper CB, Woodruff P, Kanner RE, Krishnan JA, Iyer AS, Couper D, Morrison MF
• Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
  American journal of epidemiology 2022 Oelsner EC, Krishnaswamy A, Balte PP, Allen NB, Ali T, Anugu P, Andrews HF, Arora K, Asaro A, Barr RG, Bertoni AG, Bon J, Boyle R, Chang AA, Chen G, Coady S, Cole SA, Coresh J, Cornell E, Correa A, …
• Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  Immunity 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ…
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program.
  Pediatric pulmonology 2022 Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, …
• Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.
  American journal of respiratory and critical care medicine 2022 Tang M, Elicker BM, Henry T, Gierada DS, Schiebler ML, Huang BK, Peters MC, Castro M, Hoffman EA, Fain SB, Ash SY, Choi J, Hall C, Phillips BR, Mauger DT, Denlinger LC, Jarjour NN, Israel E, …
• Characterizing COPD Symptom Variability in the Stable State Utilizing the Evaluating Respiratory Symptoms in COPD Instrument.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2022 Krishnan JK, Ancy KM, Oromendia C, Hoffman KL, Easthausen I, Leidy NK, Han MK, Bowler RP, Christenson SA, Couper DJ, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Iyer AS, Paine Iii R, Peters SP, …
• Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2022 Ronish BE, Couper DJ, Barjaktarevic IZ, Cooper CB, Kanner RE, Pirozzi CS, Kim V, Wells JM, Han MK, Woodruff PG, Ortega VE, Peters SP, Hoffman EA, Buhr RG, Dolezal BA, Tashkin DP, Liou TG, Bateman LA, …
• Trends in prevalence of depression and anxiety symptoms and effects of sociodemographic variables before and after the first wave of COVID-19 in Qatar.
  Journal of affective disorders 2022 Khaled SM, Davis V, Amro I, Ali AAM, Woodruff PW, Haddad PM
• The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium.
  American journal of respiratory cell and molecular biology 2022 Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Ghias K, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ
• Obesity alters pathology and treatment response in inflammatory disease.
  Nature 2022 Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, …
• Ambient ozone effects on respiratory outcomes among smokers modified by neighborhood poverty: An analysis of SPIROMICS AIR.
  The Science of the total environment 2022 Belz DC, Woo H, Putcha N, Paulin LM, Koehler K, Fawzy A, Alexis NE, Barr RG, Comellas AP, Cooper CB, Couper D, Dransfield M, Gassett AJ, Han M, Hoffman EA, Kanner RE, Krishnan JA, Martinez FJ, Paine R…
• A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  bioRxiv : the preprint server for biology 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, …
• Comparative Impact of Depressive Symptoms and FEV1% on Chronic Obstructive Pulmonary Disease.
  Annals of the American Thoracic Society 2022 O'Toole J, Woo H, Putcha N, Cooper CB, Woodruff P, Kanner RE, Paine R, Bowler RP, Comellas A, Hoth KF, Krishnan JA, Han M, Dransfield M, Iyer AS, Couper D, Peters SP, Criner G, Kim V, Barr RG, …
• 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
  The Journal of clinical investigation 2022 Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE
• Clinically Significant and Comorbid Anxiety and Depression Symptoms Predict Severe Respiratory Exacerbations in Smokers: A Post Hoc Analysis of the COPDGene and SPIROMICS Cohorts.
  Annals of the American Thoracic Society 2022 Iyer AS, Parekh TM, O'Toole J, Bhatt SP, Eakin MN, Krishnan JA, Yohannes AM, Woodruff PG, Cooper CB, Kanner RE, Hanania NA, Dransfield MT, Regan EA, Hoth KF, Kim V, COPDGene and SPIROMICS …
• Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease.
  Respiratory research 2021 Hernández Cordero AI, Yang CX, Li X, Milne S, Chen V, Hollander Z, Ng R, Criner GJ, Woodruff PG, Lazarus SC, Connett JE, Han MK, Martinez FJ, Reed RM, Man SFP, Leung JM, Sin DD
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• Significance of FEV3/FEV6 in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
  Chest 2021 Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL,…
• Defining Resilience to Smoking-related Lung Disease: A Modified Delphi Approach from SPIROMICS.
  Annals of the American Thoracic Society 2021 Oh AL, Mularski RA, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Criner GJ, Han MK, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Paine R, Parekh TM, Peters SP, Christenson SA, …
• Regulation of airway immunity by epithelial miRNAs.
  Immunological reviews 2021 Johansson K, Woodruff PG, Ansel KM
• Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
  EClinicalMedicine 2021 Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J,…
• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Update in Adult Asthma 2020.
  American journal of respiratory and critical care medicine 2021 Halayko AJ, Pascoe CD, Gereige JD, Peters MC, Cohen RT, Woodruff PG
• High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis.
  ERJ open research 2021 Chakrabarti A, Mar JS, Choy DF, Cao Y, Rathore N, Yang X, Tew GW, Li O, Woodruff PG, Brightling CE, Grimbaldeston M, Christenson SA, Bafadhel M, Rosenberger CM
• Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in the SPIROMICS Study.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2021 Fawzy A, Woo H, Balasubramanian A, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Couper D, Criner GJ, Dransfield MT, Han MK, Hoffman EA, Kanner RE, Krishnan JA, Martinez FJ, McCormack M…
• Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma.
  The Journal of allergy and clinical immunology 2021 Zhu Z, Camargo CA, Raita Y, Fujiogi M, Liang L, Rhee EP, Woodruff PG, Hasegawa K
• Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
  International journal of chronic obstructive pulmonary disease 2021 Zou C, Li F, Choi J, Haghighi B, Choi S, Rajaraman PK, Comellas AP, Newell JD, Lee CH, Barr RG, Bleecker E, Cooper CB, Couper D, Han M, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EC, Martinez FJ, O'…
• Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
  The Lancet. Respiratory medicine 2021 Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R, Woodruff PG, O'Neal WK, …
• Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2021 Burkes RM, Couper DJ, Barjaktarevic IZ, Cooper CB, Labaki WW, Han MK, Woodruff PG, Lazarus SC, Parekh TM, Paine R, Comellas AP, Bowler RP, Loehr LR, Putcha N, Wise RA, Brown TT, Drummond MB
• Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD.
