Philip Rosenthal, MD
Professor
Medicine
School of Medicine

Second, in collaboration with industry and academic groups, we are pursuing drug discovery, evaluating protease inhibitors, oxaboroles, and other compounds as potential antimalarial drugs. Third, we study malaria in Africa, with translational and laboratory studies at UCSF and in Uganda and Burkina Faso evaluating antimalarial drug efficacy and resistance, the molecular epidemiology of malaria, the roles of host and parasite genetic polymorphisms in treatment outcomes, antimalarial pharmacokinetics and pharmacodynamics, and related areas. Finally, a new area of interest is using genetic tools to characterize causes of febrile illness in African children. In other activities, Dr. Rosenthal is Editor-in-Chief of the American Journal of Tropical Medicine and Hygiene; Chair, Scientific Advisory Committee, WorldWide Antimalarial Resistance Network; Member, Scientific Board, Infectious Diseases Data Observatory; and a member of the World Health Organization Technical Expert Group on Malaria Chemotherapy.

• The emergence of artemisinin partial resistance in Africa: how do we respond?
  The Lancet. Infectious diseases 2024 Rosenthal PJ, Asua V, Bailey JA, Conrad MD, Ishengoma DS, Kamya MR, Rasmussen C, Tadesse FG, Uwimana A, Fidock DA
• Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda.
  medRxiv : the preprint server for health sciences 2024 Kamya MR, Nankabirwa JI, Arinaitwe E, Rek J, Zedi M, Maiteki-Sebuguzi C, Opigo J, Staedke SG, Oruni A, Donnelly MJ, Greenhouse B, Briggs J, Krezanoski PJ, Bousema T, Rosenthal PJ, Olwoch P, …
• Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in Latinx children.
  Pediatric obesity 2024 Maxwell SL, Price JC, Perito ER, Rosenthal P, Wojcicki JM
• Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.
  Hepatology (Baltimore, Md.) 2024 Pandurangi S, Mourya R, Nalluri S, Fei L, Dong S, Harpavat S, Guthery SL, Molleston JP, Rosenthal P, Sokol RJ, Wang KS, Ng V, Alonso EM, Hsu EK, Karpen SJ, Loomes KM, Magee JC, Shneider BL, Horslen SP…
• Author Correction: Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa.
  Nature reviews. Microbiology 2024 Rosenthal PJ, Asua V, Conrad MD
• Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso.
  Antimicrobial agents and chemotherapy 2024 Somé AF, Conrad MD, Kabré Z, Fofana A, Yerbanga RS, Bazié T, Neya C, Somé M, Kagambega TJ, Legac J, Garg S, Bailey JA, Ouédraogo J-B, Rosenthal PJ, Cooper RA
• Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa.
  Nature reviews. Microbiology 2024 Rosenthal PJ, Asua V, Conrad MD
• Selection of artemisinin partial resistance Kelch13 mutations in Uganda in 2016-22 was at a rate comparable to that seen previously in South-East Asia.
  medRxiv : the preprint server for health sciences 2024 Meier-Scherling CPG, Watson OJ, Asua V, Ghinai I, Katairo T, Garg S, Conrad M, Rosenthal PJ, Okell LC, Bailey JA
• Determination of sulfadoxine and pyrimethamine in microvolume human plasma using ultra high performance liquid chromatography-tandam mass spectrometry.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Sok V, Marzan F, Roh M, Guo K, Legac J, Mwebaza N, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L
• Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.
  Journal of medicinal chemistry 2024 Wang L, Bohmer MJ, Wang J, Nardella F, Calla J, Laureano De Souza M, Schindler KA, Montejo L, Mittal N, Rocamora F, Treat M, Charlton JT, Tumwebaze PK, Rosenthal PJ, Cooper RA, Chakrabarti R, Winzeler…
• Diagnosis and management of Alagille and progressive familial intrahepatic cholestasis.
  Hepatology communications 2023 Cheng K, Rosenthal P
• Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance.
  Hepatology communications 2023 Teckman J, Rosenthal P, Ignacio RV, Spino C, Bass LM, Horslen S, Wang K, Magee JC, Karpen S, Asai A, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Shneider BL, Sokol RJ, ChiLDReN (…
• Nutrition assessment and MASH severity in children using the Healthy Eating Index.
  Hepatology communications 2023 Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB, …
• Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach.
  RSC medicinal chemistry 2023 Pal K, Lala S, Agarwal P, Patel TS, Legac J, Rahman MA, Ahmedi S, Shahid N, Singh S, Kumari K, Madhav H, Sen A, Manzoor N, Dixit BC, Van Zyl R, Rosenthal PJ, Hoda N
• Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study.
  The Journal of infectious diseases 2023 Roh ME, Zongo I, Haro A, Huang L, Somé AF, Yerbanga RS, Conrad MD, Wallender E, Legac J, Aweeka F, Ouédraogo JB, Rosenthal PJ
• Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity.
  bioRxiv : the preprint server for biology 2023 Ozarslan N, Robinson JF, Buarpung S, Kim MY, Ansbro MR, Akram J, Montoya DJ, Kamya MR, Kakuru A, Dorsey G, Rosenthal PJ, Cheng G, Feeney ME, Fisher SJ, Gaw SL
• Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria.
  EBioMedicine 2023 Kirosingh AS, Delmastro A, Kakuru A, van der Ploeg K, Bhattacharya S, Press KD, Ty M, Parte L, Kizza J, Muhindo M, Devachanne S, Gamain B, Nankya F, Musinguzi K, Rosenthal PJ, Feeney ME, Kamya M, …
• Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
  The New England journal of medicine 2023 Conrad MD, Asua V, Garg S, Giesbrecht D, Niaré K, Smith S, Namuganga JF, Katairo T, Legac J, Crudale RM, Tumwebaze PK, Nsobya SL, Cooper RA, Kamya MR, Dorsey G, Bailey JA, Rosenthal PJ
• The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries.
  The American journal of tropical medicine and hygiene 2023 Nachega JB, Mbala-Kingebeni P, Rosenthal PJ, Rimoin AW, Hoff NA, Liesenborghs L, Vanlerberghe V, Andrei G, Rawat A, Wilson LA, Forrest J, Mills EJ, Hermans MP, Mulangu S, Ntoumi F, Zumla A, Muyembe-…
• Proteasome inhibitors: The next generation of antimalarial drugs?
  Cell chemical biology 2023 Rosenthal PJ
• Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
  Microbiology spectrum 2023 Kreutzfeld O, Tumwebaze PK, Okitwi M, Orena S, Byaruhanga O, Katairo T, Conrad MD, Rasmussen SA, Legac J, Aydemir O, Giesbrecht D, Forte B, Campbell P, Smith A, Kano H, Nsobya SL, Blasco B, Duffey M, …
• Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.
  Bioorganic chemistry 2023 Previti S, Ettari R, Di Chio C, Legac J, Bogacz M, Zimmer C, Schirmeister T, Rosenthal PJ, Zappalà M
• Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials.
  ACS medicinal chemistry letters 2023 Blank BR, Gut J, Rosenthal PJ, Renslo AR
• Shorter leukocyte telomere length protects against NAFLD progression in children.
  Scientific reports 2023 Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal P
• Efavirenz-Based Antiretroviral Therapy but Not Pregnancy Increased Unbound Piperaquine Exposure in Women during Malaria Chemoprevention.
  Antimicrobial agents and chemotherapy 2023 Hong H, Aslam-Mir U, Kajubi R, Wallender E, Mwebaza N, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L
• Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022.
  JAMA network open 2023 Briggs J, Takahashi S, Nayebare P, Cuu G, Rek J, Zedi M, Kizza T, Arinaitwe E, Nankabirwa JI, Kamya M, Jagannathan P, Jacobson K, Rosenthal PJ, Dorsey G, Greenhouse B, Ssewanyana I, Rodríguez-…
• Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.
  Journal of medicinal chemistry 2023 Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, …
• Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda.
  PloS one 2022 Nankabirwa JI, Bousema T, Blanken SL, Rek J, Arinaitwe E, Greenhouse B, Rosenthal PJ, Kamya MR, Staedke SG, Dorsey G
• Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents.
  European journal of medicinal chemistry 2022 Pal K, Raza MK, Legac J, Rahman A, Manzoor S, Bhattacharjee S, Rosenthal PJ, Hoda N
• Advancing detection and response capacities for emerging and re-emerging pathogens in Africa.
  The Lancet. Infectious diseases 2022 Nachega JB, Nsanzimana S, Rawat A, Wilson LA, Rosenthal PJ, Siedner MJ, Varma JK, Kilmarx PH, Mutesa L, Tanner M, Binagwaho A, Forrest J, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Ntoumi F, Zumla A, de …
• Impact of different mosquito collection methods on indicators of Anopheles malaria vectors in Uganda.
