Philippe Gascard, PhD
Professional Researcher
Pathology
School of Medicine

Grants and Projects

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• Defining a Stromal Signature that Facilitates Progression of Lethal Cancers, NIH, 2019-2024
• Red Cell Cytoskeleton Protein 4.1R in Kidney Function, NIH, 2000-2006

Publications (64)

Top publication keywords:
NeuropeptidesCellular ReprogrammingSkin NeoplasmsMelanomaSodium-Hydrogen ExchangersErythrocyte MembranePrecancerous ConditionsCytoskeletonTumor MicroenvironmentMembrane ProteinsFibroblastsStromal CellsProgrammed Cell Death 1 ReceptorBreastCytoskeletal Proteins

• A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma.
  bioRxiv : the preprint server for biology 2025 Miyara S, Frenkel S, Mayo A, Gascard P, Strasser M, Gibbs D, Weizman E, Shalom IB, Stein Y, Pan D, Caruso JA, Sangwan V, Bertos N, Berube J, Camilleri-Broet S, Oikonomopoulos S, Djambazian H, Umansky …
• Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett's Esophagus to adenocarcinoma.
  Developmental cell 2025 Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Pan D, Caruso JA, Wang X, Chen-Tanyolac C, Bai R, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Burton JB, …
• Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant Behavior.
  bioRxiv : the preprint server for biology 2025 Burton JB, Gascard P, Pan D, Bons J, Bai R, Chen-Tanyolac C, Caruso JA, Hunter CL, Schilling B, Tlsty TD
• A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction.
  bioRxiv : the preprint server for biology 2025 Pan D, Gascard P, Caruso JA, Chen-Tanyolac C, Sangwan V, Bertos N, Camilleri-Broet S, Berube J, Oikonomopoulos S, Strasser MK, Gibbs DL, Bons J, Burton JB, Rose JP, Shah S, Bai R, Lee S, Fels-Elliott …
• Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer.
  bioRxiv : the preprint server for biology 2025 Lin ML, Hickey JW, Passman A, Carlotti E, Devkumar S, Derwa YH, ChinAleong J, Hackett RJ, Evans J, Sangwan V, Novelli MR, Justo MR, Wright NA, Jansen M, Underwood TJ, Huang S, Gascard P, McLean MH, …