  Respiratory research 2021 Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, O'Neal WK, Gillenwater LA, Lynch DA, Hoffman EA, Newell JD, Comellas AP, Castaldi PJ, Miller …
• Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort.
  Respiratory research 2021 Zhang WZ, Hoffman KL, Schiffer KT, Oromendia C, Rice MC, Barjaktarevic I, Peters SP, Putcha N, Bowler RP, Wells JM, Couper DJ, Labaki WW, Curtis JL, Han MK, Paine R, Woodruff PG, Criner GJ, Hansel NN,…
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.
  Genome medicine 2021 Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ…
• Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.
  American journal of respiratory and critical care medicine 2021 Dunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler R, Christenson SA, Comellas A, Cooper CB, Couper D, Criner GJ, …
• Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma.
  American journal of respiratory and critical care medicine 2021 Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML,…
• Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
  medRxiv : the preprint server for health sciences 2021 Oelsner EC, Allen NB, Ali T, Anugu P, Andrews H, Asaro A, Balte PP, Barr RG, Bertoni AG, Bon J, Boyle R, Chang AA, Chen G, Cole SA, Coresh J, Cornell E, Correa A, Couper D, Cushman M, Demmer RT, …
• The influence of social support on COPD outcomes mediated by depression.
  PloS one 2021 Turnier L, Eakin M, Woo H, Dransfield M, Parekh T, Krishnan JA, Kanner R, Cooper CB, Woodruff PG, Wise R, Han MK, Romero K, Paulin LM, Peters S, Drummond B, Bleecker ER, Bowler R, Comellas AP, Couper …
• Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
  bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images.
  Scientific reports 2021 Li F, Choi J, Zou C, Newell JD, Comellas AP, Lee CH, Ko H, Barr RG, Bleecker ER, Cooper CB, Abtin F, Barjaktarevic I, Couper D, Han M, Hansel NN, Kanner RE, Paine R, Kazerooni EA, Martinez FJ, O'Neal …
• The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.
  bioRxiv : the preprint server for biology 2021 Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ
• Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.
  NPJ biofilms and microbiomes 2021 Opron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, Graham Barr R, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, …
• QCT-based Measures Of Airway Narrowing And Shape Changes Associated With Endobronchial Biopsy Tissue Measures of Airway Remodeling And Clinical Outcomes In Asthma.
  Journal of Allergy and Clinical Immunology 2021 Jiwoong Choi, Jonathan Boomer, In Kyu Lee, Fred Shi, Stephanie Christenson, Jenna Nguyen, Leonard Bacharier, Prescott Woodruff, Michael Peters, Sanghun Choi, Ching-Long Lin, Mario Castro
• Ratio of FEV1/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.
  Chest 2021 Fortis S, Comellas AP, Bhatt SP, Hoffman EA, Han MK, Bhakta NR, Paine R, Ronish B, Kanner RE, Dransfield M, Hoesterey D, Buhr RG, Barr RG, Dolezal B, Ortega VE, Drummond MB, Arjomandi M, Kaner RJ, Kim…
• Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects.
  Scientific reports 2020 Kim V, Jeong S, Zhao H, Kesimer M, Boucher RC, Wells JM, Christenson SA, Han MK, Dransfield M, Paine R, Cooper CB, Barjaktarevic I, Bowler R, Curtis JL, Kaner RJ, O'Beirne SL, O'Neal WK, Rennard SI, …
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  bioRxiv : the preprint server for biology 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  Research square 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort.
  International journal of chronic obstructive pulmonary disease 2020 Stott-Miller M, Müllerová H, Miller B, Tabberer M, El Baou C, Keeley T, Martinez FJ, Han M, Dransfield M, Hansel NN, Cooper CB, Woodruff P, Ortega VE, Comellas AP, Paine Iii R, Kanner RE, Anderson W, …
• A randomized, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER).
  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020 Austin CD, Gonzalez Edick M, Ferrando RE, Solon M, Baca M, Mesh K, Bradding P, Gauvreau GM, Sumino K, FitzGerald JM, Israel E, Bjermer L, Bourdin A, Arron JR, Choy DF, Olsson JK, Abreu F, Howard M, …
• Design of the Redefining Therapy in Early COPD Study.
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2020 Han MK, Ye W, Kim DY, Woodruff P, Pulmonary Trials Cooperative Investigators
• Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.
  The Journal of allergy and clinical immunology 2020 Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker …
• Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort.
  International journal of chronic obstructive pulmonary disease 2020 Cooper CB, Paine R, Curtis JL, Kanner RE, Martinez CH, Meldrum CA, Bowler R, O'Neal W, Hoffman EA, Couper D, Quibrera M, Criner G, Dransfield MT, Han MK, Hansel NN, Krishnan JA, Lazarus SC, Peters SP,…
• T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis.
  Frontiers in immunology 2020 Arger NK, Machiraju S, Allen IE, Woodruff PG, Koth LL
• COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
  American journal of respiratory and critical care medicine 2020 Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER,…
• Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.
  Scientific reports 2020 Zhang WZ, Oromendia C, Kikkers SA, Butler JJ, O'Beirne S, Kim K, O'Neal WK, Freeman CM, Christenson SA, Peters SP, Wells JM, Doerschuk C, Putcha N, Barjaktarevic I, Woodruff PG, Cooper CB, Bowler RP, …
• Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults.
  JAMA 2020 Smith BM, Kirby M, Hoffman EA, Kronmal RA, Aaron SD, Allen NB, Bertoni A, Coxson HO, Cooper C, Couper DJ, Criner G, Dransfield MT, Han MK, Hansel NN, Jacobs DR, Kaufman JD, Lin CL, Manichaikul A, …
• Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene.