  Malaria journal 2022 Mawejje HD, Asiimwe JR, Kyagamba P, Kamya MR, Rosenthal PJ, Lines J, Dorsey G, Staedke SG
• Characterizing pyrethroid resistance and mechanisms in Anopheles gambiae (s.s.) and Anopheles arabiensis from 11 districts in Uganda.
  Current research in parasitology & vector-borne diseases 2022 Mawejje HD, Weetman D, Epstein A, Lynd A, Opigo J, Maiteki-Sebuguzi C, Lines J, Kamya MR, Rosenthal PJ, Donnelly MJ, Dorsey G, Staedke SG
• Quinoline-based heterocyclic hydrazones: Design, synthesis, anti-plasmodial assessment, and mechanistic insights.
  Chemical biology & drug design 2022 Sharma B, Chowdhary S, Legac J, Rosenthal PJ, Kumar V
• Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Pregnancy in Sub-Saharan Africa: A 6-Country Retrospective Cohort Analysis.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Nachega JB, Sam-Agudu NA, Machekano RN, Rosenthal PJ, Schell S, de Waard L, Bekker A, Gachuno OW, Kinuthia J, Mwongeli N, Budhram S, Vannevel V, Somapillay P, Prozesky HW, Taljaard J, Parker A, Agyare…
• Response to "The Importance of Exercising Caution When Comparing Results from Malaria Vaccines Administered on the EPI Schedule and on a Seasonal Schedule".
  The American journal of tropical medicine and hygiene 2022 Rosenthal PJ
• Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.
  Nature communications 2022 Tumwebaze PK, Conrad MD, Okitwi M, Orena S, Byaruhanga O, Katairo T, Legac J, Garg S, Giesbrecht D, Smith SR, Ceja FG, Nsobya SL, Bailey JA, Cooper RA, Rosenthal PJ
• Prioritizing Pregnant Women for Coronavirus Disease 2019 Vaccination in African Countries.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Nachega JB, Sam-Agudu NA, Siedner MJ, Rosenthal PJ, Mellors JW, Zumla A, Hermans MP, Ntakwinja MB, Mukwege DM, Langenegger E, Mofenson LM, African Forum for Research and Education in Health (…
• East Africa International Center of Excellence for Malaria Research: Impact on Malaria Policy in Uganda.
  The American journal of tropical medicine and hygiene 2022 Namuganga JF, Nankabirwa JI, Maiteki-Ssebuguzi C, Gonahasa S, Opigo J, Staedke SG, Rutazaana D, Ebong C, Dorsey G, Tomko SS, Kizza T, Mawejje HD, Arinaitwe E, Rosenthal PJ, Kamya MR
• East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings.
  The American journal of tropical medicine and hygiene 2022 Nankabirwa JI, Rek J, Arinaitwe E, Namuganga JF, Nsobya SL, Asua V, Mawejje HD, Epstein A, Greenhouse B, Rodriguez-Barraquer I, Briggs J, Krezanoski PJ, Rosenthal PJ, Conrad M, Smith D, Staedke SG, …
• Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir.
  The American journal of tropical medicine and hygiene 2022 Nankabirwa JI, Arinaitwe E, Briggs J, Rek J, Rosenthal PJ, Kamya MR, Olwoch P, Smith DL, Rodriguez-Barraquer I, Dorsey G, Greenhouse B
• Reconstructing the SARS-CoV-2 epidemic in eastern Uganda through longitudinal serosurveillance in a malaria cohort.
  medRxiv : the preprint server for health sciences 2022 Briggs J, Takahashi S, Nayebare P, Cuu G, Rek J, Zedi M, Kizza T, Arinaitwe E, Nankabirwa JI, Kamya M, Jagannathan P, Jacobson K, Rosenthal PJ, Dorsey G, Greenhouse B, Ssewanyana I, Rodríguez-…
• Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
  Antimicrobial agents and chemotherapy 2022 Garg S, Kreutzfeld O, Chelebieva S, Tumwebaze PK, Byaruhanga O, Okitwi M, Orena S, Katairo T, Nsobya SL, Conrad MD, Aydemir O, Legac J, Gould AE, Bayles BR, Bailey JA, Duffey M, Lin G, Kirkman LA, …
• Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Hughes E, Wallender E, Kajubi R, Jagannathan P, Ochieng T, Kakuru A, Kamya MR, Clark TD, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM
• The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel.
  Pharmaceutics 2022 Gupta Y, Sharma N, Singh S, Romero JG, Rajendran V, Mogire RM, Kashif M, Beach J, Jeske W, Ogutu BR, Kanzok SM, Akala HM, Legac J, Rosenthal PJ, Rademacher DJ, Durvasula R, Singh AP, Rathi B, Kempaiah…
• STARTER Checklist for Antimalarial Therapeutic Efficacy Reporting.
  The American journal of tropical medicine and hygiene 2022 Plucinski M, Ashley EA, Bassat Q, Venkatesan M, Rosenthal PJ, Halsey E
• STARTER checklist for antimalarial therapeutic efficacy reporting.
  Malaria journal 2022 Plucinski MM, Ashley EA, Bassat Q, Venkatesan M, Rosenthal PJ, Halsey ES
• Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
  Nature communications 2022 de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, …
• Cooperation in Countering Artemisinin Resistance in Africa: Learning from COVID-19.
  The American journal of tropical medicine and hygiene 2022 Rosenthal PJ, Björkman A, Dhorda M, Djimde A, Dondorp AM, Gaye O, Guerin PJ, Juma E, Kwiatkowski DP, Merson L, Ntoumi F, Price RN, Raman J, Roos DS, Ter Kuile F, Tinto H, Tomko SS, White NJ, Barnes KI
• Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning.
  Malaria journal 2022 Das D, Vongpromek R, Assawariyathipat T, Srinamon K, Kennon K, Stepniewska K, Ghose A, Sayeed AA, Faiz MA, Netto RLA, Siqueira A, Yerbanga SR, Ouédraogo JB, Callery JJ, Peto TJ, Tripura R, Koukouikila…
• Malaria in 2022: Challenges and Progress.
  The American journal of tropical medicine and hygiene 2022 Rosenthal PJ
• Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.
  European journal of medicinal chemistry 2022 Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM, Rosenthal PJ, Prudêncio M, Santos MMM
• Changes in serum hepatitis B surface and e antigen, interferon-inducible protein 10, and aminotransferase levels during combination therapy of immune-tolerant chronic hepatitis B.
  Hepatology (Baltimore, Md.) 2022 Perrillo R, Lin HS, Schwarz KB, Rosenthal P, Lisker-Melman M, Chung RT, Prokunina-Olsson L, Cloherty G, Feld J, Hepatitis B Research Network (HBRN)
• Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry.
  Journal of chromatography open 2022 Huang L, Sok V, Aslam-Mir U, Marzan F, Whalen M, Rosenthal PJ, Aweeka F
• Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates.
  Antimicrobial agents and chemotherapy 2022 Okitwi M, Orena S, Thomas K, Tumwebaze PK, Byaruhanga O, Nsobya SL, Conrad MD, Bayles BR, Rosenthal PJ, Cooper RA
• Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.
  ACS chemical biology 2022 Brinkmann S, Semmler S, Kersten C, Patras MA, Kurz M, Fuchs N, Hammerschmidt SJ, Legac J, Hammann PE, Vilcinskas A, Rosenthal PJ, Schirmeister T, Bauer A, Schäberle TF
• Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries.
  JAMA pediatrics 2022 Nachega JB, Sam-Agudu NA, Machekano RN, Rabie H, van der Zalm MM, Redfern A, Dramowski A, O'Connell N, Pipo MT, Tshilanda MB, Byamungu LN, Masekela R, Jeena PM, Pillay A, Gachuno OW, Kinuthia J, …
• Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
  Journal of medicinal chemistry 2022 Taft BR, Yokokawa F, Kirrane T, Mata AC, Huang R, Blaquiere N, Waldron G, Zou B, Simon O, Vankadara S, Chan WL, Ding M, Sim S, Straimer J, Guiguemde A, Lakshminarayana SB, Jain JP, Bodenreider C, …
• Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
  The Journal of infectious diseases 2022 Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ
• Organ-Specific Comorbidities Are Associated With Distinct Complications After Liver Transplantation for Biliary Atresia.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2021 Taylor SA, Venkat V, Arnon R, Gopalareddy VV, Rosenthal P, Anderson SG, Anand R, Daniel JF, Society of Pediatric Liver Transplantation
• Artemisinin resistance in Africa: How urgent is the threat?
  Med (New York, N.Y.) 2021 Fidock DA, Rosenthal PJ
• Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.
  Nature communications 2021 Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M, Huang L, Duvalsaint M, Legac J, Kamya MR, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM
• Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.