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• Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis.
  Research square 2025 Moutin EB, Chang L, Giavara G, Mehmed S, Colombé M, Lourenço FC, Skoufou-Papoutsaki MN, Kemp R, Gascard P, Tlsty T, Tourigny DS, Winton DJ
• Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy.
  Pathology oncology research : POR 2024 Gascard PD, Wang X, Nosrati M, Kim KB, Kashani-Sabet M, Tlsty TD, Leong SP, Hendrix MJC
• Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon.
  Cellular and molecular gastroenterology and hepatology 2024 Moutin EB, Bons J, Giavara G, Lourenco F, Pan D, Burton JB, Shah S, Colombé M, Gascard P, Tlsty T, Schilling B, Winton DJ
• Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Caruso JA, Wang X, Murrow LM, Rodriguez CI, Chen-Tanyolac C, Vu L, Chen YY, Gascard P, Gartner ZJ, Kerlikowske K, Tlsty TD
• Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis.
  bioRxiv : the preprint server for biology 2023 Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Camilleri-Broet S, Fiset PO, Bertos N, Berube J, Djambazian H, Li…
• Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition.
  Gastroenterology 2023 Lee SH, Contreras Panta EW, Gibbs D, Won Y, Min J, Zhang C, Roland JT, Hong SH, Sohn Y, Krystofiak E, Jang B, Ferri L, Sangwan V, Ragoussis J, Camilleri-Broët S, Caruso J, Chen-Tanyolac C, Strasser M,…
• Epithelial-Stromal Interactions in Barrett's Esophagus Modeled in Human Organ Chips.
  Gastro hep advances 2023 Shimshoni E, Merry GE, Milot ZD, Oh CY, Horvath V, Gould RA, Caruso JA, Chen-Tanyolac C, Gascard P, Sangwan V, Bérubé J, Bailey SD, Hall S, Stachler MD, Ferri L, Tlsty TD, Ingber DE
• Data-independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation-associated carcinomas.
  Proteomics 2022 Bons J, Pan D, Shah S, Bai R, Chen-Tanyolac C, Wang X, Elliott DRF, Urisman A, O'Broin A, Basisty N, Rose J, Sangwan V, Camilleri-Broët S, Tankel J, Gascard P, Ferri L, Tlsty TD, Schilling B
• Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution.
  Cell systems 2022 Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ
• Stromal directives can control cancer.
  Science (New York, N.Y.) 2019 Tlsty TD, Gascard P
• SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.
  Cellular signalling 2016 Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD
• Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.
  Genes & development 2016 Gascard P, Tlsty TD
• Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.
  Scientific reports 2015 Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL
• Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.
  Organic & biomolecular chemistry 2015 Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF
• Integrative analysis of 111 reference human epigenomes.
  Nature 2015 Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon …
• Epigenetic and transcriptional determinants of the human breast.
  Nature communications 2015 Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, …
• Intermediate DNA methylation is a conserved signature of genome regulation.
  Nature communications 2015 Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, …
• Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.
  Nature communications 2014 Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB
• Phosphatidylinositol-4,5 bisphosphate (PIP(2)) inhibits apo-calmodulin binding to protein 4.1.
  Biochemical and biophysical research communications 2014 Nunomura W, Gascard P, Wakui H, Takakuwa Y
• Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.
  Genome research 2013 Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A…
• DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.
  Nature genetics 2013 Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh…
• Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.
  Molecular cell 2013 López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM
• Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD
• A physical sciences network characterization of non-tumorigenic and metastatic cells.
  Scientific reports 2013 Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, …
• Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1).
  The Biochemical journal 2012 Nunomura W, Denker SP, Barber DL, Takakuwa Y, Gascard P
• The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
  Nature 2012 Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, …
• Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.
  Experimental cell research 2012 Pinder JC, Taylor-Harris PM, Bennett PM, Carter E, Hayes NV, King MD, Holt MR, Maggs AM, Gascard P, Baines AJ
• Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis.
  International journal of cell biology 2011 Nunomura W, Gascard P, Takakuwa Y
• Similarities and differences in the structure and function of 4.1G and 4.1R135, two protein 4.1 paralogues expressed in erythroid cells.
  The Biochemical journal 2010 Nunomura W, Kinoshita K, Parra M, Gascard P, An X, Mohandas N, Takakuwa Y
• Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
  Cancer research 2009 Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ,…
• Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition.