  Chest 2020 Putcha N, Fawzy A, Matsui EC, Liu MC, Bowler RP, Woodruff PG, O'Neal WK, Comellas AP, Han MK, Dransfield MT, Wells JM, Lugogo N, Gao L, Talbot CC, Hoffman EA, Cooper CB, Paulin LM, Kanner RE, Criner G…
• Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-analysis.
  Chest 2020 Leitao Filho FS, Mattman A, Schellenberg R, Criner GJ, Woodruff P, Lazarus SC, Albert RK, Connett J, Han MK, Gay SE, Martinez FJ, Fuhlbrigge AL, Stoller JK, MacIntyre NR, Casaburi R, Diaz P, Panos RJ,…
• Long-term Sequelae of Nonobstructive Chronic Bronchitis-Is Airflow Obstruction Important?
  JAMA internal medicine 2020 Woodruff PG, Lazarus SC
• A Randomized, Placebo-Controlled Trial Evaluating Effects of Lebrikizumab on Airway Eosinophilic Inflammation and Remodeling in Uncontrolled Asthma (CLAVIER).
  The FASEB Journal 2020 Cary D. Austin, Melissa Gonzalez Edick, Ronald E. Ferrando, Margaret Solon, Miriam Baca, Kathryn Mesh, Peter Bradding, Gail M. Gauvreau, Kaharu Sumino, Mark Fitzgerald, Eliott Israel, Leif Bjermer, …
• Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.
  American journal of respiratory cell and molecular biology 2020 Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ
• The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS.
  American journal of respiratory and critical care medicine 2020 Ortega VE, Li X, O'Neal WK, Lackey L, Ampleford E, Hawkins GA, Grayeski PJ, Laederach A, Barjaktarevic I, Barr RG, Cooper C, Couper D, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Peters SP, …
• Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.
  JCI insight 2020 Zhang WZ, Rice MC, Hoffman KL, Oromendia C, Barjaktarevic IZ, Wells JM, Hastie AT, Labaki WW, Cooper CB, Comellas AP, Criner GJ, Krishnan JA, Paine R, Hansel NN, Bowler RP, Barr RG, Peters SP, …
• T2-"Low" Asthma: Overview and Management Strategies.
  The journal of allergy and clinical immunology. In practice 2020 Fitzpatrick AM, Chipps BE, Holguin F, Woodruff PG
• An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
  Cell 2020 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, …
• Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort.
  Chest 2020 Burkes RM, Ceppe AS, Doerschuk CM, Couper D, Hoffman EA, Comellas AP, Barr RG, Krishnan JA, Cooper C, Labaki WW, Ortega VE, Wells JM, Criner GJ, Woodruff PG, Bowler RP, Pirozzi CS, Hansel NN, Wise RA,…
• Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers.
  JAMA internal medicine 2020 Paulin LM, Gassett AJ, Alexis NE, Kirwa K, Kanner RE, Peters S, Krishnan JA, Paine R, Dransfield M, Woodruff PG, Cooper CB, Barr RG, Comellas AP, Pirozzi CS, Han M, Hoffman EA, Martinez FJ, Woo H, …
• Erratum: Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.
  Korean journal of radiology 2020 Cho HB, Chae KJ, Jin GY, Choi J, Lin CL, Hoffman EA, Wenzel SE, Castro M, Fain SB, Jarjour NN, Schiebler ML, Barr RG, Hansel N, Cooper CB, Kleerup EC, Han MK, Woodruff PG, Kanner RE, Bleecker ER, …
• Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis.
  International journal of chronic obstructive pulmonary disease 2019 Barjaktarevic IZ, Buhr RG, Wang X, Hu S, Couper D, Anderson W, Kanner RE, Paine Iii R, Bhatt SP, Bhakta NR, Arjomandi M, Kaner RJ, Pirozzi CS, Curtis JL, O'Neal WK, Woodruff PG, Han MK, Martinez FJ, …
• An expert consensus framework for asthma remission as a treatment goal.
  The Journal of allergy and clinical immunology 2019 Menzies-Gow A, Bafadhel M, Busse WW, Casale TB, Kocks JWH, Pavord ID, Szefler SJ, Woodruff PG, de Giorgio-Miller A, Trudo F, Fageras M, Ambrose CS
• CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis.
  Respiratory medicine 2019 Arger NK, Ho ME, Allen IE, Benn BS, Woodruff PG, Koth LL
• Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS.
  The European respiratory journal 2019 Arjomandi M, Zeng S, Barjaktarevic I, Barr RG, Bleecker ER, Bowler RP, Buhr RG, Criner GJ, Comellas AP, Cooper CB, Couper DJ, Curtis JL, Dransfield MT, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Kanner …
• An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
  Cell 2019 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, …
• Pneumoproteins are associated with pulmonary function in HIV-infected persons.
  PloS one 2019 Jeon D, Chang EG, McGing M, Hartman-Filson M, Sommers M, Lewis E, Balmes JR, Moisi D, Lederman MM, Madsen KA, Woodruff PG, Hunt PW, Huang L, Inflammation, Aging, Microbes and Obstructive Lung Disease…
• A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography.
  American journal of respiratory and critical care medicine 2019 Oelsner EC, Ortega VE, Smith BM, Nguyen JN, Manichaikul AW, Hoffman EA, Guo X, Taylor KD, Woodruff PG, Couper DJ, Hansel NN, Martinez FJ, Paine R, Han MK, Cooper C, Dransfield MT, Criner G, Krishnan …
• Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.
  Scientific reports 2019 Labaki WW, Gu T, Murray S, Curtis JL, Yeomans L, Bowler RP, Barr RG, Comellas AP, Hansel NN, Cooper CB, Barjaktarevic I, Kanner RE, Paine R, McDonald MN, Krishnan JA, Peters SP, Woodruff PG, O'Neal WK…
• Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma.