  Antimicrobial agents and chemotherapy 2021 Kanai M, Yeo T, Asua V, Rosenthal PJ, Fidock DA, Mok S
• Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study.
  Journal of pediatric gastroenterology and nutrition 2021 Hertel PM, Hawthorne K, Kim S, Finegold MJ, Shneider BL, Squires JE, Gupta NA, Bull LN, Murray KF, Kerkar N, Ng VL, Molleston JP, Bezerra JA, Loomes KM, Taylor SA, Schwarz KB, Turmelle YP, Rosenthal P…
• Are Artemisinin-Based Combination Therapies For Malaria Beginning To Fail in Africa?
  The American journal of tropical medicine and hygiene 2021 Rosenthal PJ
• Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
  Antimicrobial agents and chemotherapy 2021 Kreutzfeld O, Rasmussen SA, Ramanathan AA, Tumwebaze PK, Byaruhanga O, Katairo T, Asua V, Okitwi M, Orena S, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey J, Duffey M, Bayles BR, Vaidya AB, Cooper …
• The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
  Science translational medicine 2021 Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann…
• Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
  eLife 2021 Stokes BH, Dhingra SK, Rubiano K, Mok S, Straimer J, Gnädig NF, Deni I, Schindler KA, Bath JR, Ward KE, Striepen J, Yeo T, Ross LS, Legrand E, Ariey F, Cunningham CH, Souleymane IM, Gansané A, …
• Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.
  Malaria journal 2021 Duvalsaint M, Conrad MD, Tukwasibwe S, Tumwebaze PK, Legac J, Cooper RA, Rosenthal PJ
• Challenges and opportunities for use of long-lasting insecticidal nets to prevent malaria during overnight travel in Uganda: a qualitative study.
  Malaria journal 2021 Ekusai-Sebatta D, Arinaitwe E, Mpimbaza A, Nankabirwa JI, Drakeley C, Rosenthal PJ, Staedke SG, Muyinda H
• Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study.
  The Lancet. Microbe 2021 Tumwebaze PK, Katairo T, Okitwi M, Byaruhanga O, Orena S, Asua V, Duvalsaint M, Legac J, Chelebieva S, Ceja FG, Rasmussen SA, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Bayles BR, Rosenthal PJ, …
• Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study.
  The Lancet. Infectious diseases 2021 Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, …
• Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives.
  RSC medicinal chemistry 2021 Pal K, Raza MK, Legac J, Ataur Rahman M, Manzoor S, Rosenthal PJ, Hoda N
• Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
  Journal of medicinal chemistry 2021 Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang …
• A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.
  Bioorganic & medicinal chemistry 2021 Rani A, Sharma A, Legac J, Rosenthal PJ, Singh P, Kumar V
• Has artemisinin resistance emerged in Africa?
  The Lancet. Infectious diseases 2021 Rosenthal PJ
• Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.
  The Journal of infectious diseases 2021 Asua V, Conrad MD, Aydemir O, Duvalsaint M, Legac J, Duarte E, Tumwebaze P, Chin DM, Cooper RA, Yeka A, Kamya MR, Dorsey G, Nsobya SL, Bailey J, Rosenthal PJ
• Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
  Angewandte Chemie (International ed. in English) 2021 Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Yukawa T, Chelebieva S, Tumwebaze PK, Lafuente-Monasterio MJ, Martinez-Martinez MS, Vendome J, …
• Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.
  Malaria journal 2021 Tukwasibwe S, Traherne JA, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jiang W, Nankabirwa JI, Rek J, Arinaitwe E, Nsobya SL, Atuheirwe M, Frank M, Godwin A, Jagannathan P, Cose S, Kamya MR, …
• Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.
  Malaria journal 2021 Briggs J, Kuchta A, Murphy M, Tessema S, Arinaitwe E, Rek J, Chen A, Nankabirwa JI, Drakeley C, Smith D, Bousema T, Kamya M, Rodriguez-Barraquer I, Staedke S, Dorsey G, Rosenthal PJ, Greenhouse B
• Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity.
  Frontiers in immunology 2021 Ssewanyana I, Rek J, Rodriguez I, Wu L, Arinaitwe E, Nankabirwa JI, Beeson JG, Mayanja-Kizza H, Rosenthal PJ, Dorsey G, Kamya MR, Drakeley C, Greenhouse B, Tetteh KKA
• Prevalence of Malaria Parasite Infections among U.S.-Bound Congolese Refugees with and without Splenomegaly.
  The American journal of tropical medicine and hygiene 2021 Mwesigwa M, Webster JL, Nsobya SL, Rowan A, Basnet MS, Phares CR, Weinberg M, Klosovsky A, Naoum M, Rosenthal PJ, Stauffer WM
• Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda.
  Malaria journal 2021 Nsobya SL, Walakira A, Namirembe E, Kiggundu M, Nankabirwa JI, Ruhamyankaka E, Arinaitwe E, Conrad MD, Kamya MR, Dorsey G, Rosenthal PJ
• Year 100 of the American Journal of Tropical Medicine and Hygiene: A Remarkable Year.
  The American journal of tropical medicine and hygiene 2021 Rosenthal PJ
• Non-adherence to long-lasting insecticide treated bednet use following successful malaria control in Tororo, Uganda.
  PloS one 2020 Rek J, Musiime A, Zedi M, Otto G, Kyagamba P, Asiimwe Rwatooro J, Arinaitwe E, Nankabirwa J, Staedke SG, Drakeley C, Rosenthal PJ, Kamya M, Dorsey G, Krezanoski PJ
• Associations between Malaria-Preventive Regimens and Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Ugandan Pregnant Women.
  Antimicrobial agents and chemotherapy 2020 Nayebare P, Asua V, Conrad MD, Kajubi R, Kakuru A, Nankabirwa JI, Muhanguzi D, Dorsey G, Kamya MR, Nsobya S, Rosenthal PJ
• Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women.
  Antimicrobial agents and chemotherapy 2020 Hughes E, Imperial M, Wallender E, Kajubi R, Huang L, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N, Clark TD, Opira B, Nakalembe M, Havlir D, Kamya M, Rosenthal PJ, …
• Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo.
  Malaria journal 2020 Arinaitwe E, Nankabirwa JI, Krezanoski P, Rek J, Kamya V, Epstein A, Rosenthal PJ, Drakeley C, Kamya MR, Dorsey G, Staedke SG
• Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase.
  ACS infectious diseases 2020 Butler JH, Baptista RP, Valenciano AL, Zhou B, Kissinger JC, Tumwebaze PK, Rosenthal PJ, Cooper RA, Yue JM, Cassera MB
• Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda.
  The American journal of tropical medicine and hygiene 2020 Arinaitwe E, Mpimbaza A, Nankabirwa JI, Kamya V, Asiimwe A, Kuule JK, Kamya MR, Drakeley C, Dorsey G, Rosenthal PJ, Staedke SG
• Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda.
  Antimicrobial agents and chemotherapy 2020 Cuu G, Asua V, Tukwasibwe S, Nsobya SL, Nanteza A, Kimuda MP, Mpimbaza A, Rosenthal PJ
• Keep Politics out of Funding Decisions for Medical Research and Public Health.
  The American journal of tropical medicine and hygiene 2020 Rosenthal PJ, Bausch DG, Goraleski KA, Hill DR, Jacobson JA, John CC, Breman JG
• Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation.
  Chemical biology & drug design 2020 Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V
• Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria.
  Cellular & molecular immunology 2020 Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P, Rosenthal PJ, Cose S, Colucci F
• Perspectives on Battling COVID-19 in Countries of Latin America and the Caribbean.
  The American journal of tropical medicine and hygiene 2020 Andrus JK, Evans-Gilbert T, Santos JI, Guzman MG, Rosenthal PJ, Toscano C, Valenzuela MT, Siqueira M, Etienne C, Breman JG
• COVID-19: Shining the Light on Africa.
  The American journal of tropical medicine and hygiene 2020 Rosenthal PJ, Breman JG, Djimde AA, John CC, Kamya MR, Leke RGF, Moeti MR, Nkengasong J, Bausch DG
• Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations.
  PloS one 2020 Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E, Dorsey G, Rosenthal PJ, Aweeka F, Huang L
• Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
  Journal of medicinal chemistry 2020 Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, …
• Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy.
  ACS infectious diseases 2020 Blank BR, Gonciarz RL, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR
• The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018.
  The American journal of tropical medicine and hygiene 2020 Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey …
• The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19).
  The American journal of tropical medicine and hygiene 2020 Rosenthal PJ
• The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
  Nature communications 2020 Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, …
• Are three drugs for malaria better than two?
  Lancet (London, England) 2020 Rosenthal PJ
• Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
  mBio 2020 Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ
• Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.
  Malaria journal 2020 Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I
• Falcipain cysteine proteases of malaria parasites: An update.