  Cancer research 2007 Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH
• Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes.
  American journal of physiology. Cell physiology 2006 Rivera A, De Franceschi L, Peters LL, Gascard P, Mohandas N, Brugnara C
• New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.
  Frontiers in bioscience : a journal and virtual library 2006 Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P
• Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.
  Blood 2005 De Franceschi L, Rivera A, Fleming MD, Honczarenko M, Peters LL, Gascard P, Mohandas N, Brugnara C
• Development of a targeted transgenesis strategy in highly differentiated cells: a powerful tool for functional genomic analysis.
  Journal of biotechnology 2004 Puttini S, Ouvrard-Pascaud A, Palais G, Beggah AT, Gascard P, Cohen-Tannoudji M, Babinet C, Blot-Chabaud M, Jaisser F
• Putative tumor suppressor protein 4.1B is differentially expressed in kidney and brain via alternative promoters and 5' alternative splicing.
  Biochimica et biophysica acta 2004 Gascard P, Parra MK, Zhao Z, Calinisan VR, Nunomura W, Rivkees SA, Mohandas N, Conboy JG
• Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms.
  Genomics 2004 Parra M, Gee S, Chan N, Ryaboy D, Dubchak I, Mohandas N, Gascard PD, Conboy JG
• Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis.
  Neurobiology of disease 2003 Robb VA, Li W, Gascard P, Perry A, Mohandas N, Gutmann DH
• Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.
  Kidney international 2003 Ramez M, Blot-Chabaud M, Cluzeaud F, Chanan S, Patterson M, Walensky LD, Marfatia S, Baines AJ, Chasis JA, Conboy JG, Mohandas N, Gascard P
• Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology.
  Blood 2003 Da Costa L, Tchernia G, Gascard P, Lo A, Meerpohl J, Niemeyer C, Chasis JA, Fixler J, Mohandas N
• Structural and functional characterization of protein 4.1R-phosphatidylserine interaction: potential role in 4.1R sorting within cells.
  The Journal of biological chemistry 2001 An XL, Takakuwa Y, Manno S, Han BG, Gascard P, Mohandas N
• Cytoskeletal Proteins in Heart Muscle.
  Cellular & molecular biology letters 2001 Pinder JC, Taylor-Harris PM, Hayes NV, Gascard PD, Maggs AM, Baines AJ
• New insights into functions of erythroid proteins in nonerythroid cells.
  Current opinion in hematology 2000 Gascard P, Mohandas N
• Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain.
  The Journal of biological chemistry 2000 Parra M, Gascard P, Walensky LD, Gimm JA, Blackshaw S, Chan N, Takakuwa Y, Berger T, Lee G, Chasis JA, Snyder SH, Mohandas N, Conboy JG
• What do mouse gene knockouts tell us about the structure and function of the red cell membrane?
  Bailliere's best practice & research. Clinical haematology 1999 Mohandas N, Gascard P
• Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.
  Molecular biology of the cell 1999 Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG
• Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation.
  Blood 1998 Gascard P, Lee G, Coulombel L, Auffray I, Lum M, Parra M, Conboy JG, Mohandas N, Chasis JA
• Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1.
  Current biology : CB 1998 Walensky LD, Shi ZT, Blackshaw S, DeVries AC, Demas GE, Gascard P, Nelson RJ, Conboy JG, Rubin EM, Snyder SH, Mohandas N
• The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.
  Trends in biochemical sciences 1998 Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ, Bretscher A, Fehon RG, Gusella…
• Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.
  Genomics 1998 Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG
• The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1.
  The Journal of cell biology 1998 Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH
• Structural protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division.
  The Journal of cell biology 1997 Krauss SW, Larabell CA, Lockett S, Gascard P, Penman S, Mohandas N, Chasis JA
• Specific loss of protein kinase activities in senescent erythrocytes.
  Blood 1996 Jindal HK, Ai Z, Gascard P, Horton C, Cohen CM
• Absence of high-affinity band 4.1 binding sites from membranes of glycophorin C- and D-deficient (Leach phenotype) erythrocytes.
  Blood 1994 Gascard P, Cohen CM
• Cellular distribution of polyphosphoinositides in rat hepatocytes.
  Cellular signalling 1993 Tran D, Gascard P, Berthon B, Fukami K, Takenawa T, Giraud F, Claret M
• Trans-bilayer distribution of phosphatidylinositol 4,5-bisphosphate and its role in the changes of lipid asymmetry in the human erythrocyte membrane.
  Biochemical Society transactions 1993 Gascard P, Sulpice JC, Tran D, Sauvage M, Claret M, Zachowski A, Devaux PF, Giraud F
• Regulation and post-translational modification of erythrocyte membrane and membrane-skeletal proteins.
  Seminars in hematology 1992 Cohen CM, Gascard P
• Phosphatidylinositol 4,5-bisphosphate (PIP2) translocation in human erythrocyte membrane is a fast and active process.
  Biochemical Society transactions 1992 Sulpice JC, Gascard P, Giraud F
• Stimulation of polyphosphoinositide turnover upon activation of protein kinases in human erythrocytes.
  Biochimica et biophysica acta 1988 Giraud F, Gascard P, Sulpice JC