  Metabolites 2019 Halper-Stromberg E, Gillenwater L, Cruickshank-Quinn C, O'Neal WK, Reisdorph N, Petrache I, Zhuang Y, Labaki WW, Curtis JL, Wells J, Rennard S, Pratte KA, Woodruff P, Stringer KA, Kechris K, Bowler RP
• Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).
  Respiratory research 2019 Haghighi B, Choi S, Choi J, Hoffman EA, Comellas AP, Newell JD, Lee CH, Barr RG, Bleecker E, Cooper CB, Couper D, Han ML, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EAC, Martinez FJ, O'Neal W, Paine …
• Nasal gene expression changes with inhaled corticosteroid treatment in asthma.
  Allergy 2019 Boudewijn IM, Lan A, Faiz A, Cox CA, Brouwer S, Schokker S, Vroegop SJ, Nawijn MC, Woodruff PG, Christenson SA, Hagedoorn P, Frijlink HW, Choy DF, Brouwer U, Wisman M, Postma DS, Fingleton J, Beasley …
• Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.
  Korean journal of radiology 2019 Cho HB, Chae KJ, Jin GY, Choi J, Lin CL, Hoffman EA, Wenzel SE, Castro M, Fain SB, Jarjour NN, Schiebler ML, Barr RG, Hansel N, Cooper CB, Kleerup EC, Han MK, Woodruff PG, Kanner RE, Bleecker ER, …
• Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
  Nature genetics 2019 Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Understanding …
• Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
  The New England journal of medicine 2019 Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, …
• Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers.
  JCI insight 2019 Nakada EM, Bhakta NR, Korwin-Mihavics BR, Kumar A, Chamberlain N, Bruno SR, Chapman DG, Hoffman SM, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Woodruff PG, Amin S, Poynter ME, Desai DH, Anathy V
• Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
  American journal of respiratory and critical care medicine 2019 Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, …
• Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.
  Respiratory medicine 2019 Arger NK, Ho M, Woodruff PG, Koth LL
• Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.
  Journal of the American Heart Association 2019 Gu BH, Choi JC, Shen YH, Song LZ, Scheurer ME, Luong A, Rodriguez A, Woodruff P, Koth L, Corry DB, Kheradmand F, LeMaire SA
• Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy.
  Annals of the American Thoracic Society 2019 Wells JM, Arenberg DA, Barjaktarevic I, Bhatt SP, Bowler RP, Christenson SA, Couper DJ, Dransfield MT, Han MK, Hoffman EA, Kaner RJ, Kim V, Kleerup E, Martinez FJ, Moore WC, O'Beirne SL, Paine R, …
• New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
  Nature genetics 2019 Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou…
• A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma.
  American journal of respiratory and critical care medicine 2019 Peters MC, Ringel L, Dyjack N, Herrin R, Woodruff PG, Rios C, O'Connor B, Fahy JV, Seibold MA
• Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2019 Chin AT, Rylance J, Makumbirofa S, Meffert S, Vu T, Clayton J, Mason P, Woodruff P, Metcalfe J
• Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS.
  Chest 2019 Garudadri S, Woodruff PG, Han MK, Curtis JL, Barr RG, Bleecker ER, Bowler RP, Comellas A, Cooper CB, Criner G, Dransfield MT, Hansel NN, Paine R, Krishnan JA, Peters SP, Hastie AT, Martinez FJ, O'Neal…
• Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort.
  Respiratory research 2018 Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT, …
• Targeting Chronic Obstructive Pulmonary Disease Phenotypes, Endotypes, and Biomarkers.
  Annals of the American Thoracic Society 2018 Garudadri S, Woodruff PG
• New Spirometry Indices for Detecting Mild Airflow Obstruction.
  Scientific reports 2018 Bhatt SP, Bhakta NR, Wilson CG, Cooper CB, Barjaktarevic I, Bodduluri S, Kim YI, Eberlein M, Woodruff PG, Sciurba FC, Castaldi PJ, Han MK, Dransfield MT, Nakhmani A
• Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.
  JCI insight 2018 Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr …
• Large Differences in Small RNA Composition Between Human Biofluids.
  Cell reports 2018 Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ
• Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
  Respiratory research 2018 Haghighi B, Choi S, Choi J, Hoffman EA, Comellas AP, Newell JD, Graham Barr R, Bleecker E, Cooper CB, Couper D, Han ML, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EAC, Martinez FJ, O'Neal W, Rennard …
• Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
  Nature biotechnology 2018 Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang…
• Genome-wide association study of lung function and clinical implication in heavy smokers.
  BMC medical genetics 2018 Li X, Ortega VE, Ampleford EJ, Graham Barr R, Christenson SA, Cooper CB, Couper D, Dransfield MT, Han MLK, Hansel NN, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Woodruff PG, Hawkins GA, …
• Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
  Nature biotechnology 2018 Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, …
• Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials.
  American journal of respiratory and critical care medicine 2018 Han MK, Tayob N, Murray S, Woodruff PG, Curtis JL, Kim V, Criner G, Galban CJ, Ross BD, Hoffman EA, Lynch DA, Kazerooni E, Martinez FJ, COPDGene and SPIROMICS Investigators
• Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD.
  Chest 2018 Jin M, Lee EC, Ra SW, Fishbane N, Tam S, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Aaron SD, Reed RM, Man SFP, Leung JM, Sin DD
• Rural Residence and Chronic Obstructive Pulmonary Disease Exacerbations. Analysis of the SPIROMICS Cohort.
  Annals of the American Thoracic Society 2018 Burkes RM, Gassett AJ, Ceppe AS, Anderson W, O'Neal WK, Woodruff PG, Krishnan JA, Barr RG, Han MK, Martinez FJ, Comellas AP, Lambert AA, Kaufman JD, Dransfield MT, Wells JM, Kanner RE, Paine R, …
• At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.
  American journal of respiratory and critical care medicine 2018 Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R, Rafii S, …
• NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort.
  Respiratory medicine 2018 Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine R, Ortega VE, Peters SP, Krishnan JA, Bowler RP, …
• Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.