  Biochimica et biophysica acta. Proteins and proteomics 2020 Rosenthal PJ
• Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights.
  ACS medicinal chemistry letters 2020 Legac J, Adeniyi AA, Kisten P, Rosenthal PJ, Singh P, Kumar V
• Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates.
  Molecules (Basel, Switzerland) 2019 Aguiar L, Biosca A, Lantero E, Gut J, Vale N, Rosenthal PJ, Nogueira F, Andreu D, Fernàndez-Busquets X, Gomes P
• Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials.
  Future medicinal chemistry 2019 Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V
• Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial.
  Malaria journal 2019 Oldenburg CE, Amza A, Cooley G, Kadri B, Nassirou B, Arnold BF, Rosenthal PJ, O'Brien KS, West SK, Bailey RL, Porco TC, Keenan JD, Lietman TM, Martin DL
• Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis.
  The American journal of tropical medicine and hygiene 2019 Kortz TB, Nyirenda J, Tembo D, Elfving K, Baltzell K, Bandawe G, Rosenthal PJ, Macfarlane SB, Mandala W, Nyirenda TS
• Malaria parasites fine-tune mutations to resist drugs.
  Nature 2019 Tilley L, Rosenthal PJ
• Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates.
  Bioorganic & medicinal chemistry letters 2019 Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V
• Be Careful What You Eat!
  The American journal of tropical medicine and hygiene 2019 Rosenthal PJ
• [(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity.
  EXCLI journal 2019 de J Parra Y, Andueza L FD, Ferrer M RE, Bruno Colmenarez J, Acosta ME, Charris J, Rosenthal PJ, Gut J
• The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda.
  Antimicrobial agents and chemotherapy 2019 Conrad MD, Nsobya SL, Rosenthal PJ
• Artemisinin Resistance in Eastern India.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Rosenthal PJ
• Antimalarial drug resistance in Africa: the calm before the storm?
  The Lancet. Infectious diseases 2019 Conrad MD, Rosenthal PJ
• Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention.
  Clinical pharmacology and therapeutics 2019 Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT
• A shorter course for anti-relapse therapy against vivax malaria.
  Lancet (London, England) 2019 Rosenthal PJ
• Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand?
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Guler JL, Rosenthal PJ
• Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.
  Nature communications 2019 Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD
• Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial.
  PLoS medicine 2019 Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD, MORDOR Study Group
• Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.
  Journal of medicinal chemistry 2019 Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G
• Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda.
  PloS one 2019 Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL
• Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda.
  PloS one 2019 Mpimbaza A, Nayiga S, Ndeezi G, Rosenthal PJ, Karamagi C, Katahoire A
• Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States.
  The American journal of tropical medicine and hygiene 2019 Rosenthal PJ, Tan KR
• Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.
  Journal of medicinal chemistry 2019 Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ
• Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation.
  Bioorganic chemistry 2019 Rani A, Legac J, Rosenthal PJ, Kumar V
• Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children.
  The Journal of infectious diseases 2019 Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ
• Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda.
  The Journal of infectious diseases 2019 Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B
• Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda.
  Antimicrobial agents and chemotherapy 2019 Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ
• Malaria: How Are We Doing and How Can We Do Better?
  The American journal of tropical medicine and hygiene 2019 Rosenthal PJ, John CC, Rabinovich NR
• Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda.
  Antimicrobial agents and chemotherapy 2019 Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM
• Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children.
  Nature communications 2019 Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J
• Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG
• Volume 100 of the American Journal of Tropical Medicine and Hygiene.
  The American journal of tropical medicine and hygiene 2019 Rosenthal PJ, Vinetz JM, Siegel C, Kazura JW
• Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria.
  Malaria journal 2018 Mpimbaza A, Katahoire A, Rosenthal PJ, Karamagi C, Ndeezi G
• Artemisinin Resistance Outside of Southeast Asia.
  The American journal of tropical medicine and hygiene 2018 Rosenthal PJ
• Molecular assays for antimalarial drug resistance surveillance: A target product profile.
  PloS one 2018 Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ
• Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study.
  PloS one 2018 Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ
• Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT
• Cysteine proteases in protozoan parasites.
  PLoS neglected tropical diseases 2018 Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ
• Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R…
• Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance.
  The Journal of infectious diseases 2018 Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L
• Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz.
  The Journal of infectious diseases 2018 Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM
• Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.
  European journal of medicinal chemistry 2018 Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F
• Clinical consequences of submicroscopic malaria parasitaemia in Uganda.
  Malaria journal 2018 Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B
• "The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health.
  The American journal of tropical medicine and hygiene 2017 Dunavan CP, Rosenthal PJ
• Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation.
  European journal of medicinal chemistry 2017 Rani A, Singh A, Gut J, Rosenthal PJ, Kumar V
• Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda.
  The Journal of infectious diseases 2017 Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ
• Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda.
  The American journal of tropical medicine and hygiene 2017 Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ
• Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study.
  The American journal of tropical medicine and hygiene 2017 Mpimbaza A, Ndeezi G, Katahoire A, Rosenthal PJ, Karamagi C
• Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda.
  The American journal of tropical medicine and hygiene 2017 Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B
• Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda.
  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2017 Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ
• Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center.
  The American journal of tropical medicine and hygiene 2017 Rosenthal PJ, Goraleski KA, Rabinovich NR, Walker PF
• Plasmodium Species Infecting Children Presenting with Malaria in Uganda.
  The American journal of tropical medicine and hygiene 2017 Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL, Rosenthal PJ
• Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
  Journal of medicinal chemistry 2017 Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M
• The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017 Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T, Rosenthal PJ
• 4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation.
  European journal of medicinal chemistry 2017 Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V
• Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial.
  The American journal of tropical medicine and hygiene 2017 O'Brien KS, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL, Rosenthal PJ, Gaynor BD, Porco TC, Lietman TM
• Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
  Journal of medicinal chemistry 2017 Blank BR, Gut J, Rosenthal PJ, Renslo AR
• Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
  Journal of medicinal chemistry 2017 Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J
• Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation.
  Chemical biology & drug design 2017 Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V
• Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda.
  Malaria journal 2017 Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR, Dorsey G, Nsobya SL, Greenhouse B, Rosenthal PJ
• Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.
  EMBO molecular medicine 2017 Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA
• Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda.
  Malaria journal 2017 Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR, Rosenthal PJ, Dorsey G, Mayanja-Kizza H, Drakeley C, Greenhouse B, Tetteh KK
• Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States.
  The American journal of tropical medicine and hygiene 2017 Rosenthal PJ, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF
• Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.
  Antimicrobial agents and chemotherapy 2016 Sonoiki E, Nsanzabana C, Legac J, Sindhe KM, DeRisi J, Rosenthal PJ
• Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study.
  PLoS medicine 2016 Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ, Rosenthal PJ, Drakeley C, Lindsay SW, …
• The (International) American Society of Tropical Medicine and Hygiene.
  The American journal of tropical medicine and hygiene 2016 Rosenthal PJ, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV
• Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda.
  Open forum infectious diseases 2016 Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ
• Communicable Diseases: A Global Perspective.
  The American journal of tropical medicine and hygiene 2016 Rosenthal PJ
• Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
  Antimicrobial agents and chemotherapy 2016 Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S
• 4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation.
  European journal of medicinal chemistry 2016 Singh A, Gut J, Rosenthal PJ, Kumar V
• Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda.
  Malaria journal 2016 Rek J, Katrak S, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M, Rosenthal PJ, Dorsey G, Greenhouse B
• Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.
  ChemMedChem 2016 Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R
• Azithromycin for Malaria?
  The American journal of tropical medicine and hygiene 2016 Rosenthal PJ
• Novel squaramides with in vitro liver stage antiplasmodial activity.
  Bioorganic & medicinal chemistry 2016 Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, Prudêncio M, Moreira R, Santos MM
• Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction.
  Malaria journal 2015 Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, Greenhouse B, Rosenthal PJ, Dorsey G, Staedke SG
• Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites.
  ChemMedChem 2015 Pereira NA, Monteiro Â, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R, Rosenthal PJ, Prudêncio M, Santos MM
• Artefenomel: a promising new antimalarial drug.
  The Lancet. Infectious diseases 2015 Rosenthal PJ
• Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.
  ACS medicinal chemistry letters 2015 Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR
• The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children.
  Evidence-based medicine 2015 Rosenthal PJ
• Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network.
  The American journal of tropical medicine and hygiene 2015 Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ
• Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse…
• Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
  Journal of medicinal chemistry 2015 Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y
• Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test.
  The American journal of tropical medicine and hygiene 2015 Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A, Rosenthal PJ, Kamya MR
• Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso.
  Antimicrobial agents and chemotherapy 2015 Zongo I, Milligan P, Compaore YD, Some AF, Greenwood B, Tarning J, Rosenthal PJ, Sutherland C, Nosten F, Ouedraogo JB
• The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.
  BMC medicine 2015 WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, …
• Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates.
  European journal of medicinal chemistry 2015 Raj R, Saini A, Gut J, Rosenthal PJ, Kumar V
• Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.
  ChemMedChem 2015 Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R
• Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme.
  Archives of biochemistry and biophysics 2015 Marques AF, Gomes PS, Oliveira PL, Rosenthal PJ, Pascutti PG, Lima LM
• Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control.
  The American journal of tropical medicine and hygiene 2015 Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ, Rosenthal PJ, Drakeley C, Lindsay SW, Staedke SG, Smith DL, Greenhouse B, Dorsey G
• The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots.
  The American journal of tropical medicine and hygiene 2015 Schwartz A, Baidjoe A, Rosenthal PJ, Dorsey G, Bousema T, Greenhouse B
• N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.
  Bioorganic & medicinal chemistry 2015 Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A
• Perspectives on Ebola.
  The American journal of tropical medicine and hygiene 2015 Rosenthal PJ, Bausch DG
• Reply to Goyal et al.
  The Journal of infectious diseases 2014 Hsiang MS, Greenhouse B, Rosenthal PJ
• Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials.
  Journal of medicinal chemistry 2014 Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S, Rosenthal PJ, Hunt NH, Payne RJ
• Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2.
  European journal of medicinal chemistry 2014 Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J, Rosenthal PJ, Chibale K
• Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial.
  AIDS (London, England) 2014 Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G
• Drug delivery to the malaria parasite using an arterolane-like scaffold.
  ChemMedChem 2014 Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR
• Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.
  The Journal of infectious diseases 2014 Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Mårtensson A, Ngasala B, Conrad MD, …
• Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children.
  PloS one 2014 Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR, Havlir DV, Dorsey G, Rosenthal PJ
• Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine.
  PloS one 2014 Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N, Rosenthal PJ, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB
• Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial.
  PLoS medicine 2014 Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G
• Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.
  The American journal of tropical medicine and hygiene 2014 Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, …
• β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation.
  European journal of medicinal chemistry 2014 Gut J, Rosenthal PJ, Kumar V
• Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.
  European journal of medicinal chemistry 2014 Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V
• Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum.
  Journal of enzyme inhibition and medicinal chemistry 2014 Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES, Rosenthal PJ, Terenzi H
• Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.
  Journal of medicinal chemistry 2014 Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O'Neill PM, Lopes F
• Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M, Rosenthal PJ, Kamya MR, Tappero JW, Dorsey G
• Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda.
  The American journal of tropical medicine and hygiene 2014 Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG, Dorsey G, Greenhouse B, Rosenthal PJ
• Point of care testing for malaria using LAMP, loop mediated isothermal amplification.
  The Journal of infectious diseases 2014 Hsiang MS, Greenhouse B, Rosenthal PJ
• Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.
  European journal of medicinal chemistry 2014 Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R
• Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F, Ruel T, Clark TD, Charlebois E, Rosenthal PJ, Havlir D, Kamya MR, Tappero JW, Dorsey G
• Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities.
  Journal of medicinal chemistry 2014 Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R
• Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy.
  Journal of acquired immune deficiency syndromes (1999) 2014 Ruel TD, Kakuru A, Ikilezi G, Mwangwa F, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Kamya M, Achan J
• Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso.
  Antimicrobial agents and chemotherapy 2014 Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB, Rosenthal PJ
• Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.
  PloS one 2014 Sundararaj S, Saxena AK, Sharma R, Vashisht K, Sharma S, Anvikar A, Dixit R, Rosenthal PJ, Pandey KC
• Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.
  Malaria journal 2014 Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC
• 7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation.
  Chemical biology & drug design 2014 Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Forge D, Kumar V
• Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda.
  Malaria journal 2014 Nankoberanyi S, Mbogo GW, LeClair NP, Conrad MD, Tumwebaze P, Tukwasibwe S, Kamya MR, Tappero J, Nsobya SL, Rosenthal PJ
• Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR
• Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial.
  The American journal of tropical medicine and hygiene 2014 Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM
• Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children.
  The Journal of infectious diseases 2014 Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW, Greenhouse B, Dorsey G, Rosenthal PJ
• Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.
  Bioorganic & medicinal chemistry letters 2014 Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA
• Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda.
  The Journal of infectious diseases 2014 Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG, Rosenthal PJ
• 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation.
  Bioorganic & medicinal chemistry letters 2014 Raj R, Gut J, Rosenthal PJ, Kumar V
• Changes at our journal.
  The American journal of tropical medicine and hygiene 2014 Rosenthal PJ
• Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS.
  Bioanalysis 2014 Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L
• Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.
  ACS medicinal chemistry letters 2013 Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F
• Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.
  European journal of medicinal chemistry 2013 Singh P, Raj R, Singh P, Gut J, Rosenthal PJ, Kumar V
• 4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation.
  Chemical biology & drug design 2013 Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Kumar V
• Novel anti-plasmodial hits identified by virtual screening of the ZINC database.
  Journal of computer-aided molecular design 2013 Mugumbate G, Newton AS, Rosenthal PJ, Gut J, Moreira R, Chibale K, Guedes RC
• Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.
  ACS medicinal chemistry letters 2013 Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K
• Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability.
  Journal of medicinal chemistry 2013 Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R
• Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds.
  European journal of medicinal chemistry 2013 Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM, Rosenthal PJ, Moreira R, Prudêncio M, Lopes F
• Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.
  European journal of medicinal chemistry 2013 Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM
• Biochemical and immunological mechanisms by which sickle cell trait protects against malaria.
  Malaria journal 2013 Gong L, Parikh S, Rosenthal PJ, Greenhouse B
• Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132.
  PloS one 2013 Prasad R, Kolla VK, Legac J, Singhal N, Navale R, Rosenthal PJ, Sijwali PS
• The interplay between drug resistance and fitness in malaria parasites.
  Molecular microbiology 2013 Rosenthal PJ
• Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis.
  Phytochemistry 2013 Mba'ning BM, Lenta BN, Noungoué DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H
• An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.
  ChemMedChem 2013 Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R
• Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.
  Bioorganic & medicinal chemistry 2013 Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K
• Biological evaluation of hydroxynaphthoquinones as anti-malarials.
  Malaria journal 2013 Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes MS, Nakabashi M, Rosenthal PJ, Ferreira VF, Garcia CR
• An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia.
  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2013 Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A, Rosenthal PJ, Dorsey G, Casper C
• Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites.
  Antimicrobial agents and chemotherapy 2013 Ochong E, Tumwebaze PK, Byaruhanga O, Greenhouse B, Rosenthal PJ
• Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits.
  Molecular informatics 2013 Carrasco MP, Gut J, Rodrigues T, Ribeiro MH, Lopes F, Rosenthal PJ, Moreira R, Dos Santos DJ
• Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum.
  Journal of clinical microbiology 2013 LeClair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL, Rosenthal PJ
• Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.
  Journal of medicinal chemistry 2013 Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R
• Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine.
  ACS medicinal chemistry letters 2013 Njogu PM, Gut J, Rosenthal PJ, Chibale K
• Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids.
  ACS medicinal chemistry letters 2013 Andayi WA, Egan TJ, Gut J, Rosenthal PJ, Chibale K
• In vitro and in vivo antimalarial efficacies of optimized tetracyclines.
  Antimicrobial agents and chemotherapy 2013 Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML
• Falcipain-2 inhibition by suramin and suramin analogues.
  Bioorganic & medicinal chemistry 2013 Marques AF, Esser D, Rosenthal PJ, Kassack MU, Lima LM
• Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation.
  European journal of medicinal chemistry 2013 Raj R, Singh P, Singh P, Gut J, Rosenthal PJ, Kumar V
• Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies.
  The American journal of tropical medicine and hygiene 2013 Ikilezi G, Achan J, Kakuru A, Ruel T, Charlebois E, Clark TD, Rosenthal PJ, Havlir D, Kamya MR, Dorsey G
• Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity.
  Molecular and biochemical parasitology 2013 Cotrin SS, Gouvêa IE, Melo PM, Bagnaresi P, Assis DM, Araújo MS, Juliano MA, Gazarini ML, Rosenthal PJ, Juliano L, Carmona AK
• N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads.
  Journal of medicinal chemistry 2013 Pérez BC, Teixeira C, Albuquerque IS, Gut J, Rosenthal PJ, Gomes JR, Prudêncio M, Gomes P
• Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda.
  Malaria journal 2012 Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G
• In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites.
  Bioorganic & medicinal chemistry letters 2012 Pérez B, Teixeira C, Gomes AS, Albuquerque IS, Gut J, Rosenthal PJ, Prudêncio M, Gomes P
• Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda.
  PloS one 2012 Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B
• Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar.
  The American journal of tropical medicine and hygiene 2012 Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B
• Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.
  Future medicinal chemistry 2012 Mahajan SS, Gut J, Rosenthal PJ, Renslo AR
• Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children.
  The New England journal of medicine 2012 Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR
• Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo.