  PloS one 2018 Putcha N, Paul GG, Azar A, Wise RA, O'Neal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R, Han MK, Martinez FJ, Bowler RP, Barr…
• Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.
  The Journal of allergy and clinical immunology 2018 Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, …
• ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.
  Genome biology 2018 Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY,…
• Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD.
  Respiratory research 2018 Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Paul Man SF, Aaron SD, Reed RM, Sin DD, Canadian …
• Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
  The Journal of clinical investigation 2018 Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel …
• IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.
  American journal of respiratory and critical care medicine 2018 Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG
• Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
  Chronic obstructive pulmonary diseases (Miami, Fla.) 2018 Morris MA, Jacobson SR, Kinney GL, Tashkin DP, Woodruff PG, Hoffman EA, Kanner RE, Cooper CB, Drummond MB, Barr RG, Oelsner EC, Make BJ, Han MK, Hansel NN, O'Neal WK, Bowler RP
• Human airway branch variation and chronic obstructive pulmonary disease.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR, Kanner RE, Kaufman JD, Kleerup E…
• Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.
  The Lancet. Respiratory medicine 2017 Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R, …
• Differentiation of quantitative CT imaging phenotypes in asthma versus COPD.
  BMJ open respiratory research 2017 Choi S, Haghighi B, Choi J, Hoffman EA, Comellas AP, Newell JD, Wenzel SE, Castro M, Fain SB, Jarjour NN, Schiebler ML, Barr RG, Han MK, Bleecker ER, Cooper CB, Couper D, Hansel N, Kanner RE, …
• The value of blood cytokines and chemokines in assessing COPD.
  Respiratory research 2017 Bradford E, Jacobson S, Varasteh J, Comellas AP, Woodruff P, O'Neal W, DeMeo DL, Li X, Kim V, Cho M, Castaldi PJ, Hersh C, Silverman EK, Crapo JD, Kechris K, Bowler RP
• Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.
  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017 Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA
• Variability in objective and subjective measures affects baseline values in studies of patients with COPD.
  PloS one 2017 Anderson WH, Ha JW, Couper DJ, O'Neal WK, Barr RG, Bleecker ER, Carretta EE, Cooper CB, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Kim V, Kleerup EC, Martinez FJ, Rennard SI, Tashkin D, Woodruff PG…
• Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.
  The Journal of allergy and clinical immunology 2017 Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, …
• Airway Mucin Concentration as a Marker of Chronic Bronchitis.
  The New England journal of medicine 2017 Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA…
• Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts.
  Journal of general internal medicine 2017 Bowler RP, Hansel NN, Jacobson S, Graham Barr R, Make BJ, Han MK, O'Neal WK, Oelsner EC, Casaburi R, Barjaktarevic I, Cooper C, Foreman M, Wise RA, DeMeo DL, Silverman EK, Bailey W, Harrington KF, …
• American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.
  American journal of respiratory and critical care medicine 2017 Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer…
• Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
  The Lancet. Respiratory medicine 2017 Han MK, Quibrera PM, Carretta EE, Barr RG, Bleecker ER, Bowler RP, Cooper CB, Comellas A, Couper DJ, Curtis JL, Criner G, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Martinez CH, …
• Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD).
  Respiratory research 2017 Duffy S, Marron R, Voelker H, Albert R, Connett J, Bailey W, Casaburi R, Cooper JA, Curtis JL, Dransfield M, Han MK, Make B, Marchetti N, Martinez F, Lazarus S, Niewoehner D, Scanlon PD, Sciurba F, …
• Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.
  American journal of respiratory and critical care medicine 2017 Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, …
• Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori.
  Respiratory research 2017 Ra SW, Sze MA, Lee EC, Tam S, Oh Y, Fishbane N, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Aaron SD, Reed RM, Man SFP, Sin DD, Canadian Respiratory Research Network
• Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.
  BMJ open respiratory research 2017 Hansel NN, Paulin LM, Gassett AJ, Peng RD, Alexis N, Fan VS, Bleecker E, Bowler R, Comellas AP, Dransfield M, Han MK, Kim V, Krishnan JA, Pirozzi C, Cooper CB, Martinez F, Woodruff PG, Breysse PJ, …
• Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.
  Annals of the American Thoracic Society 2017 Martinez CH, Murray S, Barr RG, Bleecker E, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper D, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Krishnan JA, …
• Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease.
  The Journal of allergy and clinical immunology 2017 Leitao Filho FS, Won Ra S, Mattman A, Schellenberg RS, Fishbane N, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Man SFP, Aaron SD, Reed RM, Sin DD
• Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
  Cell 2017 Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM
• Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.
  American journal of respiratory and critical care medicine 2017 Martinez CH, Diaz AA, Meldrum C, Curtis JL, Cooper CB, Pirozzi C, Kanner RE, Paine R, Woodruff PG, Bleecker ER, Hansel NN, Barr RG, Marchetti N, Criner GJ, Kazerooni EA, Hoffman EA, Ross BD, Galban CJ…
• Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.
  American journal of respiratory and critical care medicine 2017 Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine R, Martinez FJ,…
• Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
  Nature genetics 2017 Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ,…
• Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.
  American journal of respiratory and critical care medicine 2017 Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, …
• Chronic Respiratory Symptoms with Normal Spirometry. A Reliable Clinical Entity?
  American journal of respiratory and critical care medicine 2017 Rodriguez-Roisin R, Han MK, Vestbo J, Wedzicha JA, Woodruff PG, Martinez FJ
• Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.
  The Journal of allergy and clinical immunology 2016 Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, …
• SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.
  American journal of respiratory and critical care medicine 2016 Sieren JP, Newell JD, Barr RG, Bleecker ER, Burnette N, Carretta EE, Couper D, Goldin J, Guo J, Han MK, Hansel NN, Kanner RE, Kazerooni EA, Martinez FJ, Rennard S, Woodruff PG, Hoffman EA, SPIROMICS …
• Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease.