  Malaria journal 2012 Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J, Rosenthal PJ
• Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers.
  Journal of acquired immune deficiency syndromes (1999) 2012 Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT
• 1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues.
  ACS medicinal chemistry letters 2012 Lu X, Altharawi A, Gut J, Rosenthal PJ, Long TE
• Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum.
  ChemMedChem 2012 Pérez B, Teixeira C, Gut J, Rosenthal PJ, Gomes JR, Gomes P
• Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.
  Bioorganic & medicinal chemistry letters 2012 Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K
• Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.
  European journal of medicinal chemistry 2012 Pérez BC, Teixeira C, Figueiras M, Gut J, Rosenthal PJ, Gomes JR, Gomes P
• Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins.
  Malaria journal 2012 Bagnaresi P, Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML
• Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis.
  Journal of chemical information and modeling 2012 Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA
• Phosphonium lipocations as antiparasitic agents.
  Bioorganic & medicinal chemistry letters 2012 Long TE, Lu X, Galizzi M, Docampo R, Gut J, Rosenthal PJ
• Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait.
  Blood 2012 Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B
• Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK
• How do we best diagnose malaria in Africa?
  The American journal of tropical medicine and hygiene 2012 Rosenthal PJ
• The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa.
  Future virology 2012 Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J
• Novel potent metallocenes against liver stage malaria.
  Antimicrobial agents and chemotherapy 2011 Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R, Rosenthal PJ, Prudêncio M, Gomes P
• Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry.
  Bioorganic & medicinal chemistry letters 2011 Singh P, Singh P, Kumar M, Gut J, Rosenthal PJ, Kumar K, Kumar V, Mahajan MP, Bisetty K
• Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis.
  The American journal of tropical medicine and hygiene 2011 Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ
• The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children.
  Transactions of the Royal Society of Tropical Medicine and Hygiene 2011 Gupta V, Perez-Perez GI, Dorsey G, Rosenthal PJ, Blaser MJ
• Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents.
  Bioorganic & medicinal chemistry 2011 Glória PM, Gut J, Gonçalves LM, Rosenthal PJ, Moreira R, Santos MM
• Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda.
  The Journal of infectious diseases 2011 Baliraine FN, Rosenthal PJ
• Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.
  Bioorganic & medicinal chemistry 2011 Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O Neill PM, Biagini GA, Lopes F, dos Santos DJ, Guedes RC
• In vitro activity of antiretroviral drugs against Plasmodium falciparum.
  Antimicrobial agents and chemotherapy 2011 Nsanzabana C, Rosenthal PJ
• Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola.
  Malaria journal 2011 Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, do Rosário VE, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M
• Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.
  Antimicrobial agents and chemotherapy 2011 Capela R, Cabal GG, Rosenthal PJ, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M
• In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants.
  Parasitology research 2011 Kemgne EA, Mbacham WF, Boyom FF, Zollo PH, Tsamo E, Rosenthal PJ
• Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward.
  Acta tropica 2011 Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ
• Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic.
  The Journal of infectious diseases 2011 Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC
• Lessons from sickle cell disease in the treatment and control of malaria.
  The New England journal of medicine 2011 Rosenthal PJ
• Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L
• Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks.
  ChemMedChem 2011 Langolf S, Machon U, Ehlers M, Sicking W, Schirmeister T, Büchhold C, Gelhaus C, Rosenthal PJ, Schmuck C
• Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria.
  Malaria journal 2011 Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U
• Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.
  Journal of medicinal chemistry 2011 Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K
• Mining a cathepsin inhibitor library for new antiparasitic drug leads.
  PLoS neglected tropical diseases 2011 Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR
• Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.
  Journal of chemical information and modeling 2011 Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA
• Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.
  Acta tropica 2011 Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ
• Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.
  Bioorganic & medicinal chemistry letters 2011 Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K
• An image-based assay for high throughput screening of Giardia lamblia.
  Journal of microbiological methods 2011 Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH
• Potent antiplasmodial extracts from Cameroonian Annonaceae.
  Journal of ethnopharmacology 2011 Boyom FF, Fokou PV, Yamthe LR, Mfopa AN, Kemgne EM, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ
• Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.
  European journal of medicinal chemistry 2011 Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R
• Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.
  Journal of medicinal chemistry 2011 Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A
• New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors.
  ChemMedChem 2011 Büchold C, Hemberger Y, Heindl C, Welker A, Degel B, Pfeuffer T, Staib P, Schneider S, Rosenthal PJ, Gut J, Morschhäuser J, Bringmann G, Schirmeister T
• Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children.
  Journal of acquired immune deficiency syndromes (1999) 2011 Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J
• Falcipains and other cysteine proteases of malaria parasites.
  Advances in experimental medicine and biology 2011 Rosenthal PJ
• FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii.
  International journal for parasitology 2010 Cruz LN, Alves E, Leal MT, Juliano MA, Rosenthal PJ, Juliano L, Garcia CR
• Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.
  Bioorganic & medicinal chemistry letters 2010 Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J
• Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy.
  Malaria journal 2010 Gama BE, de Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz Mde F
• Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon.
  Parasitology research 2010 Boyom FF, Ngouana V, Kemgne EA, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ
• Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.
  Antimicrobial agents and chemotherapy 2010 Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ
• Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents.
  Journal of medicinal chemistry 2010 Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA
• Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy.
  Journal of acquired immune deficiency syndromes (1999) 2010 Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV
• Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.
  Bioorganic & medicinal chemistry 2010 Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K
• Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
  Journal of medicinal chemistry 2010 Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, …
• Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren.
  PloS one 2010 Nankabirwa J, Cundill B, Clarke S, Kabatereine N, Rosenthal PJ, Dorsey G, Brooker S, Staedke SG
• Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.
  PLoS neglected tropical diseases 2010 Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y
• Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes.
  Journal of virological methods 2010 Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK
• Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series.
  Journal of medicinal chemistry 2010 Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval …
• Bis-alkylamine quindolone derivatives as new antimalarial leads.
  Bioorganic & medicinal chemistry letters 2010 Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd, Gut J, Rosenthal PJ, Moreira R, Paulo A
• Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria.
  AIDS (London, England) 2010 Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED
• Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.
  PloS one 2010 Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ
• Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity.
  Journal of inorganic biochemistry 2010 Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K
• Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance.
  Malaria journal 2010 Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G
• Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene.
  Malaria journal 2010 Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F, Rosenthal PJ, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M
• Chemical genetics of Plasmodium falciparum.
  Nature 2010 Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El …
• Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export.
  PloS one 2010 Sijwali PS, Rosenthal PJ
• Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.
  Antimicrobial agents and chemotherapy 2010 Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N, Greenhouse B, Ouédraogo JB, Rosenthal PJ
• Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.
  Journal of medicinal chemistry 2010 Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T
• Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids.
  Bioorganic & medicinal chemistry letters 2010 Hans RH, Gut J, Rosenthal PJ, Chibale K
• Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.
  Malaria journal 2010 Gupta V, Dorsey G, Hubbard AE, Rosenthal PJ, Greenhouse B
• In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
  Antimicrobial agents and chemotherapy 2010 Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ
• Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.
  Bioorganic & medicinal chemistry letters 2009 Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K
• Imidazoquines as antimalarial and antipneumocystis agents.
  Journal of medicinal chemistry 2009 Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J, Rosenthal PJ, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P
• Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009 Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G
• Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
  The Journal of infectious diseases 2009 Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ
• Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda.
  Malaria journal 2009 Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D
• Antimalarial activity of azadipeptide nitriles.
  Bioorganic & medicinal chemistry letters 2009 Löser R, Gut J, Rosenthal PJ, Frizler M, Gütschow M, Andrews KT
• Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda.
  Antimicrobial agents and chemotherapy 2009 Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F
• Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility.
  PloS one 2009 Johnson MK, Clark TD, Njama-Meya D, Rosenthal PJ, Parikh S
• On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
  Journal of medicinal chemistry 2009 Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C
• Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.
  Contemporary clinical trials 2009 Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J, Nonalcoholic Steatohepatitis Clinical Research Network …
• Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children.
  Malaria journal 2009 Jensen TP, Bukirwa H, Njama-Meya D, Francis D, Kamya MR, Rosenthal PJ, Dorsey G
• Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
  The Journal of infectious diseases 2009 Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN
• Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.
  Journal of acquired immune deficiency syndromes (1999) 2009 German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT
• Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.
  BMJ (Clinical research ed.) 2009 Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO
• Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
  The Journal of biological chemistry 2009 Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS
• Antiparasitic activities of novel, orally available fumagillin analogs.
  Bioorganic & medicinal chemistry letters 2009 Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang…
• Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda.
  Malaria journal 2009 Mpimbaza A, Staedke SG, Ndeezi G, Byarugaba J, Rosenthal PJ
• Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum.
  PloS one 2009 Pandey KC, Barkan DT, Sali A, Rosenthal PJ
• Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.
  Bioorganic & medicinal chemistry letters 2009 Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F
• Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.
  Bioorganic & medicinal chemistry letters 2009 Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R
• Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.
  PloS one 2009 Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ
• Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial.
  Lancet (London, England) 2009 Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJ
• Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo.
  The American journal of tropical medicine and hygiene 2009 Mobula L, Lilley B, Tshefu AK, Rosenthal PJ
• Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon.
  Journal of ethnopharmacology 2009 Boyom FF, Kemgne EM, Tepongning R, Ngouana V, Mbacham WF, Tsamo E, Zollo PH, Gut J, Rosenthal PJ
• Antimalarial compounds from the stem bark of Vismia laurentii.
  Zeitschrift fur Naturforschung. C, Journal of biosciences 2009 Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, Gut J, Rosenthal PJ, Lobstein A, Tsamo E
• Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance.
  The Journal of infectious diseases 2009 Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G
• Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.
  Journal of medicinal chemistry 2009 Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS
• The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda.
  AIDS research and human retroviruses 2009 Ssewanyana I, Baker CA, Ruel T, Bousheri S, Kamya M, Dorsey G, Rosenthal PJ, Charlebois E, Havlir D, Cao H
• Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid.
  Molecules (Basel, Switzerland) 2008 Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J, Rosenthal PJ, Schirmeister T, Leippe M, Gelhaus C
• Development of protease inhibitors for protozoan infections.
  Current opinion in infectious diseases 2008 McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P
• Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture.
  The Journal of infectious diseases 2008 Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ
• Human genetics and malaria: relevance for the design of clinical trials.
  The Journal of infectious diseases 2008 Parikh S, Rosenthal PJ
• Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities.
  European journal of medicinal chemistry 2008 Dominguez JN, Leon C, Rodrigues J, Gamboa de Dominguez N, Gut J, Rosenthal PJ
• Experimental malaria infection triggers early expansion of natural killer cells.
  Infection and immunity 2008 Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL
• Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda.
  The Journal of infectious diseases 2008 Clark TD, Greenhouse B, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G
• Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.
  PloS one 2008 Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H
• Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda.
  Malaria journal 2008 Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C, Clark TD, Nzarubara B, Njama-Meya D, Mpimbaza A, Rosenthal PJ, Kamya MR, Wabwire-Mangen F, Dorsey G, Talisuna AO
• Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children.
  Malaria journal 2008 Maiteki-Sebuguzi C, Jagannathan P, Yau VM, Clark TD, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR, Rosenthal PJ, Dorsey G, Staedke SG
• HIV RNA suppression among HIV-infected Ugandan children with measles.
  Journal of acquired immune deficiency syndromes (1999) 2008 Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV
• Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity.
  Bioorganic & medicinal chemistry letters 2008 Vale N, Matos J, Gut J, Nogueira F, do Rosário V, Rosenthal PJ, Moreira R, Gomes P
• A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.
  PloS one 2008 Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J, Rosenthal PJ, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D
• Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.
  Bioorganic & medicinal chemistry letters 2008 Verissimo E, Berry N, Gibbons P, Cristiano ML, Rosenthal PJ, Gut J, Ward SA, O'Neill PM
• Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics.
  Trends in parasitology 2008 Dahl EL, Rosenthal PJ
• Artesunate for the treatment of severe falciparum malaria.
  The New England journal of medicine 2008 Rosenthal PJ
• Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.
  Antimicrobial agents and chemotherapy 2008 Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M, Dorsey G, Rosenthal PJ, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA
• High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008 Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G
• Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides.
  Chemical & pharmaceutical bulletin 2008 Ngouamegne ET, Fongang RS, Ngouela S, Boyom FF, Rohmer M, Tsamo E, Gut J, Rosenthal PJ
• Plasmodium food vacuole plasmepsins are activated by falcipains.
  The Journal of biological chemistry 2008 Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE
• Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda.
  The Journal of infectious diseases 2008 Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G
• Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum.
  Chemical & pharmaceutical bulletin 2008 Ndjakou Lenta B, Devkota KP, Ngouela S, Fekam Boyom F, Naz Q, Choudhary MI, Tsamo E, Rosenthal PJ, Sewald N
• Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.
  Bioorganic & medicinal chemistry letters 2008 Lavrado J, Paulo A, Gut J, Rosenthal PJ, Moreira R
• Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial.
  Pediatrics 2008 Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J
• HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda.
  Journal of acquired immune deficiency syndromes (1999) 2007 Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois ED, Havlir D, Rosenthal PJ, Dorsey G
• Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones.
  Bioorganic & medicinal chemistry letters 2007 Vale N, Collins MS, Gut J, Ferraz R, Rosenthal PJ, Cushion MT, Moreira R, Gomes P
• Pattern of malaria-specific T-cell responses in a cohort of Ugandan children.
  Journal of tropical pediatrics 2007 Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H
• Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Séré Y, Rosenthal PJ, Ouédraogo JB
• Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues.
  Bioorganic & medicinal chemistry letters 2007 Biot C, Pradines B, Sergeant MH, Gut J, Rosenthal PJ, Chibale K
• Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children.
  AIDS (London, England) 2007 Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G
• World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.
  Malaria journal 2007 Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ
• Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.
  Antimicrobial agents and chemotherapy 2007 Dahl EL, Rosenthal PJ
• Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides.
  ChemMedChem 2007 Schulz F, Gelhaus C, Degel B, Vicik R, Heppner S, Breuning A, Leippe M, Gut J, Rosenthal PJ, Schirmeister T
• Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials.
  Antimicrobial agents and chemotherapy 2007 Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G
• Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole.
  The Journal of biological chemistry 2007 Subramanian S, Sijwali PS, Rosenthal PJ
• Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.
  Antimicrobial agents and chemotherapy 2007 Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ
• Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda.
  The American journal of tropical medicine and hygiene 2007 Hopkins H, Kambale W, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ
• Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial.
  JAMA 2007 Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ
• Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
  PLoS clinical trials 2007 Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G
• The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
  Structure (London, England : 1993) 2007 Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH
• A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2.
  Protein engineering, design & selection : PEDS 2007 Singh A, Walker KJ, Sijwali PS, Lau AL, Rosenthal PJ
• Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT
• Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
  Clinical pharmacology and therapeutics 2007 Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL
• Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae).
  Chemical & pharmaceutical bulletin 2007 Ndjakou Lenta B, Ngouela S, Fekam Boyom F, Tantangmo F, Feuya Tchouya GR, Tsamo E, Gut J, Rosenthal PJ, Donald Connolly J
• Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial.
  Lancet (London, England) 2007 Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB
• Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials.
  European journal of medicinal chemistry 2007 León C, Rodrigues J, Gamboa de Domínguez N, Charris J, Gut J, Rosenthal PJ, Domínguez JN
• The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005.
  Malaria journal 2006 Collins WJ, Greenhouse B, Rosenthal PJ, Dorsey G
• Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion.
  PLoS pathogens 2006 Pandey KC, Singh N, Arastu-Kapur S, Bogyo M, Rosenthal PJ
• Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections.
  The American journal of tropical medicine and hygiene 2006 Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G
• Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.
  Bioorganic & medicinal chemistry 2006 Chipeleme A, Gut J, Rosenthal PJ, Chibale K
• Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members.
  The American journal of tropical medicine and hygiene 2006 Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G
• Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.
  Antimicrobial agents and chemotherapy 2006 Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ
• False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria.
  Journal of clinical microbiology 2006 Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois ED
• Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH
• Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum.
  Molecular and biochemical parasitology 2006 Sijwali PS, Koo J, Singh N, Rosenthal PJ
• Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.
  The American journal of tropical medicine and hygiene 2006 Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ
• Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin.
  Antimicrobial agents and chemotherapy 2006 Parikh S, Liu J, Sijwali P, Gut J, Goldberg DE, Rosenthal PJ
• Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.
  Tropical medicine & international health : TM & IH 2006 Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G
• Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda.
  PLoS clinical trials 2006 Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke SG
• Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum.
  Bioorganic & medicinal chemistry letters 2006 Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ
• Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.
  Bioorganic & medicinal chemistry 2006 Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K
• Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.
  Antimicrobial agents and chemotherapy 2006 Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G
• Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda.
  The American journal of tropical medicine and hygiene 2006 Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ
• Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
  The Journal of infectious diseases 2006 Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G
• Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.
  Journal of medicinal chemistry 2006 Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M
• Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.
  The Journal of infectious diseases 2006 Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G
• CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria.
  The American journal of tropical medicine and hygiene 2006 Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P, Rosenthal PJ, Cao H, Dorsey G
• Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.
  Phytochemistry 2005 Ngouela S, Lenta BN, Noungoue DT, Ngoupayo J, Boyom FF, Tsamo E, Gut J, Rosenthal PJ, Connolly JD
• Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'.
  Experimental parasitology 2005 Singh N, Sijwali PS, Pandey KC, Rosenthal PJ
• Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
  The Journal of infectious diseases 2005 Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D
• Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.
  The American journal of tropical medicine and hygiene 2005 Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ
• Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy.