  International journal of chronic obstructive pulmonary disease 2016 Gulcev M, Reilly C, Griffin TJ, Broeckling CD, Sandri BJ, Witthuhn BA, Hodgson SW, Woodruff PG, Wendt CH
• Symptoms in Smokers with Preserved Pulmonary Function.
  The New England journal of medicine 2016 Woodruff PG, Couper D, Han MK
• Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.
  PLoS genetics 2016 Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G…
• COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry.
  PloS one 2016 Leung JM, Chen V, Hollander Z, Dai D, Tebbutt SJ, Aaron SD, Vandemheen KL, Rennard SI, FitzGerald JM, Woodruff PG, Lazarus SC, Connett JE, Coxson HO, Miller B, Borchers C, McManus BM, Ng RT, Sin DD
• Biomarkers in Severe Asthma.
  Immunology and allergy clinics of North America 2016 Wan XC, Woodruff PG
• Alternative splicing of interleukin-33 and type 2 inflammation in asthma.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, …
• Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.
  The Lancet. Respiratory medicine 2016 Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, …
• IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.
  American journal of respiratory and critical care medicine 2016 Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL
• Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis.
  American journal of respiratory and critical care medicine 2016 Brownell R, Kaminski N, Woodruff PG, Bradford WZ, Richeldi L, Martinez FJ, Collard HR
• Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort.
  Thorax 2016 Putcha N, Barr RG, Han MK, Woodruff PG, Bleecker ER, Kanner RE, Martinez FJ, Smith BM, Tashkin DP, Bowler RP, Eisner MD, Rennard SI, Wise RA, Hansel NN, SPIROMICS Investigators
• 41 Asthma Pathogenesis and Phenotypes.
  Murray and Nadel\u0027s Textbook of Respiratory Medicine 2016 Prescott G. Woodruff, Nirav R. Bhakta, John V. Fahy
• Future Research Directions in Asthma. An NHLBI Working Group Report.
  American journal of respiratory and critical care medicine 2015 Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, …
• Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.
  The Journal of allergy and clinical immunology 2015 Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V
• Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS
• Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
  Journal of translational medicine 2015 Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R, Rennard SI, Shimbo D, Woodruff PG, …
• A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
  Nature immunology 2014 Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM
• Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes.
  The European respiratory journal 2014 Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL
• Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy.
  American journal of respiratory and critical care medicine 2014 Han MK, Tayob N, Murray S, Dransfield MT, Washko G, Scanlon PD, Criner GJ, Casaburi R, Connett J, Lazarus SC, Albert R, Woodruff P, Martinez FJ
• Update in asthma 2013.
  American journal of respiratory and critical care medicine 2014 Cohn L, Woodruff PG
• Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
  PloS one 2014 Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS
• Simvastatin for the prevention of exacerbations in moderate-to-severe COPD.
  The New England journal of medicine 2014 Criner GJ, Connett JE, Aaron SD, Albert RK, Bailey WC, Casaburi R, Cooper JA, Curtis JL, Dransfield MT, Han MK, Make B, Marchetti N, Martinez FJ, Niewoehner DE, Scanlon PD, Sciurba FC, Scharf SM, Sin …
• Serum IgE clearance is facilitated by human FcεRI internalization.
  The Journal of clinical investigation 2014 Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin JS
• Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study.
  Journal of translational medicine 2014 O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, …
• Muc5b is required for airway defence.
  Nature 2013 Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG,…
• Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA.
  Annals of the American Thoracic Society 2013 Woodruff PG
• Interferon-inducible chemokines reflect severity and progression in sarcoidosis.
  Respiratory research 2013 Su R, Nguyen ML, Agarwal MR, Kirby C, Nguyen CP, Ramstein J, Darnell EP, Gomez AD, Ho M, Woodruff PG, Koth LL
• Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial.
  The European respiratory journal 2013 Woodruff PG, Chatila W, Connett JE, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Marchetti N, Rogers TJ, Scanlon PD, Sin DD, Voelker H, Wendt C, Albert RK, COPD Clinical Research Network
• Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.
  The Journal of allergy and clinical immunology 2013 Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV
• Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).
  Thorax 2013 Couper D, LaVange LM, Han M, Barr RG, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S, SPIROMICS Research Group
• 48 Immunophenotyping innate lymphoid and T helper cell populations in human asthma.
  Cytokine 2013 Laura S. Christian, Laura Simpson, John Fahy, Prescott Woodruff, K. Mark Ansel
• 98 Common genetic polymorphisms in the ST2 gene locus are associated with impaired soluble ST2 expression in the airway epithelium.
  Cytokine 2013 Erin D. Gordon, Cydney Urbanek, Shaopeng Yuan, Prescott Woodruff, John V. Fahy, Max A. Seibold
• Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis.
  Chest 2013 Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen MLT, Woodruff PG, Jones KD, Collard HR, King TE, Koth LL
• A qPCR-based metric of Th2 airway inflammation in asthma.
  Clinical and translational allergy 2013 Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG
• Double-edged sword?
  JAMA internal medicine 2013 Woodruff PG
• Regulation and function of epithelial secreted phospholipase A2 group X in asthma.
  American journal of respiratory and critical care medicine 2013 Hallstrand TS, Lai Y, Altemeier WA, Appel CL, Johnson B, Frevert CW, Hudkins KL, Bollinger JG, Woodruff PG, Hyde DM, Henderson WR, Gelb MH
• Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.
  The Journal of allergy and clinical immunology 2013 Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM
• Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K
• An integrated nano-scale approach to profile miRNAs in limited clinical samples.
  American journal of clinical and experimental immunology 2012 Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM
• Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease.
  International journal of chronic obstructive pulmonary disease 2012 Albert RK, Connett J, Curtis JL, Martinez FJ, Han MK, Lazarus SC, Woodruff PG
• Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR
• Airway epithelial miRNA expression is altered in asthma.
  American journal of respiratory and critical care medicine 2012 Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG
• Azithromycin and the risk of cardiovascular death.