  The American journal of tropical medicine and hygiene 2005 Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G
• Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.
  PLoS medicine 2005 Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G
• Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors.
  Antimicrobial agents and chemotherapy 2005 Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ
• The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ
• Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
  Journal of medicinal chemistry 2005 Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ
• Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.
  Bioorganic & medicinal chemistry 2005 Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K
• Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.
  The American journal of tropical medicine and hygiene 2005 Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F
• Synthesis and antimalarial activity of sulfonamide chalcone derivatives.
  Farmaco (Societa chimica italiana : 1989) 2005 Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ
• Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum.
  Molecular and biochemical parasitology 2005 Dahl EL, Rosenthal PJ
• Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
  Bioorganic & medicinal chemistry letters 2005 Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK
• Cysteine proteases of malaria parasites.
  International journal for parasitology 2004 Rosenthal PJ
• Host polymorphisms and the incidence of malaria in Ugandan children.
  The American journal of tropical medicine and hygiene 2004 Parikh S, Dorsey G, Rosenthal PJ
• Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.
  The American journal of tropical medicine and hygiene 2004 Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ
• Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial.
  Lancet (London, England) 2004 Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ
• Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors.
  Parasitology research 2004 Na BK, Kim TS, Rosenthal PJ, Lee JK, Kong Y
• Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes.
  Antimicrobial agents and chemotherapy 2004 Go ML, Liu M, Wilairat P, Rosenthal PJ, Saliba KJ, Kirk K
• Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.
  Bioorganic & medicinal chemistry letters 2004 Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K
• Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport.
  The Journal of biological chemistry 2004 Singh A, Rosenthal PJ
• Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
  Journal of medicinal chemistry 2004 Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K
• Antimalarial drug discovery: efficacy models for compound screening.
  Nature reviews. Drug discovery 2004 Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S
• Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ
• Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children.
  The Journal of infectious diseases 2004 Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G
• Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda.
  Tropical medicine & international health : TM & IH 2004 Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ
• Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Sijwali PS, Rosenthal PJ
• Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax.
  The Biochemical journal 2004 Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ
• 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel.
  Antimicrobial agents and chemotherapy 2003 Locher CP, Ruben PC, Gut J, Rosenthal PJ
• Antimalarial activities of novel synthetic cysteine protease inhibitors.
  Antimicrobial agents and chemotherapy 2003 Lee BJ, Singh A, Chiang P, Kemp SJ, Goldman EA, Weinhouse MI, Vlasuk GP, Rosenthal PJ
• Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants.
  Phytochemistry 2003 Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J, Rosenthal PJ
• Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.
  The Journal of biological chemistry 2003 Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ
• Antimalarial drug discovery: old and new approaches.
  The Journal of experimental biology 2003 Rosenthal PJ
• Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.
  Bioorganic & medicinal chemistry letters 2003 Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K
• Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria.
  The Journal of infectious diseases 2003 Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ
• Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children.
  The American journal of tropical medicine and hygiene 2003 Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G
• Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria.
  The American journal of tropical medicine and hygiene 2003 Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ, Dorsey G
• Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines.
  Bioorganic & medicinal chemistry 2003 Batra S, Sabnis YA, Rosenthal PJ, Avery MA
• Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies.
  Protein science : a publication of the Protein Society 2003 Sabnis YA, Desai PV, Rosenthal PJ, Avery MA
• Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
  The American journal of tropical medicine and hygiene 2003 Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR
• Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.
  The American journal of tropical medicine and hygiene 2003 Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G
• Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.
  Antimicrobial agents and chemotherapy 2003 Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ
• Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.
  Lancet (London, England) 2002 Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ
• Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.
  The Biochemical journal 2002 Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ
• Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases.
  Molecular and biochemical parasitology 2002 Shenai BR, Rosenthal PJ
• Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen.
  Bioorganic & medicinal chemistry letters 2002 Park BS, Kim DY, Rosenthal PJ, Huh SC, Lee BJ, Park E-, Kim SM, Kim JE, Kim MH, Huh TL, Choi YJ, Suh KH, Choi WS, Lee SE
• Stage-specific antimalarial activity of cysteine protease inhibitors.
  Biological chemistry 2002 Shenai BR, Semenov AV, Rosenthal PJ
• Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors.
  Journal of biomolecular structure & dynamics 2002 Sabnis Y, Rosenthal PJ, Desai P, Avery MA
• Hydrolysis of erythrocyte proteins by proteases of malaria parasites.
  Current opinion in hematology 2002 Rosenthal PJ
• Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain.
  The Journal of biological chemistry 2002 Sijwali PS, Shenai BR, Rosenthal PJ
• Cysteine proteases of malaria parasites: targets for chemotherapy.
  Current pharmaceutical design 2002 Rosenthal PJ, Sijwali PS, Singh A, Shenai BR
• Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3.
  The Biochemical journal 2001 Sijwali PS, Shenai BR, Gut J, Singh A, Rosenthal PJ
• The impact of whole genome sequence data on drug discovery--a malaria case study.
  Molecular medicine (Cambridge, Mass.) 2001 Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE
• Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial.
  Lancet (London, England) 2001 Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ
• Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2.
  Protein expression and purification 2001 Sijwali PS, Brinen LS, Rosenthal PJ
• Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.
  The Journal of infectious diseases 2001 Dorsey G, Kamya MR, Singh A, Rosenthal PJ
• Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum.
  Antimicrobial agents and chemotherapy 2001 Singh A, Rosenthal PJ
• The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
  Transactions of the Royal Society of Tropical Medicine and Hygiene 2001 Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Babirye JN, Staedke SG, Rosenthal PJ
• Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum.
  The Journal of biological chemistry 2000 Shenai BR, Sijwali PS, Singh A, Rosenthal PJ
• Difficulties in the prevention, diagnosis, and treatment of imported malaria.
  Archives of internal medicine 2000 Dorsey G, Gandhi M, Oyugi JH, Rosenthal PJ
• Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.
  The American journal of tropical medicine and hygiene 2000 Dorsey G, Kamya MR, Ndeezi G, Babirye JN, Phares CR, Olson JE, Katabira ET, Rosenthal PJ
• Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors.
  Bioorganic & medicinal chemistry 1999 Olson JE, Lee GK, Semenov A, Rosenthal PJ
• Proteases of protozoan parasites.
  Advances in parasitology 1999 Rosenthal PJ
• Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites.
  Molecular and biochemical parasitology 1998 Rosenthal PJ, Semenov A, Ploplis VA, Plow EF
• Antimalarial synergy of cysteine and aspartic protease inhibitors.
  Antimicrobial agents and chemotherapy 1998 Semenov A, Olson JE, Rosenthal PJ
• Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases.
  Molecular and biochemical parasitology 1998 Gor DO, Li AC, Wiser MF, Rosenthal PJ
• Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum.
  The Journal of infectious diseases 1998 Gor DO, Rosenthal PJ
• Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei.
  Vaccine 1998 Gor DO, Li AC, Rosenthal PJ
• Proteases of malaria parasites: new targets for chemotherapy.
  Emerging infectious diseases 1998 Rosenthal PJ
• Hemoglobin catabolism and iron utilization by malaria parasites.
  Molecular and biochemical parasitology 1996 Rosenthal PJ, Meshnick SR
• Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.
  Antimicrobial agents and chemotherapy 1996 Rosenthal PJ, Olson JE, Lee GK, Palmer JT, Klaus JL, Rasnick D
• Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites.
  Blood 1996 Gamboa de Domínguez ND, Rosenthal PJ
• Conservation of key amino acids among the cysteine proteinases of multiple malarial species.
  Molecular and biochemical parasitology 1996 Rosenthal PJ
• Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase.
  Infection and immunity 1995 Salas F, Fichmann J, Lee GK, Scott MD, Rosenthal PJ
• Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
  Experimental parasitology 1995 Rosenthal PJ
• Anti-malarial drug development using models of enzyme structure.
  Chemistry & biology 1994 Li Z, Chen X, Davidson E, Zwang O, Mendis C, Ring CS, Roush WR, Fegley G, Li R, Rosenthal PJ
• Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases.
  Journal of molecular biology 1994 Rosenthal PJ, Ring CS, Chen X, Cohen FE
• A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue.
  Biochimica et biophysica acta 1993 Rosenthal PJ
• Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
  The Journal of clinical investigation 1993 Rosenthal PJ, Lee GK, Smith RE
• Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum.
  Molecular and biochemical parasitology 1992 Rosenthal PJ, Nelson RG
• Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
  The Journal of clinical investigation 1991 Rosenthal PJ, Wollish WS, Palmer JT, Rasnick D
• Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development.
  Molecular and biochemical parasitology 1989 Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH
• A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
  The Journal of clinical investigation 1988 Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH
• Rectal leishmaniasis in a patient with acquired immunodeficiency syndrome.
  The American journal of medicine 1988 Rosenthal PJ, Chaisson RE, Hadley WK, Leech JH