  The New England journal of medicine 2012 Albert RK, Connett J, Woodruff PG
• Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
  The Journal of allergy and clinical immunology 2012 Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR, Bronchoscopic Exploratory Research Study …
• Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.
  BMC medical genomics 2012 Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE
• Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Dransfield MT, Harnden S, Burton RL, Albert RK, Bailey WC, Casaburi R, Connett J, Cooper JA, Criner GJ, Curtis JL, Han MK, Make B, Marchetti N, Martinez FJ, McEvoy C, Nahm MH, Niewoehner DE, Porszasz …
• Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
  Blood 2012 Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM
• Eri1 regulates microRNA homeostasis and mouse natural killer cell development and anti-viral function (115.9).
  The Journal of Immunology 2012 K Mark Ansel, Molly Thomas, Sarah Abdul-Wajid, Marisella Panduro, Joshua Babiarz, Misha Rajaram, Prescott Woodruff, Lewis Lanier, Vigo Heissmeyer
• Function of the airway epithelium in asthma.
  Journal of allergy 2012 Hallstrand TS, Woodruff PG, Holgate ST, Knight DA
• A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation.
  COPD 2012 COPDGene CT Workshop Group, Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, …
• Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy.
  COPD 2012 Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly…
• Azithromycin for prevention of exacerbations of COPD.
  The New England journal of medicine 2011 Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Make B, Marchetti N, Martinez FJ, Madinger NE, McEvoy C, Niewoehner DE, Porsasz J, …
• A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.
  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011 Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV
• Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis.
  American journal of respiratory and critical care medicine 2011 Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG
• Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trials.
  Proceedings of the American Thoracic Society 2011 Woodruff PG
• Human asthma phenotypes: from the clinic, to cytokines, and back again.
  Immunological reviews 2011 Bhakta NR, Woodruff PG
• Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization.
  COPD 2011 Woodruff PG, Albert RK, Bailey WC, Casaburi R, Connett JE, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Harnden SM, Kim V, Marchetti N, Martinez FJ, McEvoy CE, Niewoehner DE, Reilly JJ, …
• Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR
• The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation.
  American journal of respiratory and critical care medicine 2010 Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV
• Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV
• Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma.
  The Journal of allergy and clinical immunology 2010 Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV
• DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG
• iNKT cell subsets are associated with distinct clinical manifestations of pulmonary sarcoidosis. (37.16).
  The Journal of Immunology 2010 Laura Koth, Prescott Woodruff, Douglas Nixon, Jennifer Snyder-Cappione
• Molecular Th2 Phenotypes of Asthma: New Biomarker or NO?.
  American Journal of Respiratory and Critical Care Medicine 2010 Prescott G. Woodruff, Joseph R. Arron, John V. Fahy
• Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease.
  American journal of respiratory and critical care medicine 2009 Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV
• Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
  American journal of respiratory and critical care medicine 2009 Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ
• Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease.
  American journal of respiratory and critical care medicine 2009 Dransfield MT, Nahm MH, Han MK, Harnden S, Criner GJ, Martinez FJ, Scanlon PD, Woodruff PG, Washko GR, Connett JE, Anthonisen NR, Bailey WC, COPD Clinical Research Network
• Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice.
  COPD 2009 Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL
• Divergent Roles for Airway Epithelial MMP7 and Retinoic Acid in Experimental Asthma (140.5).
  The Journal of Immunology 2009 Sangeeta Goswami, Pornpimon Angkasekwinai, Ming Shan, Kendra J Greenlee, Wade T Barranco, Sumanth Polikepahad, Alexander Seryshev, Sanjiv Sur, Prescott Woodruff, Chen Dong, David B Corry, Farrah …
• Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
  Nature immunology 2009 Goswami S, Angkasekwinai P, Shan M, Greenlee KJ, Barranco WT, Polikepahad S, Seryshev A, Song LZ, Redding D, Singh B, Sur S, Woodruff P, Dong C, Corry DB, Kheradmand F
• Peripheral Biomarkers of an IL-13 Induced Bronchial Epithelial Gene Signature in Asthma.
  Journal of Allergy and Clinical Immunology 2009 J.R. Arron, G. Jia, B. Modrek, D.F. Choy, A.R. Abbas, P.G. Woodruff, J.V. Fahy
• Cognitive performance and grey matter density in psychosis: functional relevance of a structural endophenotype.
  Neuropsychobiology 2008 Habets P, Krabbendam L, Hofman P, Suckling J, Oderwald F, Bullmore E, Woodruff P, Van Os J, Marcelis M
• Prevalence and Risk Factors for Depressive Symptoms in Persons with Chronic Obstructive Pulmonary Disease.
  Journal of General Internal Medicine 2008 Rebecca E. Schane, Louise C. Walter, Alexis Dinno, Ken E. Covinsky, Prescott G. Woodruff
• Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.
  The Journal of allergy and clinical immunology 2008 Seibold MA, Donnelly S, Solon M, Innes A, Woodruff PG, Boot RG, Burchard EG, Fahy JV
• Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary disease.
  Journal of general internal medicine 2008 Schane RE, Walter LC, Dinno A, Covinsky KE, Woodruff PG
• Chapter 40 Chronic Obstructive Pulmonary Disease: Management of Chronic Disease.
  Clinical Respiratory Medicine 2008 Prescott G. Woodruff, Rebecca E. Schane
• Gene expression in asthmatic airway smooth muscle.
  Proceedings of the American Thoracic Society 2008 Woodruff PG
• Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.
  American journal of respiratory and critical care medicine 2007 Panettieri RA, Kotlikoff MI, Gerthoffer WT, Hershenson MB, Woodruff PG, Hall IP, Banks-Schlegel S, National Heart, Lung, and Blood Institute
• Quantitative morphology using bronchial biopsies.
  European Respiratory Review 2006 P. G. Woodruff, A. L. Innes
• Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction.
  Chest 2006 Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV
• A distinctive alveolar macrophage activation state induced by cigarette smoking.
  American journal of respiratory and critical care medicine 2005 Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ
• Dissecting asthma using focused transgenic modeling and functional genomics.
  The Journal of allergy and clinical immunology 2005 Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ
• Structural changes to airway smooth muscle in cystic fibrosis.
  Thorax 2005 Hays SR, Ferrando RE, Carter R, Wong HH, Woodruff PG
• Methodologic advancements in the study of airway smooth muscle.
  The Journal of allergy and clinical immunology 2004 Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, …
• Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma.
  The Journal of asthma : official journal of the Association for the Care of Asthma 2004 Kalayci O, Sonna LA, Woodruff PG, Camargo CA, Luster AD, Lilly CM
• Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression.
  American journal of respiratory and critical care medicine 2004 Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV
• Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens.
  The Journal of allergy and clinical immunology 2003 Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG
• Cigarette smoking among asthmatic adults presenting to 64 emergency departments.
  Chest 2003 Silverman RA, Boudreaux ED, Woodruff PG, Clark S, Camargo CA
• Insurance and quality of care for adults with acute asthma.
  Journal of general internal medicine 2002 Ferris TG, Blumenthal D, Woodruff PG, Clark S, Camargo CA, MARC Investigators
• A prospective multicenter study of factors associated with hospital admission among adults with acute asthma.
  The American journal of medicine 2002 Weber EJ, Silverman RA, Callaham ML, Pollack CV, Woodruff PG, Clark S, Camargo CA
• A prospective multicenter study of patient factors associated with hospital admission from the emergency department among children with acute asthma.
  Archives of pediatrics & adolescent medicine 2002 Pollack CV, Pollack ES, Baren JM, Smith SR, Woodruff PG, Clark S, Camargo CA, Multicenter Airway Research Collaboration Investigators
• Airway remodeling in asthma.
  Seminars in respiratory and critical care medicine 2002 Woodruff PG, Fahy JV
• A role for neutrophils in asthma?
  The American journal of medicine 2002 Woodruff PG, Fahy JV
• Antenatal Factors in the Development of Atopy and Asthma.
  2002 P.G. Woodruff, S.L. Prescott, P.G. Holt, J.V. Fahy
• Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma.
  The Journal of allergy and clinical immunology 2001 Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV
• A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects.
  Genome research 2001 Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV
• Differences between men and women in reporting of symptoms during an asthma exacerbation.
  Annals of emergency medicine 2001 Cydulka RK, Emerman CL, Rowe BH, Clark S, Woodruff PG, Singh AK, Camargo CA, MARC Investigators
• Asthma: prevalence, pathogenesis, and prospects for novel therapies.
  JAMA 2001 Woodruff PG, Fahy JV
• Relation between phase of menstrual cycle and emergency department visits for acute asthma.
  American journal of respiratory and critical care medicine 2000 Zimmerman JL, Woodruff PG, Clark S, Camargo CA
• Sudden-onset asthma exacerbations: clinical features, response to therapy, and 2-week follow-up. Multicenter Airway Research Collaboration (MARC) investigators.
  The European respiratory journal 2000 Barr RG, Woodruff PG, Clark S, Camargo CA
• Elevated plasma eotaxin levels in patients with acute asthma.
  The Journal of allergy and clinical immunology 1999 Lilly CM, Woodruff PG, Camargo CA, Nakamura H, Drazen JM, Nadel ES, Hanrahan JP
• Acute asthma among pregnant women presenting to the emergency department.
  American journal of respiratory and critical care medicine 1999 Cydulka RK, Emerman CL, Schreiber D, Molander KH, Woodruff PG, Camargo CA
• Effect of an emergency department asthma program on acute asthma care.
  Annals of emergency medicine 1999 Emond SD, Woodruff PG, Lee EY, Singh AK, Camargo CA
• Sex differences among adults presenting to the emergency department with acute asthma. Multicenter Asthma Research Collaboration Investigators.
  Archives of internal medicine 1999 Singh AK, Cydulka RK, Stahmer SA, Woodruff PG, Camargo CA
• Prospective multicenter study of relapse following treatment for acute asthma among adults presenting to the emergency department. MARC investigators. Multicenter Asthma Research Collaboration.
  Chest 1999 Emerman CL, Woodruff PG, Cydulka RK, Gibbs MA, Pollack CV, Camargo CA
• Inhaled corticosteroids for asthma: are ED visits a missed opportunity for prevention?
  The American journal of emergency medicine 1999 Singh AK, Woodruff PG, Ritz RH, Mitchell D, Camargo CA
• A PROSPECTIVE MULTICENTER STUDY OF PRIMARY CARE PROVIDER STATUS AMONG CHILDREN PRESENTING TO THE EMERGENCY DEPARTMENT WITH ACUTE ASTHMA.
  Pediatric Emergency Care 1998 Timothy G. Ferris, Ellen F. Crain, Emily Oken, Prescott G. Woodruff, Carlos A. Camargo
• Sudden-onset severe acute asthma: clinical features and response to therapy.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 1998 Woodruff PG, Emond SD, Singh AK, Camargo CA
• First episodes of psychosis in Afro-Caribbean and White people. An 18-year follow-up population-based study.
  The British journal of psychiatry : the journal of mental science 1998 Takei N, Persaud R, Woodruff P, Brockington I, Murray RM
• Auditory hallucinations and perception of external speech.
  Lancet (London, England) 1995 Woodruff P, Brammer M, Mellers J, Wright I, Bullmore E, Williams S
• Cortical response to exogenous visual stimulation during visual hallucinations.
  Lancet (London, England) 1995 Howard R, Williams S, Bullmore E, Brammer M, Mellers J, Woodruff P, David A
• Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration.
  The New England journal of medicine 1990 Furneaux HM, Rosenblum MK, Dalmau J, Wong E, Woodruff P, Graus F, Posner JB
• Results of 1000 kidney transplants in Brisbane.
  Transplantation proceedings 1989 Hardie I, Strong R, Wall D, Petrie J, Rigby R, Lynch S, Woodruff P, Quinn J, Hirst G, Balderson G